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Genes & Diseases 2023年第6期10卷 2622-2638页

作者： Feng Wang Shitong Chen Shihan Peng Xujun Zhou Houyi Tang Hanghua liang Xi Zhong He Yang Xiaoxue Ke muhan lü Hongjuan Cui State Key laboratory of Silkworm Genome Biology Southwest UniversityChongqing 400716China Department of Gastroenterology The Affiliated Hospital of Southwest Medical University25 Taiping StreetJiangyang DistrictLuzhouSichuan 646000China Cancer Center Medical Research InstituteSouthwest UniversityChongqing 400716China Jinfeng laboratory Chongqing 401329China

Protein arginine methyltransferase 1(PRMT1),a type I PRMT,is overexpressed in gastric cancer(GC)cells.To elucidate the function of PRMT1 in GC,PRMT1 expression in HGC-27 and MKN-45 cells was knocked down by short hairpin RNA(shRNA)or inhibited by PRMT1 inhibitors(AMI-1 or DClX069),which resulted in inhibition of GC cell proliferation,migration,invasion,and tumorigenesis in vitro and in vivo.MlX-interacting protein(MlXIP)and Kinectin 1(KTN1)were identified as PRMT1-binding proteins.PRMT1 recruited MlXIP to the promoter ofβ-catenin,which inducedβ-catenin transcription and activated theβ-catenin signaling pathway,promoting GC cell migration and metastasis.Furthermore,KTN1 inhibited the K48-linked ubiquitination of PRMT1 by decreasing the interaction between TRIM48 and PRMT1.Collectively,our findings reveal a mechanism by which PRMT1 promotes cell proliferation and metastasis mediated by theβ-catenin signaling pathway.

关键词： β-catenin signaling pathway Gastric cancer PRMT1 Transcriptional regulation Ubiquitination

lncRNA MIR31HG controls the proliferation and metastasis of gastric cancer by c-CBl-mediated degradation of β-catenin

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Genes & Diseases 2023年第3期10卷 712-715页

作者： Wen Peng Jiayi Zhang Shenghao Wang Feng Wang a Kun Wang Rui Geng Xiangfei Ding Jingping Zhang Biao li Xiaoxue Ke muhan lü Hongjuan Cui State Key laboratory of Silkworm Genome Biology Southwest UniversityChongqing 400716China Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Chongqing Institute for Food and Drug Control Chongqing 401121China Cancer Center Medical Research InstituteSouthwest UniversityChongqing 400716China Jinfeng laboratory Chongqing 401329China

lncMIR31HG acts as a host gene for miR-31,also known as lncHIFCAR(long non-coding HIF-1 co-activating RNA),whose deregulation has been reported to promote the development of various human cancers,including lung cancer,colorectal cancer,etc.1,2 However,the biological functions and molecular mechanisms of MIR31HG in gastric cancer are unclear.

关键词： cancer metastasis gastric

Development and validation of a nomogram for predicting in-hospital mortality of intensive care unit patients with liver cirrhosis

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World Journal of Hepatology 2024年第4期16卷 625-639页

作者： Xiao-Wei Tang Wen-Sen Ren Shu Huang Kang Zou Huan Xu Xiao-Min Shi Wei Zhang lei Shi Mu-Han lü Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina Nuclear Medicine and Molecular Imaging Key laboratory The Affiliated Hospital of Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina Department of Gastroenterology Lianshui People’Hospital of Kangda College Affiliated to Nanjing Medical UniversityHuaian 223499Jiangsu ProvinceChina

BACKGROUND liver cirrhosis patients admitted to intensive care unit(ICU)have a high mortality rate.AIM To establish and validate a nomogram for predicting in-hospital mortality of ICU patients with liver cirrhosis.METHODS We extracted demographic,etiological,vital sign,laboratory test,comorbidity,complication,treatment,and severity score data of liver cirrhosis patients from the Medical Information Mart for Intensive Care IV(MIMIC-IV)and electronic ICU(eICU)collaborative research database(eICU-CRD).Predictor selection and model building were based on the MIMIC-IV dataset.The variables selected through least absolute shrinkage and selection operator analysis were further screened through multivariate regression analysis to obtain final predictors.The final predictors were included in the multivariate logistic regression model,which was used to construct a nomogram.Finally,we conducted external validation using the eICU-CRD.The area under the receiver operating characteristic curve(AUC),decision curve,and calibration curve were used to assess the efficacy of the models.RESUlTS Risk factors,including the mean respiratory rate,mean systolic blood pressure,mean heart rate,white blood cells,international normalized ratio,total bilirubin,age,invasive ventilation,vasopressor use,maximum stage of acute kidney injury,and sequential organ failure assessment score,were included in the multivariate logistic regression.The model achieved AUCs of 0.864 and 0.808 in the MIMIC-IV and eICU-CRD databases,respectively.The calibration curve also confirmed the predictive ability of the model,while the decision curve confirmed its clinical value.CONClUSION The nomogram has high accuracy in predicting in-hospital mortality.Improving the included predictors may help improve the prognosis of patients.

