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Chinese Journal of Mechanical Engineering 2017年第5期30卷 1050-1057页

作者： Egon mueller Xiao-Li Chen Ralph Riedel Department of Factory Planning and Factory Management Technische Universitt Chemnitz

Considered as a top priority of industrial devel- opment, Industry 4.0 （or Industrie 4.0 as the German ver- sion） has being highlighted as the pursuit of both academy and practice in companies. In this paper, based on the review of state of art and also the state of practice in dif- ferent countries, shortcomings have been revealed as the lacking of applicable framework for the implementation of Industrie 4.0. Therefore, in order to shed some light on the knowledge of the details, a reference architecture is developed, where four perspectives namely manufacturing process, devices, software and engineering have been highlighted. Moreover, with a view on the importance of Cyber-Physical systems, the structure of Cyber-Physical System are established for the in-depth analysis. Further cases with the usage of Cyber-Physical System are also arranged, which attempts to provide some implications to match the theoretical findings together with the experience of companies. In general, results of this paper could be useful for the extending on the theoretical understanding of Industrie 4.0. Additionally, applied framework and proto- types based on the usage of Cyber-Physical Systems are also potential to help companies to design the layout of sensor nets, to achieve coordination and controlling of smart machines, to realize synchronous production with systematic structure, and to extend the usage of information and communication technologies to the maintenance scheduling.

关键词： Industrie 4.0 - Internet of Things Cyber-Physical System Smart factory Reference architectureIntelligent sensor nets Robot control Synchronousproduction

Enterprise applications of semantic technologies for business process management

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第4期13卷 308-310页

作者： Ralf mueller Oracle BPM Product Development

1 Introduction Today’s business process management (BPM)systems have evolved to provide rich and sophisticated tooling and runtime support for subject

关键词：业务流程管理信息技术企业应用程序语义 Web本体语言 PM系统流程模型基础设施

Apoptotic retinal ganglion cell loss is accompanied by complement and cytokine response in theβB1-CTGF primary open-angle glaucoma mouse model

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Neural Regeneration Research 2023年第2期18卷 337-338页

作者： Ana Maria mueller-Buehl Sabrina Reinehr Experimental Eye Research Institute University Eye HospitalRuhr-University BochumBochumGermany

Glaucoma is a multifactorial disease and occurs in many different *** humans,glaucoma is accounted one of the leading causes for blindness *** to glaucoma's complexity,it is still unclear what pathomechanisms may be involved in its development in humans as well as in other species,such as *** of glaucoma can be delayed because patients often do not notice a visual field loss until approximately30%of retinal ganglion cells(RGCs)are lost(Kerrigan-Baumrind et al.,2000).Although the exact undergoing pathomechanisms of glaucoma disease are not fully understood yet,an increased intraocular pressure(IOP)is related to RGCdeath and is considered the main risk factor.

关键词： glaucoma cytokine

Alcoholic liver disease and hepatitis C:A frequently underestimated combination

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World Journal of Gastroenterology 2009年第28期15卷 3462-3471页

作者： Sebastian mueller Gunda Millonig Helmut K Seitz Department of Medicine and Center for Alcohol Research Live Disease and Nutrition Salem Medical Center University of Heidelberg Zeppelinstraβe 11-33 69121 Heidelberg Germany

Alcoholic liver disease(ALD) and hepatitis C virus(HCV) infection represent, either alone or in combination, more than two thirds of all patients with liver disease in the Western *** review discusses the epidemiology and combined impact of ALD and HCV on the progres sion of liver *** and HCV affect the progres sion of liver disease to liver cirrhosis and hepatocellular carcinoma(HCC) in a synergistic ***, the risk for HCC increases f ive times with a daily alcohol con sumption of 80 g;in the presence of HCV it is increased 20fold, and a combination of both risk factors leads to a more than 100fold risk for HCC *** consumption also decreases the response to interferon treatment which is probably due to a lack of compliance than a direct effect on HCV *** molecu lar mechanisms are discussed that could explain the synergistic interaction of alcohol and HCV on disease *** include modulation of the immune response and apoptosis, increased oxidative stress via induction of CYP2E1 and the hepatic accumulation of ***, both HCV and alcohol independently cause hepatic iron accumulation in > 50% of patients probably due to suppression of the liversecreted systemic iron hormone hepcidin.A better understanding of hepcidin regulation could help in developing novel therapeutic approaches to treat the chronic disease in the *** now, it can be generally concluded that HCVinfect ed patients should abstain from alcohol and alcoholicsshould be encouraged to participate in detoxification programs.

