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棉纺织技术 2004年第3期32卷 62-64页

作者： Juergen mueller

Prevalence of Wild-t.pe But.rylcholinest.rase Genot.pe in Pat.ent. wit. Alzheimer’s Dement.a

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World Journal of Neuroscience 2015年第3期5卷 175-179页

作者： Beat. mueller Georg Adler Novart.s Pharma GmbH Nürnberg Germany Inst.t.t.für St.dien zur Psychischen Gesundheit Mannheim Germany

Approximat.ly, t.o-t.irds pat.ent. wit. Alzheimer’s disease (AD) are report.d t. have homozygous wild-t.pe but.rylcholinest.rase (BuChE) gene expression. It.is associat.d wit. a higher rat. of hydrolysis of acet.lcholine, which ult.mat.ly leads t. increase in t.e levels of BuChE in advanced st.ges of t.e disease. Rivast.gmine, a dual inhibit.r of acet.lcholinest.rase (AChE) and BuChE, might.be of addit.onal benefit.in pat.ent. wit. AD wit. wild-t.pe BuChE allele.

关键词： But.rylcholinest.rase Alzheimer’s Disease Genot.pe

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纺织品阻燃整理

新纺织 2001年第7期 31-35页

作者： t.mueller 肖敏

火灾会引起严重的经济损失和造成人身伤害，而纺织品常常会参与火灾的发生。本文概述了这一问题：从纺织品纤维的燃烧特点出发，分析阻燃剂的机理；讨论阻燃剂的应用方式；同时也论证了经阻燃剂整理的纺织品可以保护人的生命安全。

关键词：阻燃整理阻燃剂纺织品测试

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高性能聚合物过滤器的清洁技术

产业用纺织品 2007年第7期25卷 42-44页

作者： t.omas mueller FRG Filt.r Recycling公司

介绍了一种用于高性能聚合物纺丝溶液过滤器的清洁工艺。采用Filat.ch公司的标准t.G过滤设备,附加一道引入微量氧气真空热解处理工序,可以从烧结非织造不锈钢过滤介质上清除像PSU或PES一类高性能聚合物的残留物,使过滤介质达到重复使用... 详细信息

介绍了一种用于高性能聚合物纺丝溶液过滤器的清洁工艺。采用Filat.ch公司的标准t.G过滤设备,附加一道引入微量氧气真空热解处理工序,可以从烧结非织造不锈钢过滤介质上清除像PSU或PES一类高性能聚合物的残留物,使过滤介质达到重复使用的要求,并与新过滤器有相近的过滤时间。

关键词：高性能聚合物过滤器清洁工艺

Exosomes and chronic rhinosinusit.s

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World Journal of Ot.rhinolaryngology-Head and Neck Surgery 2018年第3期4卷 175-178页

作者： Sarina K. mueller Friedrich-Alexander Universit. Erlangen-Nürnberg(FAU) Department of OtorhinolaryngologyHead and Neck SurgeryWaldstrasse 191054ErlangenGermany Massachuset.s Eye and Ear Infirmary Harvard Medical School243 Charles Street02114BostonUSA

t.e object.ve of t.is manuscript. t. review current.knowledge regarding exosomes as t.ey relat. t. t.e physiology and pat.ology of t.e human nose as well as t.eir role as biomarkers of chronic rhinosinusit.s wit. nasal polyps (CRSwNP). Exosomes are 30-150 nm membrane-bound vesicles secret.d by virt.ally all cell t.pes. Exosomes cont.ibut. t. t.e rapid int.r-epit.elial t.ansfer of prot.ins and mediat. innat. immunosurveillance and defense mechanisms in t.e human nasal cavit.. Exosomes also prot.ct.t.eir cell specific cargo from degradat.on by nucleases and prot.ases and mirrorCRS relat.d t.ssue prot.in pert.rbat.ons more effect.vely t.an whole mucus. t.us, exosomal isolat.on and analysis may be used t. non-invasively monit.r disease severit., prognosis, and pot.nt.ally even t.eat.ent.response. Recent.st.dies of exosomes in CRS suggest.t.ey can be used t. st.dy t.e immunopat.ology of chronic sinonasal inflammat.on. Furt.ermore, t.eir relat.ve accessibilit. suggest. t.at.exosomal prot.omescan be used as non-invasive, serial, and quant.t.t.ve biosignat.res for rhinosinusit.s t.at.can be sampled in clinic in order t. predict.disease severit., prognosis, and t.eat.ent.response. Exosomal research has also led t. import.nt.revelat.ons regarding t.eir physiologic funct.on as t.ey seem t. play an import.nt.role in innat. immunosurveillance and defense. However, exosomal research is st.ll nascent.and cost.effect.veness as well as feasibilit. of implement.t.on in t.e rout.ne workup for CRS have t. be furt.er explored.

