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Incidence, mortality, and risk factors of immunotherapy-associated hepatotoxicity: A nationwide hospitalization analysis

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Liver Research 2021年第1期5卷 28-32页

作者： Simcha Weissman Saad Saleem Sachit Sharma Menashe Krupka Faisal Inayat muhammad aziz James H.Tabibian Department of Medicine Hackensack Meridian Health Palisades Medical CenterNorth BergenNJUSA Department of Medicine Sunrise Hospital and Medical CenterLas VegasNVUSA Department of Medicine University of Toledo Medical CenterToledoOHUSA Department of Medicine Westchester Medical CenterValhallaNYUSA Department of Medicine Allama Iqbal Medical CollegeLahorePakistan Division of Gastroenterology and Hepatology University of Toledo Medical CenterToledoOHUSA Division of Gastroenterology Department of MedicineOlive View-UCLA Medical CenterSylmarCAUSA David Geffen School of Medicine at UCLA Los AngelesCAUSA

Background and aims Anti-neoplastic immunotherapy has revolutionized cancer management;however,its safety profile with respect to liver-related injury remains largely ***,we analyzed a United States national database to determine the incidence,mortality,and predictors of hepatotoxicity in the setting of anti-neoplastic *** This was a nationwide retrospective study of hospital encounters from 2011 to 2014 using the National Inpatient Sample(NIS)*** utilized the International Classification of Diseases,Ninth Revision(ICD-9)coding system to identify all adult patients who underwent anti-neoplastic immunotherapy during *** primary outcome was the incidence of hepatotoxicity during the same *** outcomes included in-hospital mortality as well as socioeconomic and ethno-racial predictors of *** were performed using IBM SPSS Statistics *** The sample included 3002 patients who underwent inpatient anti-neoplastic *** incidence of hepatotoxicity was 10.1%,which was significantly higher as compared to a matched inpatient population(adjusted odds ratio(aOR)4.93,95%confidence interval(CI):3.80–6.40,P=0.001).No significant mortality difference was seen in those that developed hepatotoxicity compared to those who did not(aOR 0.47,95%CI:0.03–8.03,P=0.612).Age under 60(aOR 1.56,95%CI:1.23–1.78,P=0.050)and white race(aOR 1.85,95%CI:1.35–2.04,P<0.010)were independent risk factors for developing immunotherapy-associated *** In this large,nationwide database analysis,we found that anti-neoplastic immunotherapy was associated with a nearly five-fold risk of in-hospital hepatotoxicity as compared to a matched inpatient population,though without an associated mortality ***,younger age and white race were identified as predictors of immunotherapy-associated *** vigilance and prospective investigation of the

关键词： Hepatotoxicity Tumor immunotherapy Liver enzymes Outcomes Risk factors Mortality

Increased incidence of adrenal gland injury in blunt ab- dominal trauma： a computed tomography-based study from Pakistan

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Chinese Journal of Traumatology 2014年第1期17卷 31-34页

作者： muhammad Usman aziz Saleha Shahzad muhammad Ayiub Mansoor Department of Radiology Liaquat National Medical College and Hospital National Stadium Road Karachi 74800 Pakistan

Objective： To determine the frequency of adrenal injuries in patients presenting with blunt abdomi- nal trauma by computed tomography （CT）. Methods： During a 6 month period from January 1, 2011 to June 30, 2011, 82 emergency CT examinations were performed in the setting of major abdominal trauma and ret- rospectively reviewed for adrenal gland injuries. Results： A total of 7 patients were identified as having adrenal gland injuries （6 males and 1 female）. Two patients had isolated adrenal gland injuries. In the other 5 patients with nonisolated injuries, injuries to the liver （1 case）, spleen （1 case）, retroperitoneum （2 cases） and mesentery （4 cases） were identified. Overall 24 cases with liver injuries （29 %）, 11cases with splenic injuries （13%）, 54 cases with mesenteric injuries （65%）, 14 cases （17%） with retroperitoneal injuries and 9 cases with renal injuries were identified. Conclusion： Adrenal gland injury is identified in 7 patients （11.7%） out of a total of 82 patients who underwent CT after major abdominal trauma. Most of these cases were nonisolated injuries. Our experience indicates that adrenal injury resulting from trauma is more common than suggested by other reports. The rise in incidence of adrenal injuries could be attributed to the mode of injury.

