检索结果-南通市图书馆

Viral-host molecular interactions and metabolic modulation:Strategies to inhibit flaviviruses pathogenesis

World Journal of Virology 2024年第4期13卷 41-50页

作者： Zeeshan Ahmad khan Mukesh Kumar Yadav Dong-Woo Lim Hojun Kim Jing-Hua Wang abuzar Ansari Biohealth Products Research Center(BPRC) Research Center for Agedlife Redesign(RCAR)Department of Physical TherapyINJE UniversityGimhae 5084South Korea Department of Microbiology Central University of PunjabBathinda 151401India Department of Diagnostics College of Korean MedicineDongguk UniversityGoyang 10326South Korea Division of Rehabilitation Medicine of Korean Medicine Department of Oriental Rehabilitation MedicineDongguk UniversityIlsan HospitalGoyang 10326South Korea Institute of Oriental Medicine Dongguk UniversityGoyang 10326South Korea Department of Obstetrics and Gynecology Ewha Womans UniversitySeoul 07985South Korea

Flaviviruses,which include globally impactful pathogens,such as West Nile virus,yellow fever virus,Zika virus,Japanese encephalitis virus,and dengue virus,contribute significantly to human *** the ongoing emergence and resurgence of flavivirus-mediated pathogenesis,the absence of specific therapeutic options remains a challenge in the prevention and treatment of flaviviral *** the intricate processes of fusion,transcription,replication,and maturation,the complex interplay of viral and host metabolic interactions affects *** interactions involve metabolic molecules,such as amino acids,glucose,fatty acids,and nucleotides,each playing a pivotal role in the replication and maturation of *** viral-host metabolic molecular interactions hijack and modulate the molecular mechanisms of host metabolism.A comprehensive understanding of these intricate metabolic pathways offers valuable insights,potentially unveiling novel targets for therapeutic interventions against flaviviral *** review emphasizes promising avenues for the development of therapeutic agents that target specific metabolic molecules,such as amino acids,glucose,fatty acids,and nucleotides,which interact with flavivirus replication and are closely linked to the modulation of host *** clinical limitations of current drugs have prompted the development of new inhibitory strategies for flaviviruses based on an understanding of the molecular interactions between the virus and the host.

关键词： Flavivirus Nonstructural proteins Virus-host interaction Metabolism Inhibitors Vaccines

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Interpretable Detection of Malicious Behavior in Windows Portable Executables Using Multi-Head 2D Transformers

引用

Big Data Mining and Analytics 2024年第2期7卷 485-499页

作者： Sohail khan Mohammad Nauman Computer Science Department Effat College of EngineeringEffat UniversityJeddah 23341Kingdom of Saudi Arabia

Windows malware is becoming an increasingly pressing problem as the amount of malware continues to grow and more sensitive information is stored on *** of the major challenges in tackling this problem is the complexity of malware analysis,which requires expertise from human *** developments in machine learning have led to the creation of deep models for malware ***,these models often lack transparency,making it difficult to understand the reasoning behind the model’s decisions,otherwise known as the black-box *** address these limitations,this paper presents a novel model for malware detection,utilizing vision transformers to analyze the Operation Code(OpCode)sequences of more than 350000 Windows portable executable malware samples from real-world *** model achieves a high accuracy of 0.9864,not only surpassing the previous results but also providing valuable insights into the reasoning behind the *** model is able to pinpoint specific instructions that lead to malicious behavior in malware samples,aiding human experts in their analysis and driving further advancements in the *** report our findings and show how causality can be established between malicious code and actual classification by a deep learning model,thus opening up this black-box problem for deeper analysis.

关键词： machine learning malware vision transformers Windows Protable Executable(PE)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ion-acoustic waves with non-planar wavefronts

引用

Plasma Science and Technology 2024年第1期26卷 1-7页

作者： Shujaht BUKHARI muhammad SHAHID Ata-ur RAHMAN Department of Physics The University of Azad Jummu and KashmirMuzaffarabad 13100Azad Kashmir Department of Physics Women University of Azad Jammu&KashmirBagh 12500Pakistan Department of Physics Islamia College PeshawerPeshawar 25120Pakistan

The ion-acoustic(IA) mode exhibiting various orbital angular momentum(OAM) states is examined in a plasma with drifting *** constituent plasma species are modeled with a non-gyrotropic Maxwellian distribution and discussion of dispersion relation and growth rate of twisted IA waves under various conditions is *** the domain of kinetic model,the twisted IA waves are characterized by Laguerre-Gaussian(LG) solutions,where plasma distribution function and electric field are decomposed into axial and azimuthal *** plasma response function is obtained under paraxial approximations and investigated for threshold condition of instability growth rate with helical electric field *** impact of an extra electron specie on the instability is demonstrated through a comparison of twisted waves for single and double electron species.

