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Impact of non-alcoholic fatty liver disease on coronavirus disease 2019: A systematic review

World Journal of Hepatology 2024年第8期16卷 1185-1198页

作者： Abdul Moeed muhammad Omar Larik muhammad ahmed ali fahim Hafsah alim Ur Rahman Lubna Najmi Mah I Kan Changez muhammad Moiz Javed Md Al Hasibuzzaman Department of Internal Medicine Dow University of Health SciencesKarachi 74200SindhPakistan Department of Internal Medicine Dow International Medical CollegeKarachi 74200SindhPakistan Department of Internal Medicine Ziauddin UniversityKarachi 75000SindhPakistan Department of Research Yale UniversityNew Haven 06520CTUnited States Department of Internal Medicine King Edward Medical UniversityLahore 54000PunjabPakistan Institute of Nutrition and Food Science University of DhakaDhaka 1000Bangladesh Department of Medicine The Affiliated Hospital of Medical School of Ningbo UniversityNingbo 315211Zhejiang ProvinceChina

BACKGROUND Many studies have revealed a link between non-alcoholic fatty liver disease(NA-FLD)and coronavirus disease 2019(COVID-19),making understanding the relationship between these two conditions an absolute *** To provide a qualitative synthesis on the currently present data evaluating COVID-19 and *** This systematic review was conducted in accordance with the guidelines pro-vided by preferred reporting items for systematic reviews and meta-analyses and the questionnaire utilized the population,intervention,comparison,and outcome *** search strategy was run on three separate databases,PubMed/MEDLINE,Scopus,and Cochrane Central,which were systematically searched from inception until March 2024 to select all relevant *** addition,***,***,and Google Scholar were searched to identify grey *** After retrieval of 11 studies,a total of 39282 patients data were *** was found in 11.5%and 9.4%of people in NAFLD and non-NAFLD *** all,23.2%of NAFLD patients and 22%of non-NAFLD admissions diagnosed with COVID-19 were admitted to the intensive care unit,with days of stay *** support ranged from 5%to 40.5%in the NAFLD cohort and from 3.1%to 20%in the non-NAFLD *** incidence of acute liver injury showed *** improvement on days 7 and 14 between the two classifications was *** stay ranged from 9.6 days to 18.8 days and 7.3 days to 16.4 days in the aforementioned cohorts respectively,with 73.3%and 76.3%of patients being *** rates *** Clinical outcomes except mortality consistently showed a worsening trend in patients with NAFLD and concomitant *** research in conducting prospective longitudinal studies is essential for a more powerful conclusion.

关键词： Non-alcoholic fatty liver disease Coronavirus disease 2019 Mechanical ventilation Intensive care unit Acute liver injury

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Long-term outcomes of titanium-nitride-oxide coated stents and drug-eluting stents in acute coronary syndrome:A systematic review and meta-analysis

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World Journal of Cardiology 2024年第5期16卷 293-305页

作者： muhammad ahmed ali fahim Afia Salman Hira Anas Khan Syed muhammad Hasan Muskan FatimaBhojani Sarah Aslam Amna Zia Ul Haq Vishal Reddy Bejugam Beena Muntaha Nasir Wajiha Gul Abdul Moeed Abdelrahman S Abdalla muhammad Majid muhammad Sohaib Asghar Md Al Hasibuzzaman Department of Internal Medicine Dow University of Health SciencesKarachi 74200Pakistan Department of Internal Medicine North Central Bronx HospitalBronxNY 10467United States Department of Urology Center for Academic MedicineStanford University School of MedicinePalo AltoCA 33872United States Department of Cardiovascular Imaging Cleveland ClinicClevelandOH 44195United States Division of Nephrology and Hypertension Mayo Clinic RochesterRochesterMN 55905United States Institute of Nutrition and Food Science University of DhakaDhaka 1000Bangladesh