关键词： Adrenal glands Tomography, X-ray computed Abdominal injuries

Application of Synthetic Iron Oxyhydroxide with Influencing Factors for Removal of As(Ⅴ) and As(Ⅲ) from Groundwater

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Journal of Earth Science 2024年第3期35卷 998-1009页

作者： Shakeel Ahmed Talpur muhammad Yousuf Jat Baloch Chunli Su Javed Iqbal aziz Ahmed Hafeez Ahmed Talpur School of Environmental Studies China University of GeosciencesWuhan 430078China DiSPUTer Department of PsychologicalHealth and Territory SciencesUniversity“G.d′Annunzio”Chieti-Pescara66100 ChietiItaly College of New Energy and Environment Jilin UniversityChangchun 130021China School of Plant Environment and Soil SciencesLouisiana State University Agricultural CentreBaton Rouge LA 70803USA Department od Engineering and Geology University“G.d′Annunzio”Chieti-Pescara66100 ChietiItaly

Synthesized iron oxyhydroxide was applied for the adsorptive removal of As(V)and As(III)from the aquas ***,this investigation highlighted the synergistic effect of calcium carbonate in conjunction with iron oxyhydroxide,resulting in enhanced removal *** experiment was conducted under various conditions:concentration,dosage,pH,agitation,and *** characterizations such as Brunauer Emmett Teller,X-ray diffraction,scanning electron microscopy,and Fourier transform infrared spectroscopy were implied to understand adsorption *** Langmuir model revealed optimal concentrations for As(V)=500μg/L at pH-5 and As(III)=200μg/L at pH-7,resulting in 95%and 93%adsorption efficiencies,*** adsorption capacities“qm”were found to be 1266.943μg/g for As(V)and 1080.241μg/g for As(III).Freundlich model demonstrated favorable adsorption by indicating“n>1”such as As(V)=2.542 and As(III)=2.707;similarly,the speciation factor“RL<1”for both species as As(V)=0.1 and As(III)=0.5,*** kinetic study presented a pseudo-second-order model as best fitted,indicating throughout chemisorption processes for removing As(V)and As(III).Furthermore,incorporating calcium carbonate presented a significant leap in the removal efficiency,indicating As(V)from 95%to 98%and As(III)from 93%to 96%,*** findings offer profound motivation for developing effective and sustainable solutions to tackle arsenic contamination,underscoring the exceptional promise of iron oxyhydroxide in conjunction with calcium carbonate to achieve maximum removal efficiency.

关键词： adsorption arsenic As(V) As(III) iron oxyhydroxide isotherms kinetics groundwater.

Wearable activity trackers and health awareness: Nursing implications

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International Journal of Nursing Sciences 2020年第2期7卷 179-183页

作者： Karen-Leigh Edward Loretta Garvey muhammad aziz Rahman Department of Health Professions School of Health SciencesFaculty of HealthArts and DesignSwinburne University of TechnologyAustralia Human and Health Sciences University of HuddersfieldUnited Kingdom School of Nursing and Healthcare Professions Federation UniversityAustralia

Purpose:Wearable devices are commonly used to measure physical ***,it remains unclear the effect of wearing these devices on health *** aim was to provide evidence related to wearing physical activity trackers and health ***:A quantitative comparison study design was used comparing participants who wore physical activity tracking devices(n=108)and those who did not(n=112).A paper-based Physical Health Knowledge survey designed for the purpose of this research was used for data collection in ***:A difference between participants who wore physical activity tracking devices and those that did not was identified in relation to activity levels and physical health *** devices are suggested as an opportunity for nurses to engage people in physical activity with the potential to improve their health ***:Nurses are well placed in the healthcare landscape to work with patients who own an activity tracker device concerning increasing activity *** information the patient has from the device can also form the basis of health discussions between nurses and the people in their care.

