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Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： muhammad junaid Eun Jeong Lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

Applications of Decision Support System:A Case Study of Solanaceous Vegetables

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Phyton-International Journal of Experimental Botany 2021年第2期90卷 331-352页

作者： muhammad Saqib muhammad Akbar anjum Department of Horticulture Faculty of Agricultural Sciences and TechnologyBahauddin Zakariya UniversityMultan60800Pakistan

Crop simulation models constitute the major proportion in decision support systems.A large number of crop models have been developed for potato and few for tomato and *** the literature,thirty three crop models have been reported to simulate potato,nine for tomato and six for *** of these models dealt with the climate change scenario and others with the crop management practices such as sowing time,irrigation,nitrogen,and insect-pests *** most evaluated and applied models for potato include;SUBSTOR,and LINTUL-Potato,whereas CROPGRO-tomato model is the most tested and applied for *** AQUACROP is the most widely used model to simulate the water *** CROPGRO model has been tested for elevated temperatures and CO_(2) under greenhouse conditions for *** tomato and peppers,almost similar models have been applied for field conditions as well as under greenhouse environments with some *** dynamics has been widely tested by employing the EU-Rotate-N model for tomato and *** studies dealing with changing climate conditions are rare in potato and are not found for tomato and *** modify potato,tomato and peppers models for climate impact studies,it is required that they are(a)calibrated and evaluated with new cultivars under various agro-environmental conditions and(b)assessed under varying field conditions under changing climates and crop management practices,including temperature increases,water and nutrient management and their *** comprehensive model studies and modifications need a collaborative international effort and a multi-year,large scale field research studies on potato,tomato and peppers.

关键词： Crop growth models management issues simulation modeling Solanaceae

Effect of chromium on growth attributes in sunflower(Helianthus annuus L.)

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Journal of Environmental Sciences 2008年第12期20卷 1475-1480页

作者： FOZIA Andaleeb muhammad anjum Zia muhammad Ashraf ZAFAR Mahmood Khalid National Institute for Biotechnology and Genetic Engineering Department of Chemistry and Biochemistry University of Agriculture Department of Botany University of Agriculture

Heavy metal soil pollution takes place when the metal concentration of soil exceeds natural background level and causes ecological destruction and deterioration of the *** the present study,a pot experiment was conducted to evaluate the effect of chromium-contaminated soil in sunflower(Helianthus annuus L.)growth *** different levels of chromium(Cr)i.e.,20, 40,and 60 mg/kg were applied to three varieties of sunflower(G-3,G-9,and G-59).The results of morphological,chemical,and yield p...

关键词： Helianthus annuus L. soil chromium growth attributes

Graphene Nanosheets Decorated with Copper Oxide Nanoparticles for the Photodegradation of Methylene Blue

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Chemical Research in Chinese Universities 2022年第6期38卷 1518-1525页

作者： Samavia RAFIQ Zulfiqar Ali RAZA muhammad ASLAM muhammad junaid BAKHTIYAR Department of Applied Sciences National Textile UniversityFaisalabad37610Pakistan

Textile industries extensively use colorants,such as methylene blue,and if disposed off untreated,they contaminate the effluent streams,causing a severe impact on the environment and aquatic *** degradation has been found as an inevitable approach to treat ***,we decorated the copper oxide nanoparticles on graphene nanosheets during the reflux *** resultant copper oxide/graphene nanocomposites were analyzed for structural and functional *** was observed that on increasing the copper oxide contents,the z-average size of the resultant nanocomposites *** X-ray diffraction analysis demonstrated the crystalline nature of the *** surface morphology of the copper oxide nanoparticles appeared to be spherical and that of the copper oxide/graphene composite somehow *** infrared analysis indicated successful intercalation of precursors in the *** bandgap of copper oxide/graphene nanocomposites varied in the range of 1.03—1.30 eV,which indicated their effective photocatalytic *** results demonstrated that after 120 min of exposure,the methylene blue removal efficiency reached 94.0%,92.2%,and 89.4%(mass fraction)on the copper oxide/graphene nanocomposite at copper oxide nanoparticles to graphene nanosheets ratios of 1:1,1.5:1,and 2:1(mass ratio),*** photodegradation performance of the prepared nano-catalyst was found satisfactory even after five cycles.

