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海流条件下中性缆缆形及张力的理论研究

船舶力学 2016年第8期20卷 983-991页

作者：邢丹马利斌中国船舶科学研究中心江苏无锡214082

文章考虑缆绳经受的法向与切向流体阻力,在自然坐标系下推导了任意海流中缆绳的动力学方程。建立了中性缆在均匀、线性及组合海流作用下缆形与张力的参数表达式。参数表达式给出了对应海流作用下缆形及张力的物理规律,从而为参数迭代求... 详细信息

文章考虑缆绳经受的法向与切向流体阻力,在自然坐标系下推导了任意海流中缆绳的动力学方程。建立了中性缆在均匀、线性及组合海流作用下缆形与张力的参数表达式。参数表达式给出了对应海流作用下缆形及张力的物理规律,从而为参数迭代求解时迅速收敛指明了数学途径。自行编制程序,算例的定量结果进一步验证了其物理规律,也表明在长缆绳下,忽略切向阻力在工程上是不合适的。

关键词：中性缆缆形线性海流参数表达

Changes of chymase,angiotensin converting enzyme and angiotensin Ⅱ type 1 receptor expressions in the hamster heart during the development of heart failure

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Chinese Medical Journal 2005年第22期118卷 1886-1892页

作者： CHEN Peng-min LENG Xi-gang FAN Li-li ma Jun WANG Ya-fang CHEN Lan-ying Department of Biochemistry Institute of Clinical Medicine China-Japan Friendship Hospital Beijing 100029 Department of Biochemistry Fuwai Hospital and CardiovascularInstitute Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Biochemistry Institute of Biomedical EngineeringChinese Academy of Medical Sciences and Peking Union Medical College Tianjin 300192 China Department of Pharmacology Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050 China

Background Little is known about the role of dual angiotensin Ⅱ forming pathways during heart failure. In the present study, the changes of chymase and angiotensin converting enzyme （ACE） expressions in the failing hearts of hamsters were analysed. Methods Heart failure was induced by ligation of left anterior descending branch of the coronary artery. Chymase, ACE and angiotensin Ⅱ type 1 receptor （AT1R） mRNA levels were analysed by reverse transcription polymerase chain reaction （RT-PCR）. The activities of chymase and ACE were determined by radioimmunoassay （ria.. Myocardial collagen fibre analysis was performed under optical microscope. Results Left ventricular systolic pressure （LVSP） and maximum left ventricular developed pressure increase rate （ dp/dtmax, mmHg/s） gradually moved lower at 2, 3,4 and 8 weeks after operation. On the other hand, left ventricular end-diastolic pressure （LVEDP） increased gradually after operation. Compared with the control group （3.55±0. 06, 4.79±0.70）, the heart weight/body weight ratio in operation group had increased significantly at 4 weeks and 8 weeks （4. 28±0. 43, 6. 17±0.73）（P 〈0. 01 ）. Collagen staining showed that the quantity of myocardial collagen fibre increased significantly in the operation group. RT-PCR showed that the chymase mRNA level in the operation group was consistently greater than that in the control group. ATIR mRNA level was also increased significantly at 3 weeks and 4 weeks, both being 1.3 times that of the control group （ P〈0.01 ）, whereas ACE mRNA level was not changed. Higher activity of chymase was detected in operation group, being 4, 8, 13 and 19 times that of the control group at 2, 3, 4 and 8 weeks （P〈0.01 ）, respectively. ACE activity was also significantly higher at the same time, being 7, 10, 10 and 3.5 times that of the control（P〈0.01）. Angiotensin Ⅱ （Ang Ⅱ） level in operation group increased significantly, being 2.5, 2.7, 3.5 and 2 times that of the control group at 2, 3, 4 and 8 weeks, res

关键词： chymase angiotensin converting enzyme angiotensin Ⅱ· heart failure ·angiotensin Ⅱ type 1 receptor

