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Berberine Enhances Intestinal mucosal Barrier Function by Promoting Vitamin D Receptor Activity

Chinese Journal of Integrative Medicine 2024年第2期30卷 143-151页

作者： HUANG Yong-quan LIU Jia-lin chen Geng-xin SHEN Dan-ting ZHU Wang chen xin-lin LIU Feng-bin HOU Qiu-ke Graduate School Guangzhou University of Chinese MedicineGuangzhou(510405)China Department of Orthopedics the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Preventive Medicine and Health Statistics Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Gastroenterology the First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510405)China

Objective:To evaluate if berberine can act on vitamin D receptors(VDR)and thereby regulate the expression of tight junction proteins(TJPs)in irritable bowel syndrome-diarrhea-predominant(IBS-D)***:The newborn rats were induced into IBS-D rat model via neonatal maternal separation combined with acetic acid chemical *** modeling,the model was evaluated and rats were divided into the control group and berberine treatment groups(0.85,1.7 and 3.4 mg/kg,once a day for 2 weeks).The distal colon was obtained and colonic epithelial cells(CECs)were isolated and cultured after IBS-D model *** vitamin D receptor response element(VDRE)reporter gene was determined in the CECs of IBS-D rats to analyze the effect of berberine on the VDRE *** overexpression or silencing technology was used to analyze whether VDR plays a role in promoting intestinal barrier repair,and to determine which region of VDR plays a role in berberine-regulated intestinal ***:The IBS-D rat model was successfully constructed and the symptoms were improved by berberine in a dose-dependent manner(Pmucosal barrier function of IBS-D rats by promoting VDR activity,and the main site of action is the N-terminal region of VDR.

关键词： berberine Chinese medicine irritable bowel syndrome-diarrhea-predominant vitamin D receptors intestinal mucosal barrier tight junction proteins

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The Identification of Phenylalanine Ammonia-Lyase(PAL)Genes from Pinus yunnanensis and an Analysis of Enzyme Activity in vitro

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 503-516页

作者： Dejin mu Lin chen Heze Wang Zhaoliu Hu Sihui chen Shi chen Nianhui Cai Yulan Xu Junrong Tang Key Laboratory of National Forestry and Grassland Administration on Biodiversity Conservation in Southwest China Southwest Forestry UniversityKunming650224China College of Forestry Southwest Forestry UniversityKunming650224China

Phenylalanine ammonia lyase(PAL)is the rate-limiting and pivotal enzyme of the general phenylpropanoid path-way,but few reports have been found on PAL genes in Pinus *** the present study,three PAL genes were cloned and identiﬁed from *** seedlings for theﬁrst time,namely,PyPAL-1,PyPAL-2,and *** results indicated that the open-reading frames of PyPAL genes were 2184,2157,and 2385 *** tree analysis revealed that PyPALs have high homology with other known PAL genes in other *** vitro enzymatic analysis showed that all three PyPAL recombinant proteins could catalyze the deamination of L-phenylalanine to form trans-cinnamic acid,but only PAL1 and PAL2 can catalyze the conversion of L-tyrosine toρ-coumaric *** PyPAL genes were expressed in different tissues in 1-year-old ***,and such genes had different expression *** study lays a foundation for further understanding of the biosynthesis of secondary metabolites in ***.

关键词： Pinus yunnanensis phenylalanine ammonia-lyase enzyme activity in vitro functional analysis secondary metabolites

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Photoinduced Dehalocyclization to Access Oxindoles Using Formate as a Reductant

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Chinese Journal of Chemistry 2024年第11期42卷 1203-1208页

作者： Wei Ge Jia-xin Wang Ming-chen Fu Yao Fu Hefei National Research Center for Physical Sciences at the Microscale iChEMCAS Key Laboratory of Urban Pollutant ConversionAnhui Province Key Laboratory of Biomass Clean EnergyUniversity of Science and Technology of ChinaHefeiAnhui230026 China Anhui Province Key Laboratory of Value-Added Catalytic Conversion and Reaction Engineering Hefei University of TechnologyHefeiAnhui230009 China

Herein,we report an efficient and practical protocol for the photoinduced dehalocyclization of ortho-halophenylacrylamides with formate by the engagement of a CO_(2) radical anion to access substituted *** method proceeds smoothly under mild conditions and exhibits a wide range of substrate as well as remarkable functional group compatibility.