关键词： Copper oxide Graphene nanosheet Methylene blue Photocatalysis

Cobalt and sulfur co-doped nano-size TiO_2 for photodegradation of various dyes and phenol

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Journal of Environmental Sciences 2015年第11期27卷 100-109页

作者： Asima Siddiqa Dilshad Masih Dalaver anjum muhammad Siddiq KAUST Catalysis Center King Abdullah University of Science and Technology (KAUST) National Centre for Physics Quaid-i-Azam University Complex Chemistry Department Quaid-i-Azam University Imaging and Characterization Lab KAUST

Various compositions of cobalt and sulfur co-doped titania nano-photocatalyst are synthesized via sol–gel method. A number of techniques including X-ray diffraction（XRD）, ultraviolet–visible（UV–Vis）, Rutherford backscattering spectrometry（RBS）, thermal gravimetric analysis（TGA）Raman, N2 sorption, electron microscopy are used to examine composition, crystalline phase, morphology, distribution of dopants, surface area and optical properties o synthesized materials. The synthesized materials consisted of quasispherical nanoparticles of anatase phase exhibiting a high surface area and homogeneous distribution o dopants. Cobalt and sulfur co-doped titania demonstrated remarkable structural and optical properties leading to an efficient photocatalytic activity for degradation of dyes and phenol under visible light irradiations. Moreover, the effect of dye concentration catalyst dose and p H on photodegradation behavior of environmental pollutants and recyclability of the catalyst is also examined to optimize the activity of nano-photocatalys and gain a better understanding of the process.

关键词： Photocatalysis Nanoparticles Co-doped Ti O2 Dye degradation Phenol

ROBO-SPOT:Detecting Robocalls by Understanding User Engagement and Connectivity Graph

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Big Data Mining and Analytics 2024年第2期7卷 340-356页

作者： muhammad Ajmal Azad junaid Arshad Farhan Riaz College of Comnputer Science Birmingham City UniversityBirminghamB55JUUK School of Computer Science University of LincolnLincolnLN67TSUK

Robo or unsolicited calls have become a persistent issue in telecommunication networks,posing significant challenges to individuals,businesses,and regulatory *** calls not only trick users into disclosing their private and financial information,but also affect their productivity through unwanted phone ringing.A proactive approach to identify and block such unsolicited calls is essential to protect users and service providers from potential ***,this paper proposes a solution to identify robo-callers in the telephony network utilising a set of novel features to evaluate the trustworthiness of callers in a *** trust score of the callers is then used along with machine learning models to classify them as legitimate or *** use a large anonymized dataset(call detailed records)from a large telecommunication provider containing more than 1 billion records collected over 10 *** have conducted extensive evaluation demonstrating that the proposed approach achieves high accuracy and detection rate whilst minimizing the error ***,the proposed features when used collectively achieve a true-positive rate of around 97%with a false-positive rate of less than 0.01%.

关键词： social network analysis reputation unwanted calls robo-callers telephone network Spam Over Internet Technology(SPIT)

Fruits and Vegetable Diseases Recognition Using Convolutional Neural Networks

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Computers, Materials & Continua 2022年第1期70卷 619-635页

作者： Javaria Amin muhammad Almas anjum muhammad Sharif Seifedine Kadry Yunyoung Nam University of Wah WahCanttPakistan National University of Technology(NUTECH) IJP RoadIslamabadPakistan COMSATS University Islamabad Wah CampusPakistan Faculty of Applied Computing and Technology Noroff University CollegeKristiansandNorway Department of Computer Science and Engineering Soonchunhyang UniversityAsanKorea

As they have nutritional,therapeutic,so values,plants were regarded as important and they’re the main source of humankind’s energy *** pathogens will affect its leaves at a certain time during crop cultivation,leading to substantial harm to crop productivity&economic selling *** the agriculture industry,the identification of fungal diseases plays a vital ***,it requires immense labor,greater planning time,and extensive knowledge of plant *** approaches are developed and tested by different researchers to classify plant disease identification,and that in many cases they have also had important results several ***,the proposed study presents a new framework for the recognition of fruits and vegetable *** work comprises of the two phases wherein the phase-I improved localization model is presented that comprises of the two different types of the deep learning models such asYouOnly Look Once(YOLO)v2 and Open Exchange Neural(ONNX)*** localizationmodel is constructed by the combination of the deep features that are extracted from the ONNX model and features learning has been done through the convolutional-05 layer and transferred as input to the YOLOv2 *** localized images passed as input to classify the different types of plant *** classification model is constructed by ensembling the deep features learning,where features are extracted dimension of 1×1000 from pre-trained Efficientnetb0 model and supplied to next 07 layers of the convolutional neural network such as 01 features input,01 ReLU,01 Batch-normalization,02 *** proposed model classifies the plant input images into associated labels with approximately 95%prediction scores that are far better as compared to current published work in this domain.

