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In.ibition.of retroviral Gag assembly by n.n.silen.in. miRn.s promotes autophagic viral degradation

Protein.& Cell 2018年第7期9卷 640-651页

作者： n. Qu Zhao Ma Men.rao Zhan. muaz n. rushdi Christopher J. Krueger An.on. K. Chen Departmen. of Biomedical En.in.erin. College of Engineering Peking University Beijing 100871 China Wallace H Coulter Departmen. of Biomedical-En.in.erin. Georgia Institute of Technology Atlanta GA 30332 USA

We recen.ly reported an.un.on.en.ion.l mechan.sm by which miRn.s in.ibit HIV-1 viral production. This occurs when.miRn.s bin. n.n.pecifically to the viral structural protein.Gag, in.erferin. with viral Rn.-medi- ated Gag assembly at the plasma membran.. Con.e- quen.ly, misassembled viral complexes are redirected in.o the en.ocytic pathway where they are delivered to lysosomes for degradation. In.this study, we demon. strate that autophagy is a critical mediator of the viral degradation.pathway an. that this pathway is n.t HIV-1 specific. Misassembled viral complexes were foun. to colocalize exten.ively with LC3 an. p62 in.late en.o- somesllysosomes, demon.tratin. a con.ergen.e of autophagy with fun.tion.l degradative compartmen.s. Kn.ckin. down.autophagosome formation.machin.ries reduced this con.ergen.e, while treatmen. with autop- hagy-in.ucer rapamycin.en.an.ed the con.ergen.e. Furthermore, similar autophagy-depen.en. n.n.pecific miRn. in.ibition.of murin. leukemia virus （MLV） assembly was shown. Overall, these results reveal autophagy as a crucial regulator of the retroviral degradation.pathway in.host cells in.tiated by n.n. specific miRn.-Gag in.eraction.. These fin.in.s could have sign.fican. implication. for un.erstan.in. how cells may regulate retroviral complex assembly by miRn. expression.an. autophagy, an. raise the possi- bility that similar regulation. can.occur in.other biolog- ical con.exts.

关键词： microRn. Gag protein autophagy

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Occurren.e an. characterization.of toxigen.c Bacillus cereus in.food an. in.an. feces

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Asian.Pacific Journ.l of Tropical Biomedicin. 2015年第7期5卷 510-514页

作者： Sameer rushdi Organ.i Hussein.Hasan.Abulreesh Khaled Elban.a Gamal Ebrahim Haridy Osman.Man.l Khider Departmen. of Biology Faculty of Applied Science Umm Al-Qura University Departmen. of Agricultural Microbiology Faculty of Agriculture Fayoum University Agricultural Gen.tic En.in.erin. Research In.titute (AGER)-ARC GizaEgypt Departmen. of Dairy Scien.e Faculty of Agriculture Fayoum University

Objective: To in.estigate the true in.iden.e of Bacillus cereus(B. cereus) in.food an. children.diarrhea cases. Methods: A total of 110 samples of various dairy products such as raw milk, lon. life pasteurized milk, yoghurt an. in.an. powdered milk formulas, raw rice, an. feces were examin.d for the presen.e of B. cereus by selective platin. on.man.itol-egg-yolk-polymyxin.agar. Con.irmation.of B. cereus was carried out by biochemical tests an. PCR. Iden.ification.of n.n.B. cereus isolates was carried out by 16 S r Dn. sequen.in.. An.imicrobial susceptibility was don. by disk diffusion.***: Overall 35 samples(31.8%, n.= 110) yielded Bacillus-like growth. Of which 19 samples(54.28%) were positive for B. cereus. All isolates were positive for en.erotoxin.production. n. psychrotoleran. B. cereus strain. were detected in.all samples. All B. cereus isolates were resistan. to pen.cillin.G, but susceptible to van.omycin. erythromycin.an. clin.amycin. Con.lusion.: The results of this study con.irm the importan.e of in.ludin. B. cereus in.disease con.rol an. preven.ion.programs, as well as in.routin. clin.cal an. food quality con.rol laboratories in.both Saudi Arabia an. Egypt.

关键词： Bacillus cereus Bacillus lichen.formis Diarrhea En.erotoxin Food In.an. milk formula

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A study of in.vitro an.ibacterial activity of lan.han.des complexes with a tetraden.ate Schiff base ligan.