关键词： Formate CO_(2)Radical ions Oxindole Photocatalysts Cyclization Organohalides

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Salmonella Grumpensis Causing Diarrhea in Children—Shanghai municipality,China,2023

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China CDC weekly 2024年第18期6卷 396-400,I0006,I0007页

作者： Yue Liu Xuebin Xu Wenqin Wang Wenjia Xiao Yi Hu xin chen Min chen Shanghai municipal Center for Disease Control and Prevention ShanghaiChina Pudong New Area Center for Disease Control and Prevention ShanghaiChina Department of Epidemiology Key Laboratory of Public Health Safety of Ministry of EducationSchool of Public HealthFudan UniversityShanghaiChina

Summary What is already known about this topic?Foodborne diseases are a growing public health concern with a notable disease burden in *** is added by this report?Two children with diarrhea visited a healthcare facility within 24 hours on August 1 and 2,*** Grumpensis was detected in their stool samples by the public health *** genome sequencing(WGS)analysis revealed characteristics typical of outbreak *** the origin of the outbreak was unknown,the possibility of a hidden shared infection was deemed feasible.

关键词： diarrhea diseases Whole

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Relationship among Parkinson’s disease, constipation, microbes, and microbiological therapy

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World Journal of Gastroenterology 2024年第3期30卷 225-237页

作者： xin-Yang Yuan Yu-Sen chen Zhou Liu Department of Neurology Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina Institute of Neurology Guangdong Key Laboratory of Age-Related Cardiac and Cerebral DiseasesZhanjiang 524000Guangdong ProvinceChina

This comprehensive review elucidates the complex interplay between gut microbiota and constipation in Parkinson’s disease(PD),a prevalent non-motor symptom contributing significantly to patients’morbidity.A marked alteration in the gut microbiota,predominantly an increase in the abundance of Proteobacteria and Bacteroidetes,is observed in PD-related *** treatments,although safe,have failed to effectively alleviate symptoms,thereby necessitating the development of novel therapeutic *** interventions such as prebiotics,probiotics,and fecal microbiota transplantation(FMT)hold therapeutic *** prebiotics improve bowel movements,probiotics are effective in enhancing stool consistency and alleviating abdominal *** shows potential for significantly alleviating constipation symptoms by restoring gut microbiota balance in patients with *** promising developments,the causal relationship between changes in gut microbiota and PD-related constipation remains elusive,highlighting the need for further research in this expanding field.

关键词： Parkinson disease Constipation Gut microbiota Prebiotics Probiotics Fecal microbiota transplantation

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Research progress on intelligent operation and maintenance of bridges

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第2期11卷 173-187页

作者： Wanshui Han Gan Yang Shizhi chen Kai Zhou xin Xu School of Highway Chang'an UniversityXi'an 710064China

In the context of the increasing scale of bridges and the increasing service life of bridges,it is very important to carry out efficient,accurate and intelligent bridge operation and *** recent years,advanced equipment,technology and intelligent algorithms have developed *** is necessary to apply advanced equipment and algorithms to bridge operation and maintenance business to facilitate the digitalization and intelligence of bridge operation and *** grasp the research progress on the bridge intelligent operation and maintenance,this paper summarizes the research progress in recent years from the aspects of intelligent detection equipment and technology,intelligent monitoring equipment and technology,intelligent data analysis,intelligent evaluation and early warning,and intelligent repair and *** to the review,more and more smart devices have been used to replace human beings to detect dangerous and hidden bridge *** the same time,image processing,radar and other technologies have been used to analyze component damage more objectively and *** solve the shortcomings of traditional sensors such as short life and low robustness,more non-contact measurement methods have been *** have proposed various intelligent algorithms to process the massive amount of bridge health monitoring data to improve the quality of the *** achieve the rapid perception of bridge status and timely early warning of structural abnormalities,different from traditional theoretical calculations,scholars have tried to use data-driven methods to intelligently evaluate and early warning of bridge structural *** terms of intelligent repair and maintenance,more intelligent algorithms have been used to optimize structural maintenance strategies and determine the best maintenance time by integrating multisource heterogeneous *** these provide strong support for the automation,digitization and intelligence o

