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Chinese Journal of Integrative Medicine 2022年第1期28卷 88-95页

作者： muhammad Atif Farrah Naz Junaid Akhtar muhammad Imran Sidrah Saleem Javed Akram muhammad Imran muhammad ikram ullah Department of Clinical Laboratory Sciences College of Applied Medical SciencesJouf UniversitySakaka(75471)Saudi Arabia Department of Microbiology Government College UniversityFaisalabad(38000)Pakistan Department of Microbiology University of Health SciencesLahore(54600)Pakistan Department of Allied Health Sciences Sargodha Medical CollegeUniversity of SargodhaSargodha(40100)Pakistan University of Health Sciences Lahore(54600)Pakistan University Institute of Diet and Nutritional Sciences Faculty of Allied Health SciencesThe University of LahoreLahore(54590)Pakistan

COVID-19 virus is a causative agent of viral pandemic in human beings which specifically targets respiratory system of humans and causes viral *** unusual viral pneumonia is rapidly spreading to all parts of the world,currently affecting about 105 million people with 2.3 million *** review described history,genomic characteristics,replication,and pathogenesis of COVID-19 with special emphasis on Nigella sativum(***)as a treatment *** seeds are historically and religiously used over the centuries,both for prevention and treatment of different *** review summarizes the potential role of *** seeds against COVID-19 infection at levels of in silico,cell lines and animal models.

关键词： coronavirus nCoV-19 COVID-19 Nigella sativum review

Homozygosity mapping of a consanguineous Pakistani family affected with oculocutaneous albinism to Tyrosinase gene

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International Journal of Ophthalmology(English edition) 2016年第5期9卷 794-796页

作者： muhammad Shakil muhammad ikram ullah Shabbir Hussain Sabika Firasat Saqib Mahmood Haiba Kaul Department of Biochemistry University of Health Sciences Department of Biochemistry Faculty of Biological sciencesQuaid i Azam University Department of Animal Sciences Quaid i Azam University Department of Human Genetics and Molecular Biology University of Health Sciences

Dear Sir,Iam Haiba Kaul,from the Department of Biochemistry,University of Health Sciences,Lahore,Pakistan.I write to present a study of oculocutaneous albinism（OCA）in consanguineous Pakistani *** is a genetic defect... 详细信息

关键词： TYR Homozygosity mapping of a consanguineous Pakistani family affected with oculocutaneous albinism to Tyrosinase gene

Potential Inhibitory Effect of Vitamins Against COVID-19

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Computers, Materials & Continua 2021年第1期66卷 707-714页

作者： Kashaf Junaid Sumera Qasim Humaira Yasmeen Hasan Ejaz Abdullah Alsrhani muhammad ikram ullah Fahad Ahmad Abdul Rehman Department of Clinical Laboratory Sciences College of Applied Medical SciencesJouf UniversitySakakaAl JoufSaudi Arabia College of Pharmacy Jouf UniversitySakakaAl JoufSaudi Arabia Department of Microbiology and Molecular Genetics The Women’s UniversityMultanPakistan Department of Computer Sciences Kinnaird College for WomenLahorePakistan Department of Microbiology and Molecular Genetics University of the PunjabLahorePakistan

Coronavirus disease 2019(COVID-19)is a current pandemic that has affected more than 195 countries *** this severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic,when treatment strategies are not yet clear and vaccines are not available,vitamins are an excellent choice to protect against this viral *** rationale behind this study was to examine the inhibitory effect of vitamins B,C,and D against the main protease of SARSCoV-2 and angiotensin-converting enzyme 2(ACE2),which have critical rolesin the immune *** docking,performed by using MOE-Dock of the Chemical Computing Group,was used to understand the *** vitamins all docked within the active sites of the Mpro(PDB ID:6LU7)and ACE2 receptor proteins(PDB ID:6VW1).Vitamins B and C delivered maximum energy scores against both targets,while vitamin D displayed a binding energy score of−7.9532 kcal/mol for M^(pro) and−7.9297 for *** efficiency of all three vitamins is higher than the binding energy score of chloroquine(−6.889 kcal/mol),which is now under clinical *** use of vitamins is beneficial,being immune system restorative,and they also act as anti-COVID *** the potential beneficial effects of vitamin B and C are revealed through docking studies,further clinical trials are required for the validation of these results.

