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Transcranial magnetic stimulation in animal models of neurodegeneration

Neural Regeneration Research 2022年第2期17卷 251-265页

作者： Mohammad Uzair Turki Abualait muhammad arshad Woo-Kyoung Yoo Ali Mir Reem Fahd Bunyan Shahid Bashir Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University IslamabadPakistan College of Applied Medical Sciences Imam Abdulrahman Bin Faisal UniversityDammamSaudi Arabia Department of Physical Medicine and Rehabilitation Hallym University College of MedicineAnyangSouth Korea Hallym Institute for Translational Genomics&Bioinformatics Hallym University College of MedicineAnyangSouth Korea Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

Brain stimulation techniques offer powerful means of modulating the physiology of specific neural structures. In recent years, non-invasive brain stimulation techniques, such as transcranial magnetic stimulation(TMS) and transcranial direct current stimulation, have emerged as therapeutic tools for neurology and neuroscience. However, the possible repercussions of these techniques remain unclear, and there are few reports on the incisive recovery mechanisms through brain stimulation. Although several studies have recommended the use of non-invasive brain stimulation in clinical neuroscience, with a special emphasis on TMS, the suggested mechanisms of action have not been confirmed directly at the neural level. Insights into the neural mechanisms of non-invasive brain stimulation would unveil the strategies necessary to enhance the safety and efficacy of this progressive approach. Therefore, animal studies investigating the mechanisms of TMSinduced recovery at the neural level are crucial for the elaboration of non-invasive brain stimulation. Translational research done using animal models has several advantages and is able to investigate knowledge gaps by directly targeting neuronal levels. In this review, we have discussed the role of TMS in different animal models, the impact of animal studies on various disease states, and the findings regarding brain function of animal models after TMS in pharmacology research.

关键词： Alzheimer's disease depression glial cells neurorehabilitation Parkinson's disease repetitive transcranial magnetic stimulation transcranial direct current stimulation transcranial magnetic stimulation

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Two Layer Symmetric Cryptography Algorithm for Protecting Data from Attacks

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Computers, Materials & Continua 2023年第2期74卷 2625-2640页

作者： muhammad Nadeem Ali arshad Saman Riaz Syeda Wajiha Zahra Shahab SBand Amir Mosavi Department of Computer Science Abasyn UniversityIslamabad44000Pakistan Department of Computer Science National University of TechnologyIslamabad44000Pakistan Future Technology Research Center National Yunlin University of Science and TechnologyDouliuYunlin64002Taiwan Institute of Information Society University of Public ServiceBudapest1083Hungary John Von Neumann Faculty of Informatics Obuda UniversityBudapestHungary Institute of Information Engineering Automation and MathilticsSlovak University of Technology in BratislavaSlovakia

Many organizations have insisted on protecting the cloud server from the outside,although the risks of attacking the cloud server are mostly from the *** are many algorithms designed to protect the cloud server from attacks that have been able to protect the cloud server ***,the attackers have designed even better mechanisms to break these security *** cryptography is the best data protection algorithm that exchanges data between authentic *** this article,one symmetric cryptography algorithm will be designed to secure cloud server data,used to send and receive cloud server data securely.A double encryption algorithm will be implemented to send data in a secure ***,the XOR function will be applied to plain text,and then salt technique will be ***,a reversing mechanism will be implemented on that data to provide more data *** decrypt data,the cipher text will be reversed,salt will be removed,andXORwill be *** the end of the paper,the proposed algorithm will be compared with other algorithms,and it will conclude how much better the existing algorithm is than other algorithms.

关键词： Cryptography symmetric algorithm encryption decryption cipher text cloud security asymmetric algorithm

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Effect of regional factor productivity on manufacturing sector: The case of Sino-Pak economic ties

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Financial Innovation 2020年第1期6卷 95-108页

作者： muhammad Imran An HuSen muhammad Kaleem arshad Khan Bangash Nizam Ud Din Sobia Department of Economics Bacha Khan UniversityCharsaddaPakistan School of Economics Nankai UniversitTianjinChina Department of Sociology and Gender Studies Bacha Khan UniversityCharsaddaPakistan Department of Business Administration Karakoram International UniversityGilgitPakistan Government Postgraduate Jahanzeb College SwatPakistan

Introduction:Economic ties and trade blocs increase the flow of trade between participating countries and lead to different levels of economic and structural *** description:This paper focuses on the structure of industrial value-added between China and Pakistan,as the two countries recently launched the CPEC(China-Pakistan Economic Corridor)*** and evaluation:This study utilizes panel data from 1995 to 2015 to test certain factor effects on regional value-added through econometric *** results show that each country has its own economic growth rate and market size that respond differently to industrial value-added ***:Aggregate factor productivity at China is higher than in Pakistan but growth in factor productivity in the latter is higher than the former;similarly,the share of bilateral trade is higher in the case of *** each country responds differently to the new economic ties,the macroeconomic results support bilateral economic ties between them.