关键词： Bridge engineering Bridge intelligent operation and maintenance Intelligent equipment Technology and algorithms

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Impacts of angiotensin II on retinal artery changes in apolipoprotein E deficient mice

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 16-24页

作者： Li-Hui Meng Shi-Yu cheng He chen Yue-Lin Wang Wen-Fei Zhang Huan chen xin-Yu Zhao You-xin chen Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Key Lab of Ocular Fundus Diseases Chinese Academy of Medical SciencesBeijing 100730China

AIM:To investigate the impacts of angiotensin II(Ang II)on retinal artery changes in apolipoprotein E deficient(apoE^(-/-))***:ApoE^(-/-)male mice were infused by minipumps with Ang II at 1000 ng/kg·min(Ang II group)or saline(control group)for *** were underwent ophthalmic fundus examination on day 0,14,and 28 of *** examination,ribonucleic acid(RNA)sequencing and local Ang II measurement of retinas were ***:Ophthalmic fundus examination showed Ang II infusion promoted the formation of retinal arterial aneurysm-like lesions on day *** coherence tomography revealed the ganglion cell and inner plexiform layer(GCIPL)thickness in the control group was significantly thinner than that in Ang II group(P<0.001).Hematoxylin-eosin staining demonstrated diffused swelling of GCIPL layer and its disordered structure in Ang II *** electron microscopy showed Ang II infusion caused aggravation of atherosclerotic lesions,including increased swelling,roughness,disorganization of the retinal vasculature,and vacuoles ***-sequencing and gene ontology enrichment analysis demonstrated that the structure and function of cellular membrane might be disturbed and visual function might be compromised by Ang *** local level of Ang II was higher in Ang II infusion group but did not show significant differences compared to the control group(P=0.086).CONCLUSION:Ang II infusion promotes the formation of retinal arterial aneurysm-like lesions in apoE^(-/-)mice,causing aggravation of atherosclerotic lesions,more severe disorganization of the retinal vasculature and disturbance of the cellular membrane.

关键词： angiotensin II retinal artery aneurysm apoE^(-/-)mice

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Unified deep learning model for predicting fundus fluorescein angiography image from fundus structure image

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Journal of Innovative Optical Health Sciences 2024年第3期17卷 105-113页

作者： Yiwei chen Yi He Hong Ye Lina xing xin Zhang Guohua Shi Jiangsu Key Laboratory of Medical Optics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163P.R.China School of Biomedical Engineering(Suzhou) Division of Life Sciences and MedicineUniversity of Science and Technology of China Hefei 230026P.R.China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031P.R.China

The prediction of fundus fluorescein angiography(FFA)images from fundus structural images is a cutting-edge research topic in ophthalmological image *** comprises estimating FFA from fundus camera imaging,single-phase FFA from scanning laser ophthalmoscopy(SLO),and three-phase FFA also from *** many deep learning models are available,a single model can only perform one or two of these prediction *** accomplish three prediction tasks using a unified method,we propose a unified deep learning model for predicting FFA images from fundus structure images using a supervised generative adversarial *** three prediction tasks are processed as follows:data preparation,network training under FFA supervision,and FFA image prediction from fundus structure images on a test *** comparing the FFA images predicted by our model,pix2pix,and CycleGAN,we demonstrate the remarkable progress achieved by our *** high performance of our model is validated in terms of the peak signal-to-noise ratio,structural similarity index,and mean squared error.