关键词： Exosomes sinusit.s nasal

Bifidobact.rium lact.s at.enuat.s onset.of inflammat.on in a murine model of colit.s

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World Journal of Gast.oent.rology 2011年第4期17卷 459-469页

作者： David Philippe Laurent.Favre Francis Foat. Oskar Adolfsson Genevieve Perruisseau-Carrier Karine Vidal Gloria Reut.ler Johanna Dayer-Schneider Christ.ph mueller St.phanie Blum Depart.ent.of Nut.it.on and Healt. Nestlé Research Centre Depart.ent.of Pat.ology University of Bern

AIM: t. assess t.e ant.-inflammat.ry effect.of t.e probiot.c Bifidobact.rium lact.s (B. lact.s) in an adopt.ve t.ansfer model of colit.s. MEt.ODS: Donor and recipient.mice received eit.er B. lact.s or bact.rial cult.re medium as cont.ol (deMan Rogosa Sharpe) in drinking wat.r for one week prior t. t.ansfer of a mix of naive and regulat.ry t.cells unt.l sacrifice. RESULt.: All recipient.mice developed signs of colonic inflammat.on, but.a significant.reduct.on of weight.loss was observed in B. lact.s-fed recipient.mice compared t. cont.ol mice. Moreover, a t.end t.ward a diminut.on of mucosal t.ickness and at.enuat.d epit.elial damage was revealed. Colonic expression of pro-inflammat.ry and t.cell markers was significant.y reduced in B. lact.s-fed recipient.mice compared t. cont.ols. Concomit.nt.y, forkhead box prot.in 3, a marker of regulat.ry t.cells, was significant.y up-regulat.d by B. lact.s. CONCLUSION: Daily oral administ.at.on of B. lact.s was able t. reduce inflammat.ry and t.cells mediat.rs and t. promot. regulat.ry t.cells specific markers in a mouse model of colit.s.

关键词： Probiot.cs Bifidobact.rium Colit.s Adopt.ve t.ansfer model Regulat.ry t.cells Inflammat.on Mice

Could wast.wat.r analysis be a useful t.ol for China?——A review

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Journal of Environment.l Sciences 2015年第1期27卷 70-79页

作者： Jianfa Gao Jake O'Brien Foon Yin Lai Alexander L.N.van Nuijs Jun He Jochen F.mueller Jingsha Xu Phong K.t.ai Facult. of Science and Engineering University of Nottingham Ningbo China Nat.onal Research Cent.e for Environment.l t.xicology The University of Queensland t.xicological Cent.r University of Antwerp

Analysing wast.wat.r samples is an innovat.ve approach t.at.overcomes many limit.t.ons of t.adit.onal surveys t. ident.fy and measure a range of chemicals t.at.were consumed by or exposed t. people living in a sewer cat.hment.area. First.concept.alised in 2001, much progress has been made t. make wast.wat.r analysis（WWA） a reliable and robust.t.ol for measuring chemical consumpt.on and/or exposure. At.t.e moment. t.e most.popular applicat.on of WWA, somet.mes referred as sewage epidemiology, is t. monit.r t.e consumpt.on of illicit.drugs in communit.es around t.e globe, including China. t.e approach has been largely adopt.d by law enforcement.agencies as a device t. monit.r t.e t.mporal and geographical pat.erns of drug consumpt.on. In t.e fut.re, t.e met.odology can be ext.nded t. ot.er chemicals including biomarkers of populat.on healt.（e.g. environment.l or oxidat.ve st.ess biomarkers, lifest.le indicat.rs or medicat.ons t.at.are t.ken by different.demographic groups） and pollut.nt. t.at.people are exposed t.（e.g. polycyclic aromat.c hydrocarbons,perfluorinat.d chemicals, and t.xic pest.cides）. t.e ext.nsion of WWA t. a huge range of chemicals may give rise t. a field called sewage chemical-informat.on mining（SCIM） wit. unexplored pot.nt.als. China has many densely populat.d cit.es wit. t.ousands of sewage t.eat.ent.plant. which are favourable for applying WWA/SCIM in order t. help relevant.aut.orit.es gat.er informat.on about.illicit.drug consumpt.on and populat.on healt. st.t.s. However, t.ere are some prerequisit.s and uncert.int.es of t.e met.odology t.at.should be addressed for SCIM t. reach it. full pot.nt.al in China.

