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Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver

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Journal of Molecular Cell Biology 2016年第2期8卷 129-143页

作者： Pierre Theurey Emily Tubbs Guillaume Vial Julien Jacquemetton Nadia Bendridi Marie-Agnes Chauvin muhammad rizwan alam Muriel Le Romancer Hubert Vidal Jennifer Rieusset INSERM UMR-1060 CarMeN LaboratoryLyon 1 UniversityINRA U1235INSA of LyonRockefeller and Charles Merieux Lyon-Sud medical UniversitiesF-69003 LyonFrance Cancer Research Center of Lyon Centre Leon BerardUMR INSERM 1052CNRS 5286F-69373 LyonFrance Hospices Civils de Lyon Lyon-Sud HospitalEndocrinologyDiabetology and Nutrition ServiceF-69310 Pierre BeniteFrance

Mitochondria-associated endoplasmic reticulum membranes(MAM)play a key role in mitochondrial dynamics and function and in hepatic insulin *** mitochondria are important regulators of energy metabolism,the nutritional regulation of MAM in the liver and its role in the adaptation of mitochondria physiology to nutrient availability are *** this study,we found that the fasted to postprandial transition reduced the number of endoplasmic reticulum-mitochondria contact points in mouse *** of potential hormonal/metabolic signals revealed glucose as the main nutritional regulator of hepatic MAM integrity both in vitro and in *** reduced organelle interactions through the pentose phosphate-protein phosphatase 2A(PP-PP2A)pathway,induced mitochondria fission,and impaired *** MAM reduction counteracted glucose-induced mitochondrial ***,disruption of MAM integrity mimicked effects of glucose on mitochondria dynamics and *** glucose-sensing system is deficient in the liver of insulin-resistant ob/ob and cyclophilin D-KO mice,both characterized by chronic disruption of MAM integrity,mitochondrial fission,and altered mitochondrial *** data indicate that MAM contribute to the hepatic glucose-sensing system,allowing regulation of mitochondria dynamics and function during nutritional *** disruption of MAM may participate in hepatic mitochondrial dysfunction associated with insulin resistance.

关键词： MAM mitochondria dynamics hepatocytes glucose sensing pentose phosphate pathway PP2A

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Nano-Enhanced Dairy Scum Biodiesel Blends:Unleashing the Power of Aluminium Oxide for Sustainable and Efficient Engine Performance

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Journal of Thermal Science 2025年第1期 283-302页

作者： Veeranna MODI Prasad B.RAMPURE Sunil Kumar SHETTY Madeva NAGARAL Channa Keshava NAIK N Johar MGM muhammad Irsyad ABDULLAH Abdullah I.AL-MANSOUR Shamshad alam KLE College of Engineering and Technology ChikodiVisvesvaraya Technological University Nitte (Deemed to be University) NMAM Institute of Technology (NMAMIT)Department of Mechanical Engineering Aircraft Research and Design Centre HAL Department of Mechanical Engineering BGS College of Engineering and TechnologyBengaluruAffiliated to Visvesvaraya Technological University Management and Science University Department of Civil Engineering College of EngineeringKing Saud University

This study investigates the effect of aluminium oxide nanoparticlesaddition to biodiesel blends made from dairy milk scum on performance and combustion characteristics of the diesel *** dispersion of Al2O3nanoparticles in B20 blends at different concentrations was done with the help of *** number of blends were prepared for the *** Machine learning algorithms(Random Forest（RF）and CatBoost) was used for the *** results show that in comparison to biodiesel blends without nanoparticles,the kinematic viscosity and density is higher for fuel blends with *** these Fuel blends have higher calorific *** blends exhibited reduced Brake Specific Fuel Consumption（BSFC） of2.85% than the blends without nano particles(Dairy Scum Methyl Ester Biodiesel 20%+Neat Diesel 80%（in volume）,DSMEB20),57.14% less CO,40.8% less hydrocarbon,and increased NOxemissions compared to conventional diesel,contributing to the development of environmentally friendly and renewable biofuel blends with *** B20NP30 is the optimal blend for performance and emission *** study concludes with findings on enhanced Brake Thermal Efficiency（BTE） of 26.29% in 3×10-5（in volume） Al2O3nanoparticle-blended DSME B20 and other DSME B20 fuel blends,emphasizing the importance of optimal nanoparticle *** correlation matrix shows how engine load,efficiency measures（BTE,BSFC）,and emissions（CO,CO2,NOx,Smoke） are connected in complex *** results help us understand the complicated dynamics of engine performance and emission characteristics ***'s diagram for BTE and BSFC shows that CatBoost-based BTE models perform superior to RF-based models during the training as well as testing *** results were obtained for CO and CO2emission results.