BACKGROUND In severe cases of coronary artery disease,percutaneous coronary intervention provide promising *** stent used could be a drug-eluting stent(DES)or a titanium-nitride-oxide coated stent(TiNOS).AIM To compare the 5-year effectiveness and safety of the two stent *** The following systematic review and meta-analysis was conducted in accordance with the preferred reporting items for systematic reviews and meta-analysis guidelines,and PubMed/MEDLINE,Scopus,and Cochrane Central were searched from inception till August *** outcomes were major adverse cardiac events(MACE),cardiac death,myocardial infarction(MI),cardiac death or MI,and ischemia-driven total lesion revascularization(ID-TLR).RESULTS Four randomized controlled trials(RCT),which analyzed a sum total of 3045 patients with acute coronary syndrome(ACS)after a median follow-up time of 5 years were *** statistically insignificant,an increase in the ID-TLR was observed in patients receiving TiNOSs vs *** addition,MI,cardiac death and MI,and definite stent thrombosis(DST)were significantly decreased in the TiNOS *** analysis revealed no significant results with meta-regression presenting non-ST elevated MI(NSTEMI)as a statistically significant covariate in the outcome of *** TiNOS was found to be superior to DES in terms of MI,cardiac death or MI,and DST outcomes,however,the effect of the two stent types on ID-TLR and MACE was not significant.A greater number of studies are required to establish an accurate comparison of patient outcomes in TiNOS and DES.

关键词： Stents Drug-eluting Major adverse cardiac events All-cause death Meta-analysis

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Incidence and predictors of hypocalcemia in end-stage renal disease patients on denosumab therapy: A systematic review and metaanalysis

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World Journal of Meta-Analysis 2024年第3期12卷 68-78页

作者： Abdul Hannan Siddiqui Misbah Shaikh Afia Salman muhammad ahmed ali fahim Fizzah Batool Tahreem Mari Sarah Musani Muneeb Fareed Rooma Rehan Amna Hassni Urooj Nizami Ayesha Amir Abdul Moeed Salim R Surani Department of Internal Medicine Dow University of Health SciencesKarachi 74200SindhPakistan Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States

BACKGROUND Denosumab inhibits the receptor activator of nuclear factor *** markedly increases bone mineral density and has been proven to reduce the risk of ***,numerous adverse effects,notably hypocalcemia,are prevalent in patients with end-stage renal disease(ESRD).AIM To analyze the incidence and predictors of hypocalcemia caused by denosumab compared to control in patients with *** We conducted this study in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses ***,Scopus,Cochrane Central,and EMBASE were systematically searched from inception through March *** original studies investigating the effects of denosumab on patients with ESRD compared to control were *** primary outcomes of our study were the incidence of mild,severe,and very severe *** outcomes included serum levels of intact parathyroid hormone,calcium,and *** results were pooled and analyzed using a random-effects *** Seven articles comprising 3240 patients were included in our *** treated with denosumab had a significantly increased incidence of mild hypocalcemia[risk ratio(RR):2.79;95%confidence interval(CI):0.99-7.91;P=0.05;I^(2)=37%]and of very severe hypocalcemia(RR:9.58;95%CI:1.58-57.98;P=0.01;I^(2)=49%).However,an increase in the occurrence of severe hypocalcemia was non-significant(RR:4.23;95%CI:0.47-38.34;P=0.20;I^(2)=96%).Alternatively,denosumab showed a significant decrease in serum intact parathyroid hormone[mean difference(MD):-433.20,95%CI:-775.12 to-91.28,I2=98%,P=0.01],while there was a non-significant decrease in phosphate(MD:-0.47,95%CI:-1.35 to 0.41,I^(2)=88%,P=0.30)and calcium levels(MD:-0.33,95%CI:-0.95 to 0.29,I^(2)=94%,P=0.29).CONCLUSION Our study demonstrated that denosumab is significantly associated with mild and very severe hypocalcemia in patients with ESRD making it necessary to detect and prevent this side effect of treatmen

关键词： Denosumab End-stage renal disease Hypocalcemia Parathyroid hormone Dialysis

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Summary of the current guidelines for managing iatrogenic colorectal perforations and the evolving role of endoluminal vacuum therapy

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World Journal of Clinical Cases 2025年第6期13卷 1-8页

