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International Journal of Analytical Mass Spectrometry and Chromatography 2018年第1期6卷 1-19页

作者： Wei-Hsi chen Yu-Chieh Hsiao Ming-Hsin Li mu-chen tsai Chun-Fang Feng Han-Chih Chang Hung-Wen Yu Chyng-Yann Shiue Chemistry Division Institute of Nuclear Energy Research Taiwan Isotope Application Division Institute of Nuclear Energy Research Taiwan PET Center Department of Nuclear Medicine National Taiwan University Hospital Taiwan PET Center Department of Nuclear Medicine Tri-Service General Hospital Taiwan

High performance liquid chromatography coupled with tandem mass spectrometry was developed and validated as a method for the analysis of fluorinated histone deacetylase inhibitors (F-HDACi), and then employed to study their metabolism in biosystems. Four HDACi analogs labeled with the positron emission nuclide 18F constitute a group of potential positron emission tomography imaging agents, which were developed by the Institute of Nuclear Energy Research (INER) and coded as INER-1577 #1, #2, #3, and #4 during animal studies for the diagnosis of dementia. The performance of the method was found to be suitable for the determination of analog #3, and it was employed to determine the structures and fragmentation mechanisms of all four analogs and to study the biotransformations of analogs #3 and #4. The results indicated that the method used for the determination of analog #3 was suitable for determining the abundance of the analogs in chemical and biochemical tests with high precision, accuracy, reproducibility, and recovery. Weaknesses in the chemical bonding of the analogs were found to involve the fluoro, dimethylamino, and benzamide groups in a fragmentation mechanism deduced via tandem mass spectrometry. The metabolites of analogs #3 and #4 in rat liver microsomes and rat plasma were also identified to clarify their characteristic behaviors in biosystems. The major product of analogs #3 in liver microsomes was produced by hydroxylation of the benzylic carbon atom, but in rat plasma the metabolites of analog #3 were produced by hydrolysis of the benzamide group to give a diaminobiphenyl compound with the simultaneous replacement of a fluorine atom by a hydroxyl group. The metabolites of analog #4 in liver microsomes were produced by hydroxylation of the benzylic carbon atom and hydrolysis of the benzamide bond. The results of the studies characterized the chemical and biochemical behaviors of the series F-HADCi analogs.

关键词： Histone Deacetylase Inhibitors Positron Emission Tomography Imaging Agent Dementia LC-Tandem MS Fragmentation Mechanism Metabolism Pathways Epigenetics

Metalenses phase characterization by multidistance phase retrieval

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Light(Science & Applications) 2024年第9期13卷 1898-1907页

作者： Bowen Liu Jialuo cheng Maoxiong Zhao Jin Yao Xiaoyuan Liu Shaohu chen Lei Shi Din Ping tsai Zihan Geng mu Ku chen State Key Laboratory of Surface Physics Key Laboratory of Micro-and Nano-Photonic Structures(Ministry of Education)and Department of PhysicsFudan University200433 ShanghaiChina Department of Electrical Engineering City University of Hong KongKowloonHong Kong SARChina State Key Laboratory of Terahertz and Millimeter Waves City University of Hong KongKowloonHong Kong SARChina Institute for Nanoelectronic Devices and Quantum Computing Fudan University200438 ShanghaiChina Collaborative Innovation Center of Advanced Microstructures Nanjing University210093 NanjingJiangsuChina Shanghai Research Center for Quantum Sciences 201315 ShanghaiChina Centre for Biosystems Neuroscienceand NanotechnologyCity University of Hong KongKowloonHong Kong SARChina Institute of Data and Information Tsinghua Shenzhen International Graduate SchoolTsinghua University518071 ShenzhenGuangdongChina

Metalens,characterized by their unique functions and distinctive physical properties,have gained significant attention for their potential *** further optimize the performance of metalens,it is necessary to characterize the phase modulation of the *** this study,we present a multi-distance phase retrieval system based on optical field scanning and discuss its convergence and *** findings indicate that the system is capable of retrieving the phase distribution of the metalens as long as the measurement noise is low and the total length of the scanned light field is sufficiently *** system enables the analysis of focal length and aberration by utilizing the computed phase *** extend our investigation to measure the phase distribution of the metalens operating in the near-infrared(NIR)spectrum and identify the impact of defects in the sample on the ***,we conduct a comparative analysis of the phase distribution of the metalens in air and ethanol and observe the variations in the phase modulation of the metalens in different working *** system provides a straightforward method for the phase characterization of metalens,aiding in optimizing the metalens design and functionality.