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Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 193-208页

作者： K.muhammad M.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MATHEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

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Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： muhammad Junaid Eun Jeong Lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

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Effect of fineness of ash on pozzolanic properties and acid resistance of sugarcane bagasse ash replaced cement mortars

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Frontiers of Structural and Civil Engineering 2022年第10期16卷 1287-1300页

作者： Shan E ALI rizwan AZAM muhammad rizwan RIAZ Mohamed ZAWAM Department of Civil Engineering University of Engineering&Technology LahoreLahore 54890Pakistan Faculty of Engineering Cairo UniversityCairo 12613Egypt

This paper addresses the potential use of Sugar Cane Bagasse Ash(SCBA)as a pozzolanic material for partial cement replacement in concrete *** mortars containing SCBA having five different particle size distributions at a replacement rate of 20%by weight were used to study the chemical and physical pozzolanic properties of *** durability of SCBA replaced mortars was also *** with 0%retained on sieve No.325 was used to replace 20%by weight of cement and create mortar specimens that were subjected to sulfuric acid attack of varying concentrations(1%–3%by weight of water).The tested samples were observed to check visual distortion,mass loss,and compressive strength loss at 1,7,14,28,and 56 d of acidic exposure,and the results were compared to those for the control sample,that was lime water cured,at the same *** SCBA sets were found to meet the requirements for pozzolan class N specified by ASTM C *** containing SCBA with 0%or 15%retention produced better compressive strength than the control mortars after 28 ***,X-ray fluorescence and X-ray diffraction analysis showed that the SCBA had favorable chemical properties for a pozzolanic ***,SCBA replaced samples at all ages showed improved resistance against acidic attack relative to that of the control *** deterioration was seen for 3%concentrated *** study’s findings demonstrated that SCBA with an appropriate fineness could be used as a pozzolanic material,consistently with ASTM C 618.

关键词： durability cement replacement sugarcane bagasse ash fineness of ash pozzolanic properties mortar acid resistance

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Solid Waste Management:A MADM Approach Using Fuzzy Parameterized Possibility Single-Valued Neutrosophic Hypersoft Expert Settings

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 531-553页

作者： Tmader Alballa muhammad Ihsan Atiqe Ur Rahman Noorah Ayed Alsorayea Hamiden Abd El-Wahed Khalifa Department of Mathematics College of SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia 2 Department of Mathematics University of Management and TechnologyLahore54000Pakistan Department of Mathematics College of ScienceQassim UniversityBuraydah51452Saudi Arabia

The dramatic rise in the number of people living in cities has made many environmental and social problems *** search for a productive method for disposing of solid waste is the most notable of these *** scholars have referred to it as a fuzzy multi-attribute or multi-criteria decision-making problem using various fuzzy set-like approaches because of the inclusion of criteria and anticipated *** goal of the current study is to use an innovative methodology to address the expected uncertainties in the problem of solid waste site *** characteristics(or sub-attributes)that decision-makers select and the degree of approximation they accept for various options can both be indicators of these *** tackle these problems,a novel mathematical structure known as the fuzzy parameterized possibility single valued neutrosophic hypersoft expert set(ρˆ-set),which is initially described,is integrated with a modified version of Sanchez’s *** this,an intelligent algorithm is *** steps of the suggested algorithm are explained with an example that explains *** compatibility of solid waste management sites and systems is discussed,and rankings are established along with detailed justifications for their *** study’s strengths lie in its application of fuzzy parameterization and possibility grading to effectively handle the uncertainties embodied in the parameters’nature and alternative approximations,*** uses specific mathematical formulations to compute the fuzzy parameterized degrees and possibility grades that are missing from the prior *** is simpler for the decisionmakers to look at each option separately because the decision is *** the computed results,it is discovered that they are consistent and dependable because of their preferred properties.

关键词： Hypersoft expert set Sanchez’s method decision making optimization solid waste management possibility grade fuzzy parameterization

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De-convolution and De-noising of SAR Based GPS Images Using Hybrid Particle Swarm Optimization

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Chinese Journal of Electronics 2023年第1期32卷 166-176页

作者： rizwan Sadiq muhammad Bilal Qureshi muhammad Mohsin Khan Dept.of Electrical and Electronic Engineering Koc University Dept.of Electrical and Computer Engineering COMSATS University Dept.of Radiology and Biomedical Imaging Yale University Sino-Pak Center for Artificial Intelligence (SPCAI) Pak-Austria Fachhochschule:Institute of Applied Sciences and Technology (PAF-IAST)

Synthetic aperture radar(SAR) imaging is an efficient strategy which exploits the properties of microwaves to capture images. A major concern in SAR imaging is the reconstruction of image from back scattered signals in the presence of noise. The reflected signal consist of more noise than the target signal and it is a challenging problem to reduce the noise in the collected signal for better reconstruction of an image. Current studies mostly focus on filtering techniques for noise removal. This can result in an undesirable point spread function causing extreme smearing effect in the desired image. In order to handle this problem, a computational technique, particle swarm optimization(PSO) is used for de-noising purpose and later the target performance is further improved by an amalgamation of Wiener ***, to improve the de-noising performance we have exploited the singular value decomposition based morphological filtering. To justify the proposed improvements we have simulated the proposed techniques and results are compared with the conventional existing models. The proposed method revealed considerable decrease in mean square error compared to Wiener filter and PSO techniques. Quantitative analysis of image restoration quality are also presented in comparison with Wiener filter and PSO based on the improvement in signal to noise ratio and peak signal to noise ratio.