补肾调经方对控制性超促排卵小鼠甲状腺功能和卵巢储备的影响

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河北中医药学报 2024年第5期39卷 6-9页

作者：牛牧野焦元清杨海军张鑫铭马惠荣杜惠兰宋翠淼河北体育学院石家庄050041 河北省中医院石家庄050011 河北中医药大学石家庄050200 河北省中西医结合生殖疾病协同创新中心石家庄050200

目的:观察补肾调经方对控制性超促排卵(controlled ovaria. hyperstimulation,COH)小鼠甲状腺功能及卵巢储备的影响。方法:8~10周龄ICR系雌性小鼠随机分为正常组、COH组和补肾组,每组20只。COH组和补肾组采用由促性腺激素释放激素激动剂... 详细信息

目的:观察补肾调经方对控制性超促排卵(controlled ovaria. hyperstimulation,COH)小鼠甲状腺功能及卵巢储备的影响。方法:8~10周龄ICR系雌性小鼠随机分为正常组、COH组和补肾组,每组20只。COH组和补肾组采用由促性腺激素释放激素激动剂(GnRH-a)、人绝经期促性腺激素(HMG)和人绒毛膜促性腺激素(hCG)组成的COH方案,补肾组在给予以上方案的同时灌胃补肾调经方。放射免疫法(ria.检测血清四碘甲腺原氨酸(T_(4))、促甲状腺激素(TSH)、雌二醇(E_(2))和孕酮(P)水平;ELISA检测血清抗缪勒氏管激素(AMH)水平;HE染色计数卵巢组织切片不同阶段卵泡。结果:与正常组相比,COH组小鼠血清T_(4)、AMH、E_(2)和P水平降低(P<0.05),TSH水平升高(P<0.05),黄体数增加,初级卵泡和次级卵泡数减少(P<0.05);与COH组相比,补肾组小鼠血清T_(4)和AMH水平升高(P<0.05),TSH浓度降低(P<0.05),黄体数减少,初级卵泡和次级卵泡数增加(P<0.05)。结论:COH可能导致小鼠甲状腺功能障碍并降低卵巢储备,补肾调经方对改善COH小鼠甲状腺功能和卵巢储备发挥一定作用。

关键词：补肾调经方控制性超促排卵甲状腺功能卵巢储备

Effect of tanshinone combined with valsartan therapy on the renal injury and endothelial injury in patients with hypertensive nephropathy

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Journal of Hainan Medical University 2017年第8期23卷 61-65页

作者： Wen-Tao ma Fang Nie Gui-Qiang Sun Guang-Yuan Song Department of Cardiology Liaocheng Third People's Hospital in Shandong ProvinceLiaocheng CityShandong Province252000 Department of Cardiology Beijing Fuwai HospitalBeijing100037

Objective:To study the effect of tanshinone combined with valsartan therapy on the renal injury and endothelial injury in patients with hypertensive ***: A total of 72 patients with hypertensive nephropathy who were treated in our hospital between January 2013 and April 2016 were selected and randomly divided into the control group (n=36) who received conventional treatment + valsartan therapy and the observation group (n=36) who received conventional treatment + tanshinone combined with valsartan therapy, and both therapies lasted for 2 weeks. Before treatment and after 2 weeks of treatment, automatic biochemical analyzer was used to determine the renal function indexes in peripheral blood, enzyme-linked immunosorbent assay (ELISA) was used to determine the levels of endothelial injury markers and inflammatory cytokines in peripheral blood, and ria.method was used to determine the serum levels of oxidative stress ***:Before treatment, the differences in the peripheral blood renal function indexes and endothelial injury markers as well as the serum inflammatory factors and oxidative stress indexes were not statistically significant between two groups of patients. After 2 weeks of treatment, peripheral blood renal function indexes Scr and BUN levels as well as urine malb level of observation group were lower than those of control group, and endothelial injury indexes E-selectin and ET levels were lower than those of control group while NOS and CGRP levels were higher than those of control group;serum inflammatory cytokines IL-1, IL-6, CRP and TNF-α levels of observation group were lower than those of control group, and oxidative stress index GSH-Px level was higher than that of control group while MDA and AOPP levels were lower than those of control group. Conclusion: Tanshinone combined with valsartan can reduce the renal injury and endothelial injury in patients with hypertensive nephropathy, and the specific mechanism may be related to