关键词： SARS-CoV-2 vitamins docking antivirals chemical computing

Three-dimensional flow of Powell–Eyring nanofluid with heat and mass flux boundary conditions

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Chinese Physics B 2016年第7期25卷 261-268页

作者： Tasawar Hayat ikram ullah Taseer muhammad Ahmed Alsaedi Sabir Ali Shehzad Department of Mathematics Quaid-I-Azam University Nonlinear Analysis and Applied Mathematics (NAAM) Research Group Department of Mathematics Faculty of ScienceKing Abdulaziz University Department of Mathematics Comsats Institute of Information Technology

This article investigates the three-dimensional flow of Powell–Eyring nanofluid with thermophoresis and Brownian motion effects. The energy equation is considered in the presence of thermal radiation. The heat and mass flux conditions are taken into account. Mathematical formulation is carried out through the boundary layer approach. The governing partial differential equations are transformed into the nonlinear ordinary differential equations through suitable variables. The resulting nonlinear ordinary differential equations have been solved for the series solutions. Effects of emerging physical parameters on the temperature and nanoparticles concentration are plotted and discussed. Numerical values of local Nusselt and Sherwood numbers are computed and examined.

关键词： three-dimensional flow Powell–Eyring fluid nanoparticles thermal radiation

A novel variant of GALC in a familial case of Krabbe disease:Insights from structural bioinformatics and molecular dynamics simulation

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Genes & Diseases 2023年第6期10卷 2263-2266页

作者： ikram ullah muhammad Waqas muhammad Ilyas Sobia Ahsan Halim Akmal Ahmad Natalia Dominik Wahid ullah muhammad Abbas muhammad Aamir Henry Houlden Stephanie Efthymiou Ajmal Khan Ahmed Al-Harrasi Centre for Omic Sciences Islamia College University PeshawarPeshawarKhyber Pakhtunkhwa 25120Pakistan Department of Biotechnology and Genetic Engineering Hazara UniversityMansehraDhodial 21120Pakistan Natural and Medical Sciences Research Center University of NizwaNizwa 616Sultanate of Oman Department of Bioengineering University of Engineering and Applied SciencesSwatKhyber Pakhtunkhwa 19060Pakistan Department of Neuromuscular Disorders UCL Queen Square Institute of NeurologyLondon WC1N 3BGUnited Kingdom

Krabbe disease or globoid cell leukodystrophy(GLD;MIM#245200)is a rare and fatal lysosomal storage disease with an autosomal recessive mode of inheritance that results from the deficiency of galactocerebrosidase(GALC;E.C.3.***.1.46),a lysosomal enzyme encoded by the GALC gene.1 GALC breaks down galactosylceramide,a cerebroside located mainly in the myelin *** in GALC cause the accumulation of a cytotoxic metabolite,galactosylsphingosine or psychosine,which can be toxic to oligodendrocytes and Schwann cells.2 The failure to digest galactosylceramide triggers the formation of multi-nucleated globoid cells,causing severe demyelination,axonopathy,and neuronal death.3 The reported frequency of Krabbe disease is 1 in 100,000 live births with symptoms including irritability,loss of motor ability,spasticity,ataxia,visual dysfunction,seizures,andcognitive impairment.

关键词： dynamics birth GAL

A Novel Framework for Multi-Classification of Guava Disease

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Computers, Materials & Continua 2021年第11期69卷 1915-1926页

作者： Omar Almutiry muhammad Ayaz Tariq Sadad ikram ullah Lali Awais Mahmood Najam Ul Hassan Habib Dhahri College of Applied Computer Sciences King Saud University(Almuzahmiyah Branch)Riyadh11564KSA Department of Computer Science University of Central PunjabLahore54000Pakistan Department of CS&SE International Islamic UniversityIslamabad44000Pakistan Division of Science and Technology University of EducationLahore54000Pakistan Department of Electrical and Computer Engineering Dhofar UniversitySalalahOman

