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Profound loss of microbial necromass carbon in permafrost thaw-subsidence in the central Tibetan Plateau

Advances in Climate Change Research 2024年第4期15卷 647-657页

作者： Wen-Ting ZHOU Quan-Lian LI Shi-Chang KANG Xiao-Dong WU Tian ma Xiao-Bo WU Xin XIONG Tanuj SHUKLA maheswar RUPAKHETI Dipesh RUPAKHETI Da-He QIN Xiu-Feng YIN Cryosphere Research Station on the Qinghai-Tibet Plateau State Key Laboratory of Cryospheric ScienceNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Key Laboratory of Cryospheric Science and Frozen Soil Engineering Norhwest Instiute of Eco-Evironment and ResourcesChinese Academy of Scienes Lanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems and College of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou730020China Lushan Botanical Garden Chinese Academy of SciencesJiujiang 332900China Research Institute for Sustainability-Helmholtz Centre Potsdam Potsdam 14467Germany Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science and TechnologyNanjing 210044China

Climate warming is causing rapid permafrost degradation,including thaw-induced subsidence,potentially resulting in heightened carbon ***,our understanding of the levels and variations of carbon components in permafrost,particularly during the degradation process,remains *** uncertainties arising from this process lead to inaccurate assessments of the climate effects during permafrost *** vast expanses of permafrost in the Tibetan Plateau,there is limited research available on SOC components,particularly in the central Tibetan *** remarkable variations in hydrothermal conditions across different areas of the Tibetan Plateau,the existing limited studies make it challenging to assess the overall SOC components in the permafrost across the Tibetan Plateau and simulate their future *** this study,we examined the properties of soil organic carbon(SOC)and microbial necromass carbon(MicrobialNC)in a representative permafrost thaw-subsidence area at the southern edge of continuous permafrost in the central Tibetan *** results indicate that prior to the thaw-subsidence,the permafrost had a SOC content of 72.68±18.53 mg g^(-1),with MicrobialNC accounting for 49.6%.The thaw-subsidence of permafrost led to a 56.4%reduction in SOC,with MicrobialNC accounting for 70.0%of the lost *** constitutes the primary component of permafrost SOC,and it is the main component that is lost during thaw-subsidence *** in MicrobialNC are primarily correlated with factors pH,plant input,and microbial *** present study holds crucial implications for both the ecological and biogeochemical processes associated with carbon release from permafrost,and it furnishes essential data necessary for modeling the global response of permafrost to climate *** on this study and previous research,permafrost thawing in the Tibetan Plateau causes substantial loss of ***,there's remarkable heterogeneit

关键词： Tibetan Plateau Thaw-subsidence Soil organic carbon Microbial necromass carbon Amino sugars

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Two-photon live imaging of direct glia-to-neuron conversion in the mouse cortex

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Neural Regeneration Research 2024年第8期19卷 1781-1788页

作者： Zongqin Xiang Shu He Rongjie Chen Shanggong Liu Minhui Liu Liang Xu Jiajun Zheng Zhouquan Jiang Long ma Ying Sun Yongpeng Qin Yi Chen Wen Li Xiangyu Wang Gong Chen Wenliang Lei Guangdong-Hong Kong-macao Institute of CNS Regeneration(GHMICR) Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Neurosurgery The First Affiliated HospitalJinan UniversityGuangzhouGuangdong ProvinceChina Laboratory for Neuroimmunology in Health and Diseases Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhouGuangdong ProvinceChina VIB-KU Leuven Center for Brain&Disease Research LeuvenFlemish RegionBelgium