关键词： instability twist parameter wave excitation orbital angular momentum threshold limit

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modeling environmental sensitivity and risk assessment of PAHs in sediments along two marine coastal areas in Egypt

引用

Petroleum Research 2024年第1期9卷 125-142页

作者： muhammad A.El-Alfy National Institute of Oceanography and Fisheries NIOFCairoEgypt

Modeling the environmental sensitivity index(ESI)is vital in the planning and management processes,especially along the coastal *** main objectives of the study were to define the main sources of polycyclic aromatic hydrocarbons(PAHs),establish an ESI model,and measure the risk of PAHs on humans and the environment using various *** methodology of the research involved analyzing PAHs according to the EPA 550 methodology in sediments of the coastline in two important coastline areas in Egypt,namely the Gulf of Suez and the Mediterranean Sea,modeling the sensitivity of PAHs using ArcGIS 10.5 by integrating different physical,biological,and land use/cover factors,identifying the sources,and performing a risk *** sediment samples were collected from each *** produced sensitivity map could explain the highly sensitive areas along the Mediterranean Sea and Gulf of Suez coastlines(especially areas that were near drains'outlets,industrial sites,and sea ports).The highest mean PAH concentrations were Acenaphthylene and Fluorine in the Mediterranean Sea and Suez Gulf,***'s obvious that the individual PAH concentrations were within the ERL,ERM,and PEL threshold limits,indicating no adverse biological *** ratios of BaA/BaA+Chy,Flu/Flu+Py,and Ant/Ant+Phe gave an indication that most PAH sources were petrogenic(63.64%)and others(36.36%)were from petroleum *** principle component analysis(PCA)indicated a diverse correlation among the isomer ratios and LU/LC *** carcinogenic risk values were in the very low category(<10^(-6))for both children and *** most significant contributors to carcinogenicity were IP and BkFlu in the Mediterranean Sea and Suez Gulf,*** sources of carbon in seawater,especially with climatic change,may impact the aquatic environment and have impacts on organisms and coral *** it is highly recommended to keep shorelines and seawater free of oil spillage act

关键词： Polycyclic aromatic hydrocarbons(PAHs) Modeling Sensitivity Gulf of Suez And Mediterranean sea

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Long-term outcomes of titanium-nitride-oxide coated stents and drug-eluting stents in acute coronary syndrome:A systematic review and meta-analysis

引用

World Journal of Cardiology 2024年第5期16卷 293-305页

作者： muhammad Ahmed Ali Fahim Afia Salman Hira Anas khan Syed muhammad Hasan Muskan FatimaBhojani Sarah Aslam Amna Zia Ul Haq Vishal Reddy Bejugam Beena Muntaha Nasir Wajiha Gul Abdul Moeed Abdelrahman S Abdalla muhammad Majid muhammad Sohaib Asghar Md Al Hasibuzzaman Department of Internal Medicine Dow University of Health SciencesKarachi 74200Pakistan Department of Internal Medicine North Central Bronx HospitalBronxNY 10467United States Department of Urology Center for Academic MedicineStanford University School of MedicinePalo AltoCA 33872United States Department of Cardiovascular Imaging Cleveland ClinicClevelandOH 44195United States Division of Nephrology and Hypertension Mayo Clinic RochesterRochesterMN 55905United States Institute of Nutrition and Food Science University of DhakaDhaka 1000Bangladesh

BACKGROUND In severe cases of coronary artery disease,percutaneous coronary intervention provide promising *** stent used could be a drug-eluting stent(DES)or a titanium-nitride-oxide coated stent(TiNOS).AIM To compare the 5-year effectiveness and safety of the two stent *** The following systematic review and meta-analysis was conducted in accordance with the preferred reporting items for systematic reviews and meta-analysis guidelines,and PubMed/MEDLINE,Scopus,and Cochrane Central were searched from inception till August *** outcomes were major adverse cardiac events(MACE),cardiac death,myocardial infarction(MI),cardiac death or MI,and ischemia-driven total lesion revascularization(ID-TLR).RESULTS Four randomized controlled trials(RCT),which analyzed a sum total of 3045 patients with acute coronary syndrome(ACS)after a median follow-up time of 5 years were *** statistically insignificant,an increase in the ID-TLR was observed in patients receiving TiNOSs vs *** addition,MI,cardiac death and MI,and definite stent thrombosis(DST)were significantly decreased in the TiNOS *** analysis revealed no significant results with meta-regression presenting non-ST elevated MI(NSTEMI)as a statistically significant covariate in the outcome of *** TiNOS was found to be superior to DES in terms of MI,cardiac death or MI,and DST outcomes,however,the effect of the two stent types on ID-TLR and MACE was not significant.A greater number of studies are required to establish an accurate comparison of patient outcomes in TiNOS and DES.

