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Early therapeutic effect of platelet-rich fibrin combined with allogeneic bone marrow-derived stem cells on rats’ critical-sized mandibular defects

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World Journal of Stem Cells 2020年第1期12卷 55-69页

作者： muhammad a awadeen Fouad A Al-Belasy Laila E Ameen Mohamad E Helal Mohammed E Grawish Department of Oral Biology Faculty of Oral and Dental MedicineDelta University for Science and TechnologyMansoura 11152Egypt Department of Oral Surgery and Anesthesia Faculty of Oral and Dental MedicineDelta University for Science and TechnologyMansoura 11152Egypt Department of Oral Biology Faculty of DentistryMansoura UniversityMansoura 35516Egypt

BACKGROUND Critically sized bone defects represent a significant challenge to orthopaedic surgeons *** defects generally result from severe trauma or resection of a whole large *** bone grafts are the current gold standard for the reconstruction of such ***,due to increased patient morbidity and the need for a second operative site,other lines of treatment should be *** find alternative unconventional therapies to manage such defects,bone tissue engineering using a combination of suitable bioactive factors,cells,and biocompatible scaffolds offers a promising new approach for bone *** To evaluate the healing capacity of platelet-rich fibrin(PRF)membranes seeded with allogeneic mesenchymal bone marrow-derived stem cells(BMSCs)on critically sized mandibular defects in a rat *** Sixty-three Sprague Dawley rats were subjected to bilateral bone defects of critical size in the mandibles created by a 5-mm diameter trephine *** were allocated to three equal groups of 21 rats *** I bone defects were irrigated with normal saline and designed as negative *** of group II were grafted with PRF membranes and served as positive controls,while defects of group III were grafted with PRF membranes seeded with allogeneic *** rats from each group were killed at 1,2 and 4 *** mandibles were dissected and prepared for routine haematoxylin and eosin(HE)staining,Masson's trichrome staining and CD68 immunohistochemical *** Four weeks postoperatively,the percentage area of newly formed bone was significantly higher in group III(0.88±0.02)than in groups I(0.02±0.00)and II(0.60±0.02).The amount of granulation tissue formation was lower in group III(0.12±0.02)than in groups I(0.20±0.02)and II(0.40±0.02).The number of inflammatory cells was lower in group III(0.29±0.03)than in groups I(4.82±0.08)and II(3.09±0.07).CONCLUSION Bone regenerative quality of critically sized mandibula

关键词： Platelet-rich fibrin membrane Bone marrow-derived stem cells Critical-sized mandibular defects Rats Histological and immunohistochemical staining

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