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Global Effect of COVID-19 Pandemic on Cancer Patients and its Treatment:A Systematic Review

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Clinical Complementary Medicine and Pharmacology 2022年第4期2卷 12-25页

作者： Mohammad Ali Shahid ud din Wani Mubashir Hussain Masoodi Nisar Ahmad Khan H.G.Shivakumar Riyaz MAli Osmani Khalid Ahmed Khan Department of Pharmacology Al-Ameen College of PharmacyBangalore 560001India Department of Pharmaceutical Sciences School of Applied Science and TechnologyUniversity of KashmirSrinagar 190006India College of Pharmacy JSS Academy of Technical EducationNoida 201301India Department of Pharmaceutics JSS College of PharmacyJSS Academy of Higher Education and ResearchMysuru 570015India Assistant Drugs Controller Drugs Control DepartmentGovernment of KarnatakaBengaluruKarnataka 560004India

Background:At a global level,the COVID-19 disease outbreak has had a major impact on health services and has induced disruption in routine care of health institutions,exposing cancer patients to severe *** provide unin-terrupted tumor treatment throughout a pandemic lockdown is a major *** disease(COVID-19)and its causative virus,SARS-CoV-2,stance considerable challenges for the management of oncology ***-19 presents particularly severe respiratory and systemic infection in aging and immunosuppressed indi-viduals,including patients with ***:In the present review,we focused on emergent evidence from cancer sufferers that have been con-taminated with COVID-19 and cancer patients who were at higher risk of severe COVID-19,and indicates that anticancer treatment may either rise COVID-19 susceptibility or have a duple therapeutic impact on cancer as well as COVID-19;moreover,how SARS-CoV-2 infection impacts cancer ***,to assess the global effect of the COVID-19 disease outbreak on cancer and its ***:A literature survey was conducted using PubMed,Web of Science(WOS),Embase,Cochrane Library,China National Knowledge Infrastructure(CNKI),and VIral Protein domain DataBase(VIP DB)between Dec 1,2019 and Sep 23,2021,for studies on anticancer treatments in patients with *** characteristics of the patients,treatment types,mortality,and other additional outcomes were extracted and pooled for ***:This disease has a huge effect on sufferers who have cancer(s).Sufferers of COVID-19 have a greater percentage of tumor diagnoses than the rest of the ***,cancer and highest proportion is lung cancer sufferers are more susceptible to COVID-19 constriction than the rest of the ***:Sufferers who have both COVID-19 and tumor have a considerably elevated death risk than single COVID-19 positive patients *** the COVID-19 pandemic,there was a reduction in the scre

关键词： SARS-CoV-2 Cancer COVID-19 Treatment Chemotherapy

Clinical and Radiological Localization of Language Dysfunctions in Acute Ischemic Stroke

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Open Journal of Medical Imaging 2014年第2期4卷 80-85页

作者： Amira Ahmed Zaki Dwidar Taha Kamel Alloush Mahmoud Youssef Abou El-Ella Nahed salah El-din Ahmed Karima Moustafa Maher Maha Ali Mohamed Nada Mohamed Hamdy Ibrahim Faculty of Medicine Ain Shams University Cairo Egypt

Objective: To study the effect of cerebral ischemic vascular insult on the localization of language areas as regard to automatic speech, initiation, and mutism. Materials and Methods: Seventy ischemic stroke patients were selected within the first 48 h of the onset of stroke with left hemispheric stroke with aphasia. Inclusion criteria: any age above seven years, both sexes, first ever clinical stroke, admitted within the first 2 days of stroke insult. Patients underwent careful history taking, neurological examination, routine laboratory investigations, echo cardiography, and carotid duplex and language assessments. Results: Automatic speech disorders were mainly seen along left insular, left supramarginal and left frontal inferior orbital lesions. Initiation difficulty is seen mainly along as left insular, left temporal superior and left periventricular lesions. Mutism is seen along left external capsule, left internal capsule, left pallidum, left frontal inferior orbital and left inferior trigone lesions. Conclusions: Deep periventricular white matter and insular area in the dominant hemisphere play an important role in many language tasks. Thus aphasia is not a mere cortical function.

关键词： Clinicoradiological Localization Aphasia Stroke White Matter Perventricular

Early detection of hepatocellular carcinoma co-occurring with hepatitis C virus infection: A mathematical model

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World Journal of Gastroenterology 2016年第16期22卷 4168-4182页

作者： Abdel-Rahman Nabawy Zekri Amira salah El-din Youssef Yasser Mabrouk Bakr Reham Mohamed Gabr Ola Sayed Ahmed Mostafa Hamed Elberry Ahmed Mahmoud Mayla Mohamed Abouelhoda Abeer A Bahnassy Molecular Virology and Immunology Unit Cancer Biology Department National Cancer Institute Cairo University Systems and Biomedical Engineering Department Faculty of Engineering Cairo University Center for Informatics Sciences Nile University Sheikh Zayed City Pathology Department National Cancer Institute Cairo University

