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Prediction of early recurrence of hepatocellular carcinoma after liver transplantation based on computed tomography radiomics nomogram

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 543-550页

作者： Jing-Wei Zhao Xin Shu Xiao-Xia Chen Jia-Xiong liu mu-qing liu Ju Ye Hui-Jie Jiang Gui-Sheng Wang Department of Radiology the Third Medical CenterChinese PLA General HospitalThe Training Site for Postgraduate of Jinzhou Medical UniversityBeijing 100039China Department of Radiology the Third Medical CenterChinese PLA General HospitalBeijing 100039China Medical School of Chinese PLA Beijing 100853China Department of Radiology the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China

Background:Early recurrence results in poor prognosis of patients with hepatocellular carcinoma(HCC)after liver transplantation(LT).This study aimed to explore the value of computed tomography(CT)-based radiomics nomogram in predicting early recurrence of patients with HCC after ***:A cohort of 151 patients with HCC who underwent LT between December 2013 and July 2019 were retrospectively enrolled.A total of 1218 features were extracted from enhanced CT *** least absolute shrinkage and selection operator algorithm(LASSO)logistic regression was used for dimension reduction and radiomics signature *** clinical model was constructed after the analysis of clin-ical factors,and the nomogram was constructed by introducing the radiomics signature into the clinical *** predictive performance and clinical usefulness of the three models were evaluated using re-ceiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),***-bration curves were plotted to assess the calibration of the ***:There were significant differences in radiomics signature among early recurrence patients and non-early recurrence patients in the training cohort(P<0.001)and validation cohort(P<0.001).The nomogram showed the best predictive performance,with the largest area under the ROC curve in the training(0.882)and validation(0.917)***-Lemeshow testing confirmed that the nomogram showed good calibration in the training(P=0.138)and validation(P=0.396)*** showed if the threshold probability is within 0.06-1,the nomogram had better clinical usefulness than the clinical ***:Our CT-based radiomics nomogram can preoperatively predict the risk of early recurrence in patients with HCC after LT.

关键词： Radiomics Nomogram Liver transplantation Early recurrence Hepatocellular carcinoma

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CD8＋ Tc-lymphocytes immunodeviation in peripheral blood and airway from patients of chronic obstructive pulmonary disease and changes after short-term smoking cessation

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Chinese Medical Journal 2013年第19期 3608-3615页

作者： YU mu-qing liu Xian-sheng WANG Jian-miao XU Yong-jian Department of Respiratory and Critical Care Medicine TongjiHospital of Yongji Medical College Huazhong University of Scienceand Technology Wuhan Hubei 430030 China

Background Cigarette smoke induces an acute but persisting inflammation in peripheral blood and airway in chronic obstructive pulmonary disease （COPD）,and CD8＋ Tc-lymphocytes are considered as a key role in this *** aimed to investigate the Tc-lymphocytes immunodeviation in system and local airway of COPD patients and changes of the immunodeviation after short-term smoking *** Peripheral blood （PB） and bronchoalveolar lavage fluid （BALF） were collected from 42 patients （14 COPD patients,16 smokers with normal lung function and 12 nonsmokers）,while PB and induced sputum （IS） were obtained from other 19 patients （10 quitting smokers and 9 continuing smokers） at baseline and follow-up respectively of 4-week smoking *** of CD8＋ Tc-lymphocytes （%CD3＋） and Tc1/Tc2 ratios were measured by flow *** Percentages of CD8＋ Tc-lymphocytes were higher in COPD patients than those in smokers and nonsmokers in both PB and ***1/Tc2 ratio in PB and in BALF from COPD patients was greater than that from smokers and nonsmokers and negatively correlated with FEV1%*** comparing the ratios between PB and BALF,significantly positive correlation was found in COPD ***,after 4-week smoking cessation,percentages of CD8＋ Tc-lymphocytes in PB and IS in quitting smokers were decreased compared to that in baseline and continuing smokers,whereas Tc1/Tc2 ratios were not *** CD8＋ Tc1-trend immunodeviation profiles occurred in both system and local airway of COPD *** exceptional immunodeviation could not be relieved by short-term smoking cessation.

