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Correlation of Betel Quid with Oral Cancer from 1998 to 2017： A Study Based on Bibliometric Analysis

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Chinese Medical Journal 2018年第16期131卷 1975-1982页

作者： mu wang Chang Xiao Ping Ni Jian-Jun Yu Xiao-Wan wang Hong Sun Department of Otolaryngology Head and Neck Surgery Xiangya Hospital Central South University Changsha Hunan 410008 China Department of Health Policy Institute of Medical Information Chinese Academy of Medical Sciences Beijing 100020 China Department of Head and Neck Surgery Hunan Cancer Hospital Central South University Changsha Hunan 410008 China

Background： Betel quid chewing has been a major risk factor for oral cancer （OC） in southern China. This study aimed to analyze the scientific publications on the relationship between betel quid chewing and OC and construct a model to quantitatively and qualitatively evaluate pertinent publications from 1998 to 2017. Methods： The publications from 1998 to 2017 were retrieved from the Web of Science Core Collection database. Microsoft Excel, Thomson Data Analyzer, VOSviewer, and CiteSpace software were used to analyze the publication outcomes, journals, countries/regions, institutions, authors, research areas, and research frontiers. Results： A total of 788 publications on the relationship between betel quid chewing and OC published until October 25, 2017, were identified. The top 4 related journals were Journal of Oral Pathology Medicine, Oral Oncology, Plos One, and lnternational Journal of Cancer. The top five countries engaged in related research included China, India, the United States, the United Kingdom, and Malaysia. The corresponding disciplines, such as oncology, oral surgery, pathology, environmental and occupational health, and toxicology, were mainly concentrated in three disciplines. The subject ternas squamous cell carcinoma, OC, betel quid, expression, oral submucous fibrosis, India, and p53 ranked first among research hotspots. The burst terms squamous cell carcinoma, OC, betel quid, and expression ranked first in research frontiers. Conclusions： Research in this area emphasized hotspots such as squamous cell carcinoma, OC, oral submucosal fibrosis, betel quid, and tobacco. The annual number of publications steadily decreased from 1998 to 2017, with a lack of a systematic study from interdisciplinary perspectives, inadequate pertinent journals, limited regions with the practice of betel quid chewing, and insufficient participation of researchers, which indicate that as the prevalence of OC increases, particularly in China, research in this area warra

关键词： Betel Quid Bibliometric CiteSpace Oral Cancer VOSviewer

非线性最优化方法在大气-海洋科学研究中的若干应用

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中国科学：数学 2017年第10期47卷 1207-1222页

作者：穆穆王强复旦大学大气科学研究院上海200433 中国科学院海洋研究所海洋环流与波动重点实验室青岛266071 青岛海洋科学与技术国家实验室青岛266237

本文主要介绍了作者研究组近几年来将非线性最优化方法应用于大气-海洋科学研究中的有关工作,重点是基于非线性最优化所提出的条件非线性最优扰动(CNOP)方法的理论框架及近几年的发展,以及在大气-海洋科学研究中的最新应用成果,主要包... 详细信息

本文主要介绍了作者研究组近几年来将非线性最优化方法应用于大气-海洋科学研究中的有关工作,重点是基于非线性最优化所提出的条件非线性最优扰动(CNOP)方法的理论框架及近几年的发展,以及在大气-海洋科学研究中的最新应用成果,主要包括集合预报、一些高影响海-气环境事件的可预报性、模式参数敏感性的识别以及模式倾向误差和边界条件误差的评估等.此外,本文也讨论了应用CNOP方法面临的困难与挑战,并展望了未来的发展.

关键词：非线性最优化条件非线性最优扰动(CNOP) 大气海洋

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我国刑法立法的发展方向

中国刑事法杂志 2010年第1期 3-11页

作者：王牧中国政法大学刑事司法学院

在世界近、现代刑法发展的历史中,存在古典刑法和实证刑法两种不同类型的刑法。古典刑法和实证刑法看似两个学派理论争论的产物,实则根源于社会发展的需要。我国刑法目前处于古典刑法的发展阶段。在我国刑事立法政策逐渐走向成熟的过程... 详细信息