关键词： New economic geography China-Pakistan economic-ties Factor productivities

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Integration of geoelectric and hydrochemical approaches for delineation of groundwater potential zones in alluvial aquifer

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Journal of Groundwater Science and Engineering 2020年第4期8卷 366-380页

作者： Qaisar Mehmood muhammad arshad muhammad Rizwan Shanawar Hamid Waqas Mehmood muhammad Ansir Muneer muhammad Irfan Lubna Anjum Department of Irrigation&Drainage Faculty of Agricultural Engineering&TechnologyUniversity of AgricultureFaisalabad38040Pakistan Department of Agriculture(Field Wing)Government of Punjab Pakistan Key Laboratory of Remote Sensing and Geospatial Science Northwest Institute of Eco Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Khawaja Farid University of Engineering and Information Technology Pakistan Adaptive Research Farms Agriculture Department(Extension&Research Wing)PunjabPakistan PMU Agriculture DepartmentGovernment of PunjabPakistan

Geoelectric and hydrochemical approaches are employed to delineate the groundwater potential zones in District Okara,a part of Bari Doab,Punjab,***-seven VES surveys are conducted with the Electrical Resistivity *** resultant resistivity verses depth model for each site is estimated using computer-based software *** thickness maps and interpreted resistivity maps were generated from interpreted VES ***-Zarrouk parameters,transverse resistance(TR),longitudinal conductance(SL)and anisotropy(λ)were also calculated from resistivity data to delineate the potential zones of aquifer.70%of SL value is≤3S,30%of SL value is>*** to SL and TR values,the whole area is divided into three potential zones,high,medium and low potential *** spatial distribution maps show that north,south and central parts of study area are marked as good potential aquifer *** conductance values are further utilized to determine aquifer protective capacity of *** whole area is characterized by moderate to good and up to some extent very good aquifer protective area on the basis of SL *** groundwater samples from sixty-seven installed tube wells are collected for hydro-chemical *** electrical conductivity values are *** is then developed between the EC(μS/cm)of groundwater samples *** aquifer resistivity showing R2 value 0.90.

关键词： Aquifer Groundwater potential zone Longitudinal conductance VES

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Synthesis,Crystal Structure and Spectroscopic Properties of 1,2-Benzothiazine Derivatives:An Experimental and DFT Study

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Chinese Journal of Structural Chemistry 2015年第1期34卷 15-25页

作者： muhammad Nadeem arshad TARIQ Mahmood ATHER Faroque Khan muhammad Zia-Ur-Rehman ABDULLAH M.Asiri ISLAM Ullah Khan RIFFAT-Un-Nisa KHURSHID Ayub AZAM Mukhtar muhammad Tariq Saeed Chemistry Department Faculty of ScienceKing Abdulaziz University Centre of Excellence for Advanced Materials Research (CEAMR) King Abdulaziz University Department of Chemistry COMSATS Institute of Information TechnologyAbbottabad IRCBM COMSATS Institute of Information Technology Applied Chemistry Research Center PCSIR Laboratories ComplexFerozpur RoadLahore 54600Pakistan Materials Chemistry Laboratory Department of ChemistryGC University Department of Chemistry College of ScienceKing Faisal University Department of Chemistry University of EducationOkara CampusOkara-Pakistan

1,2-Benzothiazine derivatives methyl 3-methoxy-4-oxo-3,4-dihydro-2H-benzo[e] [1,2]thiazine-3-carboxylate 1,1-dioxide（1） and methyl 2-ethyl-3-hydroxy-4-oxo-3,4-dihydro-2Hbenzo[e][1,2]thiazine-3-carboxylate 1,1-dioxide（2） were synthesized, and characterized by spectroscopic techniques; 1H-NMR and infrared（IR） spectroscopy. Crystals of 1 and 2 were grown by slow evaporation of methanol and ethyl acetate, respectively and their crystal structures were investigated by single-crystal X-ray diffraction analysis. Geometric properties were calculated by the B3 LYP method of density functional theory（DFT） at the 6-31G＋（d） basis set to compare with the experimental data. Simulated properties were found in strong agreement with the experimental ones. Intermolecular forces have also been modeled in order to investigate the strength of packing and strong hydrogen bonding was observed in both compounds 1 and 2. Electronic properties such as Ionization Potential（IP）, Electron Affinities（EA） and coefficients of the highest occupied molecular orbital（HOMO） and the lowest unoccupied molecular orbital（LUMO） of com- pounds 1 and 2 were simulated for the first time.

