检索结果-南通市图书馆

Young Yum pill inhibits inflammatory mediators and nuclear factor-kappa B signaling in lipopolysaccharide-stimulated RAW 264.7 macrophages

引用

Journal of Traditional Chinese Medicine 2019年第5期39卷 624-631页

作者： Yin Chengle muhammad jahangir hossen Anfernee Kai-Wing Tse Su Tao Fu Xiuqiong Li Ting Guo Hui Zhu Peili Li Junkui Chou Jiyao Wang Yaping Yu Zhiling Centre for Cancer and Inflammation Research School of Chinese Medicine Hong Kong Baptist UniversityHong KongChina Research and Development Centre for Natural Health Products Hong Kong Baptist University Shenzhen Research Institute and Continuing EducationShenzhen 518057China Centre for Cancer and Inflammation Research School of Chinese MedicineHong Kong Baptist University Hong KongChina

OBJECTIVE: To investigate the effect of Young Yum pill (YYP) on inflammatory mediators in cultured RAW 264.7 cells and elucidate the nuclear factor- kappa B (NF-κB)-related mechanism behind the action. METHODS: YYP was extracted with 95% ethanol Lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages were used to evaluate the effect of YYP on inflammatory mediators. Production of nitric oxide (NO) and prostaglandin E2 (PGE2) were measured by Griess test and enzyme-linked immunosorbent assay, respectively. The levels of genes and proteins involved in the generation of inflammatory mediators were examined using real-time polymerase chain reaction and Western blotting, respectively. RESULTS: YYP dose-dependently suppressed LPS-induced production of NO, PGE2 and tumor necrosis factor-α(TNF-α), and elevation of mRNA and protein levels of inducible NO synthase and cyclooxygenase- 2 in RAW 264.7 macrophages. These observations were associated with decreased NF-κB p65 phosphorylation and nuclear localization, enhanced Akt (protein kinase B) phosphorylation, as well as reduced inhibitor of κB (IκB)α degradation and IκB kinase α/β phosphorylation. CONCLUSION: The present study demonstrated an inhibitory effect of YYP on the NF-κB-regulated inflammatory mediators NO, PGE2 and TNF-α in LPS-stimulated RAW 264.7 macrophages, providing a pharmacological basis for the use of YYP in treating inflammatory disorders.

关键词： Inflammation NF-kappa B Lipopolysaccharides RAW 264.7 cells Macrophages Young Yum pill

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Annual growth of Fagus orientalis is limited by spring drought conditions in Iran’s Golestan Province

引用

Journal of Forestry Research 2024年第1期35卷 128-142页

作者： Khalil Ghorbani jahangir Mohammadi Laleh Rezaei Ghaleh Department of Water Engineering Faculty of Water and Soil EngineeringGorgan University of Agricultural Sciences and Natural ResourcesGorganIran Department of Forestry Gorgan University of Agricultural Sciences and Natural ResourcesGorganIran Department of Water Engineering Faculty of AgricultureUrmia UniversityUrmiaIran

Due to the lack of a uniform and accurate defi-nition of‘drought’,several indicators have been introduced based on different variables and methods,and the efficiency of each of these is determined according to their relationship with drought.The relationship between two drought indices,SPI(standardized precipitation index)and SPEI(standard-ized precipitation-evapotranspiration index)in different sea-sons was investigated using annual rings of 15 tree samples to determine the effect of drought on the growth of oriental beech(Fagus orientalis Lipsky)in the Hyrcanian forests of northern Iran.The different evapotranspiration calcula-tion methods were evaluated on SPEI efficiency based on Hargreaves-Samani,Thornthwaite,and Penman-Monteith methods using the step-by-step M5 decision tree regression method.The results show that SPEI based on the Penman-Monteith in a three-month time scale(spring)had similar temporal changes and a better relationship with annual tree rings(R^(2)=0.81)at a 0.05 significant level.Abrupt change and a decreasing trend in the time series of annual tree rings are similar to the variation in the SPEI based on the Penman-Monteith method.Factors affecting evapotranspiration,temperature,wind speed,and sunshine hours(used in the Penman-Monteith method),increased but precipitation decreased.Using non-linear modeling methods,SPEI based on Penman-Monteith best illustrated climate changes affecting tree growth.

