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Intensive care unit complications and outcomes of adult patients with hemophagocytic lymphohistiocytosis: A retrospective study of 16 cases

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World Journal of Critical Care Medicine 2018年第6期7卷 73-83页

作者： Sumit Kapoor Christopher K Morgan muhammad asim siddique Kalpalatha K Guntupalli Department of Critical Care Medicine Montefiore Medical Center Department of Pulmonary Critical Care and Sleep Baylor College of Medicine

AIM To study the management, complications and outcomes of adult patients admitted with hemophagocytic lymphohistiocytosis(HLH) in the intensive care unit(ICU).METHODS We performed a retrospective observational study of adult patients with the diagnosis of "HLH" admitted to the two academic medical ICUs of Baylor College of Medicine between 01/01/2013 to 06/30/2017. HLH was diagnosed using the HLH-2004 criteria proposed by the Histiocyte *** Sixteen adult cases of HLH were admitted to the medical ICUs over 4 *** age of presentation was 49 years and 10(63%) were males. Median Sequential Organ Failure Assessment(SOFA) score at the time of ICU admission was 10. Median ICU length of stay(LOS) was 11.5 d and median hospital LOS was 29 d. Septic shock and acute respiratory failure accounted for majority of diagnoses necessitating ICU admission. Septic shock was the most common ICU complication seen in(88%) patients, followed by acute kidney injury(81%) and acute respiratory failure requiring mechanical ventilation(75%). Nine patients(56%) developed disseminated intravascular coagulation and eight(50%) had acute liver failure. 10 episodes of clinically significant bleeding were *** system organ failure was the most common cause of death seen in 12(75%)patients. The 30 d mortality was 37%(6 cases) and 90 d mortality was 81%(13 cases). There was no difference in mortality based on age(above or less than 50 years), SOFA score on ICU admission(more than or less than 10),immunosuppression, time to diagnose HLH or direct ICU admission versus floor *** HLH is a devastating disease associated with poor outcomes in ICU. Intensivists need to have a high degree of clinical suspicion for HLH in patients with septic shock/multi system organ failure and progressive bi/pancytopenia who are not responding to standard management in ICU.

关键词： Lymphohistiocytosis Cytopenia Hypercytokinemia Hemophagocytosis Shock

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Gly-LysPred: Identification of Lysine Glycation Sites in Protein Using Position Relative Features and Statistical Moments via Chou’s 5 Step Rule

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Computers, Materials & Continua 2021年第2期66卷 2165-2181页

作者： Shaheena Khanum muhammad Adeel Ashraf asim Karim Bilal Shoaib muhammad Adnan Khan Rizwan Ali Naqvi Kamran siddique Mohammed Alswaitti Department of Computer Science Lahore University of Management SciencesLahore54792Pakistan Department of Computer Science University of Management and TechnologyLahore54770Pakistan School of Computer Science Minhaj University LahoreLahore54770Pakistan Department of Computer Science Lahore Garrison UniversityLahore54000Pakistan Department of Unmanned Vehicle Engineering Sejong UniversitySeoulKorea Department of Information and Communication Technology School of Electrical and Computer EngineeringXiamen University MalaysiaSepang43900Malaysia

Glycation is a non-enzymatic post-translational modification which assigns sugar molecule and residues to a *** is a clinically important attribute to numerous age-related,metabolic,and chronic diseases such as diabetes,Alzheimer’s,renal failure,*** of a non-enzymatic reaction are quite challenging in *** identification in labs is a very costly and timeconsuming *** this research,we developed an accurate,valid,and a robust model named as Gly-LysPred to differentiate the glycated sites from non-glycated *** techniques using position relative features are used for feature *** algorithm named as a random forest with some preprocessing techniques and feature engineering techniques was developed to train a computational *** types of testing techniques such as self-consistency testing,jackknife testing,and cross-validation testing are used to evaluate the *** overall model’s accuracy was accomplished through self-consistency,jackknife,and cross-validation testing 100%,99.92%,and 99.88%with MCC 1.00,0.99,and 0.997 *** this regard,a user-friendly webserver is also urbanized to accumulate the whole *** features vectorization methods suggest that they can play a critical role in other web servers which are developed to classify lysine glycation.