关键词： pulmonary disease, chronic obstructive smoke CD8-positive T-lymphocytes smoking cessation

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Strong synergy between physical and chemical properties:Insight into optimization of atomically dispersed oxygen reduction catalysts

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Journal of Energy Chemistry 2024年第4期91卷 36-49页

作者： Yifan Zhang Linsheng liu Yuxuan Li Xueqin mu Shichun mu Suli liu Zhihui Dai School of Chemistry and Molecular Engineering Nanjing Tech UniversityNanjing 211816JiangsuChina State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology InstitutionWuhan 430070HubeiChina School of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023JiangsuChina

Atomically dispersed catalysts exhibit significant influence on facilitating the sluggish oxygen reduction reaction(ORR)kinetics with high atom economy,owing to remarkable attributes including nearly 100%atomic utilization and exceptional catalytic ***,accurately controlling atomic physical properties including spin,charge,orbital,and lattice degrees of atomically dispersed catalysts can realize the optimized chemical properties including maximum atom utilization efficiency,homogenous active centers,and satisfactory catalytic performance,but remains ***,through physical and chemical insight,we review and systematically summarize the strategies to optimize atomically dispersed ORR catalysts including adjusting the atomic coordination environment,adjacent electronic orbital and site density,and the choice of dual-atom *** the emphasis is on the fundamental understanding of the correlation between the physical property and the catalytic behavior for atomically dispersed ***,an overview of the existing challenges and prospects to illustrate the current obstacles and potential opportunities for the advancement of atomically dispersed catalysts in the realm of electrocatalytic reactions is offered.

关键词： Atomically dispersed catalysts Coordination environment Electronic orbitals Inter-site distance effect Oxygen reduction reaction

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New insights into developmental biology of Eimeria tenella revealed by comparative analysis of mRNA N6-methyladenosine modification between unsporulated oocysts and sporulated oocysts

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Journal of Integrative Agriculture 2024年第1期23卷 239-250页

作者： qing liu Bingjin mu Yijing Meng Linmei Yu Zirui Wang Tao Jia Wenbin Zheng Wenwei Gao Shichen Xie Xingquan Zhu Laboratory of Parasitic Diseases College of Veterinary MedicineShanxi Agricultural UniversityTaigu 030801China Research Center for Parasites&Vectors College of Veterinary MedicineHunan Agricultural UniversityChangsha 410128China

Evidence showed that N6-methyladenosine(m^(6)A)modification plays a pivotal role in influencing RNA fate and is strongly associated with cell growth and developmental processes in many ***,no information regarding m^(6)A modification in Eimeria tenella is currently *** the present study,we surveyed the transcriptome-wide prevalence of m^(6)A in sporulated oocysts and unsporulated oocysts of *** RNA immunoprecipitation sequencing(MeRIP-seq)analysis showed that m^(6)A modification was most abundant in the coding sequences,followed by stop *** were 3,903 hypermethylated and 3,178 hypomethylated mRNAs in sporulated oocysts compared with unsporulated *** joint analysis suggested that m^(6)A modification of the majority of genes was positively correlated with mRNA *** mRNA relative expression and m^(6)A level of the selected genes were confirmed by quantitative reverse transcription PCR(RT-qPCR)and *** and KEGG analysis indicated that differentially m^(6)A methylated genes(DMMGs)with significant differences in mRNA expression were closely related to processes such as regulation of gene expression,epigenetic,microtubule,autophagy-other and TOR ***,a total of 96 DMMGs without significant differences in mRNA expression showed significant differences at protein *** and pathway enrichment analysis of the 96 genes showed that RNA methylation may be involved in cell biosynthesis and metabolism of *** firstly present a map of RNA m^(6)A modification in ***,which provides significant insights into developmental biology of ***.

关键词： Eimeria tenella m^(6)A RNA methylation MeRIP-seq RNA-seq proteomic analysis

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Myosteatosis is associated with coronary artery calcification in patients with type 2 diabetes

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World Journal of Diabetes 2024年第3期15卷 429-439页

作者： Fu-Peng liu mu-Jie Guo qing Yang Yan-Ying Li Yan-Gang Wang Mei Zhang The Affiliated Hospital of Medical College qingdao University Qingdao UniversityQingdao 266071Shandong ProvinceChina Department of Endocrinology The Affiliated Hospital of Jining Medical UniversityJining 272029Shandong ProvinceChina Department of Medical Imaging The Affiliated Hospital of Jining Medical UniversityJining 272029Shandong ProvinceChina Department of Clinical Nutrition The Affiliated Hospital of Jining Medical UniversityJining 272029Shandong ProvinceChina Department of Endocrinology The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina

