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Cysteine dioxygenase type 1 (CDO1): Its functional role in physiological and pathophysiological processes

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Genes & Diseases 2023年第3期10卷 877-890页

作者： Min chen Jie-Ying Zhu Wang-Jing mu Liang Guo School of Kinesiology Shanghai University of SportShanghai 200438China Shanghai Frontiers Science Research Base of Exercise and Metabolic Health Shanghai University of SportShanghai 200438China

Cysteine dioxygenase type 1 (CDO1), belonging to the mammalian non-heme Fe(II) dioxygenases family, is a key enzyme for cysteine catabolism. Its activity and expression is regulated through multiple mechanisms. CDO1 is involved in a spectrum of physiological processes including lipid metabolism, adipogenesis, osteoblastic differentiation, redox homeostasis, fertility, bile acid metabolism, sulfide metabolism, and organismal growth and development. Many of these processes are regulated directly or indirectly by CDO1-mediated metabolism of cysteine. In pathophysiological processes, the degree of CDO1 promoter methylation is closely related to the progression and malignancy of tumors, and overexpression of CDO1 will promote ferroptosis of cancer cells. Moreover, CDO1 may ameliorate metabolic disorders through the taurine-mediated improvement of lipid metabolism and insulin sensitivity and improve neurodegenerative diseases by regulating cysteine level. Therefore, elucidation of the mechanisms underlying the role of CDO1 would provide a clearer view of the therapeutic potential and possible risks of targeting this important enzyme.

关键词： Anti-tumor Antioxidation Cysteine Promoter methylation Taurine

Deciphering Rice Lesion Mimic mutants to Understand Molecular Network Governing Plant Immunity and Growth

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Rice science 2020年第4期27卷 278-288页

作者： ZHU Xiaobo ZE mu CHERN Mawsheng chen Xuewei WANG Jing State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China State Key Laboratory of Hybrid Rice/Key Laboratory of Major Crop Diseases&Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin/Rice Research InstituteSichuan Agricultural UniversityWenjiang 611130China Department of Plant Pathology University of CaliforniaDavisCalifornia 95616USA

Plant lesion mimic mutants(lmms)generally possess autoimmunity and hypersensitive response(HR)-like cell death in the absence of biotic or abiotic *** have attracted much attention because they are useful tools for deciphering the interaction between defense signaling and *** studies have identified more than 30 lmms involved in the plant immune response and cell death in *** underlying these lmms,coding for diverse types of proteins,mainly regulate transcription,protein translation and modification,vesicular trafficking and catalyzation of ***,we presented an overview of the most recent advances on the study of lmms in rice and proposed a perspective on potential utilization of LMM genes in agriculture.

关键词： lesion mimic mutant autoimmunity cell death growth regulation rice

CO_(2) capture and conversion to value-added products promoted by MXene-based materials

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Green Energy & Environment 2022年第3期7卷 394-410页

作者： Yu chen Chong Liu Shien Guo Tiancheng mu Lei Wei Yanhong Lu Department of Chemistry and Material Science Langfang Normal UniversityNo.100 Aimin West RoadAnci DistrictLangfang065000HebeiChina College of Chemistry and Chemical Engineering Jiangxi Inorganic Membrane Materials Engineering Research CentreJiangxi Normal UniversityNo.99 Ziyang AvenueNanchang33002JiangxiChina Department of Chemistry Renmin University of ChinaNo.59 Zhongguancun StreetHaidian DistrictBeijing100872China

Carbon dioxide(CO_(2) ) capture and conversion is the key route for the mitigation of the greenhouse effect and utilization of carbon sources to obtain value-added products or *** attention is paid to the development of novel materials with high CO_(2) adsorption capacity and conversion *** is the graphene-like two-dimensional metal carbide/nitride/carbonitride owning favorable structure,morphology,high surface-bulk ratio,and physicochemical ***,we review the CO_(2) capture,sensing,and conversion by MXene and MXene-based ***,the underlying mechanism involved the capture,sensing,and conversion of CO_(2) is *** review would open a new horizon for CO_(2) valorization with high efficiency and promising widespread applications.