作者： ahmed Tawheed Ibrahim Halil Bahcecioglu Mehmet Yalniz Mubin Ozercan ali Cagri Oral Mohamed El-Kassas Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt Department of Gastroenterology Firat UniversityElazig 23119Türkiye Liver Disease Research Center College of MedicineKing Saud UniversityRiyadh 7805Saudi Arabia

Colonoscopy represents a safe procedure that is widely used in medical practice either to diagnose or treat various gastrointestinal *** the last few years,the incidence rate of perforations in colonoscopic procedures has increased,especially in therapeutic *** recent advancements in endoscopic techniques and gastrointestinal tumoral resection procedures such as endoscopic mucosal resection,endoscopic full-thickness resection,and endoscopic submucosal dissection(ESD)could be a risk factor for this increased *** incidence rate of mortality of serious colonoscopic perforations is 7.1%.The management plan for these perforations starts with conservative treatment in mild cases,endoscopic closure,and surgical management in severe ***,endoluminal vacuum therapy was found to be effective in the management of colorectal perforations and this has been reported in multiple case *** editorial provides an overview of the current guidelines for the management of iatrogenic colorectal *** insights are from the perspectives of endoscopists and *** also present a management algorithm based on the guidelines of the European Society of Gastrointestinal Endoscopy,the American Gastroenterological Association,and the World Society of Emergency *** also discussed in brief the use of endoluminal vacuum therapy in colorectal perforations.

关键词： Colon Rectum Iatrogenic colonic perforation Colonoscopy Guidelines Endovacuum Endolumical vacuum therapy Endoscopic management

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Adaptive Density-Based Spatial Clustering of Applications with Noise(ADBSCAN)for Clusters of Different Densities

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Computers, Materials & Continua 2023年第5期75卷 3695-3712页

作者： ahmed fahim Computer Science Department Prince Sattam bin Abdulaziz UniversityAflajSaudi Arabia Computer Science Department Faculty of Computers and InformationSuez UniversitySuezEgypt

Finding clusters based on density represents a significant class of clustering *** methods can discover clusters of various shapes and *** most studied algorithm in this class is theDensity-Based Spatial Clustering of Applications with Noise(DBSCAN).It identifies clusters by grouping the densely connected objects into one group and discarding the noise *** requires two input parameters:epsilon(fixed neighborhood radius)and MinPts(the lowest number of objects in epsilon).However,it can’t handle clusters of various densities since it uses a global value for *** article proposes an adaptation of the DBSCAN method so it can discover clusters of varied densities besides reducing the required number of input parameters to only *** user input in the proposed method is the *** on the other hand,is computed automatically based on statistical information of the *** proposed method finds the core distance for each object in the dataset,takes the average of these distances as the first value of epsilon,and finds the clusters satisfying this density *** remaining unclustered objects will be clustered using a new value of epsilon that equals the average core distances of unclustered *** process continues until all objects have been clustered or the remaining unclustered objects are less than 0.006 of the dataset’s *** proposed method requires MinPts only as an input parameter because epsilon is computed from *** datasets were used to evaluate the effectiveness of the proposed method that produced promising *** experiments demonstrate that the outstanding ability of the proposed method to detect clusters of different densities even if there is no separation between *** accuracy of the method ranges from 92%to 100%for the experimented datasets.

关键词： Adaptive DBSCAN(ADBSCAN) Density-based clustering Data clustering Varied density clusters

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Analysis of Factors that Affect Government Digitization:A Pilot Case Study of Pakistan

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Computers, Materials & Continua 2021年第1期66卷 291-301页

作者： Salman ahmed muhammad ali Khan Department of Computer Systems Engineering University of Engineering&TechnologyPeshawarPakistan