关键词： Gly-LysPred PseAAC post-translational modification lysine glycation Chou’s 5 step rule position relative features

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Computational and experimental investigations of a microfluidic mixer for efficient iodine extraction using carbon tetrachloride enhanced with gas bubbles

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Chinese Physics B 2023年第11期32卷 518-526页

作者： siddique muhammad Kashif 孙林李松晶 Department of Fluid Control and Automation School of Mechatronics EngineeringHarbin Institute of TechnologyHarbin 150001China

Numerous studies have been conducted on microfluidic mixers in various microanalysis systems, which elucidated the manipulation and control of small fluid volumes within microfluidic chips. These studies have demonstrated the ability to control fluids and samples precisely at the microscale. Microfluidic mixers provide high sensitivity for biochemical analysis due to their small volumes and high surface-to-volume ratios. A promising approach in drug delivery is the rapid microfluidic mixer-based extraction of elemental iodine at the micro level, demonstrating the versatility and the potential to enhance diagnostic imaging and accuracy in targeted drug delivery. Micro-mixing inside microfluidic chips plays a key role in biochemical analysis. The experimental study describes a microfluidic mixer for extraction of elemental iodine using carbon tetrachloride with a gas bubble mixing process. Gas bubbles are generated inside the microcavity to create turbulence and micro-vortices resulting in uniform mixing of samples. The bubble mixing of biochemical samples is analyzed at various pressure levels to validate the simulated results in computational fluid dynamics(CFD). The experimental setup includes a high-resolution camera and an air pump to observe the mixing process and volume at different pressure levels with time. The bubble formation is controlled by adjusting the inert gas flow inside the microfluidic chip. Microfluidic chip-based gas bubble mixing effects have been elaborated at various supplied pressures.

关键词： microfluidic mixer iodine extraction CFD simulation micro-mixing properties

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Ag-Co3O4：Synthesis,characterization and evaluation of its photo-catalytic activity towards degradation of rhodamine B dye in aqueous medium

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Chinese Journal of Chemical Engineering 2018年第6期26卷 1264-1269页

作者： muhammad Saeed Majid Muneer Nida Mumtaz Mohsin siddique Nadia Akram muhammad Hamayun Department of Chemisny Government College University Faisalabad Pakistan Department of Chemistry Bacha Khan University Charsadda Pakistan Department of Chemistry University of Gujrat Hafiz Hayat Campus Gujrat Pakistan

Synthesis,characterization of Co_3O_4 and Ag-Co_3O_4 composites and evaluation of their photo-catalytic activities towards photo-degradation of aqueous solution of rhodamine B dye under irradiation of visible light have been described in this ***_3O_4 was prepared by solid phase mechano chemical process using Co(NO_3)_2·6H_2O and NH_4 HCO_3 as precursor *** was deposited on Co_3O_4 from AgNO_3 using Calotropis gigantea extract as reducing ***,SEM and FTIR were used for characterization of prepared ***-catalytic efficiencies of as-prepared Co_3O_4 and Ag-Co_3O_4 were evaluated for aqueous phase photo-degradation of rhodamine *** was found that deposition of Ag on Co_3O_4 highly enhanced the photo-catalytic activity of Co_3O_***-catalytic degradation followed the Eley–Rideal *** 100% and 91% photo-degradation of 40 ml dye solution achieved at 313 K in 90 and 120 min over 0.05 g of Ag-Co_3O_4 as photo-catalyst using 100 and 200 mg·L^(-1) as initial concentration of dye respectively.

关键词： Co3O4 Ag-Co3O4 Photo-catalysis Photo-degradation Calotropis gigantea Rhodamine B Elay–Rideal mechanism

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Dynamic Stability Improvement of Decentralized Wind Farms by Effective Distribution Static Compensator

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Journal of Modern Power Systems and Clean Energy 2021年第3期9卷 516-525页

作者： muhammad Naveed Naz Saqif Imtiaz muhammad Kamran Liaquat Bhatti Waseem Qaiser Awan muhammad siddique Ashfaq Riaz Department of Electrical Engineering NFC Institute of Engineering&TechnologyMultanPakistan Multan Electric Power Company MultanPakistan