关键词： phase system distribution

A novel multisignature scheme for a special verifier group against clerk and rogue-key attacks

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第4期11卷 290-295页

作者： Jia-lun tsai Tzong-chen WU Kuo-yu tsai Department of Information Management National Taiwan University of Science and Technology Taiwan Information Security Center National Taiwan University of Science and Technology

The digital signature is a very important subject for network *** multiple signers and multiple verifiers,Xie and Yu(2004) pointed out that the multisignature scheme of Laih and Yen(1996) is vulnerable to a harmful *** attack can occur when a specified group of verifiers cooperate to forge a multisignature by secret key substitution following the leak of a secret key or by group public key adjustment during the process of renewing *** and Yu proposed an improvement of Laih and Yen's multisignature *** this paper,we show that Xie and Yu's scheme is vulnerable to clerk and rogue-key *** propose an improved multisignature scheme to resist such *** the proposed scheme,multiple signers can generate a multisignature for the message with the signers' secret keys,and the specified group of verifiers can cooperate to verify the validity of the multisignature with the signers' public keys and the verifiers' secret *** proposed scheme for a special verifier group not only has the advantages of Xie and Yu's scheme,but also is secure against clerk and rogue-key attacks.

关键词： multisignature Clerk attack Rogue-key attack Cryptosystem

Spectral tomographic imaging with aplanatic metalens

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Light(Science & Applications) 2019年第1期8卷 258-265页

作者： chen chen Wange Song Jia-Wern chen Jung-Hsi Wang Yu Han chen Beibei Xu mu-Ku chen Hanmeng Li Bin Fang Ji chen Hsin Yu Kuo Shuming Wang Din Ping tsai Shining Zhu Tao Li National Laboratory of Solid State Microstructures Key Laboratory of Intelligent Optical Sensing and IntegrationJiangsu Key Laboratory of Artificial Functional MaterialsCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210093China Collaborative Innovation Center of Advanced Microstructures NanjingChina Research Center for Applied Sciences Taipei11529 TaiwanChina Department of Physics Taiwan UniversityTaipei10617 TaiwanChina Graduate Institute of Electronics Engineering Taiwan UniversityTaipei10617 TaiwanChina

Tomography is an informative imaging modality that is usually implemented by mechanical scanning,owing to the limited depth-of-field(DOF)in conventional ***,recent imaging systems are working towards more compact and stable architectures;therefore,developing nonmotion tomography is highly ***,we propose a metalens-based spectral imaging system with an aplanatic GaN metalens(NA=0.78),in which large chromatic dispersion is used to access spectral focus tuning and optical zooming in the visible *** the function of wavelength-switched tomography was confirmed on cascaded samples,this aplanatic metalens is utilized to image microscopic frog egg cells and shows excellent tomographic images with distinct DOF features of the cell membrane and *** approach makes good use of the large diffractive dispersion of the metalens and develops a new imaging technique that advances recent informative optical devices.

关键词： tuning switched dispersion

Integrated-resonant metadevices:a review

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Advanced Photonics 2023年第2期5卷 7-33页

作者： Jin Yao Rong Lin mu Ku chen Din Ping tsai City University of Hong Kong Department of Electrical EngineeringHong KongChina City University of Hong Kong Centre for BiosystemsNeuroscienceand NanotechnologyHong KongChina City University of Hong Kong State Key Laboratory of Terahertz and Millimeter WavesHong KongChina

Integrated-resonant units(IRUs),associating various meta-atoms,resonant modes,and functionalities into one supercell,have been promising candidates for tailoring composite and multifunctional electromagnetic responses with additional degrees of ***-resonant metadevices can overcome many bottlenecks in conventional optical devices,such as broadband achromatism,efficiency enhancement,response selectivity,and continuous tunability,offering great potential for performant and versatile application *** focus on the recent progress of integrated-resonant *** from the design principle of IRUs,a variety of IRU-based characteristics and subsequent practical applications,including achromatic imaging,light-field sensing,polarization detection,orbital angular momentum generation,metaholography,nanoprinting,color routing,and nonlinear generation,are *** challenges in this field and opinions on future research directions are also provided.

关键词： integrated-resonant units metadevices metasurfaces nanophotonic devices planar optics

Trapped Particle Effect on Ion Cyclotron Radiofrequency Heating

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Chinese Physics Letters 1991年第7期8卷 352-355页

作者： chen Yanping CAI Shidong(tsai shihtung) Institute of Physics Academia SinicaBeijing 100080 Center of Theoretical Physics CCAST(World Laboratory)

A nonlocal theory for trapped ion absorption in ion cyclotron radiofrequency heating is *** gyrokinetic equation is adopted and a full partied orbit and wave coupling is kept.