在世界近、现代刑法发展的历史中,存在古典刑法和实证刑法两种不同类型的刑法。古典刑法和实证刑法看似两个学派理论争论的产物,实则根源于社会发展的需要。我国刑法目前处于古典刑法的发展阶段。在我国刑事立法政策逐渐走向成熟的过程中,必须注意防止刑法现代化的议题模糊我国刑法发展的目标。应以保持我国古典刑法基本品格不变为主,根据需要和可能,逐渐地、适当地引入实证刑法制度的内容。在刑法理论上,要正确消化和吸收实证刑法理论,某种意义上也就是犯罪学理论为刑法和刑法学提供的理论立场和观点;要注意防止古典刑法教条主义的不当影响,根据社会发展过程中出现的问题,改变刑法典一统刑法制度的格局,分散建立不同的制度。

关键词：刑法立法古典刑法实证刑法方向选择

Deposition and Properties of CrN_x films by High Power Pulsed Unbalanced Magnetron Sputtering

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稀有金属材料与工程 2011年第S4期40卷 160-163页

作者： mu Xiaodong,mu Zongxin,wang Chun,Jia Li,Zang Hirong,Liu Bingbing,Dong Chuang Key Laboratory of Materials Modification by Laser,Ion and Electron Beams (Dalian University of Technology),Ministry of Education,School of Physics and Optoelectronic Technology,Dalian University of Technology,Dalian 116024,China Dalian Univ Technol Sch Phys & Optoelect Technol Minist Educ Key Lab Mat Modificat Laser Ion & Electron Beams Dalian 116024 Peoples R China

High-power pulsed magnetron sputtering (HPPMS) technology has drawn extensively attention for producing ultra-high dense plasma and high ionization fractions of the sputtered species,depositing dense films with high *** films were deposited on the substrates of Si(100) using high-power pulsed unbalanced magnetron sputtering (HPPUMS) technology,and the analyses of XRD and atomic force microscope (AFM) were conducted on the properties of microstructure and surface morphology of CrNx films;the friction coefficient and the adhesion between CrNx film and substrate were measured,*** was found HPPUMS discharge is able to deposit CrNx films with super comprehensive properties:higher adhesive strength between the film and substrate and lower coefficient of *** rate of CrNx films,which was tested by interferometry,was about 4.2nm/min at 0.6Pa and the pulse power density up to 6.8kW/cm2 with the pulse repetition frequency of 0.7Hz,which is about 56% of that provided by the mid-frequency magnetron sputtering discharge under the conditions of the same average power ***,clusters with a dimension of several hundred nanometers were observed on the AFM morphology probably related to high pulse current.

关键词： plasma sources plasma-based ion implantation and deposition thin film structure and morphology deposition by sputtering

VCAN,expressed highly in hepatitis B virus-induced hepatocellular carcinoma,is a potential biomarker for immune checkpoint inhibitors

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World Journal of Gastrointestinal Oncology 2022年第10期14卷 1933-1948页

作者： mu-Qi wang Ya-Ping Li Meng Xu Yan Tian Yuan Wu Xin Zhang Juan-Juan Shi Shuang-Suo Dang Xiao-LiJia Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Department of General Surgery The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Department of Critical Care Medicine The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina

BACKGROUND As a proteoglycan,VCAN exists in the tumor microenvironment and regulates tumor proliferation,invasion,and metastasis,but its role in hepatocellular carcinoma(HCC)has not yet been *** To investigate the expression and potential mechanism of action of VCAN in *** Based on The Cancer Genome Atlas Liver Hepatocellular Carcinoma dataset,we explored the correlation between VCAN expression and clinical features,and analyzed the prognosis of patients with high and low VCAN *** potential mechanism of action of VCAN was explored by Gene Ontology analysis,Kyoto Encyclopedia of Genes and Genomes analysis,and gene set enrichment *** also explored immune cell infiltration,immune checkpoint gene expression,and sensitivity of immune checkpoint[programmed cell death protein 1(PD-1)/cytotoxic T lymphocyte antigen 4(CTLA4)]inhibitor therapy in patients with different VCAN *** mRNA expression and VCAN methylation in peripheral blood were tested in 100 hepatitis B virus(HBV)-related patients(50 HCC and 50 liver cirrhosis).RESULTS VCAN was highly expressed in HCC tissues,which was associated with a poor prognosis in HCC *** significant difference was found in VCAN mRNA expression in blood between patients with HBV-related cirrhosis and those with HCC,but there was a significant difference in VCAN methylation between the two *** correlation between VCAN and infiltrations of several different tumor immune cell types(including B cells,CD8+T cells,and eosinophils)was significantly *** was strongly related to immune checkpoint gene expression and tumor mutation burden,and could be a biomarker of sensitivity to immune checkpoint(PD1/CTLA4)*** addition,VCAN mRNA expression was associated with hepatitis B e antigen,HBV DNA,white blood cells,platelets,cholesterol,and coagulation *** High VCAN level could be a possible biomarker for poor prognosis of HCC,and its immunomodulatory mechan