Over the past decade,a growing number of studies have reported transcription factor-based in situ reprogramming that can directly conve rt endogenous glial cells into functional neurons as an alternative approach for n euro regeneration in the adult mammalian central ne rvous *** r,many questions remain regarding how a terminally differentiated glial cell can transform into a delicate neuron that forms part of the intricate brain *** addition,concerns have recently been raised around the absence of astrocyte-to-neuron conversion in astrocytic lineage-tra cing *** this study,we employed repetitive two-photon imaging to continuously capture the in situ astrocyte-to-neuron conversion process following ecto pic expression of the neural transcription factor NeuroD1 in both prolife rating reactive astrocytes and lineage-tra ced astrocytes in the mouse ***-lapse imaging over several wee ks revealed the ste p-by-step transition from a typical astrocyte with numero us short,tapered branches to a typical neuro n with a few long neurites and dynamic growth cones that actively explored the local *** addition,these lineage-converting cells were able to migrate ra dially or to ngentially to relocate to suitable ***,two-photon Ca2+imaging and patch-clamp recordings confirmed that the newly generated neuro ns exhibited synchronous calcium signals,repetitive action potentials,and spontaneous synaptic responses,suggesting that they had made functional synaptic connections within local neural *** conclusion,we directly visualized the step-by-step lineage conversion process from astrocytes to functional neurons in vivo and unambiguously demonstrated that adult mammalian brains are highly plastic with respect to their potential for neuro regeneration and neural circuit reconstruction.

关键词： astrocyte-to-neuron conversion Ca2+imaging direct lineage conversion glia astrocyte in vivo reprogramming lineage-tracing mice NeuroD1 neuron two-photon imaging

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基于外差相敏色散光谱技术的宽动态范围甲烷气体检测

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中国光学（中英文） 2024年第4期17卷 789-800页

作者：周晨马柳昊王宇武汉理工大学汽车工程学院湖北武汉430070 中国科学院长春光学精密机械与物理研究所应用光学国家重点实验室吉林长春130033

为实现痕量甲烷气体的宽动态范围高灵敏度检测,本文开展了双边带拍频抑制模式的外差相敏色散光谱技术研发,研究了电光调制器工作特性以及偏置电压调控方法,对比了抑制与非抑制模式下的色散相位谱轮廓与信噪比,并对检测性能(如线性动态... 详细信息

为实现痕量甲烷气体的宽动态范围高灵敏度检测,本文开展了双边带拍频抑制模式的外差相敏色散光谱技术研发,研究了电光调制器工作特性以及偏置电压调控方法,对比了抑制与非抑制模式下的色散相位谱轮廓与信噪比,并对检测性能(如线性动态检测范围)进行了系统研究。基于近红外分布式反馈激光器和电光调制器,搭建了外差相敏色散甲烷气体检测系统,通过探索和分析电光调制器的最佳工作区间,实现了双边带拍频抑制进而得到了大幅值、高信噪比的色散相位信号。测量了典型高频(1.2 GHz)强度调制下甲烷/氮气标气的色散相位信号,获取了色散相位信号峰峰值随气体浓度的变化规律。同时开展了波长调制光谱技术实验,对两种技术的线性度、检测动态范围和对光功率波动的抗干扰性能进行对比研究。最后,通过测量不同浓度的标气验证了该系统在宽动态、快速时间响应下的性能。所开发的基于外差相敏色散光谱技术的甲烷检测系统具有线性度高(R^(2)=0.9999),动态检测范围宽(38.5 ppm~40%),且对光功率波动免疫性高的显著优势。本文研发的基于外差相敏色散光谱技术的气体检测技术在宽动态范围检测和实际现场检测应用领域具有广阔的前景。

关键词：相敏检测色散光谱双边带拍频抑制甲烷检测宽动态范围

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深覆土梯形拱明洞静力特性及卸荷效果

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工程科学与技术 2024年第4期56卷 120-129页

作者：马莉禄云华王起才马晓波李盛张克勋兰州交通大学土木工程学院甘肃兰州730070 中铁第一勘察设计院集团有限公司陕西西安710043

为研究深覆土条件下梯形拱结构–填土相互作用对周围土压力的影响机制和卸荷机理,明确梯形拱明洞相较于传统矩形明洞的优势,采用室内模型试验和数值模拟相结合的方法,对深覆土梯形拱明洞静力特性及卸荷效果进行分析。结果表明:无减载时... 详细信息

