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Impact of gut–brain interaction in emerging neurological disorders

World Journal of Clinical Cases 2023年第1期11卷 1-6页

作者： muh-Shi Lin Yao-Chin Wang Wei-Jung Chen Woon-Man Kung Division of Neurosurgery Department of SurgeryKuang Tien General HospitalTaichung 43303Taiwan Department of Biotechnology and Animal Science College of BioresourcesNational Ilan UniversityYilan 26047Taiwan Department of Biotechnology College of Medical and Health CareHung Kuang UniversityTaichung 43302Taiwan Department of Health Business Administration College of Medical and Health CareHung Kuang UniversityTaichung 43302Taiwan Department of Emergency Min-Sheng General HospitalTaoyuan 33044Taiwan Graduate Institute of Injury Prevention and Control College of Public HealthTaipei Medical UniversityTaipei 11031Taiwan Division of Neurosurgery Department of SurgeryTaipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City 23142Taiwan Department of Exercise and Health Promotion College of Kinesiology and HealthChinese Culture UniversityTaipei 11114Taiwan

The central nervous system(CNS)is a reservoir of immune *** immune glial cells are responsible for maintenance and defense against foreign *** blood–brain barrier(BBB)prevents detrimental pathogens and potentially overreactive immune cells from entering the *** the double-edged neuroinflammatory response is overloaded,it no longer has the protective function of promoting ***,microbiota and its derivatives may emerge as pathogen-associated molecular patterns of brain pathology,causing microbiome–gut–brain axis dysregulation from the *** dysbiosis of the gastrointestinal flora leads to subsequent alterations in BBB permeability,peripheral immune cells are recruited to the *** results in amplification of neuroinflammatory circuits in the brain,which eventually leads to specific neurological *** treatment strategies for gastrointestinal disorders may protect against specific immune responses to gastrointestinal disorders,which can lead to potential protective effects in the ***,this study investigated the mutual effects of microbiota and the gut–brain axis,which may provide targeting strategies for future disease treatment.

关键词： Neuroinflammation Blood–brain barrier Microbiota Gut–brain axis Neurological disorders

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Extended Evolutionary Fast Learn-to-Walk Approach for Four-Legged Robots

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Journal of Bionic Engineering 2007年第4期4卷 255-263页

作者： muh. Anshar Mary-Anne Williams Innovation and Technology Research Laboratory Faculty of Information Technology University of Technology Sydney City Campus 15 Broadway Ultimo NSW 2007 Australia

Robot locomotion is an active research area. In this paper we focus on the locomotion of quadruped robots. An effective walking gait of quadruped robots is mainly concerned with two key aspects, namely speed and stability. The large search space of potential parameter settings for leg joints means that hand tuning is not feasible in general. As a result walking parameters are typically determined using machine learning techniques. A major shortcoming of using machine learning techniques is the significant wear and tear of robots since many parameter combinations need to be evaluated before an optimal solution is found. This paper proposes a direct walking gait learning approach, which is specifically designed to reduce wear and tear of robot motors, joints and other hardware. In essence we provide an effective learning mechanism that leads to a solution in a faster convergence time than previous algorithms. The results demonstrate that the new learning algorithm obtains a faster convergence to the best solutions in a short run. This approach is significant in obtaining faster walking gaits which will be useful for a wide range of applications where speed and stability are important. Future work will extend our methods so that the faster convergence algorithm can be applied to a two legged humanoid and lead to less wear and tear whilst still developing a fast and stable gait.

关键词： legged-robots locomotion learning genetic convergence walking gaits

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New insight into curcumin-based therapy in spinal cord injuries： CISD2 regulation

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Neural Regeneration Research 2016年第2期11卷 222-223页

作者： Chai-Ching Lin muh-Shi Lin Department of Neurosurgery Taipei City HospitalZhong Xiao BranchTaipeiTaiwanChina Department of Surgery Faculty of MedicineSchool of MedicineNational Yang-Ming UniversityTaipeiTaiwanChina Department of Biotechnology and Animal Science College of BioresourcesNational Ilan UniversityYilanTaiwanChina

Multiple protective effects of curcumin in cases of spinal cord injuries（SCIs）：Curcumin[1,7-bis（4-hydroxy-3-methoxyphenyl）-1,6-heptadiene-3,5-dione]is a nonsteroidal,naturally occurring compound commonly utilized... 详细信息

关键词： CISD2 regulation SCI New insight into curcumin-based therapy in spinal cord injuries

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Exact Solutions and Mode Transition for Out-of-Plane Vibrations of Non-uniform Beams with Variable Curvature