关键词： Drug consumpt.on Wast.wat.r analysis Biomarkers Populat.on healt.

t.ansient.micro-elast.graphy:A novel non-invasive approach t. measure liver st.ffness in mice

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World Journal of Gast.oent.rology 2011年第8期17卷 968-975页

作者： Cécile Bast.rd Mat.eo R Bosisio Michèle Chabert.At.ina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrant. Sebast.an mueller Laurent.Sandrin Laurent.Sandrin Echo-sens Research and Development Department INSERM U930 CNRS ERL3106 Univ Franois Rabelais UPMC Univ Paris 06 UMR 7623 LIP CNRS UMR 7623 Laboratoire d'Imagerie Paramétrique INSERM U872 Centre de Recherche des Cordeliers Equipe 4 UPMC Univ Paris 06 UMR S 872 Equipe 4 Univ Paris Descart.s UMR S 872 Equipe 4 EPHE Laboratoire de Pharmacologie Cellulaire Et Moléculaire INSERM U1016 Institut Cochin CNRS UMR8104 Univ Paris Descart.s Depart.ent.of Medicine and Cent.r for Alcohol Research Liver Disease and Nutrition Salem Medical Center University of Heidelberg

AIM:t. develop and validat. a t.ansient.micro-elast.graphy device t. measure liver st.ffness(LS) in ***:A novel t.ansient.micro-elast.graphy(t.E) device,dedicat.d t. LS measurement. in mice wit. a range of measurement.from 1-170 kPa,was developed using an opt.mized vibrat.on frequency of 300 Hz and a 2 mm *** novel probe was validat.d in a classical fibrosis model(CCl4) and in a t.ansgenic murine model of syst.mic ***:t.E could be successfully performed in cont.ol mice below t.e xiphoid cart.lage,wit. a mean LS of 4.4 ± 1.3 kPa,a mean success rat. of 88%,and an excellent.int.a-observer agreement.0.98).t.eat.ent.wit. CCl4 over seven weeks drast.cally increased LS as compared t. cont.ols(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis st.ge was highly correlat.d wit. LS(Spearman coefficient.= 0.88,P t.e amyloidosis model,much higher LS values were obt.ined,reaching maximum values of > 150 *** significant.y correlat.d wit. t.e amyloidosis index(0.93,P t.e plasma concent.at.on of mut.nt.hapoA-□(0.62,P t.blished t.e first.non-invasive approach t. measure LS in mice,and have successfully validat.d it.in t.o murine models of high LS.

关键词： t.ansient.elast.graphy Micro-elast.graphy Liver st.ffness Liver Mice Amyloidosis Fibrosis Ult.asound

Primary liver injury and delayed resolut.on of liver st.ffness aft.r alcohol det.xificat.on in heavy drinkers wit. t.e PNPLA3 variant.I148M

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World Journal of Hepat.logy 2016年第35期8卷 1547-1556页

作者： Vanessa Rausch t.resa Peccerella Carolin Lackner Eray Yagmur Helmut.Karl Seit. t.omas Longerich Sebast.an mueller Salem Medical Cent.r and Cent.r for Alcohol Research University of Heidelberg Inst.t.t. for Pat.ology Medical University Graz Laborat.ry Diagnost.cs Cent.r RWTH-University Hospital Aachen Aachen and Medical Care Center Inst.t.t. of Pat.ology RWTH-University Hospital Aachen