关键词： absorption wave theory

Phase characterisation of metalenses

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Light(Science & Applications) 2021年第4期10卷 551-561页

作者： Maoxiong Zhao mu Ku chen Ze-Peng Zhuang Yiwen Zhang Ang chen Qinmiao chen Wenzhe Liu Jiajun Wang Ze-Ming chen Bo Wang Xiaohan Liu Haiwei Yin Shumin Xiao Lei Shi Jian-Wen Dong Jian Zi Din Ping tsai State Key Laboratory of Surface Physics Key Laboratory of Micro-and Nano-Photonic Struaures(Ministry of Education)and Department of PhysicsFudan University200433 ShanghaiChina Department of Electronic and Information Engineering The Hong Kong Polytechnic University999077 Hong KongChina School of Physics and State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen University510275 GuangzhouChina Shanghai Engineering Research Center of Optical Metrology for Nanofabrication(SERCOM) 200433 ShanghaiChina State Key Laboratory on Tunable Laser Technology Ministry of Industry and Information Technology Key Lab of Micro-Nano Optoelectronic Information SystemShenzhen Graduate SchoolHarbin Institute of Technology518055 ShenzhenChina

Metalenses have emerged as a new optical element or system in recent years,showing superior performance and abundant ***,the phase distribution of a metalens has not been measured directly up to now,hindering further quantitative evaluation of its *** have developed an interferometric imaging phase measurement system to measure the phase distribution of a metalens by taking only one photo of the interference *** on the measured phase distribution,we analyse the negative chromatic aberration effect of monochromatic metalenses and propose a feature size of *** sensitivities of the phase response to wavelength between the Pancharatnam-Berry phase-based metalens and propagation phase-reliant metalens are directly observed in the ***,through phase distribution analysis,it is found that the distance between the measured metalens and the brightest spot of focusing will deviate from the focal length when the metalens has a low nominal numerical aperture,even though the metalens is ideal without any fabrication *** also use the measured phase distribution to quantitatively characterise the imaging performance of the *** phase measurement system will help not only designers optimise the designs of metalenses but also fabricants distinguish defects to improve the fabrication process,which will pave the way for metalenses in industrial applications.

关键词： character distribution nominal

Interface structure between epitaxial NiSi_2 and Si

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Journal of University of Science and Technology Beijing 2006年第6期13卷 558-563页

作者： Wei-Long Liu Wen-Jauh chen Ting-Kan tsai Hsun-Heng tsai Shu-Huei Hsieh Department of Materials Engineering Formosa University Yunlin China Taipei Graduate Institute of Materials Engineering Pingtung University of Science and Technology 1 Pingtung China Taipei Department of Biosystems Engineering Pingtung University of Science and Technology 1 Pingtung China Taipei

The interface structure between the Si and NiSi2 epitaxially grown on the （112） Si substrate was studied using high resolution transmission electron microscopy and computer image simulation. The results showed that the interface between Si and NiSi2 epitaxially grown on the （ 112 ） Si substrate has six different types： type A NiSi2 （111 ）/（ 111 ） Si, type A NiSi2 （001）/（001） Si, type B NiSi2 （ 111 ）/（ 111） Si, type B NiSi2 （ 112 ）/（ 1 12 ） Si, type B NiSi2 （ 271 ）/（001） Si, and type B NiSi2 （ 114 ）/（ 110 ） Si. And there are one or more different atomic structures for one type of interface.

关键词： nickel silicide interface high resolution image simulation atomic structure

Chest pain in a heart transplant recipient:A case report

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World Journal of Clinical Cases 2021年第16期9卷 3966-3970页

作者： Yu-Jen chen Chien-Sung tsai tsai-Wang Huang Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Cardiovascular Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan

BACKGROUND Heart transplantation is recommended for the treatment of patients with refractory heart *** pain after heart transplantation is usually considered noncardiac owing to the denervated ***,data from case reports on tacrolimus-induced achalasia after heart transplantation are *** aimed to present a case of tacrolimus-induced achalasia that developed after heart tran-splantation,which was successfully relieved by laparoscopic Heller *** SUMMARY A 67-year-old man with a history of Type 2 diabetes mellitus,hyperlipidemia,and dilated cardiomyopathy had congestive heart failure following orthotopic heart transplantation with tacrolimus treatment 12 years *** the 10-year follow-up after the heart transplantation,the patient presented with persistent cough,dysphagia,heartburn,and retrosternal chest pain lasting for 2 *** endoscopy revealed no specific *** years later,the patient experienced the same symptoms,including chest pain lasting for 4 *** and manometry confirmed the presence of *** reports showed that discontinuing calcineurin inhibitor(CNI)treatment and endoscopic botulinum toxin injection could treat CNI-induced *** to the risk of rejection of the transplanted heart and considering the temporary benefits of botulinum toxin injection in achalasia,the patient underwent laparoscopic Heller *** was relieved without *** months later,he had no signs of recurrence of the *** In transplant patients with chest pain and gastrointestinal symptoms, CNIinducedachalasia may be one of the differential diagnoses. Esophagogram/manometry is useful for diagnosis.

关键词： Heart transplantation Refractory heart failure Chest pain Achalasia Esophagogram Case report