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Survival and outcomes for co-infection of chronic hepatitis C with and without cirrhosis and COVID-19: A multicenter retrospective study

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World Journal of Gastroenterology 2021年第42期27卷 7362-7375页

作者： Shimaa Afify Basem Eysa Fatma abdel Hamid Omnia M Abo-Elazm Mohamed A Edris Rabab Maher Ahmed abdelhalim muhammad mostafa abdel ghaffar Dalia A Omran Hend Ibrahim Shousha Department of Gastroenterology National Hepatology and Tropical Medicine Research InstituteCairo 20222Egypt Department of Endemic Medicine Faculty of MedicineFayoum UniversityEl-Fayoum 13524Egypt Department of Biostatistics and Cancer Epidemiology National Cancer InstituteCairo 20222Egypt Department of Gastroenterology Students HospitalCairo UniversityGiza 12111Egypt The General Organization for Teaching Hospitals and Institutes Cairo 11562Egypt Department of Endemic Medicine Faculty of MedicineCairo UniversityCairo 11562Egypt

BACKGROUND Chronic liver disease,particularly cirrhosis,is associated with worse outcomes in patients infected with coronavirus disease 2019(COVID-19).AIM To assess outcomes of COVID-19 infection among patients with pre-existing hepatitis C with or without liver *** This multicenter,retrospective cohort study included all cases of confirmed coinfection of severe acute respiratory syndrome coronavirus 2 and chronic hepatitis C with or without liver cirrhosis who were admitted to six hospitals(Al-Sahel Hospital,Al-Matareya Hospital,Al-Ahrar Hospital,Ahmed Maher Teaching Hospital,Al-Gomhoreya Hospital,and the National Hepatology and Tropical Medicine Research Institute)affiliated with the General Organization for Teaching Hospitals and Institutes in *** were recruited from May 1,2020,to July 31,***,laboratory,imaging features,and outcomes were *** regression analysis was performed to detect factors affecting *** This retrospective cohort study included 125 patients with chronic hepatitis C and COVID-19 co-infection,of which 64(51.20%)had liver cirrhosis and 40(32.00%)***,cough,dyspnea,and fatigue were the most frequent symptoms in patients with liver ***,sore throat,fatigue,myalgia,and diarrhea were significantly more common in patients with liver cirrhosis than in noncirrhotic *** was no difference between patients with and without cirrhosis regarding *** patients(23.40%)with liver cirrhosis presented with hepatic *** with liver cirrhosis were more likely than non-cirrhotic patients to have combined ground-glass opacities and consolidations in CT chest scans:28(43.75%)vs 4(6.55%),respectively(P value<0.001).These patients also were more likely to have severe COVID-19 infection,compared to patients without liver cirrhosis:29(45.31%)vs 11(18.04%),respectively(P value<0.003).Mortality was higher in patients with liver cirrhosis,compar

关键词： COVID-19 Egypt Outcome Liver cirrhosis Chronic hepatitis C

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Moisture and Temperature Response of Structural and Lithology based Thermophysical and Energy Saving Traits of Limestone using Experimental and Least-Square Fitting Methods

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Journal of Thermal Science 2021年第2期30卷 551-561页

作者： Farah Anjum muhammad Yasin Naz Abdul ghaffar Shazia Shukrullah Nasser M abdel-Salam Khalid Aref Ibrahim Department of Physics University of AgricultureFaisalabad 38040Pakistan Arriyadh Community College King Saud UniversityArriyadh 11437Saudi Arabia College of Engineering Muzahimiyah BranchKing Saud UniversityRiyadh 11451Saudi Arabia Department of Physics College of Arts and SciencesUniversity of JhangJhang 35200Pakistan

Thermophysical analysis of the crustal rocks is important for heat transfer determination and insulation purposes to save energy in *** the presented work,thermophysical properties of four limestones were investigated in dry and moist state under ambient conditions by using a transient plane source method.A thermal constant analyzer was used to raise the sample temperature and to measure the thermal properties in the temperature range of 300 K to 433 *** conductivity and diffusivity were measured by developing a linear relationship between temperature response of TPS (transient plane source) sensor and dimensionless time function through least-square fitting *** experimental observations and predicted thermal conductivity of samples have shown that in-situ observations are important to determine the thermal properties *** effect of temperature on thermal properties of limestone was defined by considering the chemical composition of the samples and associated heat transfer *** thermal conductivity and diffusivity of limestone decreased while specific heat capacity increased with a rise in *** overall findings indicate that the spinoff of this research is useful in studying the reliance of thermophysical properties of rocks on their structures and lithology.

关键词： limestone thermophysical properties transient plane source(TPS) thermal conductivity

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Hepatitis C genotype 4: The past, present, and future

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World Journal of Hepatology 2015年第28期7卷 2792-2810页

作者： Tawhida Y abdel-ghaffar mostafa M Sira Suzan El Naghi Pediatric Department Ain Shams University Yassin abdel ghaffar Charity Center for Liver Disease and Research Pediatric Hepatology Department National Liver Institute Menofiya University Pediatric Department National Hepatology and Tropical Medicine Research Institute

