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Enzymatic production of N‑acetylneuraminic acid:advances and perspectives

Systems Microbiology and Biomanufacturing 2022年第1期2卷 130-146页

作者： muhammad iftikhar hussain Xiaolong Zhang Xueqin Lv Samra Basharat Umar Shahbaz Jianghua Li Guocheng Du Long Liu Yanfeng Liu Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationJiangnan UniversityWuxi 214122China Science Center for Future Foods Jiangnan UniversityWuxi 214122China

N-Acetyl-d-neuraminic acid(NeuAc),a well-known and well-studied sialic acid,is found in cell surface glycolipids and glycoproteins,where it performs a variety of biological *** use of NeuAc as a nutraceutical for infant brain development and as an intermediate for pharmaceutical production demands its production on an industrial *** extraction,chemical synthesis,enzymatic synthesis,and biosynthesis are the methods used for NeuAc *** these methods,enzymatic synthesis using N-acetyl-glucosamine(GlcNAc)2-epimerase(AGE)for epimerization and N-acetyld-neuraminic acid lyase(NAL)for aldol condensation,has been reported to produce NeuAc with high production *** this review,we discuss advances in the two-step enzymatic synthesis of NeuAc using pyruvate and GlcNAc as *** major challenges in producing NeuAc with high yield are highlighted,including multiple parameter-dependent processes,undesirable reversibility,and diminished solubility of AGEs and ***,diferent strategies applied to overcome the limitations of the two-step enzymatic production are discussed,such as pyruvate concentration and temperature shift during the process to increase conversion yield,use of mathematical and computational simulations for process optimization,enzyme engineering to make enzymes highly efcient,and the use of tags and chaperones to increase enzyme *** suggest future directions and the strategies that can be followed to improve enzymatic synthesis of NeuAc.

关键词： N-Acetyl-d-neuraminic acid Enzymatic synthesis N-Acetyl-d-neuraminic acid lyase N-Acetyl-glucosamine 2-epimerase

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M_(4)X_(3) MXenes:Application in Energy Storage Devices

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Nano-Micro Letters 2024年第10期16卷 522-542页

作者： iftikhar hussain Waqas Ul Arifeen Shahid Ali Khan Sikandar Aftab muhammad Sufyan Javed Sajjad hussain muhammad Ahmad Xi Chen Jiyun Zhao PRosaiah Khaled Fahmi Fawy Adnan Younis Sumanta Sahoo Kaili Zhang Department of Mechanical Engineering City University of Hong Kong83 Tat Chee AvenueKowloon TongHong KongPeople's Republic of China School of Mechanical Engineering Yeungnam UniversityDaehak-roGyeongsan-siGyeongbuk-do 38541South Korea Department of Semiconductor Systems Engineering and Clean Energy Sejong UniversitySeoul 05006Republic of Korea School of Physical Science and Technology Lanzhou UniversityLanzhou 730000People's Republic of China Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Department of Physics Saveetha School of EngineeringSaveetha Institute of Medical and Technical Sciences(SIMATS)ThandalamChennai 602105India Department of Chemistry Faculty of ScienceKing Khalid UniversityP.O.Box 900461413 AbhaSaudi Arabia Department of Physics College of ScienceUnited Arab Emirates UniversityP.O.Box 15551Al-AinUnited Arab Emirates School of Chemical Engineering Yeungnam UniversityGyeongsanGyeongbuk 38541South Korea

MXene has garnered widespread recognition in the scientific com-munity due to its remarkable properties,including excellent thermal stability,high conductivity,good hydrophilicity and dispersibility,easy processability,tunable surface properties,and admirable *** have been categorized into different families based on the number of M and X layers in M_(n+1)X_(n),such as M_(2)X,M_(3)X_(2),M_(4)X_(3),and,recently,M_(5)X_(4).Among these families,M_(2)X and M_(3)X_(2),par-ticularly Ti_(3)C_(2),have been greatly explored while limited studies have been given to M_(5)X_(4)MXene ***,studies on the M_(4)X_(3)MXene family have developed recently,hence,demanding a compilation of evaluated ***,this review provides a systematic overview of the latest advancements in M_(4)X_(3)MXenes,focusing on their properties and applications in energy storage *** objective of this review is to provide guidance to researchers on fostering M_(4)X_(3)MXene-based nanomaterials,not only for energy storage devices but also for broader applications.