关键词： properties value promoted

Efficient conversion of lignin waste and self-assembly synthesis of C@MnCo_(2)O_(4)for asymmetric supercapacitors with high energy density

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Green Energy & Environment 2023年第5期8卷 1479-1487页

作者： Jiahui mu Cuihuan Li Jiankang Zhang Xianliang Song Sheng chen Feng Xu Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry UniversityBeijing100083China

Lignin waste from the papermaking and biorefineries industry is a significantly promising renewable resource to prepare advanced carbon materials for diverse applications,such as the electrodes of supercapacitors;however,the improvement of their energy density remains a ***,we design a green and universal approach to prepare the composite electrode material,which is composed of lignin-phenolformaldehyde resins derived hierarchical porous carbon(LR-HPC)as conductive skeletons and the self-assembly manganese cobaltite(MnCo_(2)O_(4))nanocrystals as active *** synthesized C@MnCo_(2)O_(4)composite has an abundant porous structure and superior electronic conductivity,allowing for more charge/electron mass transfer channels and active sites for the redox *** composite shows excellent electrochemical performance,such as the maximum specific capacitance of~726 mF cm^(-2)at 0.5 mV s^(-1),due to the significantly enhanced interactive interface between LR-HPC and MnCo_(2)O_(4)*** assembled all-solid-state asymmetric supercapacitor,with the LR-HPC and C@MnCo_(2)O_(4)as cathode and anode,respectively,exhibits the highest volumetric energy density of 0.68 mWh cm^(-3)at a power density of 8.2 mW cm^(-3).Moreover,this device shows a high capacity retention ratio of~87.6%at 5 mA cm^(-2)after 5000 cycles.

关键词： C@MnCo_(2)O_(4) Lignin Self-assembly Asymmetrical supercapacitors

Preparation and Osteogenic Efficacy of Emodin-loaded Hydroxyapatite Electrospun Fibers

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Journal of Bionic Engineering 2023年第3期20卷 1060-1071页

作者： Yiwen Pan mu He Shaoqing chen Yanyan Meng Cheli Wang Xinye Ni School of Pharmacy Changzhou UniversityChangzhou213000China Department of Radiotherapy Changzhou Second People’s HospitalNanjing Medical UniversityChangzhou213000China Laboratory of Medical Physics Center Nanjing Medical UniversityNanjing210000China Changzhou Key Laboratory of Medical Physics Changzhou213000China

Biological scaffolds have been the focus of bone tissue engineering research in recent years. In this paper, emodin (EM), macromolecular compound polycaprolactone (PCL), and hydroxyapatite (HA) were used as raw materials to prepare EM/PCL/HA fibers containing different EM ratios by electrospinning, and the properties and osteogenic efficacy of EM/PCL/HA were studied. Scanning electron microscopy, transmission electron microscopy, and atomic force microscopy were used to characterize the structures of HA and the electrospun fibers. Results showed that HA has high crystallinity and loose porous structure, and the electrospun fibers have a smooth and flat surface. In vitro release results showed that EM was slowly released from EM/PCL/HA within 216 h. Cell proliferation assay in mouse embryonic osteoblast precursor cells (MC3T3-E1) exhibited that 5% EM/PCL/HA had the best effect on promoting cell proliferation. Alkaline phosphatase (ALP) and mineralized nodules staining results also showed that 5% EM/PCL/HA had the best effect on promoting osteogenic differentiation. qRT-PCR results showed that the mRNA expression level of osteoblast differentiation markers, namely, bone morphogenetic protein (BMP)-2, BMP-9, and osteocalcin were significantly upregulated by 5% EM/PCL/HA treatment. These results indicate that EM/PCL/HA is a potential osteogenic material, which can provide a reference for the development of bone injury repair materials.

