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Genetic polymorphisms of GSTM1,GSTP1 and GSTT1 genes and lung cancer susceptibility in the Bangladeshi population

Asian Pacific Journal of Tropical Biomedicine 2014年第12期4卷 982-989页

作者： Mir muhammad Nasir Uddin Maizbha Uddin Ahmed Mohammad Safiqul Islam Mohammad Siddiqul Islam muhammad shahdaat bin sayeed Yearul Kabir Abul Hasnat Department of Clinical Pharmacy and Pharmacology Faculty of PharmacyUniversity of Dhaka Department of Pharmacy Noakhali Science and Technology University Department of Biochemistry and Molecular Biology University of Dhaka

Objective:To verify possible associations between polymorphisms of glutathione S-transferase Mu(GSTM1),glutathione S-transferase θ(GSTT1) and glutathione S-transferase Pi(GSTP1)genes and susceptibility to lung ***:A total of 106 lung cancer patients and 116 controls were enrolled in a case-control *** GSTM1 and GSTT1 were analyzed using PCR while GSTP1 was analyzed using PCR-restriction fragment length *** of lung cancer was estimated as odds ratio at 95%confidence interval using unconditional logistic regression models adjusting for age,sex,and tobacco ***:GSTM1 null and GSTT1 null genotypes did not show a significant risk for developing lung cancer.A significandy elevated lung cancer risk was associated with GSTP1 heterozygous,mutant and combined heterozygous+mutant variants of *** classified by tobacco consumption status,no association with risk of lung cancer was found in case of tobacco smokers and nonsmokers carrying null and present genotypes of GSTM1 and GSTTL There is a three-fold(approximately) increase in the risk of lung cancer in case of both heterozygous(AG) and heterozygous+mutant homozygous(AG+GG) genotypes whereas there is an eightfold increase in risk of lung cancer in cases of GG with respect to AA genotype in ***:Carrying the GSTM1 and GSTT1 null genotype is not a risk factor for lung cancer and GSTP1Ile105 Val is associated with elevated risk of lung cancer.

关键词： Lung cancer Glutathione S-transferase Genetic polymorphism Smoking

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