关键词： Hypertensive nephropathy Tanshinone Valsartan Renal function Endothelial injury

Experimental study of the effect of calcium on thyroid hormone metabolism

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吉林大学学报(医学版) 1996年第3期22卷 221-225页

作者： Yue Lijie ma Li Wang Fan Zhang Xiuyun Li Guangsheng(Institute of Precl inical Sciences Department of Nuclear Medicine,The First Cl inicaI College)

ＥｘｐｅｒｉｍｅｎｔａｌｓｔｕｄｙｏｆｔｈｅｅｆｆｅｃｔｏｆｃａｌｃｉｕｍｏｎｔｈｙｒｏｉｄｈｏｒｍｏｎｅｍｅｔａｂｏｌｉｓｍＥｘｐｅｒｉｍｅｎｔａｌｓｔｕｄｙｏｆｔｈｅｅｆｆｅｃｔｏｆｃａｌｃｉｕｍｏｎｔｈｙｒｏｉ... 详细信息

ＥｘｐｅｒｉｍｅｎｔａｌｓｔｕｄｙｏｆｔｈｅｅｆｆｅｃｔｏｆｃａｌｃｉｕｍｏｎｔｈｙｒｏｉｄｈｏｒｍｏｎｅｍｅｔａｂｏｌｉｓｍＥｘｐｅｒｉｍｅｎｔａｌｓｔｕｄｙｏｆｔｈｅｅｆｆｅｃｔｏｆｃａｌｃｉｕｍｏｎｔｈｙｒｏｉｄｈｏｒｍｏｎｅｍｅｔａｂｏｌｉｓ...

关键词： calcium thyroid hormone type I iodothyronine 5’-deiodinase Keshan dis-ease experimental study

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以针刺为主治疗慢性荨麻疹的Meta分析

针刺研究 2020年第1期45卷 66-73页

作者：赵隽乔马铁明广州中医药大学针灸康复临床医学院广州510405 辽宁中医药大学针灸推拿学院沈阳110847

目的:评价以针刺为主治疗慢性荨麻疹的疗效。方法:检索近10年来收录于中国期刊全文数据库(CNKI)、万方数据库、重庆维普中文科技期刊数据库(VIP)、中国生物医学文献数据库网络版(CBM)、PubMed、Embase、Cochrane Library等数据库中以针... 详细信息

目的:评价以针刺为主治疗慢性荨麻疹的疗效。方法:检索近10年来收录于中国期刊全文数据库(CNKI)、万方数据库、重庆维普中文科技期刊数据库(VIP)、中国生物医学文献数据库网络版(CBM)、PubMed、Embase、Cochrane Library等数据库中以针刺为主治疗慢性荨麻疹的随机对照试验(randomized controlled tria.,RCT),以"荨麻疹or风疹块or瘾疹or风团"and"针灸疗法or针灸or针刺or电针or毫针or体针or穴"and"随机对照试验"以及"Urtica-ria.or Urticaria. or Hives"and"Acupuncture Therapy or Acupuncture Treatment"and"Randomized Controlled Tria. or Randomized"等词组合检索。检索时间为2008年1月至2018年10月。对筛选得到的文献进行质量评价,设计数据提取表,最后使用Review manager5.3软件对纳入文献进行分析。结果:检索到文献1095篇,共有16项RCT入选。Meta分析结果:总有效率方面,OR=3.85,95%CI为[2.61,5.69],P<0.00001。复发率方面,OR=0.28,95%CI为[0.14,0.55],P=0.0003。结论:从国内现有研究报道看,以针刺为主治疗慢性荨麻疹的疗效明显优于单独使用抗组胺药物,并且复发率更低。