关键词： Exercise Fitness trackers Health behaviour Health literacy Wearable electronic devices

Measurement of Forces and Torques during Non-Homogeneous Material Drilling Operation

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Journal of Mechanics Engineering and Automation 2011年第2期1卷 139-146页

作者： Mohd Hazny aziz muhammad Azmi Ayub Roseleena Jaafar Faculty of Mechanical Engineering Universiti Teknologi MARA Shah Alam 40450 Malaysia

The purpose of this study is to measure the forces and torques produced in the drilling process of a non-homogenous material （bone）. An automated 5 DoF CataLyst-5 robot is used during the drilling process and it is integrated to a 6 DoF force-torque sensor. A force-torque controller which is built in the Matlab Simulink environment is employed to control the drilling process of the bone. Different feed rate is used during the experimental process of the bone drilling operation. The sensor is calibrated to measure the tri-axial direction of the resultant forces and torques. The profiles of the forces and torques obtained are non-linear due to the diversity of the bone density. The profiles generated also indicated fluctuation in the interface layers of the bone.

关键词： Robotic assisted surgery bone drilling tri-axial force and torque measurement.

Gamma irradiation-induced effects on the properties of TiO_2 on fluorine-doped tin oxide prepared by atomic layer deposition

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Nuclear Science and Techniques 2018年第7期29卷 191-197页

作者： Syed Mansoor Ali M.S.Algarawi Turki S.ALKhuraiji S.S.Alghamdi muhammad Hammad aziz M.Isa Department of Physics and Astronomy College of ScienceKing Saud University National Center for Irradiation Technology King Abdulaziz City for Science and Technology Department of Physics COMSATS Institute of Information and Technology Department of Physics Faculty of ScienceUniversity of GujratHafiz Hayat Campus

The effect of gamma irradiation with different doses(25–75 kGy) on TiO_2 thin films deposited by atomic layer deposition has been studied and characterized by X-ray diffraction(XRD),photoluminescence measurements,ultraviolet–visible(UV–Vis) spectroscopy,and impedance *** XRD results for the TiO_2 films indicate an enhancement of crystallization after irradiation,which can be clearly observed from the increase in the peak intensities upon increasing the gamma irradiation *** UV–Vis spectra demonstrate a decrease in transmittance,and the band gap of the TiO_2 thin films decreases with an increase in the gamma irradiation *** Nyquist plots reveal that the overall charge-transfer resistance increases upon increasing the gamma irradiation *** equivalent circuit,series resistance,contact resistance,and interface capacitance are measured by simulation using Z-view *** present work demonstrates that gamma irradiation-induced defects play a major role in the modification of thestructural,electrical,and optical properties of the TiO_2 thin films.

关键词： TiO2 原子层 Gamma 性质氧化物 gamma Nyquist 光致发光

RSSI Based Localization of Bluetooth Devices for Visually Impaired

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Journal of Signal and Information Processing 2019年第2期10卷 37-57页

作者： muhammad Irfan aziz Thomas Owens Uzair Khaleeq-uz-Zaman muhammad Bashir Akbar National University of Sciences and Technology Islamabad Pakistan Department of Electronic and Computer Engineering Brunel University West London UK Laboratoire de Conception Fabrication Commande Ecole Nationale Supérieure d’Arts et Métiers Metz France

