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Chinese herbal medicines for prevention and treatment of colorectal cancer: From molecular mechanisms to potential clinical applications

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Journal of Integrative Medicine 2020年第5期18卷 369-384页

作者： mu-yan kong Le-yan Li Yan-mei Lou Hong-yu Chi Jin-jun Wu Joint Laboratoiy for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China.International Institute for Translational Chinese Medicine.Guangzhou University of Chinese Medicine Guangzhou 510006Guangdong ProvinceChina

Worldwide, colorectal cancer(CRC) is one of the most common malignant tumors, leading to immense social and economic burdens. Currently, the main treatments for CRC include surgery, chemotherapy,radiotherapy and immunotherapy. Despite advances in the diagnosis and treatment of CRC, the prognosis for CRC patients remains poor. Furthermore, the occurrence of side effects and toxicities severely limits the clinical use of these therapies. Therefore, alternative medications with high efficacy but few side effects are needed. An increasing number of modern pharmacological studies and clinical trials have supported the effectiveness of Chinese herbal medicines(CHMs) for the prevention and treatment of *** may be able to effectively reduce the risk of CRC, alleviate the adverse reactions caused by chemotherapy, and prolong the survival time of patients with advanced CRC. Studies of molecular mechanisms have provided deeper insight into the roles of molecules from CHMs in treating CRC. This paper summarizes the current understanding of the use of CHMs for the prevention and treatment of CRC, the main molecular mechanisms involved in these processes, the role of CHMs in modulating chemotherapyinduced adverse reactions, and CHM's potential role in epigenetic regulation of CRC. The current study provides beneficial information on the use of CHMs for the prevention and treatment of CRC in the clinic,and suggests novel directions for new drug discovery against CRC.

关键词： Colorectal neoplasms Herbal medicine Preventive medicine Medicine Chinese traditional Molecular mechanisms of pharmacological action Epigenesis genetic

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Discovery of Wolitu Pb-Zn deposit through geochemical prospecting under loess cover in Inner Mongolia, China

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Geoscience Frontiers 2017年第5期8卷 951-960页

作者： Fan Yang mu kong Huazhong Liu Jinsong Yu Shaoping Yang Zhihong Hao Dehui Zhang Kuang Cen School of Earth Sciences and Resources China University of Geosciences (Beijing) Beijing 100083 China Institute of Geophysical and Geochemical Exploration Chinese Academy of Geological Sciences Langfang 065000 Hebei China UNESCO International Centre on Global-Scale Geochemistry Langfang 065000 Hebei China Key Laboratory of Geochemical Exploration Ministry of Land and Resources China Langfang 065000 Hebei China

We report the finding of the Wolitu Pb-Zn deposit in Inner Mongolia, China, through a series of geochemical surveys. The Wolitu area, located in the loess-cover area in the Hure Banner, Tongliao City,Inner Mongolia, and neighboring the Horqin Sandy Land to the north, had no previous history of Pb-Zn mining or record of Pb-Zn mineralization. Our study identified a large Pb-Zn anomaly with potential zones of mineralization by stream sediment survey. Random rock sampling reveals limonitization at sporadic outcrops in the gullies. The high concentrations of Pb in the residual debris provided guidelines to fix the position for exploratory trench. Oxidized concealed orebodies were identified by *** orebodies in veins hosted within the structural zone between slates and marbles of the upper Carboniferous Shizuizi Formation and the Permian granite were discovered by drilling. It is computed that the ore reserve may reach up to 540,000 tones with Pb grade of 1.27% and Zn of 1.9%. This case study is an excellent example for identifying potential polymetallic deposits in loess covered terrains using geochemical exploration.

关键词： Geochemical exploration Loess-covered area Pb-Zn deposit Resource reserve Inner Mongolia

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Two cardenolide glycosides from the seed fairs of Asclepias curassavica and their cytotoxic activities

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Chinese Journal of Natural Medicines 2022年第3期20卷 202-209页

作者： JI Ai-Jia MA Qing kong mu-Yan LI Le-Yan CHEN Xin-Lian LIU Zhong-Qiu WU Jin-Jun ZHANG Rong-Rong Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China School of Pharmaceutical SciencesGuangzhou University of Chinese MedicineGuangzhou 510006China China Resources Sanjiu Medical&Pharmaceutical Co. Ltd.Shenzhen 518110China School of Pharmaceutical Sciences Sun Yat-Sen UniversityGuangzhou 510006China