关键词： MXene M_(4)X_(3)MXenes 2D materials Energy storage Properties

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荫蔽和微生物可在分子水平上调控植物激素以增强植物的耐旱性

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Journal of Plant Ecology 2022年第6期15卷 1107-1117页

作者： muhammad Ahsan Asghar Bushra Ahmad Ali Raza Bilal Adil Hafz Hassan Javed muhammad Umer Farooq Abuzar Ghafoor muhammad iftikhar hussain Iram Shafq Hassan Karim Xin Sun Wenyu Yang Gábor Kocsy Junbo Du Department of Biological Resources Agricultural InstituteCentre for Agricultural ResearchELKHMartonvásárHungary College of Agronomy Sichuan Agricultural UniversityChengdu 611130China Department of Plant Breeding and Genetics University of AgricultureFaisalabad 38000PunjabPakistan College of Resource Sichuan Agricultural UniversityChengdu 611130China Department of Field Crops Faculty of AgricultureÇukurova UniversityAdana 01330Turkey Department of Plant Biology&Soil Science Faculty of BiologyUniversity of VigoCampus As Lagoas MarcosendeVigo 36310Spain State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengduSichuan 611130China

植物在其生命周期内会受到一系列不利环境的影响。其中,干旱胁迫是限制农业生产力的重要因素之一。为了在逆境的环境中得以生存,植物进化出了识别环境胁迫严重性的机制。植物可通过多种方式调节激素活性,以减轻干旱带来的不良影响。受... 详细信息

植物在其生命周期内会受到一系列不利环境的影响。其中,干旱胁迫是限制农业生产力的重要因素之一。为了在逆境的环境中得以生存,植物进化出了识别环境胁迫严重性的机制。植物可通过多种方式调节激素活性,以减轻干旱带来的不良影响。受荫蔽和微生物调控,植株的抗旱性提高,产量损失减少。脱落酸、生长素和乙烯等植物激素,可调控多种代谢途径,在荫蔽和微生物介导的植株抗旱性增强过程中起着重要作用。如我们的调控模型所示,CLAVATA3/EMBRYOSURROUNDING REGION-RELATED 25多肽因其可影响ABA合成而在此过程中具有重要作用。

关键词：脱落酸 CLAVATA3/EMBRYOSURROUNDING REGION-RELATED 25 生长素植物生长促进根瘤菌乙烯

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Recent progress in flexible Zn-ion hybrid supercapacitors: Fundamentals, fabrication designs, and applications

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Carbon Energy 2023年第1期5卷 82-122页

作者： muhammad Sufyan Javed Sumreen Asim Tayyaba Najam muhammad Khalid iftikhar hussain Awais Ahmad Mohammed A.Assiri Weihua Han School of Physical Science and Technology Lanzhou UniversityLanzhouGansuChina Institute of Chemistry Khwaja Fareed University of Engineering and Information TechnologyPunjabPakistan College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhenGuangdongChina Department of Mechanical Engineering City University of Hong KongKowloonHong KongChina Departamento de Quimica Organica Universidad de CordobaCordobaSpain Department of Chemistry Faculty of ScienceKing Khalid UniversityAbhaSaudi Arabia

