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RNF13通过IRE1/XBP-1通路调控内质网应激介导的细胞凋亡

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现代生物医学进展 2016年第5期16卷 801-805页

作者：谷晓峰邓学峰马群风郁苗 muhammad arshad 周林康清华大学生命科学学院北京100084 军事医学科学院解放军307医院胸心外科北京100071 国际伊斯兰大学生物系伊斯兰堡巴基斯坦44000

目的:在研究内质网应激介导的细胞凋亡过程中,我们发现Ring finger protein13(RNF13)具有促进细胞凋亡的功能。我们拟研究沉默RNF13后细胞对Tunicamycin等引起的细胞凋亡的影响,以及RNF13对活性形式的caspase3,XBP1(X-box binding prote... 详细信息

目的:在研究内质网应激介导的细胞凋亡过程中,我们发现Ring finger protein13(RNF13)具有促进细胞凋亡的功能。我们拟研究沉默RNF13后细胞对Tunicamycin等引起的细胞凋亡的影响,以及RNF13对活性形式的caspase3,XBP1(X-box binding protein 1)的剪切以及IRE1(Endoplasmic reticulum to nucleus signaling 1)磷酸化的影响以有助于了解RNF13促进细胞凋亡的信号通路的研究。方法:基因沉默RNF13,利用MTT方法研究RNF13沉默后对细胞增殖的影响,RNF13基因沉默后对XBP1剪切的影响,免疫印迹观察RNF13对IRE1磷酸化的影响。结果:RNF13基因沉默效率在80%以上。RNF13基因沉默后明显抑制细胞凋亡;敲低RNF13的细胞可抵抗衣霉素以及毒胡萝卜素的诱导的细胞凋亡。Caspase-3是细胞凋亡的关键蛋白。敲低RNF13后caspase-3的活性形式明显降低(降低70%,P<0.001)。在加入衣霉素引起内质网应激的情况下,敲除RNF13的细胞XBP1的切割活性明显降低。敲除RNF13的细胞中IREl的磷酸化明显降低(降低90%,P<0.001)。结论:RNF13通过IRE1-XBP1信号通路调节细胞凋亡。

关键词：内质网应激细胞凋亡 RNF13 IRE1 XBP1

硬脂酸改性处理TC4钛合金微弧氧化膜层耐蚀性的研究

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北京化工大学学报（自然科学版） 2020年第1期47卷 67-74页

作者：王伟赵景茂魏世雄赵志杰 muhammad junaid Anjuma Vahdat Zahedi Asl 北京化工大学1.材料科学与工程学院材料科学与工程学院材料电化学过程与技术北京市重点实验室北京100029

在Ti6Al4V合金微弧氧化膜层上采用硬脂酸改性处理实现了陶瓷膜层的疏水化转变,显著提高了钛合金的耐蚀性能。利用接触角测试仪、扫描电子显微镜(SEM)、能谱仪(EDS)和傅里叶变换红外光谱仪(FT-IR)对膜层的润湿性、稳定性、微观结构和化... 详细信息

在Ti6Al4V合金微弧氧化膜层上采用硬脂酸改性处理实现了陶瓷膜层的疏水化转变,显著提高了钛合金的耐蚀性能。利用接触角测试仪、扫描电子显微镜(SEM)、能谱仪(EDS)和傅里叶变换红外光谱仪(FT-IR)对膜层的润湿性、稳定性、微观结构和化学组成进行了分析,并通过动电位极化曲线和电化学阻抗分析了其腐蚀行为。结果表明,改性处理得到的疏水微弧氧化膜层试样能有效修复微弧氧化膜层缺陷,提高钛合金的耐蚀性能,说明硬脂酸改性处理与微弧氧化技术相结合有助于拓宽微弧氧化技术在钛合金上的应用。

关键词： Ti6Al4V合金微弧氧化硬脂酸

An Insight into Different Strategies for Control and Prophylaxis of Fasciolosis:A Review

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Journal of Advances in International Veterinary Research 2022年第1期4卷 5-14页

作者： Hafiz muhammad Rizwan muhammad Sohail Sajid Haider Abbas Sadia Ghazanfer Mamoona arshad Section of Parasitology Department of PathobiologyKBCMA College of Veterinary and Animal SciencesNarowalSub-campus UVASLahorePakistan Department of Parasitology University of Agriculture FaisalabadPakistan Department of Epidemiology and Public Health University of Veterinary and Animal SciencesLahorePakistan

Fasciolosis is one of the important diseases of livestock and has zoonotic *** can cause huge economic losses due to decrease in milk and meat production,decreased feed conversion ratio,and cost of *** and prophylaxis strategies for Fasciola infection are formed based on epidemiological *** control of Fasciola infection can be attained by treating the animals with active *** use of different combinations of anthelmintics with a possible rotation is more effective against immature as well as adult *** of the intermediate host(snail)is vital for the reduction of *** to the rapid growth of snails,the eradication is quite difficult in waterlogged and marshy *** use of different grazing methods and treatment of grazing areas can also help to control fasciolosis.A variety of antigens generated by Fasciola *** been shown to protect against liver fluke *** crude antigens,excretory/secretory,and refined antigens and their combination can be used as prophylactic treatment for the control of *** use of any of the single or combination of these methods can be very effective for the control of fasciolosis.