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Computers, Materials & Continua 2016年第1期51卷 1-19页

作者： Sen-Yung Lee Shueei-muh Lin Kai-Ping Chang Department of Mechanical Engineering National Cheng Kung UniversityTainanTaiwanRepublic of China Mechanical Engineering Department Kun Shan UniversityTainanTaiwan 710-03Republic of China

The two coupled governing differential equations for the out-of-plane vibrations of non-uniform beams with variable curvature are derived via the Hamilton’s *** equations are expressed in terms of flexural and torsional displacements *** this study,the analytical method is ***,two physical parameters are introduced to simplify the *** derives the explicit relations between the flexural and the torsional displacements which can also be used to reduce the difficulty in experimental *** on the relation,the two governing characteristic differential equations with variable coefficients can be uncoupled into a sixth-order ordinary differential equation in terms of the flexural displacement *** the material and geometric properties of the beam are in arbitrary polynomial forms,the exact solutions with regard to the outof-plane vibrations of non-uniform beams with variable curvature can be obtained by the recurrence *** addition,the mode transition mechanism is revealed and the influence of several parameters on the vibration of the non-uniform beam with variable curvature is explored.

关键词： Out-of-plane vibration Variable curvature Non-uniform beam Exact solution Mode transition

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North-south difference of water mass properties across the Lembeh Strait, North Sulawesi, Indonesia

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Acta Oceanologica Sinica 2018年第12期37卷 1-8页

作者： WANG Weibo PAN Aijun EDI Kusmanto muh Hasanudin DENY Sutisna Ocean Dynamic Laboratory Third Institute of Oceanography Ministry of Natural Resources Research Center for Oceanography Indonesian Institute of Sciences

Two field observations were conducted around the Lembeh Strait in September 2015 and 2016, *** indicate that seawater around the Lembeh Strait is consisted of North Pacific Tropical Water(NPTW),North Pacific Intermediate Water(NPIW), North Pacific Tropical Intermediate Water(NPTIW) and Antarctic Intermediate Water(AAIW). Around the Lembeh Strait, there exist some north-south differences in terms of water mass properties. NPTIW is only found in the southern Lembeh Strait. Water mass with the salinity of 34.6 is only detected at 200–240 m between NPTW and NPTIW in the southern Lembeh Strait, and results from the process of mixing between the saltier water transported from the South Pacific Ocean and the lighter water from the North Pacific Ocean and Sulawesi Sea. According to the analysis on mixing layer depth, it is indicated that there exists an onshore surface current in the northern Lembeh Strait and the surface current in the Lembeh Strait is *** dramatic differences of water masses demonstrate that the less water exchange has been occurred between the north and south of Lembeh Strait. In 2015, the positive wind stress curl covering the northern Lembeh Strait induces the shoaling of thermocline and deepening of NPIW, which show that the north-south difference of airsea system is possible of inducing north-south differences of seawater properties.

关键词： water mass Lembeh Strait north-south difference

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The Recent Progress of Hot Metal Desulfurization in CSC and DSC

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Journal of Iron and Steel Research(International) 2011年第S2期18卷 64-68页

作者： LIN Yan-chian CHENG Hsien-hua WANG muh-shun Iron and Steel R&D Dept. Steelmaking Dept. CSC Kaohsiung 81233 Taiwan China

There are two kinds of existing processes for hot metal desulfurization in CSC. One is the injection process in torpedo car, the other is the impelling process in transfer ladle. Lime-based fluxes have been used for both processes. The former was introduced to CSC in 1982. The latter was adopted by CSC and DSC respectively in 2004 and 2010. This paper comprises a theoretical analysis on lime-based flux as desulfurizing agent and an experimental evaluation on impelling process of Kambara (or Kikai) Reactor with a water model and a hot model established in 2001. The comparison of recent mass-production performance for both processes in steelmaking shop has also been included.