Guava is one of the most important fruits in Pakistan,and is gradually boosting the economy of *** production can be interrupted due to different diseases,such as anthracnose,algal spot,fruit fly,styler end rot and *** diseases are usually detected and identified by visual observation,thus automatic detection is required to assist *** this research,a new technique was created to detect guava plant diseases using image processing techniques and computer *** automated system is developed to support farmers to identify major diseases in *** collected healthy and unhealthy images of different guava diseases from the *** image labeling was done with the help of an expert to differentiate between healthy and unhealthy *** local binary pattern(LBP)was used for the extraction of features,and principal component analysis(PCA)was used for dimensionality *** classification was carried out using multiple classifiers,including cubic support vector machine,Fine K-nearest neighbor(F-KNN),Bagged Tree and RUSBoosted Tree algorithms and achieved 100%accuracy for the diagnosis of fruit flies disease using Bagged ***,the findings indicated that cubic support vector machines(C-SVM)was the best classifier for all guava disease mentioned in the dataset.

关键词： Classification guava disease image processing machine learning

Autosomal recessive cerebellar ataxia with spasticity due to a rare mutation in GBA2 gene in a large consanguineous Saudi family

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Genes & Diseases 2021年第1期8卷 110-114页

作者： Hussein Algahtani Bader Shirah ikram ullah Mohammad H.Al-Qahtani Angham Abdulrahman Abdulkareem muhammad Imran Naseer King Abdulaziz Medical City King Saud bin Abdulaziz University for Health SciencesJeddahSaudi Arabia King Abdullah International Medical Research Center King Saud bin Abdulaziz University for Health SciencesJeddahSaudi Arabia Sulaiman Bin Abdullah Aba Al-Khail Centre for Interdisciplinary Research in Basic Sciences International Islamic UniversityIslamabadPakistan Center of Excellence in Genomic Medicine Research King Abdulaziz UniversityJeddahSaudi Arabia Department of Medical Laboratory Technology Faculty of Applied Medical SciencesKing Abdulaziz UniversityJeddahSaudi Arabia

The nonlysosomal glucosylceramidase b2(GBA2)gene encode an enzyme that catalyzes the hydrolysis of glucosylceramide to glucose and *** in the GBA2 gene have been reported to cause hereditary spastic paraplegia,autosomal recessive cerebellar ataxia with spasticity,and Marinescu-Sjogren-Like *** this study,we report the clinical features and genetic diagnosis of autosomal recessive cerebellar ataxia with spasticity due to a rare mutation in GBA2 gene in a large consanguineous Saudi *** included a large consanguineous Saudi family with a presumptive clinical diagnosis of ataxia at King Abdulaziz Medical City in Jeddah,Saudi *** family included six affected individuals and four unaffected in addition to the *** exome sequencing(WES)was performed for the probandⅣ-5,and Sanger sequencing was used to confirm the variant in other family *** study was performed using DNA from the parents and siblings of the *** analysis identified a homozygous variant c.2618G>A,p.(Arg873His)in GBA2 *** homozygous variant was identified in affected members of the family while the parents and the other four siblings were heterozygous carriers of the *** sibling was not available for genetic *** variant identified in our patients is classified as pathogenic considering the current evidence of the *** recessive cerebellar ataxia with spasticity is an extremely rare genetic disorder with very few cases reported in the *** conclude that the c.2617G>A mutation in GBA2 gene causes the loss of function with abolishment of the enzymatic activity that causes the *** report adds further evidence to support the pathogenicity of this *** patients had the classical clinical phenotype of cerebellar ataxia and spasticity consistent with previous reports in the literature.