One of the greatest factors that affects the economic condition of a country is its *** the model of good governance,the primary elements for stronger institution include efficiency,transparency,and accountability;and technology plays a major role in improving these ***,there are myriad of challenges when it comes to practical integration of technology in these institutions for *** is more challenging when a country is developing and one that is already weak *** is also important to mention that the challenges of digitization in public sector is not limited to developing countries *** is equally challenging,even today,in already developed countries to digitally transform their public institutions for improved policymaking and for responsive service *** factors contribute to the failure of such digitization initiatives,more so within developing *** the purpose of this paper is to identify those factors,to measure the significance of each of those factors,and to realize and overcome *** research considered the case study of Pakistan;however,the results are very likely to match the conditions of other developing regions around the *** questionnaires and interviews,valuable feedback was gathered from up to 25 senior government officers that are closely associated with digitization initiatives in public *** feedback to the questions were overall *** results indicate the most significant of factors that affect government digitization in this developing region,including some factors that were not expected.

关键词： E-governance government digitization information management sustainability

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Physico-chemical analysis and antimicrobial potential of Apis dorsata,Apis mellifera and Ziziphus jujube honey samples from Pakistan

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Asian Pacific Journal of Tropical Biomedicine 2014年第8期4卷 633-641页

作者： Hira fahim Javid Iqbal Dasti Ihsan ali Safia ahmed muhammad Nadeem Department of Microbiology Qauid-i-Azam University IslamabadPakistan PCSIR Research Laboratories Thokar Niaz BaigLahorePakistan

Objective:To evaluale physico-chemical properties and antimicrobial potential of indigenous honey samples against different reference strains including Escherichia coli ATCC *** aerogenes ATCC *** aeruginosa ATCC *** subtilis *** aureus ATCC *** typhi ATCC 14028,Klebsiella pneumonia ATCC *** niger ATCC *** oligasparus *** albicans ATCC14053 and Candida utilis ATCC ***:By using standard methods samples were evaluated for their antimicrobial properties including additive effect of starch and non—peroxidase activity,antioxidative properties(phenol contents,flavonoid contents,1,1-diphenyl-2-pierylhydrazyl radical scavenging activity).Prior to this evaluation,complete physico-chemical properties including pH,color,ash contents,protein contents,moisture contents,hydroxymethyl furfural contents,total sugar contents,reducing sugar and non-reducing sugar contents were ***:Relatively higher ash contents were found in the Siddar honey i.e.(0.5900±0.0336)%and small honey showed relatively higher protein contents i.e.(777.598±9.880) mg/*** moisture contents of tested honey samples ranged between 13.8%—16,6%,total sugar contents foam 61.672%-72.420%and non-reducing sugar contents from 1.95%—3.93%.Presences of phenolic contents indicate higher antioxidant potential of these honey *** bacteria showed clear inhibition zones in response to tested honey samples whereas fungi and yeast showed inhibition at higher concentrations of these honey *** Escherichia *** *** *** aeruginosa and Aspergillus niger,overall the small honey showed the higher activity than other honey ***:Physico-chemical analysis of honey samples confirmed good quality of honey according to the standards set by European Union Commission and Codex alimcntarius *** of these honey samples confirms antim

关键词： Ziziphus jujube honey Antimicrobial properties Non-peroxidase activity Antioxidative properties

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Experimental Study on Heat Storage Properties Comparison of Paraffin/Metal Foams Phase Change Material Composites

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Journal of Thermal Science 2024年第2期33卷 469-478页

作者： Waqar ahmed Abid HUSSAIN Hanzla SHAHID Imran ali Hafiz muhammad ali Department of Mechanical Engineering University of Engineering and TechnologyTaxila47080Pakistan Department of Mechanical Engineering Institute of Space TechnologyIslamabadPakistan Department of Mechanical Mechatronics and Manufacturing EngineeringUniversity of Engineering and Technology LahoreFaisalabad CampusPunjabPakistan Mechanical Engineering Department King Fahd University of Petroleum and MineralsDhahran31261Saudi Arabia Interdisciplinary Research Center for Renewable Energy and Power Systems(IRC-REPS) King Fahd University of Petroleum and MineralsDhahran31261Saudi Arabia