One of the most exciting new developments in energy storage technology is flexible Zn-ion hybrid supercapacitors(f-ZIHSCs),which combine the high energy of Zn-ion batteries with high-power supercapacitors to satisfy the needs of portable flexible ***,the development of f-ZHSCs is still in its infancy,and there are numerous barriers to overcome before they can be widely implemented for practical *** review gives an up-to-date description of recent achievements and underlying concepts in energy storage mechanisms of f-ZIHSCs and emphasizes the critical role of cathode,anode,and electrolyte materials systems in speeding the prosperity of *** innovative nanostructured-based cathode materials for f-ZIHSCs include carbon(e.g.,porous carbon,heteroatom-doped carbon,biomass-derived porous carbon,graphene,etc.),metal-oxides,MXenes,and metal/covalentorganic frameworks,and other materials(e.g.,activated carbon,phosphorene,etc.)are mainly ***,the latest developments in flexible anode and electrolyte frameworks and impacts of electrolyte compositions on the electrochemical properties of f-ZIHSC are ***,the advancements based on fabrication designs,including quasi-solid-state,micro,fiber-shaped,and all climate-changed f-ZIHSCs,are discussed in ***,a summary of current challenges and recommendations for the future progress of advanced f-ZIHSC are *** review article is anticipated to further understand the viable strategies and achievable approaches for assembling high-performance f-ZIHSCs and boost the technical revolutions on cathode,anode,and electrolytes for f-ZIHSC devices.

关键词： electrode electrolyte flexible MOFs MXenes Zn-ion hybrid supercapacitor

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Animal- and Human-Inspired Nanostructures as Supercapacitor Electrode Materials: A Review

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Nano-Micro Letters 2022年第12期14卷 151-175页

作者： iftikhar hussain Charmaine Lamiel Sumanta Sahoo muhammad Sufyan Javed muhammad Ahmad Xi Chen Shuai Gu Ning Qin Mohammed AAssiri Kaili Zhang Department of Mechanical Engineering City University of Hong Kong83 Tat Chee AvenueKowloonHong KongPeople’s Republic of China Department of Chemical Engineering University of WyomingLaramieWY 82071USA Department of Chemistry Madanapalle Institute of Technology and ScienceMadanapalleAndhra Pradesh 517325India School of Physical Science and Technology Lanzhou UniversityLanzhou 730000People’s Republic of China Department of Chemistry Faculty of ScienceKing Khalid UniversityAbha 61413Saudi Arabia

Human civilization has been relentlessly inspired by the nurturing lessons;nature is teaching *** birds to airplanes and bullet trains,nature gave us a lot of perspective in aiding the progress and development of countless industries,inventions,transportation,and many *** only that nature inspired us in such technological advances but also,nature stimulated the advancement of micro-and ***-inspired nanoarchitectures have been consid-ered a favorable structure in electrode materials for a wide range of *** offers various positive attributes,especially in energy storage applications,such as the formation of hierarchical two-dimen-sional and three-dimensional interconnected networked structures that benefit the electrodes in terms of high surface area,high porosity and rich surface textural features,and eventually,delivering high capacity and outstanding overall material *** this review,we compre-hensively assessed and compiled the recent advances in various nature-inspired based on animal-and human-inspired nanostructures used for *** comprehensive review will help researchers to accommodate nature-inspired nanostructures in industrializing energy storage and many other applications.

关键词： Nature-inspired nanostructure Supercapacitors Energy storage Animal-inspired and human-inspired nanostructures

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Multi Layered Rule-Based Technique for Explicit Aspect Extraction from Online Reviews

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Computers, Materials & Continua 2022年第12期73卷 4641-4656页

作者： Mubashar hussain Toqir A.Rana Aksam iftikhar M.Usman Ashraf muhammad Waseem Iqbal Ahmed Alshaflut Abdullah Alourani School of Systems and Technology University of Management and TechnologyLahore54770Pakistan Department of Computer Science and It The University of LahoreLahore54000Pakistan School of Computer Sciences Universiti Sains Malaysia(USM)Penang11800Malaysia Department of Computer Science Comsats University IslamabadLahore54000Pakistan Department of Computer Science GC Women University SialkotPakistan Department of Software Engineering The Superior UniversityLahore53700Pakistan Faculty of Computing and It Albaha UniversityAlbahaSaudi Arabia Department of Computer Science Majmaah UniversitySaudi Arabia