关键词： Efficientnetb0 open exchange neural network features learning softmax YOLOv2

Crosstalk of liver immune cells and cell death mechanisms in different murine models of liver injury and its clinical relevance

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Hepatobiliary & Pancreatic Diseases International 2017年第3期16卷 245-256页

作者： Hilal Ahmad Khan muhammad Zishan Ahmad junaid Ali Khan muhammad Imran Arshad Institute of Microbiology University of Agriculture Faisalabad Pakistan Institute of Pharmacy Physiology and Pharmacology University of Agriculture Faisalabad Pakistan Department of Pathology The University of Faisalabad (TUF) Faisalabad Pakistan

BACKGROUND： Liver inflammation or hepatitis is a result of pluripotent interactions of cell death molecules, cytokines, chemokines and the resident immune cells collectively called as microenvironment. The interplay of these inflammatory mediators and switching of immune responses during hepatotoxic, viral, drug-induced and immune cell-mediated hepatitis decide the fate of liver pathology. The present review aimed to describe the mechanisms of liver injury, its relevance to human liver pathology and insights for the future therapeutic *** SOURCES： The data of mouse hepatic models and rele- vant human liver diseases presented in this review are system- atically collected from PubMed, ScienceDirect and the Web of Science databases published in English. RESULTS： The hepatotoxic liver injury in mice induced by the metabolites of CC14, acetaminophen or alcohol represent ne- crotic cell death with activation of cytochrome pathway, for- mation of reactive oxygen species （ROS） and mitochondrial damage. The Fas or TNF-a induced apoptotic liver injury was dependent on activation of caspases, release of cytochrome c and apoptosome formation. The ConA-hepatitis demonstrat- ed the involvement of TRAIL-dependent necrotic/necroptotic cell death with activation of RIPK1/3. The a-GalCer-induced liver injury was mediated by TNF-a. The LPS-induced hepatitis involved TNF-a, Fas/FasL, and perforin/granzyme cell death pathways. The MHV3 or Poly（I：C） induced liver injury was mediated by natural killer cells and TNF-a signaling. The necrotic ischemia-reperfusion liver injury was mediated by hypoxia, ROS, and pro-inflammatory cytokines; however, necroptotic cell death was found in partial hepatectomy. The crucial role of immune ceils and cell death mediators in viral hepatitis （HBV, HCV）, drug-induced liver injury, non-alcohol- ic fatty liver disease and alcoholic liver disease in human were discussed. CONCLUSIONS： The mouse animal models of hepatitis provide a parallel appro

关键词： liver immunobiology hepatitis therapy mode of cell death

From Molecular Pathology of COVID-19 to Nigella Sativum as a Treatment Option:Scientific Based Evidence of Its Myth or Reality

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Chinese Journal of Integrative Medicine 2022年第1期28卷 88-95页

作者： muhammad Atif Farrah Naz junaid Akhtar muhammad Imran Sidrah Saleem Javed Akram muhammad Imran muhammad Ikram Ullah Department of Clinical Laboratory Sciences College of Applied Medical SciencesJouf UniversitySakaka(75471)Saudi Arabia Department of Microbiology Government College UniversityFaisalabad(38000)Pakistan Department of Microbiology University of Health SciencesLahore(54600)Pakistan Department of Allied Health Sciences Sargodha Medical CollegeUniversity of SargodhaSargodha(40100)Pakistan University of Health Sciences Lahore(54600)Pakistan University Institute of Diet and Nutritional Sciences Faculty of Allied Health SciencesThe University of LahoreLahore(54590)Pakistan

COVID-19 virus is a causative agent of viral pandemic in human beings which specifically targets respiratory system of humans and causes viral *** unusual viral pneumonia is rapidly spreading to all parts of the world,currently affecting about 105 million people with 2.3 million *** review described history,genomic characteristics,replication,and pathogenesis of COVID-19 with special emphasis on Nigella sativum(***)as a treatment *** seeds are historically and religiously used over the centuries,both for prevention and treatment of different *** review summarizes the potential role of *** seeds against COVID-19 infection at levels of in silico,cell lines and animal models.

关键词： coronavirus nCoV-19 COVID-19 Nigella sativum review