Two cardenolide glycosides,corotoxigenin 3-0-[β-D-glucopyranosyl-(l→4)-6-deoxy-β-D-glucopyranoside](1)and coroglaucigenin 3-0-[β-D-glucopyranosyl-(l→4)-6-deoxy-β-D-glucopyranoside](2),were isolated from the seed fairs of Asclepias *** structures of 1-2 were determined based on the combination of the analysis of their MS,NMR spectroscopic data and acid *** inhibitory effects of compounds 1 and 2 on human colorectal carcinoma cells(HCT116),non-small cell lung carcinoma cells(A549)and hepatic cancer cells(SMMC-7721)were *** results showed that both compounds 1 and 2 significantly inhibited the viability,proliferation,and migration of A549,HCT116 and SMMC-7721 cells,suggesting that compounds 1 and 2 can be applied in the treatment of lung,colon and liver cancers in clinical *** study may not only provide a scientific basis for clarifying the active ingredients in ***,but also help to understand its antitumor activity,which can promote the application of *** in clinical treatment of various cancers.

关键词： Asclepias curassavica Cardenolide glycosides Structure identification Cytotoxic activity

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Factors associated with improvement in waist-to-height ratio among newly diagnosed type 2 diabetes patients treated with acarbose or metformin:A randomized clinical trial study

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World Journal of Diabetes 2020年第11期11卷 514-526页

作者： Lu-Lu Song Xin Wang Zhao-Jun Yang Xiao-mu kong Xiao-Ping Chen Bo Zhang Wen-Ying Yang Department of Endocrinology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND The waist-to-height ratio(WHtR)is a promising anthropometric measure used to evaluate cardiovascular risk in diabetes and metabolic syndrome *** metformin and acarbose in Chinese as the initial hypoglycaemic treatment trial demonstrated that acarbose and metformin reduced the WHtR after 24 wk of *** To investigate the factors associated with a decrease in the WHtR in newly diagnosed Chinese type 2 diabetes patients receiving acarbose or metformin *** At 24 wk,343 patients in the acarbose treatment and 333 patients in the metformin treatment were included in this *** the basis of the reduction in the WHtR,these participants were divided into the following two groups:LowΔWHtR group and highΔWHtR *** and related parameters associated with a highΔWHtR were investigated using univariate and multivariate logistic regression *** A significant decrease in the WHtR was observed in both treatment groups(acarbose:-0.015,95%confidence interval[CI]:-0.018 to-0.012,P<0.001;metformin:-0.013,95%CI:-0.016 to-0.010,P<0.001).In both the acarbose and metformin groups,the WHtR of the women was more likely to be reduced than that of the *** the acarbose group,a lower baseline area under the curve of glucagon-like peptide 1(AUCGLP-1)was associated with a highΔWHtR(odds ratio[OR]=0.796,P<0.001),while a higher baseline AUCGLP-1 was associated with a highΔWHtR in the patients treated with metformin(OR=1.133,P=0.025).Regarding the changes from baseline,an increase in AUCGLP-1 was associated with a highΔWHtR in the acarbose(OR=1.121,P=0.016)but not metformin group.A higher reduction in high-density lipoprotein cholesterol/non-highdensity lipoprotein cholesterol was also associated with a highΔWHtR in the acarbose arm(OR=20.735,P=0.001).In the metformin arm,a higher reduction in fasting plasma glucose(OR=0.843,P=0.039)and total cholesterol was associated with a highΔWHtR(OR=0.743,P=0.013).CONCLUSION A lower glucag

关键词： Waist-to-height ratio Abdominal obesity Type 2 diabetes Association Acarbose Metformin

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The efficacy and safety of Vortioxetine in patients with major depressive disorder:a systematic review and meta-analysis

The efficacy and safety of Vortioxetine in patients with maj...