关键词： Fundus fluorescein angiography image fundus structure image image translation unified deep learning model generative adversarial networks

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Synergistic enhancement on mechanical properties and corrosion resistance of biodegradable Mg-Zn-Y alloy via V-microalloying

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Journal of Magnesium and Alloys 2024年第2期12卷 530-545页

作者： Jiaxin Zhang xin Ding Ruirun chen Wenchao Cao Jinshan Zhang Rui Zhao National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of TechnologyNo.92West Dazhi StreetHarbinHeilongjiang 150001China College of Materials Science and Engineering Taiyuan University of TechnologyNo.79West Yingze StreetTaiyuanShanxi 030024China

For the sake of improving the mechanical properties and corrosion resistance of biodegradable Mg alloy synergistically,various content of element V(0,0.05,0.10,0.15,0.20 wt.%)are introduced into an Mg-Zn-Y alloy with long-period stacking ordered(LPSO)structure,and the effects of V on its microstructure,mechanical properties and corrosion resistance are investigated *** results indicate that the grains are effectively refined by V addition,and the primaryα-Mg in Mg-Zn-Y-V0.1 alloy is most significantly refined,with grain size being decreased by 62%.The amount of 18R LPSO structure is increased owing to the V *** growth mode of the second phase(W-phase and 18R LPSO structure)is transformed to divorced growth pattern,which ascribes to the thermodynamic drive force of V to promote the nucleation of LPSO ***,18R LPSO structure presents a continuous *** to grains refinement and modification of second phase,the tensile strength and strain of alloys are both enhanced ***,the ultimate tensile strength and the elongation of V0.1 alloy are 254 MPa and 15.26%,which are 41%and 61%higher than those of V-free alloy,*** to the continuously distributed 18R LPSO structure with refined grains and stable product film,the weight loss and hydrogen evolution corrosion rates of V0.1 alloy are 7.1 and 6.2 mmy^(-1),respectively,which are 42.6%and 45.4%lower than those of V-free alloy.

关键词： Corrosion Mechanical property V-microalloying LPSO SKPFM

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Effect of tungsten carbide particles on microstructure and mechanical properties of Cu alloy composite bit matrix

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Journal of Iron and Steel Research(International) 2024年第2期31卷 519-530页

作者： Ding-qian Dong Feng-yuan He xin-hui chen Hui Li Kai-hua Shi Hui-wen Xiong xin Xiang Li Zhang College of Mechanical Engineering Sichuan University of Science and EngineeringZigong643000SichuanChina State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083HunanChina Zigong Cemented Carbide Co. Ltd.Zigong643011SichuanChina Material Corrosion and Protection Key Laboratory of Sichuan Province Sichuan University of Science and EngineeringZigong643000SichuanChina

Copper alloy composite bit matrix was prepared by pressureless vacuum infiltration,using at least one of the three kinds of tungsten carbide particles,for example,irregular cast tungsten carbide,monocrystalline tungsten carbide and sintered reduced tungsten carbide *** effects of powder particle morphology,particle size and mass fraction of tungsten carbide on the microstructure and mechanical properties of copper alloy composite were investigated by means of scanning electron microscopy,X-ray diffraction and abrasive wear test in *** results show that tungsten carbide morphology and particle size have obvious effects on the mechanical properties of copper alloy *** tungsten carbide partially dissolved in the copper alloy binding phase,and layers of Cu_(0.3)W_(0.5)Ni_(0.1)Mn_(0.1)C phase with a thickness of around 8–15μm were formed on the edge of the cast tungsten *** 45%irregular crushed fine cast tungsten carbide and 15%monocrystalline cast tungsten carbide were used as the skeleton,satisfactory comprehensive performance of the reinforced copper alloy composite bit matrix was obtained,with the bending strength,impact toughness and hardness reaching 1048 MPa,4.95 J/cm^(2) and 43.6 HRC,*** main wear mechanism was that the tungsten carbide particles firstly protruded from the friction surface after the copper alloy matrix was worn,and then peeled off from the matrix when further wear occurred.

关键词： Polycrystalline diamond compact Pressureless vacuum infiltration Copper alloy composite bit matrix Microstructure characterization Abrasive wear behavior

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