关键词： 1,2-benzothiazine B3LYP/6-31+G (d) density functional theory (DFT) HUMO-LUMO crystal structures

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Facile Synthesis as well as Structural, Raman, Dielectric and Antibacterial Characteristics of Cu Doped ZnO Nanoparticles

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Journal of Materials Science & Technology 2015年第3期31卷 300-304页

作者： Javed Iqbal Nauman Safdar Tariq Jan muhammad Ismail S.S.Hussain arshad Mahmood Shaheen Shahzad Qaisar Mansoor Laboratory of Nanoscience and Technology Department of Physics International Islamic University Institute of Biomedical and Genetic Engineering (IBGE) Nano Devices Labs National Institute of Lasers and Optronics (NILOP) Department of Bioinformatics and Biotechnology International Islamic University

Here, undoped and Cu doped ZnO nanoparticles(NPs) have been prepared by chemical co-precipitation technique. X-ray diffraction(XRD) results reveal that Cu ions are successfully doped into ZnO matrix without altering its wurtzite phase. The single wurtzite phase of ZnO is retained even for 10 wt% Cu doped ZnO sample. It is observed from the electron microscopy results that higher level of Cu doping varies the morphology of ZnO NPs from spherical to flat NPs. Moreover, the particle size is found to increase with the increase in Cu doping level. Raman spectroscopy results further confirm that Cu dopant has not altered the wurtzite structure of ZnO. Impedance spectroscopy results reveal that the dielectric constant and dielectric loss have increasing trend with Cu doping. Cu doping has been found to slightly decrease the bactericidal potency of ZnO nanoparticles.

关键词： Cu doped ZnO Nanoparticles Co-precipitation method

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Breeding for pre-harvest sprouting resistance in bread wheat under rainfed conditions

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Frontiers of Agricultural Science and Engineering 2018年第2期5卷 253-261页

作者： muhammad ZEESHAN Waheed arshad muhammad Imran KHAN Shiraz ALI Ali NAWAZ Amina BATOOL muhammad TARIQ muhammad Imran AKRAM muhammad Amjad ALI Barani Agricultural Research Station Barani Agricultural Research Institute Soil and Water Conservation Research Station Department of Plant Pathology and Centre of Agricultural Biochemistry & Biotechnology University of AgricultureFaisalabad

Pre-harvest sprouting in wheat is the germination of seeds within the spikes when rains occur after or during grain ripening, which occurs commonly in the barani tract of Pakistan. Therefore, 10 cultivars and five advanced lines of spring bread wheat were evaluated for pre-harvest sprouting resistance. After natural rainfall,seeds were immediately collected from the wet spikes and tested for germinating ability. Three different germination tests were applied to hand-threshed seed:(1) spikes threshed on the day of sampling and germination tested immediately,(2) spikes threshed on the day of sampling and germination tested 1 week later, and(3) spikes threshed 1 week after sampling and germination test immediately after threshing. Seeds and spikes kept for 1 week were place on blotting paper at room *** BARS-09, 09 FJ17, Doukkala-12, NARC-09 and Ouassou-20 exhibited higher sprouting resistance while other genotypes were susceptible to pre-harvest sprouting in each of the three tests. A diallel crossing was conducted with six susceptible and two resistant genotypes to assess the genetic behavior of pre-harvest sprouting *** combining ability(CA) demonstrated a higher proportion of additive genetic effects for sprouting resistance, because of higher variance of general and specific CA for both parameters under study. Doukkala-12 and BARS-09 showed increased pre-harvest sprouting resistance in their F1 descendants.

关键词： bread wheat germination index general combining ability pre-harvest sprouting specific combining ability

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An Efficient Technique to Prevent Data Misuse with Matrix Cipher Encryption Algorithms

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Computers, Materials & Continua 2023年第2期74卷 4059-4079页

作者： muhammad Nadeem Ali arshad Saman Riaz Syeda Wajiha Zahra Ashit Kumar Dutta Moteeb Al Moteri Sultan Almotairi Department of Computing Abasyn UniversityIslamabadPakistan Department of Computer Science National University of TechnologyIslamabadPakistan Department of Computer Science and Information Systems College of Applied SciencesAlMaarefa UniversityRiyadh13713Kingdom of Saudi Arabia Department of Management Information Systems Business Administration CollegeKing Saud UniversityRiyadh11451Saudi Arabia Department of Natural and Applied Sciences Faculty of Community CollegeMajmaah UniversityMajmaah11952Saudi Arabia

Many symmetric and asymmetric encryption algorithms have been developed in cloud computing to transmit data in a secure *** cryptography is a data encryption mechanism that consists of different steps and prevents the attacker from misusing the *** paper has developed an efficient algorithm to protect the data from invaders and secure the data from *** this algorithm is applied to the cloud network,the attacker will not be able to access the *** encrypt the data,the values of the bytes have been obtained by converting the plain text to ASCII.A key has been generated using the Non-Deterministic Bit Generator(NRBG)mechanism,and the key is XNORed with plain text bits,and then Bit toggling has been *** that,an efficient matrix cipher encryption algorithm has been developed,and this algorithm has been applied to this *** capability of this algorithm is that with its help,a key has been obtained from the plain text,and only by using this key can the data be decrypted in the first steps.A plain text key will never be used for another plain *** data has been secured by implementing different mechanisms in both stages,and after that,a ciphertext has been *** the end of the article,the latest technique will be compared with different *** will be a discussion on how the present technique is better than all the other techniques;then,the conclusion will be drawn based on comparative analysis.