为研究深覆土条件下梯形拱结构–填土相互作用对周围土压力的影响机制和卸荷机理,明确梯形拱明洞相较于传统矩形明洞的优势,采用室内模型试验和数值模拟相结合的方法,对深覆土梯形拱明洞静力特性及卸荷效果进行分析。结果表明:无减载时,梯形拱明洞两侧回填土沉降大于上方回填土沉降,两侧回填土土压力向明洞上方转移,土压力随着填土高度的增大而增大,基本呈线性变化趋势;减载时,明洞上方回填土沉降大于两侧回填土沉降,回填土内部产生土拱效应,明洞上方回填土土压力向两侧转移,铺设减载层不会改变深覆土明洞结构受力分布,但会极大地减小其内力及变形,并提高结构安全系数;减载后,梯形拱明洞的最大轴力、最大正弯矩和最大负弯矩分别减少17.5%、34.1%、29.9%,最大变形减小32.9%。矩形和梯形两种截面形式下明洞的最大轴力均出现在中隔墙底部,最大正弯矩、最小安全系数和最大变形均出现在顶板中央位置;铺设减载层后两种截面形式拱明洞最小安全系数分别增大42.6%和100.0%,梯形拱明洞安全系数提高的比例更大,效果更显著。该研究可为深覆土梯形拱明洞结构的设计和施工提供理论指导和技术支持。

关键词：深覆土梯形拱明洞静力特性卸荷效果

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Cancer immunotherapy with envelopedself-amplifying mRNA CARG-2020 thatmodulates IL-12,IL-17 and PD-L1 pathways toprevent tumor recurrence

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Acta Pharmaceutica Sinica B 2024年第1期14卷 335-349页

作者： Ju Chen Bhaskara Reddy madina Elham Ahmadi Timur Olegovich Yarovinsky marie marthe Krady Eileen Victoria Meehan Isabella China Wang Xiaoyang Ye Elise Pitmon Xian-Yong ma Bijan Almassian Valerian Nakaar Kepeng Wang Department of Immunology School of MedicineUniversity of Connecticut Health CenterFarmingtonCT 06030USA CaroGen Corporation FarmingtonCT 06030USA The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine Foshan Hospital of Traditional Chinese MedicineFoshan 528000China The Loomis Chaffee School WindsorCT 06095USA

Targeting multiple immune mechanisms may overcome therapy resistance and further improve cancer immunotherapy for ***,we describe the application of virus-like vesicles(VLV)for delivery of three immunomodulators alone and in combination,as a promising approach for cancer *** vectors were designed to deliver single chain interleukin(IL)-12,shorthairpin RNA(shRNA)targeting programmed death ligand 1(PD-L1),and a dominant-negative form of IL-17 receptor A(dn-IL17ra)as a single payload or as a combination *** delivery of the VLV vector expressing IL-12 alone,as well as the trivalent vector(designated CARG-2020)eradicated large established ***,only CARG-2020 prevented tumor recurrence and provided long-term survival benefit to the tumor-bearing mice,indicating a benefit of the combined *** abscopal effects of CARG-2020 on the non-injected contralateral tumors,as well as protection from the tumor cell re-challenge,suggest immune-mediated mechanism of protection and establishment of immunological ***,CARG-2020 potently activates Th1 immune mechanisms and inhibits expression of genes related to T cell exhaustion and cancer-promoting *** ability of CARG-2020 to prevent tumor recurrence and to provide survival benefit makes it a promising candidate for its development for human cancer immunotherapy.

关键词： Virus-like vesicles Oncolytic virus IL-12 IL-17 PD-L1 T cell exhaustion Combination therapy Cancer immunotherapy

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车轮多边形相位差对车辆动力性能的影响

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兰州理工大学学报 2024年第2期50卷 55-64页

作者：马运章铁科纵横(天津)科技发展有限公司天津301700

为研究同轮对两侧车轮圆周多边形存在相位差的问题,建立基于轮对柔性的刚柔耦合车辆-轨道动力学模型,分析不同运行速度下同轮对两侧存在相同阶数车轮多边形时相位差变化对轮轨动态响应的影响,进一步探究对车轮磨耗演变行为的影响.结果表... 详细信息

为研究同轮对两侧车轮圆周多边形存在相位差的问题,建立基于轮对柔性的刚柔耦合车辆-轨道动力学模型,分析不同运行速度下同轮对两侧存在相同阶数车轮多边形时相位差变化对轮轨动态响应的影响,进一步探究对车轮磨耗演变行为的影响.结果表明:3阶车轮多边形存在相位差时,随着相位差增大轮轨间垂向冲击减缓,而轮轨间横向冲击加剧,并且轮轨蠕滑特性和磨耗功受到显著影响;同时,3阶车轮多边形存在相位差时,速度提升严重影响轮轨蠕滑特性,并且增大轮轨磨耗功可加剧车轮多边形成;25阶车轮多边形存在相位差时,尤其在相位差周期一半左右轮轨力波动范围较大,并且轮轨蠕滑特性所受影响最显著,磨耗功波动范围最大,从而进一步加剧了车轮多边形的磨耗演变;相位差的存在加剧了一侧车轮的磨耗速率,改变了车轮的磨耗位置,需要及时进行镟修处理.

