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三氧化二砷治疗血液病后合并带状疱疹的临床研究

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白血病．淋巴瘤 2011年第7期20卷 412-414页

作者：张旗慕俐君王晓波李莉康志杰闫金松大连医科大学附属第二医院血液科 116027

目的分析三氧化二砷（ATO）治疗血液病后合并带状疱疹感染患者的临床特征及其可能的发生机制。方法将研究对象分为研究组（应用ATO）和对照组（未应用ATO），观察两组带状疱疹发病率，以及研究组中发生带状疱疹和未发生带状疱疹患者的... 详细信息

目的分析三氧化二砷（ATO）治疗血液病后合并带状疱疹感染患者的临床特征及其可能的发生机制。方法将研究对象分为研究组（应用ATO）和对照组（未应用ATO），观察两组带状疱疹发病率，以及研究组中发生带状疱疹和未发生带状疱疹患者的平均化疗次数。结果研究组带状疱疹发病率为23．95％（23／96），发生带状疱疹者平均化疗7．60次，未发生带状疱疹者平均化疗7．72次（Z=0．976，P=0．296）；对照组带状疱疹发病率7．89％（3／38），两组间带状疱疹发病率差异有统计学意义（x^2=4．492，P=0．034）。结论ATO治疗血液疾病可以增加带状疱疹的发病率，可能与其激活水痘一带状疱疹病毒有关。

关键词：血液病三氧化二砷疱疹带状免疫抑制法

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微机测控网络在智能大厦中的应用

德州学院学报 2005年第4期21卷 63-67页

作者：穆立君彭楚武湖南信息职业技术学院湖南长沙410001 湖南大学湖南长沙410001

介绍了智能大厦的概念及构成;分析了测控网络的现状和总线构成的测控网络的技术特点,对LonWorks总线的核心技术进行了深入地研究,并将它们应用到智能大厦的自控网络系BAS(Building Auto-mation System)中.

关键词：智能大厦测控网络现场总线 LonWorks

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不明原因发热90例临床分析

大连医科大学学报 2013年第6期35卷 566-570页

作者：李伟平孙健王晓波张旗慕俐君大连医科大学附属第二医院血液内科辽宁大连116027

目的探讨不明原因发热(fever of unknown origin,FUO)的病因分布及临床特点,减少误诊率。方法回顾性分析2008年1月—2011年10月于大连医科大学附属第二医院血液科住院的90例FUO患者的临床资料,包括病史、症状、体征,实验室检查,影像学... 详细信息

目的探讨不明原因发热(fever of unknown origin,FUO)的病因分布及临床特点,减少误诊率。方法回顾性分析2008年1月—2011年10月于大连医科大学附属第二医院血液科住院的90例FUO患者的临床资料,包括病史、症状、体征,实验室检查,影像学检查及病理检查。采用独立样本t检验,比较不同病因相关生化指标的差异。结果 90例患者中81例确诊,确诊率90%。病因包括:感染性疾病43例占53.1%,其中结核14例,占感染性疾病首位;恶性肿瘤10例占12.3%,其中非霍奇金淋巴瘤5例,血管免疫母细胞性T细胞淋巴瘤4例;结缔组织病10例占12.3%,其中成人Still’s病5例占50%;其他疾病18例占22.2%,其中噬血细胞性淋巴组织细胞增生症(hemophagocytic lymphohistiocytosis,HLH)11例,占61.11%;未确诊病例9例占9%。结论感染性疾病是本组FUO患者的主要病因,其中结核所占比例最高。此外噬血细胞性淋巴组织细胞增生症,非霍奇金淋巴瘤也常见。

关键词：不明原因发热噬血细胞性淋巴组织细胞增生症血管免疫母细胞性T细胞淋巴瘤

不同加工工艺鹿茸组分对慢性再生障碍性贫血患者骨髓造血细胞体外增殖影响的比较

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沈阳药科大学学报 2014年第9期31卷 715-720页

作者：李召宋振岚徐晓艳慕俐君李伟平山东大学齐鲁医院山东青岛266000 大连医科大学附属第二医院辽宁大连116023 烟台山医院山东烟台264100

目的研究冷、热两种工艺加工的鹿茸提取物,对正常、慢性再生障碍性贫血患者骨髓的单个核细胞(mononuclear cell,MNC)体外增殖、分化的影响,为临床合理应用提供实验依据。方法从10例健康者、10例慢性再生障碍性贫血(aplastic anemia,AA)... 详细信息

目的研究冷、热两种工艺加工的鹿茸提取物,对正常、慢性再生障碍性贫血患者骨髓的单个核细胞(mononuclear cell,MNC)体外增殖、分化的影响,为临床合理应用提供实验依据。方法从10例健康者、10例慢性再生障碍性贫血(aplastic anemia,AA)患者骨髓中获取MNC,分别在普通培养液(阴性对照组),加热炸茸C组分的培养液(试验组1)及加冷工艺茸A、B、D、E组分的培养液(试验组2)中培养。MTT比色法检测细胞的增殖活性;CFU-mix集落半固体培养观察集落生长情况;细胞免疫化学染色测定bcl-2、突变型p53的表达。数据处理采用单因素方差分析(one-way ANOVA),结果用x珋±s表示。结果正常骨髓组:试验组2细胞增殖活性及CFU-mix集落数均明显高于试验组1及阴性对照组;bcl-2和突变型p53的表达各组之间均无明显差异。AA骨髓组:试验组2中D、E组分细胞增殖活性和CFU-mix集落数均明显高于阴性对照组及试验组1。Bcl-2的表达:试验组2中D、E组分组显著高于阴性对照组和试验组1。突变型p53的表达三组之间均无明显差异。结论两种不同工艺的鹿茸相比,冷工艺茸具有更强的生物学效应,故在鹿茸的加工上推荐冷工艺。