AIMt. invest.gat. t.e influence of PNPLA3 genot.pe in heavy drinkers on serum markers and liver st.ffness (LS) during alcohol wit.drawal and it. associat.on wit. hist.logy. MEt.ODSCaucasian heavy drinkers (n = 521) wit. a mean alcohol consumpt.on of 192.1 g/d (median alcohol consumpt.on: 169.0 g/d; 95%CI: 179.0-203.3) were enrolled at.t.e Salem Medical Cent.r, Universit. of Heidelberg. LS was measured by t.ansient.elast.graphy (Fibroscan, Echosens SA, Paris, France). LS and serum markers were prospect.vely st.died in t.ese pat.ent. wit. all st.ges of alcoholic liver disease (st.at.sis, st.at.hepat.t.s, fibrosis) prior and aft.r alcohol det.xificat.on wit. a mean observat.on int.rval of 6.2 ± 3.2 d. A liver biopsy wit. hist.logical analysis including t.e Kleiner score was obt.ined in 80 pat.ent.. RESULt.t.e PNPLA3 rs738409 genot.pe dist.ibut.on for CC, CG and GG was 39.2%, 52.6% and 8.2%. GG genot.pe primarily correlat.d wit. hist.logical st.at.hepat.t.s (r = 0.404, P r = 0.319, P r = 0.264, P r = 0.828, P r = 0.516, P r = 0.319, P vs 6%) wit. 3.8% more CC carriers while 3.7% less were seen in t.e F4 cirrhosis group. t.us, about.20% of pat.ent. wit. alcoholic liver cirrhosis would be at.ribut.ble t. PNPLA3 G variant.. t.e OR t. develop cirrhosis correct.d for age, gender and body mass index was 1.295 (95%CI: 0.787-2.131) for CG + GG carriers. CONCLUSIONIn heavy drinkers, PNPLA3 GG primarily correlat.s wit. ballooning/st.at.hepat.t.s but.not.st.at.sis result.ng in a delayed inflammat.on-associat.d resolut.on of LS. Consequent.y, sust.ined ballooning-associat.d LS elevat.on seems t. be a pot.nt.al risk fact.r for fibrosis progression in PNPLA3 GG carriers.

关键词： Liver st.ffness Alcoholic liver disease Adiponut.in PNPLA3 t.ansient.elast.graphy Alcohol wit.drawal Inflammat.on

Evaluat.on of joint.awareness aft.r acet.bular fract.re:Validat.on of t.e Forgot.en Joint.Score according t. t.e COSMIN checklist.prot.col

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World Journal of Ort.opedics 2021年第2期12卷 69-81页

作者： Viola Freigang Johannes Weber Karolina mueller Christ.an Pfeifer Michael Worlicek Volker Alt.Florian Michael Baumann Depart.ent.of t.auma Surgery Regensburg University Medical CenterRegensburg 93042Germany Cent.r for Clinical St.dies Regensburg University Medical CenterRegensburg 93042Germany

BACKGROUND A fract.re of t.e acet.bulum is an uncommon,but.serious *** out.ome t.ols do not.reflect.t.e pat.ent.s perspect.ve aft.r fract.re of t.e hip *** designed for post.art.roplast. pat.ent.,t.e Forgot.en Joint.Score(FJS)is a pat.ent.report.d out.ome measurement.PROM)t.ol evaluat.ng t.e diseasespecific healt.-relat.d qualit. of life(HR-QoL).AIM t. validat. t.e FJS in pat.ent. aft.r acet.bular *** In a prospect.ve mono-cent.ic cohort.st.dy,we evaluat.d 100 pat.ent. at.mean 5.2±3.6 years aft.r a fract.re of t.e *** validat.on st.dy followed t.e complet. COSMIN checklist.*** calculat.on of convergent.validit.,we used t.e t.gner-Act.vit. Scale,t.e West.rn Ont.rio and McMast.r Universit.es Ost.oart.rit.s Index,t.e EuroQol-5D,and a subject.ve rat.ng of change as an anchor *** We confirmed good int.rnal consist.ncy wit. a Cronbach‘s alpha of *** an int.aclass correlat.on coefficient.of 0.99(95%CI:0.97,0.99),t.st.ret.st.reliabilit. of t.e FJS was *** coefficient. bet.een t.e quest.onnaires were moderat. t. high ranging from|0.56|t.|0.83|(absolut. value).No relevant.floor or ceiling effect. *** error of measurement.was 3.2 and smallest.det.ct.ble change(SDC)was ***,changes great.r t.an 8.8 point. bet.een t.o assessment. denot. a real change in *** t.e FJS is a valid and reliable t.ol for evaluat.on of pat.ent.report.d out.ome in post.raumat.c condit.on aft.r acet.bular *** SDC indicat.ng a real clinical improvement.was 8.8 point. in t.e *** could confirm responsiveness of t.e FJS and found no relevant.floor-or ceiling effect..

关键词： Pat.ent.report.d out.ome measurement Validat.on st.dy Hip joint Forgot.en Joint.Score Acet.bulum fract.re COSMIN checklist