关键词：高速列车刚柔耦合车轮多边形相位差磨耗

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Paracremonium moubasheri,a new species from an alkaline sediment of Lake Hamra in Wadi-El-Natron,Egypt with a key to the accepted species

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Studies in Fungi 2019年第1期4卷 216-222页

作者： Al-Bedak OA Ismail ma Mohamed ra Assiut University Mycological Centre(AUMC) Assiut UniversityAssiutEgypt Department of Botany and Microbiology Faculty of ScienceAssiut UniversityAssiutEgypt

During surveys of extremophilic fungi in hypersaline,alkaline lakes of Wadi-El-Natron,Egypt,an interesting fungus was recovered from a mud sample collected from Lake Hamra in Wadi-El-Natron,*** likelihood analysis of Internal Transcribed Spacer(ITS)gene along with morphological comparisons of related taxa revealed a novel taxon,Paracremonium moubasheri which is described and illustrated in the current *** moubasheri can be distinguished from the known species of the genus by its large conidia,in addition to the presence of chlamydospores.

关键词： Acremonium-like Hypersaline Hypocreales new taxon Phylogeny

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Ricolinostat驱动初级纤毛的解聚降低了X线损伤的心肌纤维化

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中国药理学通报 2024年第10期40卷 1844-1849页

作者：马承旭马小妮马丽华傅松波成建国兰州大学第一医院内分泌科甘肃兰州730000 兰州大学第一医院医学检验中心甘肃兰州730000 兰州大学第一临床医学院内分泌专业临床药理基地甘肃兰州730000

目的评价Ricolinostat对X线辐射诱导心肌纤维化和心肌成纤维细胞初级纤毛损伤的影响。方法 8 Gy剂量单次全身照射Wistar大鼠,腹腔注射Ricolinostat, ELISA测定血清肌钙蛋白T(troponinT,TnT)和脑钠肽(brain natriuretic peptide, BNP)水... 详细信息

目的评价Ricolinostat对X线辐射诱导心肌纤维化和心肌成纤维细胞初级纤毛损伤的影响。方法 8 Gy剂量单次全身照射Wistar大鼠,腹腔注射Ricolinostat, ELISA测定血清肌钙蛋白T(troponinT,TnT)和脑钠肽(brain natriuretic peptide, BNP)水平;HE和masson染色检测心肌组织纤维化程度,免疫荧光检测心肌组织和心肌成纤维细胞初级纤毛及Ⅰ型胶原含量;qRT-PCR和Western blot检测心肌组织和心肌成纤维细胞组蛋白去乙酰化酶6(histone deacetylase 6,HDAC6)的基因和蛋白水平。结果与对照组相比,X线辐射增加大鼠心肌组织胶原紊乱和Ⅰ型胶原含量,促进心肌成纤维细胞增殖,上调了心肌成纤维细胞中HDAC6的表达(P> 0.05),增加心肌组织和心肌成纤维细胞初级纤毛的形成。经过Ricolinostat治疗后,心肌组织和心肌成纤维细胞中HDAC6的表达水平和初级纤毛形成降低(P<0.05)。胶原纤维排列稍显整齐,胶原体积分数降低,血清中TnT(P<0.01)和BNP水平降低。结论 Ricolinostat能够驱动初级纤毛的解聚,降低了X线损伤诱导的心肌纤维化,具有治疗放射性心肌纤维化的潜在价值。

关键词： Ricolinostat 初级纤毛 X线 HDAC6 心肌成纤维细胞心肌纤维化

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Attenuation of the Activation of NLRP3 Inflammasome in Fibroblast Like Synoviocytes of Rheumatoid Arthritis by Baicalin through Regulating the Let-7i-3p/PI3K/Akt/NF-κB Signaling Axis