关键词： VCAN Hepatocellular carcinoma Hepatitis B virus Immune checkpoints Tumor microenvironment

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帕特里克·莫迪亚诺的“非典型性自撰”

当代外国文学 2019年第1期40卷 125-131页

作者：王牧广东外语外贸大学西方语言文化学院

2014年的诺贝尔文学奖得主,法国作家帕特里克·莫迪亚诺一直以其独特的艺术风格和创作技巧闻名于世。本文将结合近年来"自撰"理论的产生和发展分析他的作品特点,继而研究莫迪亚诺"非典型性自撰"的创作技巧与表现形式,并阐明其心理动机... 详细信息

2014年的诺贝尔文学奖得主,法国作家帕特里克·莫迪亚诺一直以其独特的艺术风格和创作技巧闻名于世。本文将结合近年来"自撰"理论的产生和发展分析他的作品特点,继而研究莫迪亚诺"非典型性自撰"的创作技巧与表现形式,并阐明其心理动机和美学倾向,旨在揭示作家对现代文学理论的创新与发展,以及他对现实世界的观照印象和对文学世界的理想构建。

关键词：帕特里克·莫迪亚诺非典型性自撰模棱两可隐性现实

Plasma Membrane Localization and Potential Endocytosis of Constitutively Expressed XA21 Proteins in Transgenic Rice

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Molecular Plant 2010年第5期3卷 917-926页

作者： Fang Chen Ming-Jun Gao Yan-Song Miao Yue-Xing Yuan mu-Yang wang Qun Li Bi-Zeng Mao Li-Wen Jiang Zu-Hua He National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China Present address: Department of Molecular Cellular and Developmental Biology Yale University New Haven CT 06511 USA Department of Biology and Molecular Biotechnology Program The Chinese University of Hong Kong Shatin New Territories Hong Kong China Present address: Department of Emergency Medicine Thomas Jefferson University Philadelphia PA 19107 USA Biotechnology Institute Zhejiang University Hanghzou 310029 China

The rice pattern recognition receptor （PRR） XA21 confers race-specific resistance in leaf infection by bacterial blight Xathornonas oryzae pv. oryzae （Xoo）, and was shown to be primarily localized to the endoplasmic reticulum （ER） when expressed with its native promoter or overexpressed in the protoplast. However, whether the protein is still ER- localization in the intact cell when overexpressed remains to be identified. Here, we showed that XA21, its kinase-dead mutant XA21PK736EP and the triple autophosphorylation mutant XA21PS686AJT688AJS699A GFP fusions were primarily localized to the plasma membrane （PM） when overexpressed in the intact transgenic rice cell, and also localized to the ER in the transgenic protoplast. The transgenic plants constitutively expressing the wild-type XA21 or its GFP fusion displayed racespecific resistance to Xoo at the adult and seedling stages. XA21 and XA21PK736EP could be internalized probably via the SCAMP-positive early endosomal compartment in the protoplast, suggesting that XA21 might be endocytosed to initiate resistance responses during pathogen infection. We also established a root infection system and demonstrated that XA21 also mediated race-specific resistance responses to Xoo in the root. Our current study provides an insight into the nature of the XA21-mediated resistance and a practical approach using the root cell system to further dissect the cellular signaling of the PRR during the rice-Xoo interaction.

关键词： Rice XA21 pattern recognition receptor bacterial bight cellular localization internalization root infection race-specific resistance.

Electrochemical Synthesis of Silver Nanostructures:Morphological Control and Characterization

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Electrochemical Synthesis of Silver Nanostructures:Morpholog...

An in vitro Understanding of the Prism Structure Formation in Tooth Enamel

中国晶体学会第六届学术年会暨会员代表大会（功能分子晶体分会）

作者： Xi wang Di Zhao Shaojie Fu mu wang National Laboratory of Solid State Microstructures School of PhysicsNanjing University

Noble metal nanostructures have received widespread attention for their rich plasmonic properties in recent *** surface plasmon(LSP)features greatly enhanced electric fields near the metal nanostructures’surface,which can be employed in various applications,such as chemical sensing and biosensing,photothermal therapy and solar cells.A facile synthesis of

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An in vitro Understanding of the Prism Structure Formation i...