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Prediction of early recurrence of hepatocellular carcinoma after liver transplantation based on computed tomography radiomics nomogram

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 543-550页

作者： Jing-Wei Zhao Xin Shu Xiao-Xia Chen Jia-Xiong liu mu-qing liu Ju Ye Hui-Jie Jiang Gui-Sheng Wang Department of Radiology the Third Medical CenterChinese PLA General HospitalThe Training Site for Postgraduate of Jinzhou Medical UniversityBeijing 100039China Department of Radiology the Third Medical CenterChinese PLA General HospitalBeijing 100039China Medical School of Chinese PLA Beijing 100853China Department of Radiology the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China

Background:Early recurrence results in poor prognosis of patients with hepatocellular carcinoma(HCC)after liver transplantation(LT).This study aimed to explore the value of computed tomography(CT)-based radiomics nomogram in predicting early recurrence of patients with HCC after ***:A cohort of 151 patients with HCC who underwent LT between December 2013 and July 2019 were retrospectively enrolled.A total of 1218 features were extracted from enhanced CT *** least absolute shrinkage and selection operator algorithm(LASSO)logistic regression was used for dimension reduction and radiomics signature *** clinical model was constructed after the analysis of clin-ical factors,and the nomogram was constructed by introducing the radiomics signature into the clinical *** predictive performance and clinical usefulness of the three models were evaluated using re-ceiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),***-bration curves were plotted to assess the calibration of the ***:There were significant differences in radiomics signature among early recurrence patients and non-early recurrence patients in the training cohort(P<0.001)and validation cohort(P<0.001).The nomogram showed the best predictive performance,with the largest area under the ROC curve in the training(0.882)and validation(0.917)***-Lemeshow testing confirmed that the nomogram showed good calibration in the training(P=0.138)and validation(P=0.396)*** showed if the threshold probability is within 0.06-1,the nomogram had better clinical usefulness than the clinical ***:Our CT-based radiomics nomogram can preoperatively predict the risk of early recurrence in patients with HCC after LT.

关键词： Radiomics Nomogram Liver transplantation Early recurrence Hepatocellular carcinoma

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CD8＋ Tc-lymphocytes immunodeviation in peripheral blood and airway from patients of chronic obstructive pulmonary disease and changes after short-term smoking cessation

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Chinese Medical Journal 2013年第19期 3608-3615页

作者： YU mu-qing liu Xian-sheng WANG Jian-miao XU Yong-jian Department of Respiratory and Critical Care Medicine TongjiHospital of Yongji Medical College Huazhong University of Scienceand Technology Wuhan Hubei 430030 China

Background Cigarette smoke induces an acute but persisting inflammation in peripheral blood and airway in chronic obstructive pulmonary disease （COPD）,and CD8＋ Tc-lymphocytes are considered as a key role in this *** aimed to investigate the Tc-lymphocytes immunodeviation in system and local airway of COPD patients and changes of the immunodeviation after short-term smoking *** Peripheral blood （PB） and bronchoalveolar lavage fluid （BALF） were collected from 42 patients （14 COPD patients,16 smokers with normal lung function and 12 nonsmokers）,while PB and induced sputum （IS） were obtained from other 19 patients （10 quitting smokers and 9 continuing smokers） at baseline and follow-up respectively of 4-week smoking *** of CD8＋ Tc-lymphocytes （%CD3＋） and Tc1/Tc2 ratios were measured by flow *** Percentages of CD8＋ Tc-lymphocytes were higher in COPD patients than those in smokers and nonsmokers in both PB and ***1/Tc2 ratio in PB and in BALF from COPD patients was greater than that from smokers and nonsmokers and negatively correlated with FEV1%*** comparing the ratios between PB and BALF,significantly positive correlation was found in COPD ***,after 4-week smoking cessation,percentages of CD8＋ Tc-lymphocytes in PB and IS in quitting smokers were decreased compared to that in baseline and continuing smokers,whereas Tc1/Tc2 ratios were not *** CD8＋ Tc1-trend immunodeviation profiles occurred in both system and local airway of COPD *** exceptional immunodeviation could not be relieved by short-term smoking cessation.

关键词： pulmonary disease, chronic obstructive smoke CD8-positive T-lymphocytes smoking cessation

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Condylar remodeling accompanying splint therapy

Condylar remodeling accompanying splint therapy

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中华口腔医学会第14次全国口腔医学学术会议（2012年会）

作者： M.D.Candidate:mu-qing liu Peking University School & Hospital of Stomatology

Objective:The aim of this study was to evaluate osseous changes accompanying anterior repositioning splint(ARS) therapy in patients with temporomandibular joint disk displacement. Methods:Cone-beam computerized tomogr... 详细信息

关键词： Temporomandibular disorders Disc displacement Anterior repositioning splint Condylar remolding Cone-beam CT

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Protective effect of neurotrophin-3 secreting myoblasts against kainic acid-induced exitotoxic lesions in rat hippocampus

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中国实验血液学杂志 1997年第3期5卷 321-322页

作者： Yuanyue mu, Hong liu, qing Guo, Ming Fan Beijing Institute of Basic Medical Sciences, Beijing100850

Neurotrophic factors are able to promote neuronalsurvival and prevent neuronal death induced by variousinjuries and have potential uses in the treatment ofneuronal degenerative diseases and neuropathy. Due tothe existence of brain blood barrier, neurotrophic factorscan not be ased in CNS diseases directly. Gene therapy isa good candidate to overcome this problem.