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Medicinal Plant 2024年第2期15卷 69-73,76页

作者： Wei ZHANG Li WANG Yuxin YANG Rui ma Li WANG Ling HUANG Qiaofeng WAN Department of Pathogenic Biology and Immunology School of Basic MedicineNingxia Medical UniversityYinchuan 750004China Department of Rheumatology Ningxia Medical University General HospitalYinchuan 750003China School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004China

[Objectives]To study the effect and mechanism of baicalin on the activation of NLRP3 inflammasome in human fibroblast like synoviocytes of rheumatoid arthritis(HFLS-ra).[Methods]To confirm that baicalin alleviated the activation of NLRP3 inflammasome in HFLS-ra,the expression of NLRP3 before and after baicalin treatment was observed by *** blot was used to detect the protein expression of p-PI3K,p-Akt,NF-κB p65,NLRP3,ASC and caspase-1 after baicalin treatment for 48 h,and the contents of IL-1 and IL-18 in the supernatents were detected by *** order to explore the mechanism of baicalin alleviating the activation of NLRP3 inflammasome,the corresponding relationship between let-7i-3p and PIK3CA was verified by double luciferin and Westen blot *** expression of let-7i-3p and PI3K before and after baicalin intervention was detected by ***-7i-3p interference was used to verify whether baicalin mitigated the activation of enhanced NLRP3 inflammasome.[Results]Baicalin(50 and 100 mg/L)significantly reduced the activation of NLRP3 inflammasome,inhibited the protein expressions of p-PI3K,p-Akt,NF-κB p65,NLRP3,ASC and caspase-1,and the secretion of IL-1 and ***-7i-3p and PIK3CA had a targeted correspondence,and baicalin up-regulated the expression of let-7i-3p and down-regulated the expression of *** attenuated the activation of NLRP3 inflammasome enhanced by let-7i-3p interference.[Conclusions]Baicalin can up-regulate let-7i-3p expression,inhibit PI3K/Akt/NF-κB signal transduction,and thus reduce the activation of NLRP3 inflammasome in HFLS-ra.

关键词： Baicalin Rheumatoid arthritis Human fibroblast like synoviocytes of rheumatoid arthritis NLRP3 inflammasome miRNA Dual-luciferase

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聚硅氮烷/MoS_(2)高温自润滑涂层的制备及性能研究

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摩擦学学报（中英文） 2024年第6期44卷 752-762页

作者：李谋吉杨武芳汤洁马正峰王睿麻拴红于波周峰中国科学院兰州化学物理研究所固体润滑国家重点实验室甘肃兰州730000 中国科学院大学北京100049

高温固体自润滑涂层因具有优异的摩擦学性能和极好的附着力,已被广泛应用于航空、航天等领域.本文中采用陶瓷前驱体聚硅氮烷为粘接剂,MoS_(2)为润滑填料制备了1种新型的宽温域减摩抗磨涂层.系统探究了各因素对涂层摩擦学性能的影响,并... 详细信息

高温固体自润滑涂层因具有优异的摩擦学性能和极好的附着力,已被广泛应用于航空、航天等领域.本文中采用陶瓷前驱体聚硅氮烷为粘接剂,MoS_(2)为润滑填料制备了1种新型的宽温域减摩抗磨涂层.系统探究了各因素对涂层摩擦学性能的影响,并利用扫描电镜(SEM)、X射线衍射(XRD)和raman等表征分析涂层的微观组织、物相组成及磨损机理.结果表明:聚硅氮烷/MoS_(2)涂层不仅和基底结合力强,且在25~300℃较宽温域范围内具有优异的减摩抗磨性能.其中300℃热处理的涂层在200℃、9 N及90 r/min的测试条件下具有最佳润滑性能:平均摩擦系数为0.05,磨损率为7.6×10^(-5)mm^(3)/(N·m).涂层在中高温下体现出优异的润滑和耐磨性能,这主要得益于MoS_(2)特殊层状结构和弱的剪切应力以及高硬度无机非晶态陶瓷相SiOC的形成.该涂层的成功制备有望为高温工况下服役的零部件表面润滑防护提供理论依据及数据支持.

关键词：聚硅氮烷二硫化钼宽温域高温润滑耐磨涂层

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