In the field of sentiment analysis,extracting aspects or opinion targets fromuser reviews about a product is a key *** the polarity of an opinion is much more useful if we also know the targeted Aspect or *** based approaches,like dependency-based rules,are quite popular and effective for this ***,they are heavily dependent on the authenticity of the employed parts-of-speech(POS)tagger and dependency *** popular rule based approach is to use sequential rules,wherein the rules formulated by learning from the user’s ***,in general,the sequential rule-based approaches have poor generalization ***,existing approaches mostly consider an aspect as a noun or noun phrase,so these approaches are unable to extract verb *** this article,we have proposed a multi-layered rule-based(ML-RB)technique using the syntactic dependency parser based rules along with some selective sequential rules in separate layers to extract noun ***,after rigorous analysis,we have also constructed rules for the extraction of verb *** verb rules primarily based on the association between verb and opinion *** proposed multi-layer technique compensates for the weaknesses of individual layers and yields improved results on two publicly available customer review *** F1 score for both the datasets are 0.90 and 0.88,respectively,which are better than existing *** improved results can be attributed to the application of sequential/syntactic rules in a layered manner as well as the capability to extract both noun and verb aspects.

关键词： Explicit aspect aspect extraction opinion mining rule-based verb aspects

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Effect of rare earth and transition metal La-Mn substitution on electrical properties of co-precipitated M-type Ba-ferrites nanoparticles

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Journal of Rare Earths 2019年第2期37卷 193-197页

作者： muhammad Ayub iftikhar hussain Gul Khalid Nawaz Khurram Yaqoob Thermal Transport Laboratory School of Chemical and Materials Engineering (SCME) National University of Sciences and Technology (NUST)

In the current research work Ba_(1-x)La)xMn)yFe_(12-y)O_(19) hexa-ferrite nanoparticles of different compositions were synthesized using chemical co-precipitation technique. The structural properties were explored using X-ray diffractions(XRD), scanning electron microscopy(SEM) and Fourier transmission infrared spectroscopy(FTIR). XRD indexed pattern confirms the formation of M-type hexagonal phase. The crystallite size of synthesized samples ranges from 13 to 34 ± 2 nm. FTIR peaks observe also confirmed the presence of metaloxygen bond of the desired product. The position of peak at 467 cm^(-1) corresponds to A_2 u vibration for octahedral Fe(4+)-O and peak position E1 u corresponds to vibration of Fe(3+)O4 octahedral bonds. The band v_1 in range(677-559 cm^(-1)) and v_2 in frequency range(356-419 cm^(-1)) are associated to A and B *** properties of all compositions were measured with frequency. The dielectric constant, loss and tangent loss decrease from 26 to 9, 25 to 2 and 0.94 to 0.14, respectively with frequency. DC electrical resistivity is increased with dopant concentration increasing from 2.15 × 10~4 to 1.92 ×10~5 Ω·cm.

关键词： Co-precipitation Electrical properties Dielectric X-ray diffraction Rare earths

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Field evaluation of some bait additives against Indian crested porcupine(Hystrix indica)(Rodentia:Hystricidae)

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Integrative Zoology 2013年第3期8卷 285-292页

作者： muhammad MUSHTAQ iftikhar hussain Afsar MIAN Shahid MUNIR Irfan AHMED Abdul Aziz KHAN Department of Zoology PMAS Arid Agriculture UniversityRawalpindiPakistan Wildlife Management PMAS Arid Agriculture UniversityRawalpindiPakistan National Agricultural Research Centre IslamabadPakistan

This research study evaluated the effect of different additives on the bait consumption by Indian crested porcupine,a serious forest and agricultural pest,under field *** additives(saccharin,common salt,bone meal,fish meal,peanut butter,egg yolk,egg shell powder,yeast powder,mineral oil and coconut oil)at 2 and 5%each were tested for their relative preference,using groundnut-maize(1:1)as basic *** the additives were tested under a no-choice test *** control tests,no additive was mixed with the basic *** at 5%concentration significantly enhanced the consumption of bait over the basic bait,while 2%saccharin supplemented bait resulted in a non-significant bait *** other additives did not enhance the consumption of the bait material;rather,these worked as ***,the repellency was lowest with the common salt,followed by egg yolk,egg shell powder,bone meal,peanut butter,mineral oil,fish meal and yeast powder,while coconut remained the most repellent *** present study suggested that groundnut-maize(1:1)supplemented with 5%saccharin was the preferred bait combination,and can be used with different rodenticides for the management of Indian crested porcupine.

