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Pharmacology & Pharmacy 2023年第5期14卷 156-175页

作者： mst. boby aktar bithy Milon Kumar Ghosh Ashim Kumar Md. Rafiqul Islam Khan Mir Imam Ibne Wahed Ranjan Kumar Barman Laboratory of Pharmaceutics Department of Pharmacy Faculty of Science University of Rajshahi Rajshahi Bangladesh Department of Pharmacy Faculty of Biological Sciences Islamic University Kushtia Bangladesh

Cefuroxime Axetil (CA) a widely used cephalosporin antibiotic displays low aqueous solubility and high membrane penetrability. This results in its solubility driven variable and/or low oral bioavailability and therapeutic efficacy as a major drawback. Thus, most of the goal of our study was to increase the solubility as well as dissolution rate of CA using the simple and cost-effective solid dispersion (SD) method. At first, the SD formulations of CA were prepared at various weight ratios of Carplex-67 and PEG-4000 by solvent evaporation technique. These new formulations were then subjected to an in-vitro drug release performance study and tested for physicochemical characterization to distinguish the thermal behavior, crystallinity, interactions phenomena, and surface morphology. Among the formulated Cefuroxime Axetil Solid Dispersion (CSD), CSD-8 which contained CA, Carplex-67, and PEG-4000 at the weight ratio 1:3:2, respectively showed the most significant (p in-vitro dissolution in water, Gastric Simulated Fluid (GSF), and Intestinal Simulated Fluid (ISF). This study also showed a significant (p < 0.001) increase in drug release compared to the marketed product. Therefore, it is supposed to be a promising alternative to conventional antimicrobial therapy.

关键词： Carplex-67 Cefuroxime Axetil Improved Dissolution PEG-4000 Solid Dispersion Solvent Evaporation

Development and Evaluation of Stable Paracetamol Loaded Solid Dispersion with Enhanced Analgesic and Hepatoprotective Property

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Pharmacology & Pharmacy 2023年第4期14卷 123-143页

作者： Ashim Kumar Milon Kumar Ghosh mst. boby aktar bithy Md. Rafiqul Islam Khan Md. Monimul Huq Mir Imam Ibne Wahed Ranjan Kumar Barman Laboratory of Pharmaceutics Department of Pharmacy Faculty of Science University of Rajshahi Rajshahi Bangladesh Department of Pharmacy Faculty of Biological Sciences Islamic University Kushtia Bangladesh Department of Statistics Faculty of Science University of Rajshahi Rajshahi Bangladesh

Paracetamol (PCM) is enlisted in the WHO model list as an essential medicine for pain and palliative care, but at overdose, it causes hepatic damage. This study was designed to assess the analgesic efficacy and hepatoprotective property of a solid dispersion (SD) loaded with PCM. A number of PCM loaded formulations (PSDs) were fabricated using silica alone or in combination with polyethylene glycol and/or Na-citrate followed by in-vitro dissolution profiling. Selected PSDs with improved dissolution profile were subjected to solid-state characterization (DSC, PXRD, FTIR, and SEM), stability study along with investigation of in-vivo analgesic efficacy and effect on hepatocytes. Among these, PSD10 showed a rapid and significantly higher in-vitro drug release than pure PCM. This improvement was distinct to other PSDs also. Solid-state characterization of PSD10 authenticated the conversion of crystalline PCM to amorphous form upon formulation. Subsequent oral administration of PSD10 in Swiss albino mice showed 1.44-fold greater analgesic efficacy than pure PCM at dose 30 mg/kg. Besides, at acute toxic dose, liver histology of PSD10 mice was comparable with NC mice indicating hepatic protection upon formulation, whereas the PCM mice showed extensive hepatic necrosis which was also endorsed by significantly higher values of SGPT, SGOT, and ALP than PSD10 mice. Finally, an accelerated stability study of PSD10 performed according to the guideline of ICH noticed no remarkable deviation in its dissolution performance as well as crystalline nature. Thus, this newly developed PSD10 may be a safe and promising alternative for pain management and palliative care.

关键词： Paracetamol Solid Dispersion Dissolution Analgesic Activity Hepatocyte Particle Surface Property Stability

A Novel LSB Steganography Technique for Enhancing Cloud Security

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Journal of Information Security 2024年第3期15卷 355-377页

作者： Ahsan Ullah Md. Inzamul Haque Md. Mokarom Hossain Md. Sadman Ahammad mst. Nishita aktar Department of Computer Science and Engineering World University of Bangladesh Dhaka Bangladesh

Steganography is a technique that is frequently used to hide hidden information in multimedia artifacts including music, video, and images. In order to protect data saved in the cloud, this paper presents a steganography method for encrypting sound utilizing LSB-based computation. By using the least significant bit (LSB) of a byte to represent a message and then substituting each LSB bit with a binary message and encrypting a significant quantity of data. The proposed system uses the LSB technique of picture steganography, Multi-Level Encryption Algorithm (MLEA) and Two-Level Encryption Algorithm (TLEA) data encryption to give the highest level of cloud security. Compared to other current schemes, the performance of the suggested method is 1.732125% better on average.

关键词： Steganography LSB Cloud Computing Security Cryptography TLEA MLEA

Preparation and Structural Properties of ZnAl_xFe_2-xO₄ Spinel Oxide

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American Journal of Analytical Chemistry 2016年第2期7卷 203-209页

作者： Shahzad Hossain Goutam Dev mst. Sanjida aktar Muhammad Kamrul Hasan A. K. M. Zakaria Tapash Kumar Datta Imtiaz Kamal Sk. Md. Yunus Md. Habibul Ahsan Abul Kalam Azad Institute of Nuclear Science & Technology Bangladesh Atomic Energy Commission Dhaka Bangladesh Faculty of Integrated Technologies Universiti Brunei Darussalam Gadong Brunei Darussalam Department of Physics Shahjalal University of Science and Technology Sylhet Bangladesh

The ZnAlxFe2-xO4 (x = 0.0, 0.2 and 0.4) spinel ferrites were prepared by the conventional solid state reaction in air at 1350°C. The X-ray diffraction of all the three samples showed sharp Bragg peaks indicating the formation of a single phase spinel structure. The lattice parameters of the samples were determined from the X-ray diffraction data using the Nelson-Riley extrapolation method. The lattice parameters, cation distribution and oxygen position parameters have also been determined by refining the data by the Rietveld method. Rietveld refinement of the XRD data reveals all the samples to possess cubic symmetry corresponding to the space group Fd3m. Lattice parameters were found to decrease with increasing Al concentration, i.e. 8.4322, 8.4002, and 8.3984 Åfor x = 0.0, 0.2 and 0.4, respectively.

关键词： Polycrystalline Ferrite X-Ray Diffraction Spinel Ferrite Rietveld Refinement Space Group Fd3m Lattice Parameter