关键词： Stents Drug-eluting Major adverse cardiac events All-cause death Meta-analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The big data challenge-and how polypharmacology supports the translation from pre-clinical research into clinical use against neurodegenerative diseases and beyond

引用

Neural Regeneration Research 2024年第8期19卷 1647-1648页

作者： Sven Marcel Stefan muhammad Rafehi Drug Development and Chemical Biology Lübeck Institute of Experimental Dermatology(LIED)University of Lübeck and University Medical Center Schleswig-HolsteinLübeckGermany Department of Pathology Section of NeuropathologyTranslational Neurodegeneration Research and Neuropathology LabUniversity of Oslo and Oslo University HospitalOsloNorway School of Medical Sciences Faculty of Medicine and HealthUniversity of SydneySydneyNSWAustralia Institute of Clinical Pharmacology University Medical Center GöttingenGöttingenGermany Department of Medical Education Augsburg University MedicineAugsburgGermany

Introductory comments:The identification and validation of disease-modifying proteins are fundamental aspects in drug ***,the m ultifactority of n eurodegen era tive diseases poses a real challenge for targeted ***,the behavior of individually(over-)expressed to rget proteins in vitro is likely to differ from their actual functional behavior when embedded in cascades and pathways in vivo.

关键词： translation beyond likely

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Metabolic complications of psychotropic medications in psychiatric disorders:Emerging role of de novo lipogenesis and therapeutic consideration

引用

World Journal of Psychiatry 2024年第6期14卷 767-783页

作者： Mohammad M khan Zaw Ali khan Mohsin Ali khan Laboratory of Translational Neurology and Molecular Psychiatry Department of BiotechnologyEra’s Lucknow Medical College and Hospitaland Faculty of ScienceEra UniversityLucknow 226003India Era’s Lucknow Medical College and Hospital Era UniversityLucknow 226003India

Although significant advances have been made in understanding the pathophysiology of psychiatric disorders(PDs),therapeutic advances have not been very *** psychotropic medications can reduce classical symptoms in patients with PDs,their long-term use has been reported to induce or exaggerate various pre-existing metabolic abnormalities including diabetes,obesity and non-alcoholic fatty liver disease(NAFLD).The mechanism(s)underlying these metabolic abnormalities is not clear;however,lipid/fatty acid accumulation due to enhanced de novo lipogenesis(DNL)has been shown to reduce membrane fluidity,increase oxidative stress and inflammation leading to the development of the aforementioned metabolic ***,emerging evidence suggest that DNL dysregulation and fatty acid accumulation could be the major mechanisms associated with the development of obesity,diabetes and NAFLD after long-term treatment with psychotropic medications in patients with *** support of this,several adjunctive drugs comprising of anti-oxidants and antiinflammatory agents,that are used in treating PDs in combination with psychotropic medications,have been shown to reduce insulin resistance and development of *** conclusion,the above evidence suggests that DNL could be a potential pathological factor associated with various metabolic abnormalities,and a new avenue for translational research and therapeutic drug designing in PDs.

关键词： Psychotropic medications Metabolic complications De novo lipogenesis Obesity Diabetes Non-alcoholic fatty liver disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Impact of Domain Name Server(DNS)over Hypertext Transfer Protocol Secure(HTTPS)on Cyber Security:Limitations,Challenges,and Detection Techniques

引用

Computers, Materials & Continua 2024年第9期80卷 4513-4542页

作者： muhammad Dawood Shanshan Tu Chuangbai Xiao muhammad Haris Hisham Alasmary muhammad Waqas Sadaqat Ur Rehman Faculty of Information Technology Beijing University of TechnologyBeijing100124China National Center of Robotics and Automation University of Engineering and TechnologyPeshawar25000Pakistan Department of Computer Science College of Computer ScienceKing Khalid UniversityAbha61421Saudi Arabia School of Computing and Engineering Sciences Faculty of Engineering and ScienceUniversity of GreenwichLondonSE109LSUnited Kingdom School of Engineering Edith Cowan UniversityPerthWA 6027Australia School of Computer Science and Engineering University of SalfordManchesterM54BRUnited Kingdom

The DNS over HTTPS(Hypertext Transfer Protocol Secure)(DoH)is a new technology that encrypts DNS traffic,enhancing the privacy and security of ***,the adoption of DoH is still facing several research challenges,such as ensuring security,compatibility,standardization,performance,privacy,and increasing user *** significantly impacts network security,including better end-user privacy and security,challenges for network security professionals,increasing usage of encrypted malware communication,and difficulty adapting DNS-based security ***,it is important to understand the impact of DoH on network security and develop newprivacy-preserving techniques to allowthe analysis of DoH traffic without compromising user *** paper provides an in-depth analysis of the effects of DoH on *** discuss various techniques for detecting DoH tunneling and identify essential research challenges that need to be addressed in future security ***,this paper highlights the need for continued research and development to ensure the effectiveness of DoH as a tool for improving privacy and security.