关键词： Symmetric cryptography ciphertext encryption decryption cloud security matrix cipher

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A Highly Secured Image Encryption Scheme using Quantum Walk and Chaos

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Computers, Materials & Continua 2022年第10期73卷 657-672页

作者： muhammad Islam Kamran Muazzam A.Khan Suliman A.Alsuhibany Yazeed Yasin Ghadi arshad Jameel Arif Jawad Ahmad Department of Computer Science Quaid-i-Azam UniversityIslamabad45320Pakistan Department of Computer Science College of ComputerQassim UniversityBuraydah51452Saudi Arabia Department of Computer Science and Software Engineering Al Ain UniversityAbu Dhabi15551UAE Institute for Energy and Environment University of StrathclydeGlasgowG11XQUK School of Computing Edinburgh Napier UniversityEdinburghEH105DTUK

The use of multimedia data sharing has drastically increased in the past few decades due to the revolutionary improvements in communication technologies such as the 4th generation(4G)and 5th generation(5G)*** have proposed many image encryption algorithms based on the classical random walk and chaos theory for sharing an image in a secure *** of the classical random walk,this paper proposes the quantum walk to achieve high image *** random walk exhibits randomness due to the stochastic transitions between states,on the other hand,the quantum walk is more random and achieve randomness due to the superposition,and the interference of the wave *** proposed image encryption scheme is evaluated using extensive security metrics such as correlation coefficient,entropy,histogram,time complexity,number of pixels change rate and unified average intensity *** experimental results validate the proposed scheme,and it is concluded that the proposed scheme is highly secured,lightweight and computationally *** the proposed scheme,the values of the correlation coefficient,entropy,mean square error(MSE),number of pixels change rate(NPCR),unified average change intensity(UACI)and contrast are 0.0069,7.9970,40.39,99.60%,33.47 and 10.4542 respectively.

关键词： Cryptography chaotic maps logistic map quantum walk security

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COVID-19 and comorbidities of hepatic diseases in a global perspective

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World Journal of Gastroenterology 2021年第13期27卷 1296-1310页

作者： Aqsa Ahmad Syeda Momna Ishtiaq Junaid Ali Khan Rizwan Aslam Sultan Ali muhammad Imran arshad Institute of Microbiology University of Agriculture FaisalabadFaisalabad 38040PunjabPakistan Institute of Physiology and Pharmacology University of Agriculture FaisalabadFaisalabad 38040PunjabPakistan

The worldwide outbreak of coronavirus disease 2019(COVID-19) has challenged the priorities of healthcare system in terms of different clinical management and infection transmission, particularly those related to hepatic-disease comorbidities. Epidemiological data evidenced that COVID-19 patients with altered liver function because of hepatitis infection and cholestasis have an adverse prognosis and experience worse health outcomes. COVID-19-associated liver injury is correlated with various liver diseases following a severe acute respiratory syndrome-coronavirus type 2(SARS-CoV-2) infection that can progress during the treatment of COVID-19 patients with or without pre-existing liver disease. SARS-CoV-2 can induce liver injury in a number of ways including direct cytopathic effect of the virus on cholangiocytes/hepatocytes, immune-mediated damage, hypoxia, and sepsis. Indeed, immediate cytopathogenic effects of SARSCoV-2 via its potential target, the angiotensin-converting enzyme-2 receptor, which is highly expressed in hepatocytes and cholangiocytes, renders the liver as an extra-respiratory organ with increased susceptibility to pathological outcomes. But, underlying COVID-19-linked liver disease pathogenesis with abnormal liver function tests(LFTs) is incompletely understood. Hence, we collated COVID-19-associated liver injuries with increased LFTs at the nexus of pre-existing liver diseases and COVID-19, and defining a plausible pathophysiological triad of COVID-19, hepatocellular damage, and liver disease. This review summarizes recent findings of the exacerbating role of COVID-19 in pre-existing liver disease and vice versa as well as international guidelines of clinical care, management, and treatment recommendations for COVID-19 patients with liver disease.

关键词： Liver disease COVID-19 Pathophysiology Epidemiology Prophylaxis

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