关键词： liver cirrhosis Intensive care unit Nomogram Predicting model Mortality

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中国数字乡村发展统计测度与时空异质性研究

中国软科学 2024年第5期 80-89页

作者：毛军梁沐晗谢嘉豪海南师范大学数学与统计学院海南海口571158

中国政府积极推动着数字技术与乡村发展融合发展的数字乡村建设。引入因果推断方法研究影响因素对数字乡村建设在不同时期中的平均处理效应(ATE)的重要程度,并通过构建空间杜宾模型对其时空特征与溢出效应进行探析。研究表明:第一,科技... 详细信息

中国政府积极推动着数字技术与乡村发展融合发展的数字乡村建设。引入因果推断方法研究影响因素对数字乡村建设在不同时期中的平均处理效应(ATE)的重要程度,并通过构建空间杜宾模型对其时空特征与溢出效应进行探析。研究表明:第一,科技创新水平对数字乡村建设的影响,由前期的负向作用(ATE=-1.908)转为后期的正向作用(ATE=1.936),后期中低科技创新水平地区的ATC>ATT,说明中低科技创新水平地区创新效果会优于科技创新水平高的地区;第二,数字乡村发展具有较强的时间积累性,受到经济要素流动等影响,呈现出明显的“棘轮效应”特征和空间依赖性,本地科技创新水平、产业结构升级将对本地数字乡村发展产生正面影响,邻近地区的科技创新水平、产业结构升级对本地数字乡村发展并未产生实际影响。由此可见,加强数字化农业技术创新供给能力、稳步推进产业结构升级对中国数字乡村的区域协调发展具有重要意义。

关键词：数字乡村发展统计测度时空异质性因果推断

违实条件句前件小句语义表征加工机制的ERP研究

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语言科学 2024年第1期23卷 44-58页

作者：梁牧寒范琳北京外国语大学外国语言研究所北京100089

本研究采用ERP技术,通过操纵汉语违实条件句和因果条件句前件小句中语义信息与语境信息的一致性,对违实条件句前件小句语义表征加工的时间进程进行了考察。研究发现:1)在句首连词位置,“要是”比“因为”引发了更大的P3a成分和P600成分... 详细信息

本研究采用ERP技术,通过操纵汉语违实条件句和因果条件句前件小句中语义信息与语境信息的一致性,对违实条件句前件小句语义表征加工的时间进程进行了考察。研究发现:1)在句首连词位置,“要是”比“因为”引发了更大的P3a成分和P600成分;2)在前件小句句中动词位置,语境不一致条件引发了更大的P600成分;3)在前件小句句末名词位置,在因果条件句中,语境不一致条件比一致条件诱发了更大的N400成分,而在违实条件句中该效应并未出现。结果表明,读者对汉语违实条件句前件小句中语义表征的加工分为三个阶段:首先,假设连词“要是”作为违实成分,引发了违实语境的建立;之后,读者建构并加工假设表征;最后读者建构起事实表征,并对假设表征和事实表征共同加工。本研究支持并扩展了双重表征理论。

关键词：汉语违实条件句前件小句加工机制双重表征事件相关电位

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基于GIS的乡镇级洪涝水淹风险研究

自然灾害学报 2024年第1期33卷 63-73页

作者：高牧寒秦昆王妮满陈昆武汉大学遥感信息工程学院湖北武汉430079 自然资源部海南测绘资料信息中心海南海口570100

洪涝灾害是最严重的自然灾害之一。乡镇排水系统差,相关数据与技术受限,脆弱性高,亟需技术支持。空间信息技术在洪涝灾害研究中主要采用被动遥感与GIS,但被动遥感数据获取困难,以灾后评估为主。提出了一种基于GIS的乡镇级洪涝水淹风险... 详细信息

洪涝灾害是最严重的自然灾害之一。乡镇排水系统差,相关数据与技术受限,脆弱性高,亟需技术支持。空间信息技术在洪涝灾害研究中主要采用被动遥感与GIS,但被动遥感数据获取困难,以灾后评估为主。提出了一种基于GIS的乡镇级洪涝水淹风险分析方法,服务于洪涝灾前评估;以湖北省随州市何店镇为研究区,主要应用开源数据资料,根据历史降雨、土壤和地形等特征分析不同重现期的降雨与积水过程,划分水淹风险等级,并提供避险建议。结果表明,研究成果基本符合实地调研情况,能够较准确地反映研究区水淹风险,可为乡镇级洪涝灾害科学决策提供有效的数据与技术支持。

关键词：地理信息系统乡镇洪涝灾害降雨量模拟重现期水淹分析

On the functions of astrocyte-mediated neuronal slow inward currents

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Neural Regeneration Research 2024年第12期19卷 2602-2612页

作者： Balázs Pál Department of Physiology Faculty of MedicineUniversity of DebrecenDebrecenHungary