关键词： DNS DNS over HTTPS cybersecurity machine learning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Antibody Pattern: Correlation of Age and Gender in ANA and Anti-ds-DNA Prevalence

引用

Journal of Clinical and Nursing Research 2024年第6期8卷 373-381页

作者： Usama Ahmed Hijazi Mallick Amber khan muhammad Zubair Department of Medicine School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060China Dow International Medical College Karachi Pakistan Department of Biosciences Shaheed Zulfikar Ali Bhutto Institute of Science and Technology(SZABIST)KarachiPakistan Institute of Biological Sciences Khwaja Fareed University of Engineering and Information TechnologyRahim Yar KhanPakistan

The study was designed to find the prevalence of ANA antibodies and anti-dsDNA antibodies in samples tested at AFIP Rawalpindi and their correlation with age and gender and to find positive and negative predictive values of ANA *** this purpose,twelve thousand nine hundred sixty-seven(12,967)patients were analyzed for ANA with four hundred sixty-eight(468)healthy samples tested as control and four thousand seven hundred three(4,703)patients tested for ds-DNA *** data of all samples tested by indirect immunofluorescence(IF)for ANA antibodies and dsDNA antibodies was *** address positive and negative predictive values another control group(autoimmunity not suspected)of serum samples was taken from the healthy *** the first group,age,gender,ANA antibodies and ds-DNA antibodies results(both tests performed by IIF)data was collected from a computer record cell;for the second control group,ANA antibodies were performed by IIF.12,967 and 4,703 samples(Group 1)were tested for ANA antibodies and dsDNA antibodies,respectively,during this period.1,119(9%)and 99(2%)were found positive for ANA antibodies and ds DNA *** these positive samples,850(76%)and 73(74%)were females *** predisposition towards autoimmunity(ANA)was found significant with a P value of(P=0.001).Relation of age was also found significant with anti-ANA antibodies with a P value of(P=0.001).This study shows a negative correlation between age(P=0.025)and gender(P=0.001)with anti-dsDNA which is also *** prevalence was found below the mean age of 38 years(SD±16.635)for ANA antibodies and the mean age of 35 years(SD±15.066)for ds-DNA *** age of ANA antibodies and dsDNA antibodies positive patients ranged from 1 year old to 98 years old and 2 years old to 95 years old *** the second(autoimmunity-free)control group,a total of 468 samples were tested for ANA antibodies and 9(2%)were found ***

关键词： ANA Anti ds-DNA Autoimmunity SLE Immune fluorescence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Model Agnostic Meta-Learning(MAML)-Based Ensemble Model for Accurate Detection of Wheat Diseases Using Vision Transformer and Graph Neural Networks

引用

Computers, Materials & Continua 2024年第5期79卷 2795-2811页

作者： Yasir Maqsood Syed muhammad Usman Musaed Alhussein Khursheed Aurangzeb Shehzad Khalid muhammad Zubair Department of Creative Technologies Faculty of Computing and Artificial IntelligenceAir UniversityIslamabad44000Pakistan Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia Department of Computer Engineering Bahria School of Engineering and Applied SciencesBahria UniversityIslamabad44000Pakistan Laboratory for Neuro&Psychophysiology KU LeuvenLeuven3000Belgium

Wheat is a critical crop,extensively consumed worldwide,and its production enhancement is essential to meet escalating *** presence of diseases like stem rust,leaf rust,yellow rust,and tan spot significantly diminishes wheat yield,making the early and precise identification of these diseases vital for effective disease *** advancements in deep learning algorithms,researchers have proposed many methods for the automated detection of disease pathogens;however,accurately detectingmultiple disease pathogens simultaneously remains a *** challenge arises due to the scarcity of RGB images for multiple diseases,class imbalance in existing public datasets,and the difficulty in extracting features that discriminate between multiple classes of disease *** this research,a novel method is proposed based on Transfer Generative Adversarial Networks for augmenting existing data,thereby overcoming the problems of class imbalance and data *** study proposes a customized architecture of Vision Transformers(ViT),where the feature vector is obtained by concatenating features extracted from the custom ViT and Graph Neural *** paper also proposes a Model AgnosticMeta Learning(MAML)based ensemble classifier for accurate *** proposedmodel,validated on public datasets for wheat disease pathogen classification,achieved a test accuracy of 99.20%and an F1-score of 97.95%.Compared with existing state-of-the-art methods,this proposed model outperforms in terms of accuracy,F1-score,and the number of disease pathogens *** future,more diseases can be included for detection along with some other modalities like pests and weed.

关键词： Wheat disease detection deep learning vision transformer graph neural network model agnostic meta learning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：