关键词： Climate change Drought index Hyrcanian forests SPEI'Annual growth rings Fagus orientalis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Assistive techniques and their added value for tremor classification in multiple sclerosis

引用

Neural Regeneration Research 2024年第5期19卷 977-978页

作者： Nabin Koirala Abdulnasir hossen Ioannis U.Isaias Jens Volkmann Muthuraman Muthuraman Child Study Center School of MedicineYale UniversityNew HavenCTUSA Department of Electrical&Computer Engineering Sultan Qaboos UniversityAl-KhodMuscatOman Neural Engineering with Signal Analytics and Artificial Intelligence Department of NeurologyUniversity Hospital of WürzburgWürzburgGermany Centro Parkinson e Parkinsonism Azienda Socio Sanitaria Territoriale G.Pini-CTO20126 MilanItaly

Tremor occurs in about half of multiple sclerosis(MS)patients.MS tremor has a broad frequency range of 2.5-7 Hz,with a higher prevalence of postural tremor(44%)compared to intentional tremor(6%)(Alusi et al.,2001).Tremor may affect the upper and lower extremities,head,and trunk,and may even affect the vocal cords in isolated cases of palatal tremor.MS tremor is classically attributed to lesions of the brain stem,cerebellum,or cerebellar peduncles,and tremor intensity has been shown to correlate with the number of lesions or their functional connections.However,recent work has demonstrated that inflammatory damage to the cerebello-thalamic and cortico-thalamic pathways might also play an important role in causing tremor,as it co-occurs with other signs and symptoms of MS such as dysarthria,dysmetria,dysdiadochokinesia,and dystonia(Alusi et al.,2001).

关键词： tremor sclerosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhancing PDF Malware Detection through Logistic Model Trees

引用

Computers, Materials & Continua 2024年第3期78卷 3645-3663页

作者： muhammad Binsawad Department of Information Systems King Abdulaziz UniversityP.O.Box 80217Jeddah21589Saudi Arabia

Malware is an ever-present and dynamic threat to networks and computer systems in cybersecurity,and because of its complexity and evasiveness,it is challenging to identify using traditional signature-based detection approaches.The study article discusses the growing danger to cybersecurity that malware hidden in PDF files poses,highlighting the shortcomings of conventional detection techniques and the difficulties presented by adversarial methodologies.The article presents a new method that improves PDF virus detection by using document analysis and a Logistic Model Tree.Using a dataset from the Canadian Institute for Cybersecurity,a comparative analysis is carried out with well-known machine learning models,such as Credal Decision Tree,Naïve Bayes,Average One Dependency Estimator,Locally Weighted Learning,and Stochastic Gradient Descent.Beyond traditional structural and JavaScript-centric PDF analysis,the research makes a substantial contribution to the area by boosting precision and resilience in malware detection.The use of Logistic Model Tree,a thorough feature selection approach,and increased focus on PDF file attributes all contribute to the efficiency of PDF virus detection.The paper emphasizes Logistic Model Tree’s critical role in tackling increasing cybersecurity threats and proposes a viable answer to practical issues in the sector.The results reveal that the Logistic Model Tree is superior,with improved accuracy of 97.46%when compared to benchmark models,demonstrating its usefulness in addressing the ever-changing threat landscape.

关键词： Malware detection PDF files logistic model tree feature selection cybersecurity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progress in electrocatalytic nitrate reduction for green energy: Catalyst engineering, mechanisms, and techno-economic feasibility

引用

Journal of Energy Chemistry 2024年第8期95卷 380-406页

作者： Hafiz muhammad Adeel Sharif Hafiz muhammad Farooq Khan Sadeeq Ullah Yuwei Wang muhammad Ahmad Bo Yang Changping Li muhammad Bilal Asif Research Center for Eco-Environmental Engineering Dongguan University of Technology College of Chemistry and Engineering Shenzhen University FMH College of Medicine and Dentistry School of Environment and Civil Engineering Research Center for Eco-Environment Engineering Dongguan University of Technology Advanced Membranes and Porous Materials Center (AMPMC) Physical Sciences and Engineering (PSE) King Abdullah University of Science and Technology (KAUST)

Ammonia（NH3） is an irreplaceable chemical that has been widely demanded to keep the sustainable development of modern society.However,its industrial production consumes a huge amount of energy and releases extraordinary greenhouse gases（GHGs）,leading to various environmental issues.Achieving the green production of ammonia is a great challenge,which has been extensively pursued in the last decade.In this review,the most promising strategy,electrochemical nitrate reduction reaction（e-NO3RR）,is comprehensively investigated to give a complete understanding of its development and mechanism and provide guidance for future directions.However,owing to the complex reactions and limited selectivity,a comprehensive understanding of the mechanisms is crucial to further development and commercialization.Moreover,NO3-RR is a promising strategy for simultaneous water treatment and NH3production.A detailed overview of the recent progress in NO3-RR for NH3production with nontransition and transition metal based electrocatalysts is summarized.In addition,critical advanced techniques,future challenges,and prospects are discussed to guide future research on transition metal-based catalysts for commercial NH3synthesis by NO3-reduction.