关键词： Emodin Hydroxyapatite Electrospinning Bone regeneration

Reduced water dissociation barrier on constructing Pt-Co/CoO_(x)interface for alkaline hydrogen evolution

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Nano Research 2022年第6期15卷 4958-4964页

作者： Yandong Wang Wei Wu Runzhe chen Caoxin Lin Shichun mu Niancai cheng College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

Water dissociation process is generally regarded as the rate-limiting step for alkaline hydrogen evolution reaction(HER),and severely inhibits the catalytic efficiency of Pt based *** overcome this problem,the in-situ constructed interfaces of PtCo alloy and amorphous cobalt oxide(CoO_(x))on the carbon powder are *** amorphous CoO_(x)at Pt-Co/CoO_(x)interfaces not only provide active sites for water dissociation to facilitate Volmer step,but also produce the strong electronic transfer with ***,the obtained interfacial catalysts exhibit outstanding alkaline HER performance with a Tafel slope of 29.3 mV·dec^(−1)and an ultralow overpotential of only 28 mV at 10 mA·cm^(−2).Density functional theory(DFT)reveals that the electronic accumulation on the interfacial Co atom in Pt-Co/CoO_(x)constructing the novel active site for water *** to the Pt-Co,all of the energy barriers for water adsorption,water dissociation and hydrogen adsorption/desorption are reduced in Pt-Co/CoO_(x)interfaces,suggesting a boosted HER kinetics for alkaline HER.

关键词： interfacial construction amorphous cobalt oxide water dissociation dual active site electronic regulation

Recent advances in non-thermal plasma(NTP)catalysis towards C1 chemistry

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Chinese Journal of Chemical Engineering 2020年第8期28卷 2010-2021页

作者： Huanhao chen Yibing mu Shanshan Xu Shaojun Xu Christopher Hardacre Xiaolei fan State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 210009China Department of Chemical Engineering and Analytical Science School of EngineeringThe University of ManchesterM139PLUnited Kingdom School of Chemistry Cardiff UniversityMain BuildingPark PlaceCardiff CF103ATUnited Kingdom UK Catalysis Hub Research Complex at HarwellRutherford Appleton LaboratoryHarwellOxon OX110FAUnited Kingdom

C1 chemistrymainly involves the catalytic transformation of C1molecules(i.e.,CO,CO2,CH4 and CH3OH),which usually encounters thermodynamic and/or kinetic *** address these limitations,non-thermal plasma(NTP)activated heterogeneous catalysis offers a number of advantages,such as relatively mild reaction conditions and energy efficiency,in comparison to the conventional thermal *** review presents the state-of-the-art for the application of NTP-catalysis towards C1 chemistry,including the CO2 hydrogenation,reforming of CH4 and CH3OH,and water-gas shift(WGS)*** the hybrid NTP-catalyst system,the plasma-catalyst interactions ***,this reviewalso includes a brief discussion on the fundamental research into themechanisms of NTP activated catalytic C1 chemistry,such as the advanced characterisation methods(e.g.,in situ diffuse reflectance infrared Fourier transform spectroscopy,DRIFTS),temperatureprogrammed plasma surface reaction(TPPSR),kinetic ***,prospects for the future research on the development of tailor-made catalysts for NTP-catalysis systems(which will enable the further understanding of its mechanism)and the translation of the hybrid technique to practical applications of catalytic C1 chemistry are discussed.

关键词： Non-thermal plasma(NTP) Heterogeneous catalysis C1 chemistry Mechanism In situ characterisation

Semi-Probabilistic Evaluation of System Redundancy for Existing Offshore Structures

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China Ocean Engineering 1995年第1期10卷 1-8页

作者： Zhang, Shengkum chen, Kaisheng mu, Yung

In this paper, a new definition of structure system redundancy is proposed in view of the various measures for structure redundancy. By introducing the terms of structure system failure at the mechanism level and equivalent reliability index, the safety for existing offshore platforms can be evaluated by the semi-probabilistic method presented in this paper. Some numerical examples are given and satisfactory results have been obtained.

关键词： residual strength semi-probabilistic method damaged structure redundancy reliability index critical value

Design and Synthesis of Chiral Molecular Tweezers Based on Deoxycholic Acid

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Chinese Chemical Letters 2001年第5期12卷 413-416页

作者： Cui Hua XUE Qi Ming mu Shu Hua chen The faculty of chemistry Sichuan UniversityChengdu 610064

A series of new chiral molecular tweezers have been designed and synthesized by using deoxycholic acid as spacer and aromatic amines as arms. Instead of using toxic phosgene, the triphosgene was employed in synthesis of the molecular tweezers receptors. These chiral molecular tweezers showed good enantioselectivity for D-amino acid methyl esters.

关键词： Molecular tweezers synthesis deoxycholic acid recognition.