Hepatitis C virus(HCV) genotype(GT) 4 represents 12%-15%(15-18 million) of total global HCV infection. It is prevalent in Northern and Equatorial Africa and the Middle East, and is also present in some countries in Europe. GT-4(and subtype 4a in particular) dominates the HCV epidemic in Egypt. In underdeveloped countries, risk factors associated with HCV infection may be due to unsafe medical practices or other factors such as familial transmission, mother's HCV status, or illiteracy. HCV prevention and control programs should include health education, increased community awareness towards the disease, controlling infection distribution in healthcare centers, proper sterilization of medical and dental instruments, and ensuring safe supply of blood and blood-products. Response rates to a 48-wk combined pegylated-interferon(PEG-IFN) and ribavirin(RBV) treatment range from 40%-69%, and HCV-GT-4 has been considered better than GT-1 but worse than GT-2 and GT-3 in treatment with PEG-IFN/RBV. However, with the introduction of the HCV-GT-1 effective protease inhibitors boceprevir and telaprevir in 2011, HCV-GT-4 became the "most difficult(GT) to treat". Recently, the direct-acting antivirals(DAAs) with pan- genotypic activities simeprevir, sofosbuvir, and daclatasvir have been recommended in triple regimens with PEG-IFN/RBV for the treatment of HCV-GT-4. An IFN-free regimen will be available for treatment of all genotypes of HCV in the near future. To date, several DAAs have been developed and are currently being evaluated in various combinations in clinical trials. As new regimens and new agents are being approved by the Food and Drug Administration, we can expect the guidelines for HCV treatment to be changed. The availability of shorter, simpler, and more tolerable treatment regimens can reduce the morbidity and mortality associated with HCV infection. With such a large number of therapeutic agents available, we can end up with a range of choices that we can select from

关键词： Hepatitis C virus Genotypes Transmission Pegylated-interferon Ribavirin Direct acting antivirals Hepatitis C virus vaccine

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Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children

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World Journal of Gastroenterology 2014年第16期20卷 4681-4691页

作者： Suzan El Naghi Tawhida Y abdel-ghaffar Hanaa El-Karaksy Elham F abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y abdel-ghaffar Nermin A Ehsan Ahmed M El-Hennawy mostafa M Sira Pediatric Department National Hepatology and Tropical Medicine Research Institute11441 CairoEgypt Yassin abdel ghaffar Charity Center for Liver Disease and Research 2851 CairoEgypt Pediatric Department Ain Shams University11566 CairoEgypt Department of Pediatrics Cairo University Pediatric Hospital11562 CairoEgypt Pediatric Hepatology Department National Liver InstituteMenofiya UniversityShebin El-koom32511 MenofiyaEgypt Biochemistry Department National Liver Institute32511 MenofiyaEgypt Clinical Pathology Department Ain Shams University11566 CairoEgypt Pathology Department National Liver InstituteMenofiya UniversityShebin El-koom32511 MenofiyaEgypt Pathology Department Cairo UniversityFaculty of MedicineKasr El-Aini11562 CairoEgypt

AIM: To investigate the safety and efficacy of a Hansenula-derived PEGylated (polyethylene glycol) interferon (IFN)-alpha-2a (Reiferon Retard) plus ribavirin customized regimen in treatment-naïve and previously treate... 详细信息

关键词： Children Chronic hepatitis C Hansenula polymorpha PEGylated interferon Response rate Ribavirin Treatment

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Investigation of SARS-CoV-2 Main Protease Potential Inhibitory Activities of Some Natural Antiviral Compounds Via Molecular Docking and Dynamics Approaches

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Phyton-International Journal of Experimental Botany 2022年第5期91卷 1089-1104页

作者： Nada M.mostafa muhammad I.Ismail Amr M.El-Araby Dina M.Bahgat Ahmed M.Elissawy Ahmed M.mostafa Omayma A.Eldahshan abdel Nasser B.Singab Department of Pharmacognosy Faculty of PharmacyAin Shams UniversityCairo11566Egypt Department of Pharmaceutical Chemistry Faculty of PharmacyThe British University in EgyptCairo11837Egypt Department of Pharmaceutical Chemistry Faculty of PharmacyAin Shams UniversityCairo11566Egypt Department of Biochemistry Faculty of PharmacyAin Shams UniversityCairo11566Egypt Center for Drug Discovery and Development Research Ain Shams UniversityCairo11566Egypt

Coronaviruses caused an outbreak pandemic disease characterized by a severe acute respiratory distress syndrome leading to the infection of more than 200 million patients and the death of more than 4 million *** primary treatment is either supportive or *** products have an important role in the development of various ***,screening of natural compounds with reported antiviral activities can lead to the discovery of potential inhibitory entities against *** the current study,an in-silico molecular docking experiment was conducted on the effects of some of these natural antiviral phytoconstituents,(e.g.,procyanidin B2,theaflavin,quercetin,ellagic acid,caffeoylquinic acid derivatives,berginin,eudesm-1β,6α,11-triol and arbutin),on the crystal structure of SARS-CoV-2 main protease(PDB ID:6w63)using AutoDock-Vina *** of the docked compounds revealed good binding affinity,with procyanidin B2(–8.6 Kcal/mol)and theaflavin(–8.5 Kcal/mol)showing a better or similar binding score as the ligand(–8.5 Kcal/mol).Molecular dynamics simulations were carried out at 100 ns and revealed that procyanidin B2 forms a more stable complex with SARS-CoV-2 main protease than *** B2,theaflavin,and 4,5-dicaffeoylquinic acid were evaluated for toxicity by ProTox-II webserver and were non-toxic according to the predicted LD50 values and safe on different organs and ***,these phytoconstituents showed good ADME properties and acceptable lipophilicity,as evaluated using *** the tested compounds,procyanidin B2 showed the highest lipophilic *** is worth mentioning that these natural inhibitiors of SARS-CoV-2 main protease are components of green and black tea that can be used as a supporting supplement for COVID patients or as potential nuclei for further drug design and development campaigns.

关键词： Coronavirus natural products SARS-CoV-2 main protease molecular docking molecular dynamics tea

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