BACKGROUND Myosteatosis,rather than low muscle mass,is the primary etiologic factor of sarcopenia in patients with type 2 diabetes mellitus(T2DM).Myosteatosis may lead to a series of metabolic dysfunctions,such as insulin resistance,systematic inflammation,and oxidative stress,and all these dysfunctions are closely associated with the acceleration of T2DM and *** To investigate the association between myosteatosis and coronary artery calcification(CAC)in patients with *** Patients with T2DM,who had not experienced major cardiovascular events and had undergone both abdominal and thoracic computed tomography(CT)scans,were *** mean skeletal muscle attenuation was assessed using abdominal CT images at the L3 *** CAC score was determined from thoracic CT images using the Agatston scoring *** was diagnosed according to Martin’s *** CAC(SCAC)was defined when the CAC score exceeded *** regression and decision tree analyses were *** A total of 652 patients with T2DM were *** them,167(25.6%)patients had *** regression analysis demonstrated that myosteatosis,age,duration of diabetes,cigarette smoking,and alcohol consumption were independent risk factors of *** was significantly associated with an increased risk of SCAC(OR=2.381,P=0.003).The association between myosteatosis and SCAC was significant in the younger patients(OR=2.672,95%CI:1.477-4.834,P=0.002),but not the older patients(OR=1.456,95%CI:0.863-2.455,P=0.188),and was more prominent in the population with lower risks of *** decision tree analyses prioritized older age as the primary variable for *** older patients,cigarette smoking was the main contributing factor for SCAC,while in younger patients,it was *** Myosteatosis is a novel risk factor for atherosclerosis in patients with T2DM,especially in the population with younger ages and fewer traditional ri

关键词： Type 2 diabetes Myosteatosis muscle quality Coronary artery calcification Atherosclerosis Cardiovascular diseases

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Layered coordination polymer with two-dimensional covalent bismuth-organic networks:Semiconductor and lithium ion storage

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Nano Research 2024年第3期17卷 2181-2185页

作者： mu-qing Li Yulin Cao Lei Qin Hua Cheng Weimin Yang Zhouguang Lu School of Materials Science and Environmental Engineering Shenzhen Polytechnic UniversityShenzhen 518055China Industrial Training Center Shenzhen Polytechnic UniversityShenzhen 518055China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China

Single crystals of a bismuth-based coordination polymer(CP)with carboxyl-thiol ligands,[Bi(C_(8)H_(2)O_(4)S_(2))(C2H8N)]n(Bi-DSBDC-DMA,DMBDC=2,5-disulfur-1,4-dicarboxylate,DMA=dimethylamine),have been successfully synthesized.X-ray diffraction analysis reveals that Bi-DSBDC-DMA possesses a layered structure,with two-dimensional(2D)Bi-DSBDC networks alternating with layers composed of dimethylamine *** material demonstrates semiconducting properties,featuring an optical bandgap of 2.2 eV and an electrical conductivity of 2×10^(-8) S/***,electrodes based on this material exhibit a capacity of 250 mAh/g after 200 cycles for lithium-ion storage.

关键词： bismuth layer coordination polymer(CP) semiconductor lithium ion storage

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Contact engineering for temperature stability improvement of Bi-contacted MoS2 field effect transistors

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Science China(Information Sciences) 2024年第06期67卷 172-179页

作者： Zizheng liu qing ZHANG Xiaohe HUANG Chunsen liu Peng ZHOU State Key Laboratory of Integrated Chip and Systems School of MicroelectronicsZhangjiang Fudan International Innovation CenterFudan University Frontier Institute of Chip and System Shanghai Key Lab for Future Computing Hardware and SystemFudan University Shaoxin Laboratory

Semimetallic bismuth（Bi） is one of the most effective strategies for reducing the contact resistance of two-dimensional transition metal dichalcogenide field effect transistors（FETs）. However, the low melting point of Bi contact（271.5℃） limits its reliable applications. In this study, we demonstrated that the temperature stability of Bi-contacted electrodes could be improved by inserting a high-melting point semimetallic antimony（Sb） between the Bi contacting layer and the gold（Au） capping layer. The proposed Bi/Sb/Au contact electrodes tended to form a metal mixture with a continuous surface during the heating process（Voids appeared on the surface of the Bi/Au contact electrodes after heating at 120℃）. Because of the improved contacting layer formed by the semimetal Bi/Sb alloy, the fabricated Bi/Sb/Au-contacted molybdenum sulfide（MoS2） FETs with different gate lengths demonstrated higher on-state current stability after heating treatment than the Bi/Au contact. Because of the Bi/Sb/Au contact and poly（methyl methacrylate） package, the MoS2FETs demonstrated time stability of at least two months from the almost unchanged transfer characteristics. The electrical stability indicates that the insertion of semimetallic Sb is a promising technology for reliable Bi-based contact.