关键词： neurotrophin hippocampus neuronal neurotrophic overcome degenerative neuropathy candidate titer dorsal

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Regenerative remolding of condyle detected by cone-beam computed tomography following splint therapy

Regenerative remolding of condyle detected by cone-beam comp...

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第10次全国口腔颌面医学影像学专题研讨会暨国家级口腔颌面医学影像诊断学新进展学习班

作者： mu-qing liu,Hui-Min Chen,Kai-Yuan Fu Department of Oral and Maxillofacial Radiology,Peking University School and Hospital of Stomatology.

Aims:The aim of this study was to evaluate osseous changes accompanying anterior repositioning splint(ARS) therapy in patients with temporomandibular joint disk displacement. Methods:Cone-beam computerized tomography(...

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可食中草药保鲜剂对冬枣贮藏品质的影响

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食品科技 2011年第3期36卷 38-41页

作者：许牡丹刘青刘艳曾令军陕西科技大学西安710021

研究丁香、良姜、苦参和甘草的提取液对冬枣的保鲜效果。冬枣分别在质量浓度为20mg/mL的丁香、苦参、甘草醇提取液和良姜水提取液中浸泡2min,常温贮藏,每5d测1次生理生化指标。结果表明,良姜水提取液处理能使冬枣保持较高的营养品质,中... 详细信息

研究丁香、良姜、苦参和甘草的提取液对冬枣的保鲜效果。冬枣分别在质量浓度为20mg/mL的丁香、苦参、甘草醇提取液和良姜水提取液中浸泡2min,常温贮藏,每5d测1次生理生化指标。结果表明,良姜水提取液处理能使冬枣保持较高的营养品质,中草药的醇提取液没有达到预期的保鲜效果。比较4种可食性中草药保鲜剂可得,良姜水提取液处理冬枣在常温贮藏时具有较好的保鲜作用。

关键词：冬枣中草药保鲜剂可食

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Preparation of FeCoNi medium entropy alloy from Fe^(3+)-Co^(2+)-Ni^(2+)solution system

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 92-101页

作者： Zongyou Cheng qing Zhao Mengjie Tao Jijun Du Xingxi Huang Chengjun liu Key Laboratory for Ecological Metallurgy of multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower *** this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen *** phases and magnetic properties of FeCoNi medium entropy alloy were *** showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal *** alloy prepared by hydrogen reduction was uniform and showed a relatively high ***,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy alloy sol-gel co-precipitation carbothermal hydrogen reduction

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不同包装方式对冬枣贮藏效果的影响

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食品科技 2010年第11期35卷 74-77页

作者：刘艳许牡丹刘青曾令军陕西科技大学生命科学与工程学院西安710021

以冬枣为试材,在常温条件下(18～20℃),研究硅窗和打孔包装对冬枣的贮藏保鲜效果。定期统计其转红指数、腐烂指数和软果率,同时测定硬度、Vc、总糖、总酸及乙醇含量等指标的变化,分析表明:硅窗和打孔包装对冬枣的保鲜效果均优于对照组,... 详细信息

以冬枣为试材,在常温条件下(18～20℃),研究硅窗和打孔包装对冬枣的贮藏保鲜效果。定期统计其转红指数、腐烂指数和软果率,同时测定硬度、Vc、总糖、总酸及乙醇含量等指标的变化,分析表明:硅窗和打孔包装对冬枣的保鲜效果均优于对照组,打孔包装效果明显优于硅窗组,试验条件下以打2个孔保鲜效果最佳。

关键词：硅窗袋打孔袋冬枣保鲜

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Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie liu qinghua Zeng qing Tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

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巯基棉纤维对多种微量元素吸附性能的研究

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环境科学学报 1981年第2期 180-189页

作者：俞穆清刘桂琴中国科学院长春地理研究所

本文研究了自制的巯基棉纤维对十六种微量元素的定量吸附条件、吸附速度、吸附量、吸附强弱顺序和解脱条件。讨论了巯基棉纤维的制备、保存、稳定性、再生使用及吸附时共存物的干扰与消除等问题。实验得知,巯基棉纤维是一种良好的固体... 详细信息

本文研究了自制的巯基棉纤维对十六种微量元素的定量吸附条件、吸附速度、吸附量、吸附强弱顺序和解脱条件。讨论了巯基棉纤维的制备、保存、稳定性、再生使用及吸附时共存物的干扰与消除等问题。实验得知,巯基棉纤维是一种良好的固体吸附剂,它可以定量吸附水溶液中多种微量重金属离子和某些非金属离子,具有富集倍数大、吸附率高、吸附速度快、选择性强、解脱性能好等优点,且制备简单、操作方便、易于推广。

关键词：巯基棉富集吸附条件巯基棉纤维强弱顺序微量元素痕量元素原子吸收吸附性能

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