关键词： Radar remote sensing Wiener filters Filtering Statistical analysis Radar polarimetry Particle swarm optimization Synthetic aperture radar

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Natural convection of CuO–water nanofluid filled in a partially heated corrugated cavity:KKL model approach

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Communications in Theoretical Physics 2020年第8期72卷 27-42页

作者： rizwan Ul Haq muhammad Usman Ebrahem A Algehyne Department of Electrical Engineering Bahria UniversityIslamabadPakistan BIC-ESAT College of EngineeringPeking UniversityBeijing 100871China State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering SciencePeking UniversityBeijing 100871China Department of Mathematics Faculty of SciencesUniversity of TabukP.O.Box 741Tabuk 71491Saudi Arabia

In this article, flow and heat transfer inside a corrugated cavity is analyzed for natural convection with a heated inner obstacle. Thermal performance is analyzed for Cu O–water inside a partially heated domain by defining the constraint along the boundaries. For nanofluid analysis, the Koo and Kleinstreuer Li(KKL) model is implemented to deal with the effective thermal conductivity and viscosity. A heated thin rod is placed inside the corrugated cavity and the bottom portion of the corrugated cavity is partially heated. The dimensionless form of nonlinear partial differential equations are obtained through the compatible transformation along with the boundary constraint. The finite element method is executed to acquire the numerical solution of the obtained dimensional system. Streamlines, isotherms and heat transfers are analyzed for the flow field and temperature distribution. The Nusselt number is calculated at the surface of the partially heated domain for various numerical values of emerging parameters by considering the inner obstacle at cold, adiabatic and heated conditions. The computational simulation was performed by introducing various numerical values of emerging parameters. Important and significant results have been attained for temperature and velocities(in both x-and y-directions) at the vertically and horizontally mean positions of the corrugated duct.

关键词： heat transfer nanofluid finite element method KKL corrugated cavity

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High sensitive pressure sensors based on multiple coating technique

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Chinese Physics B 2020年第2期29卷 442-445页

作者： rizwan Zahoor Chang Liu muhammad rizwan Anwar Fu-Yan Lin An-Qi Hu Xia Guo School of Electronic Engineering State Key Laboratory for Information Photonics and Optical CommunicationsBeijing University of Posts and TelecommunicationsBeijing 100876China

A multi-coating technique of reduced graphene oxide(RGO)was proposed to increase the sensitivity of paper-based pressure *** maximum sensitivity of 17.6 kPa^-1 under the 1.4 kPa was *** electrical sensing mechanism is attributed to the percolation *** paper pressure sensors were applied to monitor the motor vibration,which indicates the potential of mechanical flaw detection by analyzing the waveform difference.

关键词： paper sensor reduced graphene oxide sensitivity

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Coronavirus: A “Mild” Virus Turned Deadly Infection

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Computers, Materials & Continua 2021年第5期67卷 2631-2646页

作者： rizwan Ali Naqvi muhammad Faheem Mushtaq Natash Ali Mian muhammad Adnan Khan Atta-ur-Rahman muhammad Ali Yousaf muhammad Umair rizwan Majeed Department of Unmanned Vehicle Engineering Sejong UniversitySeoul05006Korea Department of Information Technology Khwaja Fareed University of Engineering and Information TechnologyRahim Yar Khan64200Pakistan School of Computer and Information Technology Beaconhouse National UniversityTarogilLahore53700Pakistan Riphah School of Computing&Innovation Faculty of ComputingRiphah International UniversityLahore CampusLahore54000Pakistan Department of Computer Science College of Computer Science and Information TechnologyImam Abdulrahman Bin Faisal UniversityDammam31441Saudi Arabia Faculty of Information Technology University of Central PunjabLahore54782Pakistan Directorate of IT The Islamia University of BahawalpurBahawalpur63100Pakistan

Coronaviruses are a family of viruses that can be transmitted from one person to *** strains have only been mild viruses,but the current form,known as coronavirus disease 2019(COVID-19),has become a deadly *** outbreak originated in Wuhan,China,and has since spread *** symptoms of COVID-19 include a dry cough,sore throat,fever,and nasal *** drugs,pathogen–host interaction,and 2 weeks of isolation have been recommended for the treatment of the *** operating procedures,such as the use of face masks,hand sanitizer,handwashing with soap,and social distancing,are also ***,travel bans for cities,states,and countries have been put in place,along with lockdowns to control the *** restrictions,mask use,sanitizer or soap use,and avoidance of touching the face and nose have produced encouraging results,whereas the effectiveness of antibiotics has not been *** results of isolation for the recovery of infected people have also been *** bans and lockdowns have caused a slump in economies,and unemployment has risen sharply,resulting in an increase in mental health cases *** date,vaccines have been developed and are in use in certain countries,but following standard operating procedures remain *** countries following the guidelines can eradicate this *** Zealand was the rst country to eliminate the virus from their territory.

关键词： Coronavirus severe acute respiratory syndrome middle east respiratory syndrome world health organization

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