关键词： hot metal desulfurization injection process impelling process

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Shoreline Change Analysis in Demak, Indonesia

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Journal of Environmental Protection 2017年第8期8卷 940-955页

作者： Komariah Ervita muh Aris Marfai Faculty of Geography Universitas Gadjah Mada Yogyakarta Indonesia

Demak Regency is located in Central Java Province Indonesia bordering the Java Sea. Intense activities in the coastal area of Demak have caused changes in the shoreline. This paper aimed to determine the shoreline change for 25 years and to identify the major factors that influenced those changes in the coastal area of Demak. A shoreline change analysis was conducted based on Multitemporal Landsat satellite imagery with sensors of Thematic Mapper (TM), Enhanced Thematic Mapper plus (ETM+), and Operational Land Imager (OLI). This study used the data from multitemporal Landsat imagery of year 1990, 1994, 1999, 2002, 2008, 2011, and 2015. Identification of the shoreline was performed through band ratio, histogram threshold, and composite band 457 methods. An erosion and accretion analysis has been done using the wind data via the processing of Wind Rose Plot (WRPLOT), wave prediction using Sverdrup Munk Bretschneider (SMB) method, tide data processing to know the value of Mean High Water Level (MHWL), Mean Sea Level (MSL), Mean Low Water Level (MLWL), and Lowest Low Water Level (LLWL), as well as currents data processing that has been implemented to achieve the goal. The research results showed that the shoreline change in Demak Regency was quite distinct compared to several previous years due to erosion and accretion processes. The greatest shoreline change happened in Sayung District and Wedung District. Sayung District was likely to experience erosion process while Wedung District tended to show accretion process. Several physical factors that became the major influence on these changes were the wind, waves, currents, and tides.

关键词： Shoreline Dynamics Erosion Accretion Demak Regency Indonesia

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Identification of K-Casein Polymorphism in Bali Cattle

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Journal of Agricultural Science and Technology(A) 2012年第3期2卷 397-401页

作者： muh Affan Mu＇in Andoyo Supriyantono Faculty of Animal Science Fishery and Marine Science Papua State University Manokwari West Papua Indonesia

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AUTOCRINE ACTIONS OF NADPH OXTOASE-DERIVED O2-IN CORONARY ARTERIAL MYOCYTES

AUTOCRINE ACTIONS OF NADPH OXTOASE-DERIVED O2-IN CORONARY AR...

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第十五届国际药理学大会

作者： Rachel W.muh Department of Pharmacology and Toxicology Medical College of VirginiaVirginia Commonwealth UniversityRichmond VA 23298

＜正＞ The present study tested the hypothesis that extracellular O2. ? derived from NADPH oxidase （NOX） serves as an autocrine to activate physiological response in coronary arterial myocytes （CAMs）. By simultaneously monitoring intracellular（[O2.-]i） and extracellular O2.-([O2.-]o levels,M1 - receptor agonist oxotremorine （OXO） was found to stimulate a more rapid increase in [O2.-]O than [O2.-]i in CAMs. Addition of SOD outside cells blocked OXO- induced increases in both [O2.-]i and [O2.-]o. Silencing NOX subunit. Nox 1 by siRNAblocked increases in both [O2.-]i and [O2.-]o,but silencing Nox 4 only attenuated increase in [O2.-]*** ESR spectrometry. OXO was found to increase [O2.-]o by 35 %, which was blocked by Nox 1 siRNA （by 74%）. This Ml - activation of NOX stimulated SOD - blockable Ca2+ release in CAMs （△[Ca2+]i=821+++++67 nM）. NOX was also shown to be activated by NO donor, spermine NONOate （by 67 % ）. These results suggest that NOX - derived [O2.-]o exerts an autocrine action to stimulate intracellular Ca2+ release and that NOX can be activated by NO. which may counteract the action of excessive NO around CAMs.

关键词： NADPH oxidase autocrine redox signaling coronary artery

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An ECFSM-based Maximal Progress Protocol Verification

An ECFSM-based Maximal Progress Protocol Verification

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计算机，通信，控制与电力工程国际会议

作者： Chung-Ming Huang Jenq-muh Hsu Institute of Information Engineering National Cheng Kung University

ISBN: (纸本)0780312333

A number 6f protocol verification reduction techniques were proposed in the *** of these techniques are suitable for verifying communicating protocols specified in the Communicating Finite State Machine(CFSM) ***,it is impossible to formally specify communicating protocols with predicates and variables using the CFSM *** Extended Communicating Finite State Machine(ECFSM) model,which incorporates the mechanism for representing variables and predicates,can formally model communicating protocols with variables and predicates. To have more efficient verification for ECFSM-specified protocols,we propose an integrated ECFSM-based global state reduction technique in this *** new method is based on two techniques:the dead variables analysis which can reduce the number of global states,and the ECFSM-based maximal progress state exploration which can speed up the global state reachability *** our new ECFSM-based method,the maximal progress protocol verification can be directly applied to the Formal Description Techniques(FDTs) which are based on the extended state transition model,i.e.,ISO's Estelle and CCITT's SDL.

关键词： Protocol An ECFSM-based Maximal Progress Protocol Verification

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