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Prediction of hereditary nonpolyposis colorectal cancer using mRNA MSH2 quantitative and the correlation with nonmodifiable factor

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World Journal of Gastrointestinal Pathophysiology 2021年第6期12卷 134-146页

作者： Tjahjadi Robert Tedjasaputra Mochammad Hatta muh Nasrum Massi Rosdiana Natzir Agussalim Bukhari Rina Masadah muh Lutfi Parewangi Prihantono Prihantono Rinda Nariswati Vincent Tedjasaputra Department of Internal Medicine Tarakan General HospitalMedical Faculty University of HasanuddinJakarta 10720DKI JakartaIndonesia Department of Immunology and Biomolecular Hasanuddin UniversityMakassar 90245South SulawesiIndonesia Department of Microbiology Faculty of MedicineUniversity of HasanuddinMakassar 90245South SulawesiIndonesia Department of Biochemistry Meidcal Faculty University of HasanuddinMakassar 90245South SulawesiIndonesia Department of Nutrition Faculty of MedicineHasanuddin UniversityMakassar 90245South SulawesiIndonesia Department of Pathology Anatomy Faculty of MedicineHasanuddin UniversityMakassar 20945South SulawesiIndonesia Department of Internal Medicine Faculty of MedicineHasanuddin UniversityMakassar 20945South SulawesiIndonesia Department of Surgery Faculty of MedicineHasanuddin UniversityMakassar 90245South SulawesiIndonesia Department of Statistic School of Computer ScienceBina Nusantara University JakartaJakarta 11530Indonesia American Association for the Advancement of Science(AAAS) Science and Technology Policy FellowAlexandriaVA 22314United States

BACKGROUND Hereditary non-polyposis colon cancer is a dominantly inherited syndrome of colorectal cancer(CRC),with heightened risk for younger *** studies link its susceptibility to the DNA sequence polymorphism along with Amsterdam and Bethesda ***,those fail in term of *** To determine a clear cut-off of MSH2 gene expression for CRC heredity grouping ***,the study also aims to examine the association of risk factors to the CRC *** The cross-sectional study observed 71 respondents from May 2018 to December 2019 in determining the CRC hereditary status through MSH2 mRNA expression using reverse transcription-polymerase chain reaction and the disease’s risk *** were analyzed through Chi-Square,Fischer exact,t-test,Mann-Whitney,and multiple *** There are significant differences of MSH2 within CRC group among tissue and blood;yet,negative for significance between *** the blood gene expression fifth percentile,the hereditary CRC cut-off is 11059 fc,dividing the 40 CRC respondents to 32.5%with hereditary *** risk factors include age,family history,and ***,after multivariate control,age is just a ***,the study develops a probability equation with area under the curve 82.2%.CONCLUSION Numerous factors have significant relations to heredity of CRC ***,true important factors are staging and family history,while age and others are *** study also established a definite cut-off point for heredity CRC based on mRNA MSH2 expression,11059 *** findings shall act as concrete foundations on further risk factors and/or genetical CRC future studies.

关键词： Colorectal cancer MSH2 gene Non-modifiable factors Risk probability

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Government and Community Involvement in Environmental Protection and Flood Risk Management: Lessons from Keko Machungwa, Dar es Salaam, Tanzania

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Journal of Environmental Protection 2014年第9期5卷 760-771页

作者： Tumpale Sakijege Junun Sartohadi muh Aris Marfai Gabriel Kassenga Samson Kasala Department of Environmental Science and Management Ardhi University Dar es Salaam Tanzania Department of Urban and Regional Planning Ardhi University Dar es Salaam Tanzania Faculty of Geography Gadjah Mada University Yogyakarta Indonesia

Since the 1960s, most cities in developing countries have faced a high rate of urbanization, which in turn has caused more harm to low-income earners, in urban areas. A majority of low-income earners most often face difficulties in accessing land in planned areas, as a result they are forced to build houses in unplanned settlements that are vulnerable to natural hazards. The situation is worse to the extent that people encroach the most vulnerable areas (hazard lands). As concentration of people increases, these unplanned areas become more unsafe to live in. This is partly due to the risks associated with natural hazards particularly flooding. Further, vulnerability of unplanned settlements in developing countries is aggravated by hosts of problems caused by many factors, including inadequate Government involvement in: environmental protection especially managing hazard lands and helping the community to minimize risks associated with hazards. This paper addresses this issue. It argues that community and Government initiatives are vital to any strategy for flood risk reduction and environmental protection in general. The study employed both the primary and the secondary data sources. Data collection tools and techniques involved in this study included: Checklist to various leaders, interview using questionnaires, focus group discussion, analysis of aerial photographs and non participant observation. A total of 70 households from within Keko Machungwa were interviewed. The study revealed that flooding is largely contributed by construction done by a large scale developer on a water course;and when affected community initiated a strategy to solve the problem they partially succeed due to inadequate support from the Government and other stakeholders. These findings could be useful to strengthen policy and legislation in environmental protection, management and flood control as well as in intervening land use conflicts between local community and developers.