关键词： Alcoholic liver disease Chronic hepatitis C Steatosis Steatohepatitis Fibrosis Cirrhosis Reactiveoxygen species Hepatocellular carcinoma Iron accu-mulation

Surfel-based surface modeling for robotic belt grinding simulation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第7期7卷 1215-1224页

作者： REN Xiang-yang mueller Heinrich KUHLENKOETTER Bernd Robotics Research Institute University of Dortmund Dortmund 44227 Germany Informatik VII University of Dortmund Dortmund 44227 Germany

The new flee-form surface modelling technology for robotic belt grinding simulation presented in this paper is based on discrete surfel elements generated from the surface approximation point set and can facilitate the simulation implementation. A local process model exploits the advantage of surfel representation to compute the material removal rate and the final surface grinding error can be easily carried out. With the help of this system, robot programmers can improve the path planning and predict potential problems by visualizing the manufacturing process.

关键词： Surface modelling Surfel Belt-grinding simulation

Equilibrium Segregation to Free Surface:Kinet ics and Experiment

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Chinese Physics Letters 1999年第5期16卷 364-366页

作者： CAO Ze-xian Ralf mueller WANG En-ge NIE Yu-xin State Key Laboratory for Surface Physics Institute of PhysicsChinese Academy of SciencesBeijing 100080 Department of Physics University Kaiserslautern67653 KaiserslauternGermany

Fick's first law is modified with an additional term df(x)/dx to describe the segregation phenomenon,f(x)is a local,analytical function related to the depth profile at *** thus can be determined experimentally by depth profiling *** starting in an initially homogeneous solid is described by an inhomogeneous diffusion equation on the half-infinite *** with and without formation of overlayer suggests different boundary *** solution for the Ansatz f(x)=as exp(-x/d_(s))is in perfect agreement with experimental results on sulphur segregation to the surface of *** from the detailed kinetics,activation energy can be inferred from the surface concentration evolution under different *** sulphur segregation in titanium,E_(act)=718 meV/atom.

关键词： technique. titanium sulphur

State of the art of friction modelling at interfaces subjected to elastohydrodynamic lubrication(EHL)

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Friction 2021年第2期9卷 207-227页

作者： Zhuming BI Donald W.mueller Chris W.J.ZHANG Civil and Mechanical Engineering Purdue University Fort WayneIN 46805USA Department of Mechanical Engineering University of SaskatchewanSaskatoon SK S7N 5A9Canada

Elastohydrodynamic lubrication(EHL)is a type of fluid-film lubrication where hydrodynamic behaviors at contact surfaces are affected by both elastic deformation of surfaces and lubricant *** of contact interfaces under EHL is challenging due to high nonlinearity,complexity,and the multi-disciplinary *** paper aims to understand the state of the art of computational modelling of EHL by(1)examining the literature on modeling of contact surfaces under boundary and mixed lubricated conditions,(2)emphasizing the methods on the friction prediction occurring to contact surfaces,and(3)exploring the feasibility of using commercially available software tools(especially,Simulia/Abaqus)to predict the friction and wear at contact surfaces of objects with relative reciprocating motions.

关键词： elastohydrodynamic lubrication(EHL) lubricant rheology finite element analysis(FEA) friction prediction Simulia/Abaqus surface roughness coefficient of friction(CoF)

Heme oxygenase-1 as a therapeutic target in inflammatory disorders of the gastrointestinal tract

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World Journal of Gastroenterology 2010年第25期16卷 3112-3119页

作者： Vijith Vijayan Sebastian mueller Eveline Baumgart-Vogt Stephan Immenschuh Institute for Anatomyand Cell Biology Justus-Liebig-University Giessen 35392 Gies-sen Germany Salem Medical Center and Center of Al-cohol Research University of Heidelberg 69121 HeidelbergGermany Institute for Transfusion Medicine Hannover Medical School 30625 Hannover Germany

Heme oxygenase (HO)-1 is the inducible isoform of the first and rate-limiting enzyme of heme degradation. HO-1 not only protects against oxidative stress and apoptosis, but has received a great deal of attention in recent years because ofits potent anti-inflammatory functions. Studies with HO-1 knockout animal models have led to major advances in the understanding of how HO-1 might regulate inflammatory immune responses, although little is known on the underlying mechanisms. Due to its beneficial effects the targeted induction of this enzyme is considered to have major therapeutic po- tential for the treatment ofinflammatory disorders. This review discusses current knowledge on the mechanisms that mediate anti-inflammatory protection by HO-1. More specifically, the article deals with the role of HO-1 in the pathophysiology of viral hepatitis, inflammatorybowel disease, and pancreatitis. The effects of specific HO-1 modulation as a potential therapeutic strategy in experimental cell culture and animal models of these gastrointestinal disorders are summarized. In conclusion, targeted regulation of HO-1 holds major promise for future clinical interventions in inflammatory diseases of the gastrointestinal tract.