关键词：鹿茸造血再生障碍性贫血

Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue mu Ning Zhang Dongyu Wei Guoqing Yang lilingxuan Yao Xinyue Xu Yang li junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu li mu Xi Xu Tianyi Huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

Proportion of Uterine Malignant Tumors in Patients with Laparoscopic Myomectomy： A National multicenter Study in China

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Chinese Medical Journal 2017年第22期130卷 2661-2665页

作者： Hua Yang Xiao-Chuan li Chen Yao Jing-He Lang Hang-Mei Jin Ming-Rong Xi Gang Wang Lu-Wen Wang Min Hao Yan Ding Jie Chen Jian-Qing Zhang Lu Han Cheng-Xiu Guo Xiang Xue Yan li Jian-Hua Zheng Man-Hua Cui Huai-Fang li Guang-Shi Tao Long Chen Su-Min Wang An-Wei LU Ze-Hua Huang Qing liu Ya-li Zhuang Xiang-Hua Huang Gen-Hai Zhu Ou-Ping Huang li-Na Hu mu-jun li Hong-lin Zhou Jing-Hui Song Lan Zhu Department of Obstetrics and Gynecology Peking Union Medical College Hospital Beijing 100730 China Department of Biostatistics Peking University Clinical Research Institute Peking University First Hospital Beijing 100871 China Department of Obstetrics and Gynecology Zhejiang University Affiliated Obstetrics and Gynecology Hospital Zhejiang Hangzhou 310006 China Department of Obstetrics and Gynecology West China Second Hospital of Sichuan University Cbengdu Sichuan 610041 China Department of Obstetrics and Gynecology The First People's Hospital of Foshan City Foshan Guangdong 528010 China Department of Obstetrics and Gynecology Maternal and Child Health Hospital of Henan Province Zhengzhou Henan 450052 China Department of Obstetrics and Gynecology The Second Hospital of Shanxi Medical University Datong Shanxi 030001 China Department of Obstetrics and Gynecology The First Affiliated Hospital of Xinjiang Medical University Urumchi Xinjiang 830000 China Department of Obstetrics and Gynecology People's Hospital of Fujian Province Fuzhou Fujian 350000 China Department of Obstetrics and Gynecology Qinghai Red Cross Hospital Xining Qinghai 810000 China Department of Obstetrics and Gynecology Dalian Maternity Hospital Dalian Liaoning 116021 China Department of Obstetrics and Gynecology Tianjin Central Maternity Hospital Tianjin 300100 China Department of Obstetrics and Gynecology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of Obstetrics and Gynecology General Hospital of Ningxia Medical University Yinchuan Ningxia Hui Autonomous Region 750003 China Department of Obstetrics and Gynecology The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150007 China Department of Obstetrics and Gynecology The Second Hospital of Jilin University Changchun Jilin 130041 China Department of Obstetrics and Gynecology Shanghai Tongji Hospital Shanghai 200065 China Department of Obstetrics and Gynec

Background： The Food and Drug Administration recently announced that the use of morcellation may cause fibroids or pelvic dissemination and metastasis of uterine sarcoma; therefore, the use of morcellation is limited in the USA. A large sample study is necessary to assess the proportion of uterine malignant tumors found in patients with laparoscopic myomectomy. Methods： A national multicenter study was performed in China. From 2002 to 2014, 33,723 cases were retrospectively selected. We calculated the prevalence and recorded the clinical characteristics of the patients with malignancy after morcellation application. A total of 62 cases were finally pathologically confirmed as malignant postoperatively. Additionally, the medical records of the 62 patients were analyzed in details. Results： The proportion of postoperative malignancy after morcellation application was 0.18% （62/33,723） for patients who underwent laparoscopic myomectomy. Nearly 62.9% （39/62） of patients had demonstrated blood flow signals in the uterine fibroids before surgery. And, 23 （37.1%） patients showed rapid growth at the final preoperative ultrasound. With respect to the pathological types, 38 （61.3%） patients had detectable endometrial stromal sarcoma, 13 （21.0%） had detectable uterine leiomyosarcoma, only 3 （3.2%） had detectable carcinosarcoma, and 5 （8.1%） patients with leiomyoma had an undetermined malignant potential. Conclusions： The proportion of malignancy is low after using moreellation in patients who undergo laparoscopie myomectomy. Patients with fast-growing uterine fibroids and abnormal ultrasonic tumor blood flow should be considered for malignant potential, and morcellation should be avoided.

关键词： Laparoscopic Myomectomy Morcellation Sarcoma