Slow inward currents are known as neuronal excitatory currents mediated by glutamate release and activation of neuronal extra synaptic N-met hyl-D-aspartate receptors with the contribution of astrocytes.These events are significantly slower than the excitatory postsynaptic currents.Parameters of slow inward currents are determined by seve ral factors including the mechanisms of astrocytic activation and glutamate release,as well as the diffusion pathways from the release site towards the extra synaptic recepto rs.Astrocytes are stimulated by neuronal network activity,which in turn excite neurons,forming an astrocyte-neuron feedback loop.Mostly as a consequence of brain edema,astrocytic swelling can also induce slow inward currents under pathological conditions.There is a growing body of evidence on the roles of slow inward currents on a single neuron or local network level.These events often occur in synchro ny on neurons located in the same astrocytic domain.Besides synchronization of neuronal excitability,slow inward currents also set synaptic strength via eliciting timing-dependent synaptic plasticity.In addition,slow inward currents are also subject to non-synaptic plasticity triggered by long-la sting stimulation of the excitatory inputs.Of note,there might be important regionspecific differences in the roles and actions triggering slow inward currents.In greater networks,the pathophysiological roles of slow inward currents can be better understood than physiological ones.Slow inward currents are identified in the pathophysiological background of autism,as slow inward currents drive early hypersynchrony of the neural networks.Slow inward currents are significant contributors to paroxysmal depolarizational shifts/interictal spikes.These events are related to epilepsy,but also found in Alzheimer's disease,Parkinson's disease,and stroke,leading to the decline of cognitive functions.Events with features overlapping with slow inward currents(excitatory,N-methyl-Daspartate-receptor mediated currents with astrocyti

关键词： astrocyte cortical spreading depolarization gliotransmission glutamate neural synchronization NMDA receptor paroxysmal depolarizational shift slow inward current

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炎症性肠病传统治疗药物的疗效和临床价值

中华消化杂志 2024年第1期44卷 28-32页

作者：冯百岁张目涵郑州大学第二附属医院消化内科郑州450014

炎症性肠病(IBD)是一类病因尚不明确的消化道慢性炎症性疾病, 包括溃疡性结肠炎(UC)和克罗恩病。虽然近些年来越来越多的生物制剂和小分子药物用于IBD的治疗, 但传统药物(氨基水杨酸制剂、糖皮质激素、免疫抑制剂)仍有很重要的地位。现... 详细信息

炎症性肠病(IBD)是一类病因尚不明确的消化道慢性炎症性疾病, 包括溃疡性结肠炎(UC)和克罗恩病。虽然近些年来越来越多的生物制剂和小分子药物用于IBD的治疗, 但传统药物(氨基水杨酸制剂、糖皮质激素、免疫抑制剂)仍有很重要的地位。现根据国内外相关指南和最近研究进展, 总结IBD传统药物在UC和克罗恩病中的应用, 以及应用过程中需要注意的问题。

关键词：炎症性肠病传统药物氨基水杨酸制剂糖皮质激素类免疫抑制剂

碳酸钙在受限空间内成核生长过程的分子动力学模拟

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硅酸盐学报 2024年第2期52卷 579-591页

作者：王攀路兴海王慕涵张悦许洪建侯东帅青岛理工大学土木工程学院山东青岛266033 青岛第一市政工程有限公司山东青岛266033

碳酸钙的形成会一定程度上改变混凝土的内部结构,进而影响混凝土的宏观性能,然而碳酸钙在混凝土内部成核生长机理尚未明确。为了探究碳酸钙在混凝土内部的形成过程和成核机制,本工作采用分子动力学模拟方法,研究了碳酸钙在不同受限空间... 详细信息

碳酸钙的形成会一定程度上改变混凝土的内部结构,进而影响混凝土的宏观性能,然而碳酸钙在混凝土内部成核生长机理尚未明确。为了探究碳酸钙在混凝土内部的形成过程和成核机制,本工作采用分子动力学模拟方法,研究了碳酸钙在不同受限空间中的形成过程和成核机理。结果表明:碳酸钙的成核生长主要依靠离子之间结合形成离子键;不同基体对碳酸钙团簇的吸附效果不同,这是因为碳酸钙与基体界面主要是钙氧离子键相连接,而水化硅酸钙基体界面处具有更多游离钙离子和羟基,能够为碳酸钙的形成提供更多的成核位点;同时,不同的受限空间孔径的大小对碳酸钙的形成速度也有较大影响。通过分析碳酸钙成核过程发现,碳酸钙团簇的形成不遵循经典成核理论,而是与预成核机制相符。本研究有助于进一步理解碳酸钙在混凝土中的形成过程,为混凝土中碳酸钙成核过程提供理论指导。

关键词：碳酸钙成核生长混凝土受限空间分子动力学模拟

Complex-frequency waves:beat loss and win sensitivity

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light(Science & Applications) 2024年第2期13卷 181-183页

作者： Qingqing Cheng Tao l School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai200093China Department of Respiratory Diseases and Critical Medicine Quzhou Hospital Affiliated to Wenzhou Medical UniversityQuzhou324000China National laboratory of Solid State Microstructures College of Engineering and Applied SciencesNanjing UniversityNanjing210093China

Recent experiments have demonstrated that synthesized complex-frequency waves can impart a virtual gain to molecule sensing systems,which can effectively restore information lost due to intrinsic molecular damping.The enhancement notably amplifies the signal of trace molecular vibrational fingerprints,thereby substantially improving the upper limit of sensitivity.

关键词： thereby Complex limit