Localization for visually impaired people in dynamically changing environments with unexpected hazards and obstacles is a current need. Many techniques have been discussed in the literature with respect to location-based services and techniques used for the positioning of devices. Time difference of arrival (TDOA), time of arrival (TOA) and received signal strength (RSS) have been widely used for the positioning but narrow band signals such as Bluetooth cannot efficiently utilize TDOA or TOA. Received signal strength indicator (RSSI) to measure RSS, has been found to be more reliable. RSSI measurement estimations depend heavily on the environmental interference. RSSI measurement estimations of Bluetooth systems can be improved either by improving the existing methodologies used to implement them or by using fusion techniques that employ Kalman filters to combine more than one RSSI method to improve the results significantly. This paper focuses on improving the existing methodology of measuring RSSI by proposing a new method using trilateration for localization of Bluetooth devices for visually impaired people. To validate the new method, class 2 Bluetooth devices (Blue Giga WT-12) were used with an evaluation board. The software required was developed in National Instruments LabView. The PCB was designed and manufactured as well. Experiments were then conducted, and surface plots of Bluetooth modules were obtained to show the signal interference and other environmental effects. Lastly, the results were discussed, and relevant conclusions were drawn.

关键词： Bluetooth Localization Navigation Assistance Received Signal Strength Indicator Visually Impaired

Design of a Simulation Framework for Evaluation of Robot Vision and Manipulation Algorithms

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Design of a Simulation Framework for Evaluation of Robot Vis...

Evaluation of Pear Varieties for Physiochemical Traits Grown under Climatic Conditions of Soon Valley, Pakistan

Asian Simulation Conference/The 6th International conference on system Simulation and Scientific Computing

作者： Baerbel Mertsching muhammad Zaheer aziz Ralf Stemmer GET Lab University of Paderborn Pohlweg 47-49 33098 Paderborn Germany GET Lab University of Paderborn Pohlweg 47-49 33098 Paderborn Germany GET Lab University of Paderborn Pohlweg 47-49 33098 Paderborn Germany

In continuation of our previous work on simulation of robots in a virtual environment, we propose the next version of the simulation framework according to requirements of our ongoing research on algorithms of robot vision and manipulation. A dynamic 3D environment has been created in which the simulated robot is manipulated. Multiple methods to operate the robot are provided including control by input devices, graphical user interface, and program commands. In the current version, visual sensors comprising of simulated stereo cameras are built on the robot to obtain visual input from the virtual world. The interface to the simulator core is made transparent so that the control could directly be shifted to the real hardware platform when algorithms have been successfully tested. The system is designed to be modular and flexible in order to accommodate future extensions and enhancements, such as inclusion of non-visual sensors.

关键词： Robot Simulator, Virtual Environment, Robot Vision

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American Journal of Plant Sciences 2018年第11期9卷 2217-2226页

作者： Malik Mohsin Abbas Hira Fai muhammad Maaz aziz Sahar Rashid Hameed Ullah Rashad Qadri muhammad Azam Horticultural Research Institute Faisalabad Pakistan Horticultural Research Station Murree Pakistan Institute of Horticultural Sciences University of Agriculture Faisalabad Faisalabad Pakistan

The study carried out aimed at characterizing the pear cultivars and to explore the specific cultivar most suitable to be commercially grown in Soon valley region. Nine pear varieties (Leconte, Bagugosha, Bartlet pear, Concord, Pear selection-1, Pear Red, Pear White, Kashmiri Nashpati and Kashmiri Nakh) were tested for their physiochemical quality attributes. The observations made during the study revealed that variety Bagugosha scored maximum (7.95, 8.10) in taste and flavor respectively. The same variety produced maximum fruit size (5081 mm2), fruit weight (205 g), soluble solid contents (15%) and total sugars (9.56%). However, fruit yield per plant was maximum (98.80 kg) in Bartlet pear variety and Bagugosha produced fruitweight of 60.20 kg. Titratable acidity was determined maximum (0.44%) in Kashmiri Nakh. Number of seeds were maximum (8.20) in Bartlet Pear as well as in Bgugosha. The exploration of this research study revealed that the Bagugosha is the prime quality cultivar to be suggested for commercial cultivation in Soon valley compared to all nine evaluated varieties.

关键词： Pear Physiological Traits Climate Soon Valley