关键词： Fasciolosis Control Chemotherapy Grazing management Prophylactic treatment

Sentiment Analysis Based on Performance of Linear Support Vector Machine and Multinomial Naïve Bayes Using Movie Reviews with Baseline Techniques

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Journal on Big Data 2023年第1期5卷 1-18页

作者： Mian muhammad Danyal Sarwar Shah Khan Muzammil Khan muhammad Bilal Ghaffar Bilal Khan muhammad arshad Department of Computer Science City University of Science&TechnologyPeshawar25000Pakistan Department of Computer Science and Software Technology University of SwatSwat19200Pakistan Department of Computer Software Engineering University of Engineering&Technology MardanMardan23200Pakistan Department of Computer Science IQRA National UniversitySwat19200Pakistan

Movies are the better source of *** year,a great percentage of movies are *** comment on movies in the form of reviews after watching *** it is difficult to read all of the reviews for a movie,summarizing all of the reviews will help make this decision without wasting time in reading all of the *** mining also known as sentiment analysis is the process of extracting subjective information from textual *** mining involves identifying and extracting the opinions of individuals,which can be positive,neutral,or *** task of opinion mining also called sentiment analysis is performed to understand people’s emotions and attitudes in movie *** reviews are an important source of opinion data because they provide insight into the general public’s opinions about a particular *** summary of all reviews can give a general idea about the *** study compares baseline techniques,Logistic Regression,Random Forest Classifier,Decision Tree,K-Nearest Neighbor,Gradient Boosting Classifier,and Passive Aggressive Classifier with Linear Support Vector Machines and Multinomial Naïve Bayes on the IMDB Dataset of 50K reviews and Sentiment Polarity Dataset Version *** applying these classifiers,in pre-processing both datasets are cleaned,duplicate data is dropped and chat words are treated for better *** the IMDB Dataset of 50K reviews,Linear Support Vector Machines achieve the highest accuracy of 89.48%,and after hyperparameter tuning,the Passive Aggressive Classifier achieves the highest accuracy of 90.27%,while Multinomial Nave Bayes achieves the highest accuracy of 70.69%and 71.04%after hyperparameter tuning on the Sentiment Polarity Dataset Version *** study highlights the importance of sentiment analysis as a tool for understanding the emotions and attitudes in movie reviews and predicts the performance of a movie based on the average sentiment of all the reviews.

关键词： Opinion mining machine learning movie reviews IMDB Dataset of 50K reviews Sentiment Polarity Dataset Version 2.0

Environmental Assessment and Analysis of Chemical Properties of Drinking Water Using Geo-Spatial Technologies: Examples from Lahore Metropolitan

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Advances in Remote Sensing 2018年第3期7卷 259-275页

作者： Ali Imam Mirza Ali Iqtadar Mirza Tabasam Jamal Syed Shehzad Hassan muhammad A. Butt Atif Ali Hafsa Batool Rashid Mahmood Attia Naz Azam Sohail Imran Saddique Kaukab Sana Alvi Javed Ahmad Safeer Ali Muneeb Aamir Azeem Akhtar arshad Javed Department of Geography GC University Lahore Pakistan Remote Sensing Group Department of Space Science University of the Punjab Lahore Pakistan

The contamination of drinking water in Pakistan is a serious threat to its citizens. Urbanization leads to an increased demand of drinking water supply that leads to excessive drawdown that further causes lowering of water table. The current WASA (Water and Sanitation Authority) supply network does not fulfill the demand of a growing metropolitan city of Lahore. The drawdown of Lahore is absolutely reliant on Water and Sanitation Authority (WASA) water supply network that causes numerous problems due to inappropriate management of groundwater capital and increased urbanization. This research investigates groundwater qualities: Alkalinity, Arsenic, Calcium, chloride, Total Hardness, Magnesium, Nitrate, pH and Total Dissolved solids using geographic information system (GIS). Residents of high concentrated towns, like Samnabad Town, Allama Iqbal Town, Gulberg, Data Ganj Bakhsh Town, Ravi Town and Wahga town witness cut-down of water supply mainly due to over burden on tube wells. Chemical properties of drinking water show that most of the parameters were within the allowable limits of WHO whereas the pH, and arsenic values are higher than the average. Arsenic is a carcinogenic element which causes cancer and is higher in the drinking water. Finally, this study identifies highly contaminated groundwater zones and makes it convenient to find actual pollutants. Therefore, plans are needed to protect the aquifer.

关键词： Water Contamination Urbanization Geographic Information System (GIS) Chemical Properties Carcinogenic Elements WHO WebGIS RS WASA DNA pH TDS

Construction of Bifunctional Vertical Nanochannels in GOM with Swift Heavy Ion Irradiation for Enhancing the Stability and Nano ltration Performance

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IMP & HIRFL Annual Report 2022年第1期 132-132页

作者： Zhang Zhenhua Liang Zhihao Guo Zaichao Gui Xiaoyu muhammad junaid Zhao Zhuo Ma Jingyi Fang Zhenghui Mo Dan Duan Jinglai Liu Jie Yao Huijun Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000GuangdongChina

Separation and purification technology is becoming increasingly important,especially with the rapid industrial development,which brings huge demands in energy and environment^([1,2]).Nano ltration(NF)membrane technology is gaining more attention on the scale of ion separation and purification([3,4]),particularly,graphene oxide(GO)nanosheets have gained signi cant interest due to their simple fabrication.

关键词： Swift gained Vertical