关键词：慢性荨麻疹针刺疗法随机对照试验 Meta分析

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一种基于GWT技术的AJAX应用框架

微计算机信息 2008年第27期24卷 149-151页

作者：刘波马世龙北京航空航天大学计算机学院 100083

作为一种技术发展趋势,ria.构下的富客户端正在迅速取代B/S模式架构下的瘦客户端。作为富客户端的一种实现技术,GWT有着广阔的应用前景。本文在分析GWT技术特点的基础上,提出了一种基于GWT技术的层次化、可扩展的A-JAX应用框架,并对框... 详细信息

作为一种技术发展趋势,ria.构下的富客户端正在迅速取代B/S模式架构下的瘦客户端。作为富客户端的一种实现技术,GWT有着广阔的应用前景。本文在分析GWT技术特点的基础上,提出了一种基于GWT技术的层次化、可扩展的A-JAX应用框架,并对框架各层次的设计进行了分析和描述。目前该应用框架已经在北京航空航天大学与航天部门合作的某环境试验数据应用系统中得到实际运用。

关键词：富客户端 AJAX GWT 框架

一种以RIF元模型为中心的语义Web规则互换方法

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小型微型计算机系统 2011年第7期32卷 1379-1386页

作者：王星严丽马宗民东北大学信息科学与工程学院沈阳110819 东北大学软件学院沈阳110819

作为W3C(WWW Consortium)的推荐标准,RIF(Rule Interchange Format)致力于语义Web中不同规则语言之间以及不同规则系统之间的规则互换.以RIF为中心互换规则是规则互换发展的必然趋势.本文首先定义RIF的元模型,给出RIF规则的UML Profile... 详细信息

作为W3C(WWW Consortium)的推荐标准,RIF(Rule Interchange Format)致力于语义Web中不同规则语言之间以及不同规则系统之间的规则互换.以RIF为中心互换规则是规则互换发展的必然趋势.本文首先定义RIF的元模型,给出RIF规则的UML Profile;然后构建以RIF为中心的规则互换结构ria.Rule Interchange Architecture),它支持RIF与主要规则语言SWRL(Semantic Web Rule Language),RuleML(Rule markup Language)和R2ML(REWERSE Rule markup Language)之间的互换以及这四种语言的抽象语法和具体语法之间的互换;此外分析互换过程中出现的信息缺失问题并提出相应的对策;最后基于ATL(Atlas Transformation Language)转换语言,设计实现规则互换原型系统ria.1.0.

关键词： RIF 语义Web 规则互换元模型 ria 信息缺失 ria 1.0

北京市丰台区3所小学学生家长食盐知信行现状调查

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职业与健康 2018年第13期34卷 1784-1787页

作者：王焱焱李洁赵静肖贵勇马晓曼王佳佳北京市丰台区疾病预防控制中心营养与食品卫生科北京100071

目的了解学生家长的食盐相关知识、态度和行为情况,为减盐干预提供依据。方法采取随机整群抽样方法,抽取北京市丰台区3所小学3~4年级学生家长进行食盐相关知信行问卷调查,问卷内容包括学生家长基本信息、食盐知识、态度和行为情况等。... 详细信息

目的了解学生家长的食盐相关知识、态度和行为情况,为减盐干预提供依据。方法采取随机整群抽样方法,抽取北京市丰台区3所小学3~4年级学生家长进行食盐相关知信行问卷调查,问卷内容包括学生家长基本信息、食盐知识、态度和行为情况等。结果共调查571名学生家长,成人食盐推荐摄入量为6 g的知晓率为55.69%,女性知晓率高于男性,差异有统计学意义(χ~2=4.22,P<0.05);高盐调味品全部知晓率仅3.15%,含有较多"看不到的盐"食品的全部知晓率仅为8.41%,女性知晓率高于男性,差异有统计学意义(χ~2=4.16,P<0.05);仅21.72%的人购买食品时经常参考营养成分表,36.78%的人做饭时经常使用低钠盐,最常食用的高盐调味品为酱油。结论北京市丰台区小学生家长对食盐相关知识知晓率较低,食盐相关行为尚有待改善,应提高其认识高盐食品的能力,养成良好的饮食习惯。

关键词：小学生家长食盐知信行