Heat storage properties of phase change materials(PCMs) are essential characteristics that perform a key role in thermal heat energy storage *** thermal properties of PCMs can be improved by developing metal foam/PCM *** addition of metal foam in PCMs has a significant effect on the thermal characteristics of *** this paper,the heat storage properties of two different metal foam/PCM composites were experimentally *** behavior of paraffin in metal foam(copper and iron-nickel)/paraffin composites concerning pure paraffin at a constant heat flux of 1000 W/m^(2) in three directions simultaneously(x,y,and z) was *** was infiltrated into copper and iron-nickel foams to develop composite materials which resulted in enhancing the thermal conductivity of the paraffin.A comparative analysis is made on the heat storage properties of paraffin in copper and iron-nickel foams/paraffin *** temperature distribution during the phase transition process is experimentally *** comparison indicates that temperature uniformity in copper foam/paraffin composite is better than in iron-nickel foam/paraffin composite and pure paraffin at the same heat *** results show that at heat flux of 1000 W/m^(2),the heat storage time for copper foam/paraffin composite is 20.63% of that of iron-nickel foam/paraffin composite.

关键词： heat storage capacity paraffin/metal foam composite temperature uniformity heat storage rate phase transition process

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Survey and technological analysis of laser and its defense applications

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Defence Technology（防务技术） 2021年第2期17卷 583-592页

作者： Syed Affan ahmed Mujahid Mohsin Syed muhammad Zubair ali Department of Avionics Engineering-College of Aeronautical Engineering(CAE) National University of Sciences and Technology(NUST)RisalpurKPKPakistan

The laser technology has made remarkable progress over the past couple of *** is being widely employed in diverse domains,such as holography,space sciences,spectroscopy,medical sciences,micro and power electronics,industrial engineering,and most distinctively,as directed energy military *** to their active transmissions,laser systems are similar to microwave radars to some extent;however,unlike conventional radars,the laser operates at very high frequencies thus making it a potent enabler of narrow-beam and high energy aerial deployments,both in offensive and defensive *** modern avionics systems,laser target indicators and beam riders are the most common devices that are used to direct the Laser Guided Weapons(LGW)accurately to the ground ***,compact size and outstanding angular resolution of laser-based systems motivate their use for drones and unmanned aerial ***,the narrow-beam divergence of laser emissions offers a low probability of intercept,making it a suitable contender for secure transmissions and safety-critical ***,the developments in space sciences and laser technology have given synergistic potential outcomes to use laser systems in space *** paper comprehensively reviews laser applications and projects for strategic defense actions on the ground or in ***,a detailed analysis has been done on recent advancements of the laser technology for target indicators and *** also reviews the advancements in the field of laser communications for surveillance,its earlier state of the art,and ongoing scientific research and advancements in the domain of high energy directed laser weapons that have revolutionized the evolving military *** offering a comprehensive taxonomy,the paper also critically analyzes some of the recent contributions in the associated domains.

关键词： Laser systems Laser military applications Directed energy weapons Non-lethal weapons Laser military projects Survey Taxonomy

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Multifaceted roles of extracellular RNAs in different diseases

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Military Medical Research 2023年第3期10卷 359-368页

作者： Abdullah muhammad Sohail muhammad Babar Khawar ali Afzal ali Hassan Sara Shahzaman ahmed ali Molecular Medicine and Cancer Therapeutics Lab Department of ZoologyFaculty of SciencesUniversity of Central PunjabLahorePakistan Applied Molecular Biology and Biomedicine Lab Department of ZoologyUniversity of NarowalNarowalPakistan

Extracellular RNAs(exRNAs) are novel circulating factors that can be used as biomarkers in various diseases. Their unique and diverse kinds, as well as their role as biomarkers, make them significant biomarkers. There has been immense work carried out since the discovery of exRNAs in circulation and other biological fluids to catalog and determine whether exRNAs may be utilized as indicators for health and illness. In this review, we aim to understand the current state of exRNAs in relation to various diseases and their potential as biomarkers. We will also review current issues and challenges faced in using exRNAs, with clinical and lab trials, that can be used as viable markers for different diseases.

关键词： Extracellular RNAs(exRNAs) Extracellular vehicles(EVs) Cancer Biomarkers Exosomes

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