关键词： Antioxidant Heme oxygenase Hepatitis Immunity Inflammation Inflammatory bowel disease Oxidative stress Pancreatitis

Non-invasive diagnosis of alcoholic liver disease

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World Journal of Gastroenterology 2014年第40期20卷 14626-14641页

作者： Sebastian mueller Helmut Karl Seitz Vanessa Rausch Department of Internal Medicine Salem Medical Center University of Heidelberg 69121 Heidelberg Germany Center for Alcohol Research University of Heidelberg 69121 Heidelberg Germany

Alcoholic liver disease(ALD)is the most common liver disease in the Western *** many reasons,it isunderestimated and *** early diagnosis is absolutely essential since it(1)helps to identify patients at genetic risk for ALD;(2)can trigger efficient abstinence namely in non-addicted patients;and(3)initiate screening programs to prevent life-threateningcomplications such as bleeding from varices,spontaneous bacterial peritonitis or hepatocellular *** two major end points of ALD are alcoholic liver cirrhosis and the rare and clinically-defined alcoholic hepatitis(AH).The prediction and early diagnosis of both entities is still insufficiently solved and usually relies on acombination of laboratory,clinical and imaging *** is not widely conceived that conventional screeningtools for ALD such as ultrasound imaging or routine laboratory testing can easily overlook ca.40%of manifest alcoholic liver ***-invasive methods such as transient elastography(Fibroscan),acoustic radiation force impulse imaging or shear wave elastography have significantly improved the early diagnosis of *** algorithms allow either the exclusion or the exact definition of advanced fibrosis stages in ca.95%of *** correct interpretation of liver stiffness requires a timely abdominal ultrasound and actual transaminase *** non-invasive methods such as controlled attenuation parameter,serum levels of M30 or M65,susceptometry or breath tests are under current evaluation to assess the degree of steatosis,apoptosis and iron overload in these *** biopsy still remains an important option to rule out comorbidities and to confirm the prognosis namely for patients with AH.

关键词： Alcoholic hepatitis Alcoholic steatohepatitis Alcoholic liver disease Non-invasive Liver stiffness Serum marker Steatosis

Neuromuscular trunk activation patterns in back pain patients during one-handed lifting

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World Journal of Orthopedics 2017年第2期8卷 142-148页

作者： Juliane mueller Tilman Engel Stephan Kopinski Frank Mayer Steffen mueller University Outpatient Clinic Sports Medicine and Sports OrthopaedicsUniversity of Potsdam

AIM To analyze neuromuscular activity patterns of the trunk in healthy controls(H) and back pain patients(BPP) during one-handed lifting of light to heavy loads. METHODS After assessment of back pain(graded chronic pain scale according to von Korff) all subjects(n = 43) performed a warm-up(treadmill walking). Next, subjects were instructed to lift 3 × a 20 kg weight placed in front of them(with both hand) onto a table(height: 0.75 m). Subsequently, all subjects lifted with one hand(left-side, 3 repetitions) a weight of 1 kg(light), 10 kg(middle) and 20 kg(heavy) in random order from the ground up onto the table left of them. Trunk muscle activity was assessed with a 12-lead EMG(6 ventral/6 dorsal muscles; 4000 Hz). EMG-RMS(%) was averaged over the 3 repetitions and analyzed for the whole one-handed lifting cycle, then normalized to RMS of the two-handed lifting. Additionally, the mean(normalized) EMG-RMS of four trunk areas [right/left ventral area(VR/VL); right/left dorsal area(DR/DL)] was calculated. Data were analyzed descriptively(mean ± SD) followed by student's t-test comparing H and BPP(α = 0.05). With respect to the unequal distribution of subjects in H and BPP, a matched-group analysis was conducted. Seven healthy controls were gender- and age-matched(group H_(matched)) to the 7 BPP. In addition, task failure was calculated and compared between H/H_(matched) vs BPP using χ~2. RESULTS Seven subjects(3m/4f; 32 ± 7 years; 171 ± 7 cm; 65 ± 11 kg) were assigned to BPP(pain grade ≥ 2) and 36(13m/23f; 28 ± 8 years; 174 ± 10 cm; 71 ± 12 kg) to H(pain grade ≤ 1). H and BPP did not differ significantly in anthropometrics(P > 0.05). All subjects were able to lift the light and middle loads, but 57% of BPP and 22% of H were not able to lift the heavy load(all women). χ~2 analysis revealed statistically significant differences in task failure between H vs BPP(P = 0.03). EMG-RMS ranged from 33% ± 10%/30% ± 9%(DL, 1 kg) to 356% ± 148%/283% ± 80%(VR, 20 kg) in H/BPP with n

关键词： Lifting Core Trunk EMG MISPEX