关键词： Ammonia synthesis Electrolysis Green energy Nitrate reduction Pollution to solution Transition metal catalysts

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

An indicator model for assessing community resilience to the COVID-19 pandemic and its validation: A case study in Hong Kong

引用

Journal of Safety Science and Resilience 2024年第2期5卷 222-234页

作者： Nan Liao muhammad Nawaz Departnent of Geography Faculty Art and Social SciencesSingapore 65166666Singapore

The COVID-19 outbreak had a significant negative impact on the world,and the fifth wave of COVID-19 in Hong Kong brought a considerable shock to Chinese society.There is a growing call for more resilient cities.However,empirical evidence and validation of modeling studies of resilience indicators for urban community responses to the COVID-19 pandemic still need to be provided.In this study,a resilience assessment indicator model comprising 4 subsystems,7 indicators,and 12 variables was developed to assess the resilience of Hong Kong communities in response to COVID-19(i.e.,Resilience Index).Furthermore,this study utilized regression models such as geographically weighted regression(GWR)and multiscale GWR(MGWR)to validate the resilience model proposed in this study at the model and variable levels.In the regression model,the Resilience Index and the individual variables in the resilience model are explanatory variables,and the outcomes of the COVID-19 pandemic(confirmed cases,confirmation rate,discharged cases,discharge rate)are dependent variables.The results showed that:(i)the resilience of Hong Kong communities to the COvID-19 pandemic was not strong in general and showed some clustered spatial distribution characteristics;(i)the validation results at the model level showed that the Resilience Index did not explain the consequences of the COvID-19 pandemic to a high degree;(ii)the validation results at the variable level showed that the MGWR model was the best at identifying the relationships between explanatory variables and the dependent variable;and(iv)compared with the model-level assessment results,the variable-level assessment explained the consequences of the COvID-19 pandemic better than the model level assessment results.The above analysis and the spatial distribution maps of the resilience variables can provide empirically based and targeted insights for policymakers.

关键词： Resilience Community resilience CoVID-19pandemic Resilience assessment indicator model Resilience model validation MGWR

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Consequences of Rényi entropy on the thermal geometries and Hawking evaporation of topological dyonic dilaton black hole

引用

Communications in Theoretical Physics 2024年第2期76卷 102-110页

作者： muhammad Yasir Xia Tiecheng muhammad Usman Shahid Chaudhary Department of Mathematics Shanghai University and Newtouch Center for Mathematics of Shanghai UniversityShanghai200444China Department of Natural Sciences and Humanities University of Engineering and Technology LahoreNew CampusPakistan

The thermodynamics of black holes(BHs)has had a profound impact on theoretical physics,providing insight into the nature of gravity,the quantum structure of spacetime and the fundamental laws governing the Universe.In this study,we investigate thermal geometries and Hawking evaporation of the recently proposed topological dyonic dilaton BH in anti-de Sitter(Ad S)space.We consider Rényi entropy and obtain the relations for pressure,heat capacity and Gibbs free energy and observe that the Rényi parameter and dilaton field play a vital role in the phase transition and stability of the BH.Moreover,we use Weinhold,Ruppeiner and Hendi Panahiyah Eslam Momennia models to evaluate the scalar curvature of the BH and find out that the divergence points of the scalar curvature coincides with the zero of specific heat.Finally,using Stefan–Boltzmann law,we determine that the BH without a dilaton field evaporates far more quickly compared to the dilaton BH in Ad S space.

关键词： topological dyonic dilaton black hole phase transition thermal geometry Hawking evaporation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Depositional and Bio-Sequence Stratigraphic Framework of Late Cretaceous Kawagarh Formation,Kala-Chitta Range,Pakistan:Equivalent of Gurpi Formation(Iran)

引用

Journal of Earth Science 2024年第2期35卷 332-348页

作者： muhammad Awais Bilal Wadood muhammad Ishaq muhammad Bilal Zeeshan Zafar Nasar Khan Aminullah Khan Department of Geology University of SwabiAnbar-SwabiKhyber PakhtunkhwaSwabi23561Pakistan Department of Earth Environmental and Resources SciencesUniversity of Naples FedericoⅡNaples80126Italy State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi’an710069China National Centre of Excellence in Geology University of PeshawarPeshawarKhyber Pakhtunkhwa25130Pakistan Department of Geological Engineering School of Earth Sciences and EngineeringXi’an Shiyou UniversityXi’an610500China Department of Petroleum Geology and Engineering School of Earth ResourcesChina University of GeosciencesWuhan430074China Department of Geology University of MalakandDir Lower18800ChakdaraPakistan Department of Earth and Environmental Sciences KU LeuvenLeuven3001Belgium