关键词： temperature stability semimetallic bismuth contact semimetallic antimony contact MoS$_{2}$ FETs time stability

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Isogeometric Analysis for the Arbitrary AFG Microbeam with Two-Phase Nonlocal Stress-Driven Model

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Acta Mechanica Solida Sinica 2024年第2期37卷 341-360页

作者： Pei-Liang Bian Zhaowei liu Hai qing Tiantang Yu Department of Engineering Mechanics Hohai UniversityNanjing211100China State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China

Scale effects play critical roles in the mechanical responses of *** isogeometric analysis was developed here to investigate the mechanical responses of an axially functionally graded *** Euler–Bernoulli beam model was utilized,and size effects in the structure were modeled with a stress-driven two-phase local/nonlocal integral *** governing equation of microstructures was given in an equivalent differential form with two additional constitutive boundary *** framework was verified and utilized to analyze the microbeam’s static and dynamic mechanical *** present work showed great potential for modeling various types of functionally graded microstructures.

关键词： Isogeometric analysis Size effect Functionally graded material Nonlocal theory Euler-Bernoulli beam

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Cobalt-loaded carbon nanotubes boosted aerobic ciprofloxacin transformation driven by sulfide:A comprehensive mechanism investigation

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Chinese Chemical Letters 2024年第3期35卷 127-134页

作者： Han-qing Zhao Peili Lu Fei Chen Chen-Xuan Li Rui Yan Yang mu State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044China CAS Key Laboratory of Urban Pollutant Conversion Department of Environmental Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment College of Environment and EcologyChongqing UniversityChongqing 400045China College of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China

Sulfide oxidation under aerobic conditions can produce active oxygen for the transformation of organic pollutants in aquatic ***,the catalytic performance of transition metal-supported carbon material on this process is poor *** study found that Co-loaded carbon nanotubes(CNTs)was able to realize the efficient aerobic transformation of antibiotic ciprofloxacin(CIP)by sulfide,with the pseudo-first order reaction rate constant improved from 0.013 h^(-1)without catalyst to 0.44–0.71 h^(-1)with 100 mg/L Co-loaded *** oxygen(^(1)O_(2))was the main active specie playing key roles in the process of CIP aerobic transformation with presence of Co-loaded *** studies indicated that the excellent electron transfer ability of Co-loaded CNTs might play an important role to promote the electron transfer and facilitate the formation of intermediate H_(2)O_(2)and^(1)O_(2).Additionally,the Co-loaded CNTs/sulfide system effectively reduced the acute toxicity of organic pollutant,and Co-loaded CNTs showed remarkable cycling stability and negligible *** study gives a better understanding for the Co-loaded CNTs mediated aerobic antibiotics transformation by sulfide,and provide a reference for the application of Co-loaded carbon materials on organics aerobic transformation by sulfide.

关键词： Ciprofloxacin Aerobic transformation Co-loaded carbon nanotubes Sulfide Singlet oxygen

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Vertically grown MoS_(2)nanosheets on graphene with defect-rich structure for efficient sodium storage

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Rare Metals 2024年第3期43卷 1062-1071页

作者： Ying Wang Jia-Peng He Han-qing Pan qing-Peng Wang Lei Zhang Yong-Chang liu qing-Hong Wang School of Chemistry&Materials Science Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional MaterialsJiangsu Normal UniversityXuzhou221116China Institute of Biopharmaceutical Research Liaocheng UniversityLiaocheng252059China Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyState Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing100083China Centre for Catalysis and Clean Energy Gold Coast CampusGriffith UniversityGold CoastQLD4222Australia

The synthesis of a perpendicular growth structure of MoS_(2)nanosheets on graphene for efficient sodium storage is challenging yet ideal due to the benefits of open ion diffusion channels and high electronic *** this study,we have successfully fabricated a novel structure of vertical MoS_(2)nanosheets on graphene,with ZnS nanoparticles serving as bonding points(MoS_(2)/ZnS/G),through a facile hydrothermal *** the synthesis process,Zn^(2+)not only acts as a landing site for the vertical growth of MoS_(2)nanosheets but also triggers the formation of a defect-rich structure in the final *** unique architecture of MoS_(2)/ZnS/G effectively combines the advantages of a vertically aligned geometry and a defectrich structure for energy *** resulting structure displays shortened transport paths for electrons/ions,enhanced conductivity,improved structural integrity,and an increased number of active sites for promising electrochemical *** expected,when used as anode for sodium-ion batteries,the as-synthesize d MoS_(2)/ZnS/G exhibits excellent rate capability(high capacity of 298 mAh·g^(-1)at 5 A·g^(-1))and good cycling stability(a capacity decay of 0.056%per cycle after 500 cycles at 1 A·g^(-1)).According to the kinetic investigations,the electrochemical process of the MoS_(2)/ZnS/G sample is primarily governe d by a pseudocapacitive behavior,which enhances the charge/discharge kinetics and allows the MoS_(2)/ZnS/G structure to remain intact during cycling.

关键词： MoS_(2) Perpendicular growth Graphene Sodium storage Electrochemical performance

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