Dynamic instability of decentralized wind energy farms is a major issue to deliver continuous green energy to electricity *** instability is caused by variations of voltage and frequency parameters due to intermittencies in wind ***,droop control and inverter-based schemes have been proposed to regulate the voltage by balancing reactive power,while inertial control,digital mapping tech-nique of proportional-integral-differential(PID)controller and efficiency control strategy have been developed to regulate the *** this paper,voltage stability is improved by a new joint strategy of distribution static compensator(DSTATCOM)six-pulse controller based reactive power management among decentralized wind turbines and controlled charging of capacitor *** frequency stability is ensured by a joint coordinated utilization of capacitor bank and distributed wind power turbines dispatching through a new DSTATCOM six-pulse controller *** both strategies,power grid is contributed as a backup source with less *** new joint strategies for voltage and frequency stabilities will enhance the stable active power delivery to end users.A system test case is developed to verify the proposed joint *** test results of the proposed new schemes are proved to be effective in terms of stability improvement of voltage,frequency and active power generation.

关键词： Dynamic instability decentralized wind energy farms voltage instability frequency instability distribution static compensator(DSTATCOM) reactive power management in-termittency

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Liquid-phase aerobic oxidation of benzyl alcohol catalyzed by mechanochemically synthesized manganese oxide

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Chinese Science Bulletin 2013年第19期58卷 2354-2359页

作者： ILYAS Mohammad siddique Mohsin SAEED muhammad National Centre of Excellence in Physical Chemistry University of Peshawar Department of Chemistry Government College University

Benzyl alcohol oxidation by molecular oxygen using solid manganese oxide as a catalyst and n-heptane as the solvent was studied in the liquid phase. The catalyst was synthesized by a simple mechanochemical process at room temperature and was characterized by different physical methods. The catalyst was highly active and 100% selective for benzyl alcohol conversion to benzaldehyde. The solid catalyst can be recovered from the reaction mixture by simple filtration and can be re-used. We found n-heptane to be an excellent solvent for the oxidation reaction, and that the catalyst did not leach into solution.

关键词：机械化学合成催化氧化苯甲醇锰氧化物液相固体催化剂反应混合物化学过程

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Minimal Doubly Resolving Sets of Certain Families of Toeplitz Graph

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Computer Modeling in Engineering & Sciences 2023年第6期135卷 2681-2696页

作者： muhammad Ahmad Fahd Jarad Zohaib Zahid Imran siddique Department of Mathematics University of Management and TechnologyLahore54770Pakistan Department of Mathematics Cankaya UniversityEtimesgutAnkara06790Turkey Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung40402Taiwan

The doubly resolving sets are a natural tool to identify where diffusion occurs in a complicated *** realworld phenomena,such as rumour spreading on social networks,the spread of infectious diseases,and the spread of the virus on the internet,may be modelled using information diffusion in *** is obviously impractical to monitor every node due to cost and overhead limits because there are too many nodes in the network,some of which may be unable or unwilling to send information about their *** a result,the source localization problem is to find the number of nodes in the network that best explains the observed *** problem can be successfully solved by using its relationship with the well-studied related minimal doubly resolving set problem,which minimizes the number of observers required for accurate *** paper aims to investigate the minimal doubly resolving set for certain families of Toeplitz graph Tn(1,t),for t≥2 and n≥t+*** come to the conclusion that for Tn(1,2),the metric and double metric dimensions are equal and for Tn(1,4),the double metric dimension is exactly one more than the metric ***,the double metric dimension for Tn(1,3)is equal to the metric dimension for n=5,6,7 and one greater than the metric dimension for n≥8.

关键词： Family of Toeplitz graph resolving sets metric dimension doubly resolving sets double metric dimension

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Status and Social Capital:A Cross-Sectional Quantitative Investigation of Flood Survivors in South Punjab,Pakistan

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International Journal of Disaster Risk Science 2022年第4期13卷 549-560页

作者： muhammad siddique Akbar muhammad Rizwan Safdar Farhan Navid Yousaf Daniel P.Aldrich Institute of Social and Cultural Studies University of the PunjabLahore 054590Pakistan Security and Resilience Studies Program Department of Political ScienceNortheastern UniversityBostonMA 02115USA

A growing body of evidence underscores that social capital mitigates the impact of natural hazards such as *** we know less about the distribution of social ties in developing countries regularly hit by *** study examined the differences between demographic groups in South Punjab,Pakistan affected by the 2010 floods,comparing respondents'levels of social capital measured through proxies such as received social support,perceived community cohesion,accessibility to leadership,and general level of *** carried out univariate and multivariate analyses of factors including gender,education,occupation,landholding,family size,annual income,number of livestock,and home *** data collected in face-to-face interviews with 450 flood survivors,our analysis showed no statistically significant difference in the flood victims'scores on all four scales based on gender and family ***,education,occupation,landholding,annual income,and home stability statistically correlated with levels of social *** with high levels of education,high levels of land,higher home stability,and a government job typically had higher scores in all four measurements of social *** results show strong inequality in the distribution of social capital,with better connections and assistance coming to those who already have better socioeconomic positions in society.