The present study is focused on evaluation of deep marine pelagic sediments of Late Cretaceous Kawagarh Formation of Kala-Chitta Range in the context of microfacies analysis,paleoenvironmental interpretation,planktonic foraminiferal biostratigraphy,sequence stratigraphy and diversification of species.A total of thirty three rock samples were collected from the measured section.Three microfacies are interpreted,namely planktonic foraminifera wackestone,planktonic foraminifera mudstone and sandy mudstone indicating low energy depositional environment i.e.,outer ramp.The biostratigraphic studies show plentiful planktonic foraminifera species of Globotruncana,Heterohelix and Globotruncanita.However,no association of benthic or siliceous organisms was observed.On the basis of available species assemblage,a single local planktonic foraminifera biozone i.e.,Globotruncana-Heterohelix-Globotruncanita Assemblage Biozone is established.The biozone information is combined with published literature and Lower Santonian to Middle Maastrichtian age has been assigned to the Kawagarh Formation.The trend of species occurrences evinces that species number decreases over time with pulsated rise in the Kawagarh Formation.The Kawagarh Formation carbonates show an overall Transgressive Systems Tract(TST).The Kawagarh Formation of Pakistan evinces analogous characteristics to that of the Late Cretaceous Gurpi Formation of Iran based on the geologic age,outcrop lithology,microfacies,planktonic foraminiferal assemblages,depositional setting and sequence stratigraphy.

关键词： depositional fabric biostratigraphy sequence stratigraphy Late Cretaceous Kawagarh Formation Pakistan Gurpi Formation Iran

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cold plasma-induced effects on electromagnetic wave scattering in waveguides:a mode-matching analysis

引用

Communications in Theoretical Physics 2024年第3期76卷 144-156页

作者： Shahana Rizvi muhammad Afzal Department of Mathematics Capital University of Science and TechnologyIslamabadPakistan

This article presents advancements in an analytical mode-matching technique for studying electromagnetic wave propagation in a parallel-plate metallic rectangular waveguide.This technique involves projecting the solution onto basis functions and solving linear algebraic systems to determine scattering amplitudes.The accuracy of this method is validated via numerical assessments,which involve the reconstruction of matching conditions and conservation laws.The study highlights the impact of geometric and material variations on reflection and transmission phenomena in the waveguide.

关键词： electromagnetic waves scattering cold plasma metallic conducting mode-matching technique

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Federated Machine Learning Based Fetal Health Prediction Empowered with Bio-Signal Cardiotocography

引用

Computers, Materials & Continua 2024年第3期78卷 3303-3321页

作者： muhammad Umar Nasir Omar Kassem Khalil Karamath Ateeq Bassam SaleemAllah Almogadwy muhammad Adnan Khan muhammad Hasnain Azam Khan muhammad Adnan Department of Computer Sciences Bahria University Lahore CampusLahore54000Pakistan Faculty of Information Technology Liwa CollegeAbu Dhabi00000United Arab Emirates Department of Computing Skyline University CollegeSharjah1797United Arab Emirates Department of Computer Science Taibah UniversityMedina42353Saudi Arabia Riphah School of Computing and Innovation Faculty of ComputingRiphah International UniversityLahore CampusLahore54000Pakistan Department of Engineering and Development Dubizzle LabsLahore54000Pakistan Department of Software Faculty of Artificial Intelligence and SoftwareGachon UniversitySeongnam-si13120Korea

Cardiotocography measures the fetal heart rate in the fetus during pregnancy to ensure physical health because cardiotocography gives data about fetal heart rate and uterine shrinkages which is very beneficial to detect whether the fetus is normal or suspect or pathologic.Various cardiotocography measures infer wrongly and give wrong predictions because of human error.The traditional way of reading the cardiotocography measures is the time taken and belongs to numerous human errors as well.Fetal condition is very important to measure at numerous stages and give proper medications to the fetus for its well-being.In the current period Machine learning(ML)is a well-known classification strategy used in the biomedical field on various issues because ML is very fast and gives appropriate results that are better than traditional results.ML techniques play a pivotal role in detecting fetal disease in its early stages.This research article uses Federated machine learning(FML)and ML techniques to classify the condition of the fetus.This study proposed a model for the detection of bio-signal cardiotocography that uses FML and ML techniques to train and test the data.So,the proposed model of FML used numerous data preprocessing techniques to overcome data deficiency and achieves 99.06%and 0.94%of prediction accuracy and misprediction rate,respectively,and parallel the proposed model applying K-nearest neighbor(KNN)and achieves 82.93%and 17.07%of prediction accuracy and misprediction accuracy,respectively.So,by comparing both models FML outperformed the KNN technique and achieved the best and most appropriate prediction results as compared with previous studies the proposed study achieves the best and most accurate results.

关键词： Cardiotocography ML FML fetal disease bio-signal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：