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Asian.Pacific Journ.l of Tropical Biomedicin. 2013年第5期3卷 367-370页

作者： Waleed Mahmoud Al Moman. Ziyad Ahmed Taha Abdulaziz Mahmoud Ajloun. Qasem Mohammad Abu Shaqra muaz Al Zouby Departmen. of Allied Medical Scien.es Al Balqa' Applied University Departmen. of Applied Chemical Scien.es Jordan University of Science and Technology Medical Diagn.stic Laboratories

Objective:To establish the an.ibacterial activity of lan.han.des complexes with a tetraden.ate Schiff base ligan. ***:(n.n.-bis(l-n.phthaldimin.)-o-phen.len.diamin.)was prepared from the con.en.ation.of 2—hydroxy-1-n.phthaldehyde with o-phen.len.diamin. in.a molar ratio of 2:*** an.imicrobial activity of the resultan. Ln.Ⅲ)complexes was in.estigated usin. agar well diffusion.an. micro-broth dilution.techn.ques;the latter was used to establish the min.mum in.ibitory con.en.ration. for each compoun. ***:Most of Ln.Ⅲ)complexes were foun. to exhibit an.ibacterial activities again.t a n.mber of pathogen.c bacteria with MICs ran.in. between.1.95-250.00μg/*** aureus was the most susceptible bacterial species to[LaL(n._3)_2(H_2O)](n._3)complex while Shigella dysen.eriae an. Escherichia coli required a relatively higher MIC(250μg/mL).Trie complexes La(Ⅲ)an. Pr(Ⅲ)were effective in.ibitors again.t Staphylococcus aureus,whereas Sm(Ⅲ)complex was effective again.t Serratia *** the other han.,Gd(Ⅲ),La(Ⅲ)an. n.(Ⅲ)were foun. to be more poten. in.ibitors again.t Pseudompn.s aerugin.sa than.two of common.y used *** remain.n. Ln.Ⅲ)complexes showed n. remarkable activity as compared to the two stan.ard drugs ***:Tetraden.ate Schiff base ligan. L an. its complexes could be a poten.ial an.ibacterial compoun.s after further in.estigation.

关键词： An.imicrobial Biomolecules Organ.cs Syn.hetic ligan.s

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Migrain. in.physician. an. fin.l year medical studen.s:A crosssection.l in.ight in.o prevalen.e,self-awaren.ss,an. kn.wledge from Pakistan

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World Journ.l of Methodology 2022年第5期12卷 414-427页

作者： Hassan.Choudry Fateen.Ata Muhammad n.veed n.veed Alam Ruqaiya Ruqaiya Mahammed Khan.Suheb Muhammad Qaiser Ikram Muhammad Muzammil Chouhdry muaz muaz Departmen. of Respiratory Medicin. University Hospital of LeicesterLeicester LE1United Kingdom Departmen. of In.ern.l Medicin. Hamad Medical CorporationDoha 0000Qatar Departmen. of n.urology Faisalabad Medical UniversityFaisalabad 38000PunjabPakistan Departmen. of n.urocritical Care AdventhealthOrlandoFlorida 33662United States

BACKGROUn. Despite its high prevalen.e,migrain. remain. un.erdiagn.sed worldwide.A sign.fican. reason.is the kn.wledge gap in.physician. regardin. diagn.stic criteria,clin.cal features,an. other clin.cal aspects of *** To measure the kn.wledge deficit in.physician. an. medical studen.s an. to assess the prevalen.e of migrain. in.the same *** An.on.in. question.aire was developed an. distributed amon. physician. an. fin.l year medical studen.s on.duty in.various medical an. surgical specialties of Allied an. DHQ Hospitals,Faisalabad,between.October 2018 an. October *** criteria were public practicin. physician. who experien.e headaches,while those who n.ver experien.ed headaches were *** question. assessed respon.en.s on.their kn.wledge of triggers,diagn.sis,man.gemen.,an. prophylaxis of the migrain. *** were asked to diagn.se themselves usin. embedded ICHD-3 diagn.stic criteria for differen. types of ***,tables,an. figures were made usin. Microsoft Office 2016 an. Microsoft Visio,an. data an.lysis was don. in.R Studio *** We had 213 respon.en.s an. 175 fulfilled in.lusion.criteria,with 99(52%),58(30%)an. 12(6.3%)belon.in. to specialties of medicin.,surgery,an. others,*** gen.ers were symmetrically represen.ed(88 male an. 87 female).Fifty-two(24.4%)of our 213 respon.en.s were diagn.sed with migrain.,with 26(50%)bein. aware of *** had higher prevalen.e amon. study participan.s(n.28,32.2%)compared to males(n.20,22.7%,P=0.19).A majority(62%)of subjects n.ver con.ulted an. doctor for their ***,a majority(62%)either n.ver heard or did n.t remember the diagn.stic criteria of *** 38%falsely believed that havin. an. type of aura is essen.ial for diagn.sin. *** con.ultation.rate was 37%(n.65),an. migrain.urs were sign.fican.ly more likely to have con.ulted a doctor,an. a n.urologist in.particular(Pn.ulters an. migrain.urs fared bet

关键词： Migrain. Headache disorders Kn.wledge study Prevalen.e Kn.wledge Epidemiology Public health

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