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中国解剖学会2015年年会

作者： Guo Baolin Luo Shicheng kong mu Yan Yudong Wang Yayun Department of Anatomy K.K.Leung Brain Research Centrethe Fourth Military Medical University

＜正＞Collaborative Innovation Center for Brain Science,Fudan *** trials on vortioxetine have yielded conflicting evidence concerning its overall efficacy for the treatment of major depressive disorder（MDD）at varying *** assess the efficacy and safety of vortioxetine on MDD,we conducted a meta-analysis of six randomized controlled trials（RCTs）,

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AMBIGUITY FUNCTION OF INTERPULSE COSTAS FH RADAR SIGNAL

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Journal of Electronics(China) 2000年第2期17卷 153-160页

作者： mu Shanxiang kong Dechun Li Xingguo He Guodong (Nanjing University of Science and Technology, Nanjing 210094) Nanjing University of Science and Technology Nanjing

A new radar waveform utilizing Costas sequences and interpulse Frequency Hopping (FH) technique is developed, which is a good high range resolution radar signal. The interpulse Costas FH coherent pulse train is introduced and the system block diagram using the interpulse Costas FH waveform is given. In the paper, ambiguity function is employed to study interpulse Costas FH radar. The mathematical expression of the ambiguity function for this waveform is derived. The advantages of the waveform are interpreted by computer simulation.

关键词： Ambiguity function Costas sequences Interpulse frequency hopping

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Novel compound heterozygous mutations in the hemojuvelin gene in a juvenile hemochromatosis patient:A case report

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World Journal of Clinical Cases 2024年第19期12卷 3961-3970页

作者： Ling-Ding Xie Xiao-mu kong Jing-Xia Shen Tai-Ling Wang Jing Ma Yun-Fen Zhang Xiao-Ping Chen Department of Endocrinology China-Japan Friendship HospitalBeijing 100029China Department of Tumor Radiotherapy and Chemotherapy Qian’an People’s HospitalQian’an 064400Hebei ProvinceChina Department of Pathology China-Japan Friendship HospitalBeijing 100029China Department of Endocrinology Aksu First People's HospitalAksu Region 843000Xinjiang Uygur Autonomous RegionChina Department of Metabolic Diseases Qian’an Traditional Chinese Medical HospitalQian’an 064400Hebei ProvinceChina

BACKGROUND Juvenile hemochromatosis(JH)is an early-onset,rare autosomal recessive disorder of iron overload observed worldwide that leads to damage in multiple *** mutations in the hemojuvelin(HJV)gene are the major cause of *** SUMMARY A 34-year-old male Chinese patient presented with liver fibrosis,diabetes,hypogonadotropic hypogonadism,hypophysis hypothyroidism,and skin *** test revealed a markedly elevated serum ferritin level of 4329μg/L and a transferrin saturation rate of 95.4%.Targeted exome sequencing and Sanger sequencing revealed that the proband had a novel mutation c.863G>A(p.R288Q)in the HJV gene which was transmitted from his father,and two known mutations,c.18G>C(p.Q6H)and c.962_963delGCinsAA(p.C321*)in cis,which were inherited from his *** p.R288W mutation was previously reported to be pathogenic for hemochromatosis,which strongly supported the pathogenicity of p.R288Q reported for the first time in this *** 72 wk of intensive phlebotomy therapy,the patient achieved a reduction in serum ferritin to 160.5μg/*** patient's clinical symptoms demonstrated a notable *** This study highlights the importance of screening for hemochromatosis in patients with diabetes and hypogonadotropic *** also suggests that long-term active phlebotomy could efficiently improve the prognosis in severe JH.

关键词： Juvenile hemochromatosis Liver cirrhosis Diabetes Iron overload Phlebotomy Case report

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西藏冲江铜矿区及其外围找矿前景地球化学评价

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地质与勘探 2007年第6期43卷 7-11页

作者：孔牧刘华忠杨少平中国地质大学北京100083 中国地质科学院地球物理地球化学勘查研究所廊坊065000

西藏冲江斑岩铜矿的发现是西藏冈底斯东段找矿工作的重大突破之一。在发现找矿线索、确定成矿类型和评价找矿前景的过程中,勘查地球化学起了十分重要的作用。区域化探圈定了异常范围,异常查证追踪查证工作确定了矿化类型和找矿有利地段... 详细信息

西藏冲江斑岩铜矿的发现是西藏冈底斯东段找矿工作的重大突破之一。在发现找矿线索、确定成矿类型和评价找矿前景的过程中,勘查地球化学起了十分重要的作用。区域化探圈定了异常范围,异常查证追踪查证工作确定了矿化类型和找矿有利地段。通过测区系统的地球化学勘查工作,结合地质资料,认为冲江斑岩铜矿存在较为典型的斑岩铜矿地球化学模式,矿体剥蚀程度较浅,具有寻找大型斑岩铜钼矿床的良好远景。

关键词：西藏冲江斑岩铜矿找矿前景地球化学评价

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