AIM: To develop a mathematical model for the early detection of hepatocellular carcinoma(HCC) with a panel of serum proteins in combination with α-fetoprotein(AFP).METHODS: Serum levels of interleukin(IL)-8, soluble intercellular adhesion molecule-1(s ICAM-1), soluble tumor necrosis factor receptor Ⅱ(s TNF-RⅡ), proteasome, and β-catenin were measured in 479 subjects categorized into four groups:(1) HCC concurrent with hepatitis C virus(HCV) infection(n = 192);(2) HCV related liver cirrhosis(LC)(n = 96);(3) Chronic hepatitis C(CHC)(n = 96); and(4) Healthy controls(n = 95). The R package and different modules for binary and multi-class classifiers based on generalized linear models were used to model the data. Predictive power was used to evaluate the performance of the model. Receiver operating characteristic curve analysis over pairs of groups was used to identify the best cutoffs differentiating the different groups. RESULTS: We revealed mathematical models, based on a binary classifier, made up of a unique panel of serum proteins that improved the individual performance of AFP in discriminating HCC patients from patients with chronic liver disease either with or without cirrhosis. We discriminated the HCC group from the cirrhotic liver group using a mathematical model(-11.3 + 7.38 × Prot + 0.00108 × s ICAM + 0.2574 ×β-catenin + 0.01597 × AFP) with a cutoff of 0.6552, which achieved 98.8% specificity and 89.1% sensitivity. For the discrimination of the HCC group from the CHC group, we used a mathematical model [-10.40 + 1.416 × proteasome + 0.002024 × IL + 0.004096 × s ICAM-1 +(4.251 × 10-4) × s TNF + 0.02567 ×β-catenin + 0.02442 × AFP] with a cutoff 0.744 and achieved 96.8% specificity and 89.7% sensitivity. Additionally, we derived an algorithm, based on a binary classifier, for resolving the multi-class classification problem by using three successive mathematical model predictions of liver disease status. CONCLUSION: Our proposed mathematical model may be a use

关键词： Mathematical model Hepatocellular carcinoma α-fetoprotein Soluble intercellular adhesion molecule-1

磁辐射3D非稳态流动体系的传热强化:Al和γ-Al2O3纳米粒子的对比研究（英文）

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Journal of Central South University 2019年第5期26卷 1233-1249页

作者： Naveed AHMED ADNAN Umar KHAN Syed Zulfiqar Ali ZAIDI Imran FAISAL Syed Tauseef MOHYud-din Department of Mathematics Faculty of SciencesHITEC UniversityTaxila CanttPakistan Department of Mathematics Mohi-ud-Din Islamic UniversityNerian SharifAzad Jammu and KashmirPakistan Department of Mathematics and Statistics Hazara UniversityMansehraPakistan Department of Mathematics COMSATS University IslamabadAbbottabad CampusPakistan Department of Mathematics Taibah UniversityMedinaSaudi Arabia

本文研究了水和乙二醇基纳米流体的胶体性质。考虑了洛伦兹力和热辐射的影响,通过相似变化,完成了控制方程的无量纲转化。然后,应用龙格-库塔法,对流动模型的非线性特性进行数值分析,对有关流速、温度、流线、等温线等流动参数的特性进... 详细信息

本文研究了水和乙二醇基纳米流体的胶体性质。考虑了洛伦兹力和热辐射的影响,通过相似变化,完成了控制方程的无量纲转化。然后,应用龙格-库塔法,对流动模型的非线性特性进行数值分析,对有关流速、温度、流线、等温线等流动参数的特性进行图解分析。结果表明,洛伦兹力有利于旋转速度,不利于其他旋转参数。体积分数和热辐射参数对Al和γ-Al2O3纳米流体的温度有正相关强化作用。此外,对于较高的旋转参数,研究其反向流动问题。与文献结果进行了比较,结果显示具有较高的吻合度。旋转有利于流体的流动速度,辐射流体越多,流体温度越高,而且体积分数的增加提高了热导率和电导率。

关键词：传统流体铝和铝氧化物磁场热辐射 Runge-Kutta方案剪切应力局部热传递速率

A review on Malaysian medicinal plants having anti-hyperglycemic activity

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Journal of Coastal Life Medicine 2016年第11期4卷 898-901页

作者： Kifayatullah muhammad Shahimi Mustapha Mohd Amin muhammad Hameed Sardar Ullah Izhar Department of Pharmacology and Toxicology Faculty of PharmacyLincoln University CollegePetaling JayaSelangorMalaysia Department of Zoology University of KarachiKarachiPakistan University of Malakand Khyber PakhtunkhwaPakistan Mohi ud din Islamic Institute of Pharmaceutical Sciences MirpurAzad KashmirPakistan

The use of natural products as a source of remedies has long history since ancient ***,medicinal plants are traditional practices for an extensive range of therapeutics and pharmacological activities like hypoglycemic,immunological,antiviral,anti-inflammatory,anti-hepatic,cardiovascular and central nervous *** the past,the use of plant based medicines was mainly restricted to developing countries because of insufficient resources,but currently the trend is changed and natural products as a source of medicines are growing rapidly in developed *** is confirmed from research articles that nearly about 75%-80%of the reserved zone inhabitants used natural products for their health *** all,about 250000-500000 species of plants exist worldwide and almost 800 plants have been documented for use in folklore systems of *** to this,Malaysia is being accepted as one of the largest biodiversity *** Malaysia,12000 species of natural products exist and 1200 are documented to have remedial potential against various *** the market,a variety of allopathic drugs are available,but are linked to various side ***,there is rising interest in the direction to plant based medicines remedies with a basic tactic towards the *** anti-diabetic drugs from natural products source in current use and their same way of producing action are preferred mainly due to affordable price,easy availability and minor harmful effect on human ***,the aim of the present research work was to review various Malaysian medicinal plants having potential in attenuation of high level of blood *** over the world,diabetes mellitus is claimed to be one of the most common chronic hereditary non-communicable disease,fourth leading cause of mortality in the most developed *** disease is also spreading in many developing and newly industrialized *** to International Diabetes Federation,the diabetes

关键词： Diabetes mellitus Medicinal plants Anti-diabetic activity Beta cell Insulin dependent diabetes mellitus Non-insulin dependent diabetes mellitus