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A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism

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Journal of Molecular Cell Biology 2022年第2期14卷 56-71页

作者： Lianju Qin Jing Zhang Yujie Xiao Kang Liu Yugui Cui Fangyan Xu Wenkai Ren Yanggang Yuan Chunyan Jiang Song Ning Xiaoxue Ye Ming Zeng Hanyang Qian Anning Bian Fan Li guang Yang Shaowen Tang Zhihong Zhang Juncheng Dai Jing guo Qiang Wang Bin Sun Yifei Ge Chun Ouyang Xueqiang Xu Jing Wang Yaoyu Huang Hongqing Cui Jing Zhou Meilian Wang Zhonglan Su Yan Lu Di Wu Jingping Shi Wei Liu Li Dong Yinbing Pan Baiqiao Zhao Ying Cui Xueyan Gao Zhanhui Gao Xiang Ma Aiqin Chen Jie Wang Meng Cao Qian Cui Li Chen Feng Chen Youjia Yu Qiang Ji Zhiwei Zhang mufeng gu Xiaojun Zhuang Xiaolin Lv Hui Wang Yanyan Pan Ling Wang Xianrong Xu Jing Zhao Xiuqin Wang Cuiping Liu Ningxia Liang Changying Xing Jiayin Liu Ningning Wang State Key Laboratory of Reproductive Medicine Center of Clinical Reproductive MedicineThe First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Nephrology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjing 211166China Department of Pathology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Cardiology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Rheumatology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Obstetrics The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Dermatology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Burn and Plastic Surgery The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Nuclear Medicine The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Infection The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Anesthesiology and Pain Management The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Nephrology The First People’s Hospital of LianyungangLianyungang 222061China Department of Nephrology Northern Jiangsu People’s HospitalYangzhou 225001China Department of General Medicine Geriatric Hospital of Nanjing Medical UniversityNanjing 210024China Department of Nephrology BenQ Medical CenterThe Affiliated BenQ Hospital of Nanjing Medical Uni

Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven ***,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified *** of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was *** release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were *** further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude *** the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the *** followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear *** biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged *** infusion or local treatment-related adverse events ***,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity.

关键词： calciphylaxis chronic kidney disease vascular calcification multidisciplinary rescue human amnion-derived mesenchymal stem cells preclinical research regenerative medicine

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南京医科大学捐献遗体接受工作的实践与思考

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解剖学杂志 2023年第3期46卷 273-275页

作者：王国庆毛志远庄晓俊古慕峰张永杰南京医科大学人体解剖学系人体解剖学实验室南京211166

1前言无偿捐献者所提供的遗体是人体解剖学教学与科研的重要基石[1],捐献者的“奉献与大爱”精神更为人体解剖学教学提供了无比珍贵的思政教育源泉[2-3]。但总体而言,我国无偿捐献遗体工作的开展在不同地区有较大差异,部分医学院校的解... 详细信息

1前言无偿捐献者所提供的遗体是人体解剖学教学与科研的重要基石[1],捐献者的“奉献与大爱”精神更为人体解剖学教学提供了无比珍贵的思政教育源泉[2-3]。但总体而言,我国无偿捐献遗体工作的开展在不同地区有较大差异,部分医学院校的解剖学教研工作也会因遗体捐献数量的不足而受限[4-5]。南京医科大学红十字志愿捐献遗体登记与接受站自1996年建站以来,在南京市红十字会的领导与“南京市志友组织”的支持下,遗体接受工作获得了较大的发展。

关键词：教研工作思政教育医学院校遗体捐献人体解剖学教学红十字会捐献者南京医科大学

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临床血清磷酸化Tau蛋白检测结果回顾及试剂盒分析

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东南大学学报（医学版） 2024年第2期43卷 256-262页

作者：陈德柱陶月蔡敏琪古慕峰孙志明顾寿永姜坤柏兵南京医科大学鼓楼临床医学院核医学科江苏南京210008 南京大学医学院附属鼓楼医院检验科江苏南京210008 江苏大学鼓楼临床医学院检验科江苏南京210008 南京医科大学人体解剖学系南京医科大学人脑组织库江苏南京211166 国家卫生健康委计划生育药具不良反应监测中心江苏省卫生健康发展研究中心江苏省生育力保护与卫生技术评估重点实验室江苏南京210036 江苏省老年病医院江苏南京210024 南京医科大学鼓楼临床医学院检验科江苏南京210008

目的:对南京鼓楼医院检验科所开展的血清磷酸化Tau蛋白(p-Tau)检测结果进行回顾,并分析可能存在的问题,提供对该检测方法更加全面的认识。方法:收集已有的检测数据,对其进行疾病诊断分类,并观察阿尔茨海默病、认知减退、痴呆及其它各类... 详细信息

目的:对南京鼓楼医院检验科所开展的血清磷酸化Tau蛋白(p-Tau)检测结果进行回顾,并分析可能存在的问题,提供对该检测方法更加全面的认识。方法:收集已有的检测数据,对其进行疾病诊断分类,并观察阿尔茨海默病、认知减退、痴呆及其它各类疾病下的p-Tau阳性率。利用细胞与脑组织类参照样品对该方法试剂盒的性能进行初步验证。结果:共包括546例患者数据。其中诊断为阿尔茨海默病的患者p-Tau阳性率为16.7%,诊断为痴呆和认知功能减退的患者阳性率为23.7%、12.1%。试剂盒对梯度稀释于血清中的参照品不能有效显示线性,不能有效检测出细胞与脑组织参照样品中的p-Tau,对手工加入临床血清标本中的参照品也不能提供预期的叠加值,显示较差的回收率。结论:该试剂盒对p-Tau检测的阳性率较低,其准确性仍需要改进并提高。

关键词：阿尔茨海默病痴呆认知障碍血清磷酸化Tau蛋白

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An Electromagnetic Perspective of Artificial Intelligence Neuromorphic Chips

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Electromagnetic Science 2023年第3期1卷 50-67页

作者： Er-Ping Li Hanzhi Ma Manareldeen Ahmed Tuomin Tao Zheming gu mufeng Chen Quankun Chen Da Li Wenchao Chen ZJU-UIUC Institute College of Information Science and Electronic EngineeringZhejiang UniversityHangzhou 310000China

The emergence of artificial intelligence has represented great potential in solving a wide range of complex ***,traditional general-purpose chips based on von Neumann architectures face the“memory wall”problem when applied in artificial intelligence *** on the efficiency of the human brain,many intelligent neuromorphic chips have been proposed to emulate its working mechanism and neuron-synapse *** the emergence of spiking-based neuromorphic chips,the computation and energy efficiency of such devices could be enhanced by integrating a variety of features inspired by the biological *** with the rapid development of neuromorphic chips,it is of great importance to quickly initiate the investigation of the electromagnetic interference and signal integrity issues related to neuromorphic chips for both CMOS-based and memristor-based artificial intelligence integrated ***,this paper provides a review of neuromorphic circuit design and algorithms in terms of electromagnetic issues and opportunities with a focus on signal integrity issues,modeling,and ***,the heterogeneous structures of neuromorphic circuits and other circuits,such as memory arrays and sensors using different integration technologies,are also reviewed,and locations where signal integrity might be compromised are ***,we provide future trends in electromagnetic interference and signal integrity and outline prospects for upcoming neuromorphic devices.

关键词： Signal integrity Electromagnetic interference Electromagnetic design Neuromorphic chips Heterogeneous integration

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