关键词： additives baits evaluation Hystrix indica Indian crested porcupine

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Intelligent Breast Cancer Prediction Empowered with Fusion and Deep Learning

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Computers, Materials & Continua 2021年第4期67卷 1033-1049页

作者： Shahan Yamin Siddiqui iftikhar Naseer muhammad Adnan Khan muhammad Faheem Mushtaq Rizwan Ali Naqvi Dildar hussain Amir Haider School of Computer Science National College of Business Administration and EconomicsLahore54000Pakistan School of Computer Science Minhaj University LahoreLahore54000Pakistan Department of Computer Science&Information Technology Superior UniversityLahore54000Pakistan Department of Computer Science Faculty of ComputingRiphah International UniversityLahore CampusLahore54000Pakistan Department of Information Technology Khwaja Fareed University of Engineering and Information TechnologyRahim Yar Khan64200Pakistan Department of Unmanned Vehicle Engineering Sejong UniversitySeoul05006Korea School of Computational Sciences Korea Institute for Advanced Study(KIAS)85 HoegiroDongdaemunguSeoul02455Korea Department of Intelligent Mechatronics Engineering Sejong UniversitySeoul05006Korea

Breast cancer is the most frequently detected tumor that eventually could result in a significant increase in female mortality *** to clinical statistics,one woman out of eight is under the threat of breast *** and inheritance patterns may be a reason behind its spread among ***,some preventive measures,such as tests and periodic clinical checks can mitigate its risk thereby,improving its survival chances *** diagnosis and initial stage treatment can help increase the survival *** that purpose,pathologists can gather support from nondestructive and efficient computer-aided diagnosis(CAD)*** study explores the breast cancer CAD method relying on multimodal medical imaging and decision-based *** multimodal medical imaging fusion,a deep learning approach is applied,obtaining 97.5%accuracy with a 2.5%miss rate for breast cancer prediction.A deep extreme learning machine technique applied on feature-based data provided a 97.41%***,decisionbased fusion applied to both breast cancer prediction models to diagnose its stages,resulted in an overall accuracy of 97.97%.The proposed system model provides more accurate results compared with other state-of-the-art approaches,rapidly diagnosing breast cancer to decrease its mortality rate.

关键词： Fusion feature breast cancer prediction deep learning convolutional neural network multi-modal medical image fusion decision-based fusion

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Abundance and Breeding of the Common Skittering Frog(Euphlyctis cyanophlyctis)and Bull Frog(Hoplobatrachus tigerinus)at Rawal Lake,Islamabad,Pakistan

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Asian Herpetological Research 2011年第4期2卷 245-250页

作者： Fozia TABASSUM muhammad RAIS Maqsood ANWAR Tariq MEHMOOD iftikhar hussain Shahid ALI KHAN Department of Wildlife Management Pir Mehr Ali Shah Arid Agriculture University

The population density and breeding of two frog species, i. e., the Skittering Frog （Euphlyctis eyanophlyctis） and the Bull Frog （Hoplobatrachus tigerinus） were studied at Rawal Lake, Islamabad, Pakistan, by using visual encounter method from September 2009 to August 2010. Mean population density for the two frogs was 1.55 ± 0.44 frogs per ha, with that for the Skittering Frog being 1.09 ± 0.33 frogs/ha and that of the Bull Frog 0.46 ± 0.11 frog/ha, respectively. It is concluded that both frog species are explosive breeders, i. e., their breeding activities were confined to the first showers of the monsoon season. The mean spawn weight of the Skittering Frog was 1.5 g with more than 1000 eggs in each spawn, while that of the Bull Frog was 0.26 g with less than 1000 eggs in a spawn. The spawning sites of the two species were investigated in detail. Generally, no threat to their populations was observed. However, the opening of the spillway of Rawal Dam following the torrential rain destroyed the breeding sites of the frogs. It is maintained that the event did not produce any significant impact on their populations and breeding as the two species were quite common.

关键词： Ranidae population status breeding habitat destruction

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