关键词： Environmental Protection Community Government Flood Risks Keko Machungwa

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The Long-Term Morphodynamic of Barito Delta, Southern Kalimantan, Indonesia

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Journal of Environmental Science and Engineering(B) 2012年第10期1卷 1196-1202页

作者： Deasy Arisanty Junun Sartohadi muh. Aris Marfai Danang Sri Hadmoko Faculty of Geography Gadjah Mada University Bulaksumur 55281 Yogyakarta Indonesia

Barito Delta morphodynamic had contradictive role with its potency and problem. Potency in Barito Delta may support the development of Banjarmasin City, but development of Barito Delta may decrease the capacity of transportation in Barito River. Multitemporal topographic map and Landsat satellite image during the period 1862-2008 were used to analyze the long-term delta morphodynamic. The analysis consisted of delta growth, yearly growth, growth orientation, delta shape, and shoreline changes. The research showed that the Barito Delta had developed during the period 1862-2008. Barito Delta had developed to south orientation. The growth of Barito Delta during the period 1862-1946 was 27.82 km2 or 0.33 km2/year. However, during the period 1946-1997, Barito Delta growth was 175.82 km2 or 3.45 km2/year. Area of Barito Delta decreased during the period 1997-2004. The reduction of Barito Delta area was 4.73 km2 or 0.67 km2/year. Area of Barito Delta in years 2004-2008 increased about 3.38 km2 or 0.84 km2/year. Shoreline during the period 1862-2008 had changed. Accretion occurred in Kuala Lupak River during the period 1862-1997, but erosion occurred during the period 1997-2004. The delta morphodynamics were influenced by human activities in watershed and delta such as landuse change and land degradation.

关键词：三角洲地区加里曼丹动力学 Landsat 海岸线变化形态印尼土地利用变化

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The Morphodynamics of Wulan Delta and Its Impacts on the Coastal Community in Wedung Subdistrict, Demak Regency, Indonesia

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Journal of Environmental Protection 2016年第1期7卷 60-71页

作者： muh Aris Marfai Desy Wahyuning Tyas Idham Nugraha Ayu Fitriatul’Ulya Widiana Riasasi Faculty of Geography Universitas Gadjah Mada Yogyakarta Indonesia

Wulan Delta in Central Java has been experiencd coastal morphodynamics due to interface between Wulan River’s sedimentation and Java sea’s oceanographic process. This paper aims to analyze Wulan Delta’s morphodynamics as well as its impacts on the socio-economic condition of the community. The morphodynamics is interpreted visually and digitally using a maximum livelihood analysis of multiscale and multi-temporal images. The socio-economic impact is defined by field observations and in-depth interviews to the community and stakeholders. Analysis during the period of 1931-2010 showed that Wulan Delta had been changed morphologically from straight with small arc-like (arcuate) to bird-foot (digitate) with a plausible change into rounded (lobate) in the future, which represented dominant sedimentation by oceanographic rather than fluvial processes. Land expansion in Wulan Delta led to landuse change in Wedung, i.e. expansion of settlement area to 167 ha and fish pond area to 1014 ha in 2000-2010. Most settlements in the area, which are built linearly to river levees, own a high vulnerability to both river flood and tidal inundation. Therefore, dissemination about knowledge of the disaster and coastal zone management, as a means of increasing awareness, becomes necessary in integrating the coastal management in Wulan Delta together with improvement in infrastructure and proper regional development. The proper development strategy for the coastal village is aggressive maintenance strategy, including public infrastructure revitalization, quality improvement for human resources, and silvofishery system. Law enforcement on coastal zoning regulations is necessary to achieve an integrated and sustainable coastal zone management.

关键词： Coastal Morphodynamics Wulan Delta Demak Regency

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The Recent Progress of Hot Metal Desulfurization in CSC and DSC

The Recent Progress of Hot Metal Desulfurization in CSC and ...

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The 2nd International Symposium on Clean Steel(ISCS 2011)

作者： LIN Yan-chian CHENG Hsien-hua WANG muh-shun HUANG Jun-lin Iron and Steel R&D Dept. Steelmaking Dept. CSC Steelmaking Dept. DSC

There are two kinds of existing processes for hot metal desulfurization in *** is the injection process in torpedo car,the other is the impelling process in transfer ***-based fluxes have been used for both *** former was introduced to CSC in *** latter was adopted by CSC and DSC respectively in 2004 and *** paper comprises a theoretical analysis on lime-based flux as desulfurizing agent and an experimental evaluation on impelling process of Kambara （or Kikai） Reactor with a water model and a hot model established in *** comparison of recent mass-production performance for both processes in steelmaking shop has also been included.

