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GeDiPNet: Online resource of curated gene-disease associations for polypharmacological targets discovery

Genes & Diseases 2023年第3期10卷 647-649页

作者： Indra Kundu mridula sharma Ram Shankar Barai Khushal Pokar Susan Idicula-Thomas Biomedical Informatics Centre Indian Council of Medical Research-National Institute for Research in Reproductive and Child HealthMumbai 400012India

There are numerous online databases dedicated to genes associated with human diseases.The redundancy and lack of consistency of disease terms in these databases pose a significant impediment in high throughput data analysis.To address this,we developed GeDiPNet by compiling data available on gene-disease associations from six popular open access sources namely DisGeNET,1 ClinGen.

关键词： databases online analysis.

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Extraocular retinoblastoma in Indian children:clinical,imaging and histopathological features

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International Journal of Ophthalmology(English edition) 2013年第4期6卷 481-486页

作者： Sumita Sethi Neelam Pushker Seema Kashyap Sanjay sharma mridula Mehta Sameer Bakhshi Saurbhi Khurana Supriyo Ghose Oculoplasty and Pediatric Ophthalmology Services Dr.Rajendra Prasad Centre for Ophthalmic SciencesAll India Institute of Medical Sciences Department of Ocular Pathology Dr.Rajendra Prasad Centre for Ophthalmic SciencesAll India Institute of Medical Sciences Department of Radiodiagnosis All India Institute of Medical Sciences Department of Medical Oncology Dr.B.R.Ambedkar Institute Rotary Cancer HospitalAll India Institute of Medical Sciences

AIMTo study eyes with extraocular dissemination (EORB), with the following aims: first to establish the mean lag period and to understand various reasons for delayed presentation, second to study their imaging profile... 详细信息

关键词： extraocular retinoblastoma imaging histopathological features

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Effect of Higher Mean Arterial Pressure with Norepinephrine on Tissue Oxygenation and Perfusion in Patients of Septic Shock

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International Journal of Clinical Medicine 2012年第5期3卷 407-410页

作者： Sandeep sharma mridula Pawar Mohandeep Kaur Nidhi Srivastava Saurav Mustafi Department Of Anaesthesiology and Intensive Care P.G.I.M.E.R Dr Ram Manohar Hospital New Delhi.

The current survival sepsis guideline proposes the use of vasopressors and fluid resuscitation to maintain the mean arterial pressure (MAP) ≥ 65 mmHg. Titrating catecholamine infusion to achieve higher MAP has been demonstrated to improve tissue oxygenation, microcirculation, renal function and overall outcome of the patient in some studies and literature on actual hemodynamic goals is scarce. AIM: To study the influence of two MAP on tissue oxygenation and perfusion parameters in patients of septic shock on norepinephrine infusion. SUBJECT AND MATERIALS: Forty adult patients with the diagnosis of septic shock were enrolled. In all patients norepinephrine was titrated to first stabilize the MAP at 65 ± 5 mmHg (Set I), followed by MAP of 85 ± 5 mmHg (Set II). Heart rate (HR), Central venous oxygen saturation (SCVO2), Transcutaneous partial pressure of oxygen (PtcO2) by TCM 400/TINA (using miniature Clark electrode), Arterial partial pressure of oxygen(PaO2), PtO2/PaO2 ratio, Urine output and Serum Base deficit were recorded in each Set after 2 hrs of stabilization. RESULTS: There was a significant increase in transcutaneous partial pressure of oxygen PtcO2 (p tO2/PaO2 (p < 0.0001), ScvO2 (p < 0.0001), urine output (p < 0.006) on increasing the MAP from 65mmHg to 85mmHg. Serum base deficit also improved (p < 0.0001). CONCLUSION: Higher MAP with norepinephrine is associated with better perfusion, oxygenation parameters in patients with established septic shock. These findings suggest that there is improvement in tissue oxygenation parameters using escalating doses of norepinephrine to achieve higher MAP without inherent adverse

关键词： Mean Arterial Pressure Norepinephrine Septic Shock Tissue Oxygenation

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Synthesis of Fluorite-Type Nanopowders by Citrate-Nitrate Auto-Combustion Process: A Systematic Approach

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Materials Sciences and Applications 2012年第2期3卷 110-115页

作者： mridula Biswas Prasanta Kumar Ojha Chadalapaka Durga Prasad Nitin Madhusudan Gokhale Suresh Chandra sharma 不详

Citrate-nitrate autocombustion process is a promising synthesis route in the field of nanomaterials. This route involves many controlling parameters which ultimately affect properties of the products. In the present research work, the effect of concentration of fuel to that of metal nitrates has been studied in a systematic manner. The nature of exothermic reaction was analyzed with DSC-TGA and the powder properties were characterized by XRD, TEM and BET measurement. The properties of the powders have been explained with respect to fuel content, vigorousness of the exothermic reaction, combustion temperature and duration. The most vigorous reaction was found to occur for the composition with FER of 0.50 with the production of the smallest crystallite size of 9 nm.

关键词： Combustion Synthesis DSC-TGA XRD TEM

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