关键词： Flood survivors Pakistan Social capital South Punjab

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Scenario of dengue infection & its control in Pakistan: An up-date and way forward

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Asian Pacific Journal of Tropical Medicine 2018年第1期11卷 15-23页

作者： muhammad Zubair Yousaf Adeena siddique Usman Ali Ashfaq muhammad Ali Department of Biological Sciences Forman Christian College(A Chartered University) Department of Bioinformatics and Biotechnology Government College University Faisalabad Department of Biotechnology Quad-e Azam University Islamabad

Dengue fever is one of the major health problems in tropical and subtropical areas throughout the world. The causative agent of dengue fever is the dengue virus which is an enveloped single stranded RNA virus belongs to the family Flaviviridae and has five distinct serotypes(DENV-1,DENV-2, DENV-3, DENV-4 and DENV-5). Dengue virus is transmitted to human via bite of Aedes aegypti and Aedes albopictus mosquitoes. The clinical symptoms of dengue fever ranging from mild to severe form as dengue hemorrhagic fever and dengue shock syndrome. Pakistan is dengue endemic since 1994 but from 2006, Pakistan faced the worst condition regarding dengue in which thousands of people affected by the disease and hundreds of people lost their lives. DENV-2, DENV-3 and DENV-1 are the prevalent serotypes in Pakistan. Common diagnostic techniques are being used in Pakistan such as enzyme-linked immunosorbent assay,polymerase chain reaction and rapid diagnostic tests, while differential diagnosis, limitations of diagnostic methods and poor health care system are the real challenges in dengue *** climatic conditions, unplanned urbanization, travelling etc., are major factors responsible for dengue epidemics in Pakistan. This presentation provides update about dengue circumstances in Pakistan and also describes the way how to improve dengue situation in Pakistan.

关键词： Dengue infection Diagnosis Treatment Prevention Pakistan

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Aggregation Operators for Interval-Valued Pythagorean Fuzzy Soft Set with Their Application to Solve Multi-Attribute Group Decision Making Problem

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Computer Modeling in Engineering & Sciences 2022年第6期131卷 1717-1750页

作者： Rana muhammad Zulqarnain Imran siddique Aiyared Iampan Dumitru Baleanu Department of Mathematics University of Management and TechnologySialkot CampusLahore54770Pakistan Department of Mathematics University of Management and TechnologyLahore54000Pakistan Department of Mathematics School of ScienceUniversity of PhayaoMae KaMueangPhayao56000Thailand Department of Mathematics Cankaya UniversityBalgat Ankara06530Turkey Institute of Space Sciences Magurele-Bucharest077125Romania Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung40447Taiwan

Interval-valued Pythagorean fuzzy soft set(IVPFSS)is a generalization of the interval-valued intuitionistic fuzzy soft set(IVIFSS)and interval-valued Pythagorean fuzzy set(IVPFS).The IVPFSS handled more uncertainty comparative to IVIFSS;it is the most significant technique for explaining fuzzy information in the decision-making *** this work,some novel operational laws for IVPFSS have been *** on presented operational laws,two innovative aggregation operators(AOs)have been developed such as interval-valued Pythagorean fuzzy soft weighted average(IVPFSWA)and interval-valued Pythagorean fuzzy soft weighted geometric(IVPFSWG)operators with their fundamental properties.A multi-attribute group decision-making(MAGDM)approach has been established utilizing our developed operators.A numerical example has been presented to ensure the validity of the proposed MAGDM ***,comparative studies have been given between the proposed approach and some existing *** obtained results through comparative studies show that the proposed technique is more credible and reliable than existing approaches.

关键词： Interval-valued Pythagorean fuzzy soft set IVPFSWA operator IVPFSWG operator MAGDM

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