关键词： hot metal desulfurization injection process impelling process

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The Impact of Joint Replacement on Driver Function and Safety

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Open Journal of Orthopedics 2012年第3期2卷 121-125页

作者： Stephanie J. muh Yousef Shishani Jonathan Streit Carissa Ann Lucas Vinod Sahgal Matthew Kraay Reuben Gobezie Case Shoulder and Elbow Service Case Western Reserve University School of Medicine University Hospitals of Cleveland Cleve- land USA Cleveland Shoulder Institute University Hospitals of Cleveland Cleveland USA Department of Hematology/Oncology—Solid Tumor Department The Cleveland Clinic Cleveland USA Department of Orthopaedics Case Western Reserve University School of Medicine University Hospitals of Cleveland Cleveland USA

Background: The timing of return-to-driving following total joint replacement has not been well-defined. The primary aim is to study the impact of joint replacement on driver safety. A secondary aim is to investigate the possible predictors for increased car accidents in patients undergoing total joint replacement surgery. This data will provide the background to support further prospective studies on the relationship of driver safety to joint replacement surgery. Methods: A retrospective analysis of driver safety in the postoperative period was performed by analyzing the self-reporting of 485 patients who had undergone a Total Hip Arthroplasty (n = 196), Total Knee Arthroplasty (n = 258) or Total Shoulder Arthroplasty (n = 31). The mean age was 70 (28 - 88) with 164 male (34%) and 319 female (66%). Patients were mailed a questionnaire and the responses were analyzed to determine what factors affect driving after joint replacement. Results: Overall, increased patient age and gender were associated with increased accidents following surgery. Our subgroup analysis demonstrated that in patients undergoing TSA, increased patient age was associated with increased accidents. TKA patients showed that older patient age predicted increased accidents following surgery. Conclusions: While age and gender are correlated with increased accidents after joint replacement in general, no factors specific to joint replacement surgery are related to increased incidence of accidents.

关键词： Total Hip Arthroplasty Total Knee Arthroplasty Total Shoulder Arthroplasty Driving Driver Safety Traffic Accidents

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趣味纸艺

趣味纸艺

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1999年

作者：（德）安德烈亚·米（Andrea muh）陆新译

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Application of Cyclopentadiene and its Derivatives in Natural Product Synthesis

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有机化学 1993年第2期13卷 186-188页

作者： CHANG Nein Chen DAY Huo-muh CHIU Chih-Tsao CHANG Chi-Peng HSU Lung-Fu Department of Chemistry National Sun Yat-Sen University, Kaohsiung, Taiwan 国立孙逸仙大学化学系

Approaches toward the synthesis of iridoids and 9-isocyanopupukeanane starting from cy-clopentadiene are discussed.

关键词： cyclopentadiene natural product application

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Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition

Interplay between HDAC3 and WDR5 is essential for hypoxia-in...

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2012年中国科协海峡两岸青年科学家学术活动月——第九...

作者： Min-Zu Wu Ya-Ping Tsai muh-Hwa Yang Chi-Hung Huang Shyue-Yih Chang Cheng-Chi Chang Shu-Chun Teng 吴国瑞 Institutes of Biochemistry & Molecular Biology National Yang-Ming University Clinical Medicine National Yang-Ming University Genome Research Center National Yang-Ming University Division of Hematology-Oncology Departments of MedicineTaipei Veterans General Hospital

Epithelial-mesenchymal transition(EMT)is important for organ development,metastasis, cancer *** organ *** mechanisms to coordinately regulate hypoxia-induced EMT remain *** we show that HIF-1 -induced histone deacelylase 3(HDA C3)is essential for hypoxia-induced EMT and metastatic phenotypes Change of specific chromatin states is associated with hypoxia-induced ***

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一年級学生理解两步应用題的心理分析

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心理学报 1962年第2期 99-110页

作者：朱曼殊王默君

一、研究目的与方法按上海市新編五年制小学数学教材,一年級下学期要学完100以內加、减两步应用題和表內乘、除两步应用題,最后到四則混合运算并列出解題計划和綜合列式。对一年級学生提出上述要求尚属新的試探,究竟一年級学生在解答... 详细信息

一、研究目的与方法按上海市新編五年制小学数学教材,一年級下学期要学完100以內加、减两步应用題和表內乘、除两步应用題,最后到四則混合运算并列出解題計划和綜合列式。对一年級学生提出上述要求尚属新的試探,究竟一年級学生在解答各类两步題时,其思維过程具有什么特点,能否順利完成教学任务,有待心理学工作者进行研究。我們在对一年級学生理解一步題的分析研究的基础上,对理解两步題的情况又进行了初步研究。

关键词：运算方法运算方式列式题目运算顺序应用题被乘数精神分析心理分析

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