关键词： Ataxia with spasticity Autosomal recessive GBA2 Novel mutation Saudi Arabia

Fission studies of gold induced by (1665 MeV) π^- using a CR-39 detector

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Chinese Physics C 2012年第2期36卷 132-135页

作者： muhammad ikram Shahzad Zafar Yasin Gul Sher Physics Division PINSTECHP.O.NiloreIslamabadPakistan

The fission cross section and fission probability of 197Au, induced by （1665 MeV） π-, have been studied using CR-39 track detectors. A 4π-geometry was used to count track statistics. A beam of negative pions of 1665 MeV was produced at AGS of Brookhaven National Laboratory, USA, and allowed to fall normally on the stack. Two detectors from the stack were scanned for fission fragment tracks after etching in 6N NaOH at 70 ℃. The statistics of fission fragment tracks in both detectors were obtained. It was found that there was a marked asymmetry of registered tracks with respect to the forward and backward hemispheres. This asymmetry could be partly accounted for on the basis of momentum transfer to the struck nucleus. On the basis of counting statistics fission cross section was measured, and fission probability was determined by dividing the fission cross section with the reaction cross section. The fission cross-section and fission probability were compared with the computed values using the caseade-exciton model code CEM95.

关键词： CR-39 fission cross section CEM95

A Comparison of Image Processing Techniques for Optical Interference Fringe Analysis

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Photonic Sensors 2015年第4期5卷 304-311页

作者： muhammad FAROOQ Aasma ASLAM Babar HUSSAIN Ghazanfar HUSSAIN Masroor ikram National Institute of Lasers and Optronics Lehtrar Road lslamabad 45650 Pakistan Hazara University Mansehra and NUST lslamabad 21300 Pakistan University of North Carolina at Charlotte Department of Electrical and Computer Engineering 9201 University City Boulevard Charlotte 28223 USA pakistan Institute of Engineering and Applied Sciences lslamabad 45650 Pakistan

We present a comparison of different techniques for the analysis of the shift and tilt in optical interference fringes. Fringe center, Radon transform, and Gaussian approximation methods are used for fringe analysis. We have measured the tilt and shift between two relevant fringe pattems. The error in tilt measurement was about 2%, and the displacement of the order of few nanometers was measured by the fringe shift analysis. The comparison between the techniques is analyzed with respect to percentage error.

关键词： Interferometry fringes tilt shift imaging

Stochastic neuro-swarming intelligence paradigm for the analysis of magneto-hydrodynamic Prandtl-Eyring fluid flow with diffusive magnetic layers effect over an elongated surface

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Chinese Journal of Chemical Engineering 2024年第10期74卷 295-311页

作者： Zeeshan ikram Butt Iftikhar Ahmad muhammad Shoaib Syed Ibrar Hussain Hira Ilyas muhammad Asif Zahoor Raja Department of Mathematics University of GujratGujrat 50700Pakistan Yuan Ze University AI CenterTaoyuanTaiwan 320China Department of Mathematics and Computer Science University of PalermoVia Archirafi 34Palermo 90123Italy Department of Mathematics University of HoustonHoustonTX 77204USA Department of Physical Sciences University of ChenabGujrat 50700Pakistan Future Technology Research Centre National Yunlin University of Science and TechnologyYunlinTaiwan 64002China

In recent years,the integration of stochastic techniques,especially those based on artificial neural networks,has emerged as a pivotal advancement in the field of computational fluid *** techniques offer a powerful framework for the analysis of complex fluid flow phenomena and address the uncertainties inherent in fluid dynamics *** this trend,the current investigation portrays the design and construction of an important technique named swarming optimized neuroheuristic intelligence with the competency of artificial neural networks to analyze nonlinear viscoelastic magneto-hydrodynamic Prandtl-Eyring fluid flow model,with diffusive magnetic layers effect along an extended *** currently designed computational technique is established using inverse multiquadric radial basis activation function through the hybridization of a well-known global searching technique of particle swarm optimization and sequential quadratic programming,a technique capable of rapid convergence *** most appropriate scaling group involved transformations that are implemented on governing equations of the suggested fluidic model to convert it from a system of nonlinear partial differential equations into a dimensionless form of a third-order nonlinear ordinary differential *** transformed/reduced fluid flow model is solved for sundry variations of physical quantities using the designed scheme and outcomes are matched consistently with Adam's numerical technique with negligible magnitude of absolute errors and mean square ***,it is revealed that the velocity of the fluid depreciates in the presence of a strong magnetic field *** efficacy of the designed solver is depicted evidently through rigorous statistical observations via exhaustive numerical experimentation of the fluidic problem.

关键词： PrandtleEyring fluid Particle swarm optimization Hydrodynamic Neural networks Computational fluid dynamics