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Neuronal and endothelial transglutaminase-2 expression in experimental autoimmune encephalomyelitis and multiple sclerosis

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Neural Regeneration Research 2022年第7期17卷 1471-1472页

作者： Damien D.Pearse mousumi ghosh Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Department of Neurological Surgery University of Miami Miller School of MedicineMiamiFLUSA Neuroscience Program Interdisciplinary Stem Cell InstituteUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Veterans Affairs Veterans Affairs Medical CenterMiamiFLUSA

Multiple sclerosis(MS)is a neurological condition characterized by the disruption of the blood-brain barrier,immune system activation,and infla mmation that is accompanied by glial reactivity,neuronal cell death,axon demyelination,and axotomy.Pathological changes result in functional loss including paralysis,migraine,vision problems,spasticity,and neuropathic pain.

关键词： sclerosis paralysis autoimmune

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Advent of clean and green technology for preparation of low-cholesterol dairy cream powder:supercritical fluid extraction process

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Food Quality and Safety 2018年第4期2卷 205-211页

作者： mousumi ghosh Chitra J. Shubhangi Srivastava Hari Niwas Mishra Agricultural and Food Engineering Department Indian Institute of Technology KharagpurNalanda roadKharagpurWest Mednipore721302India

Objectives:Due to health issues related to cholesterol and the emphasis on manufacture of low cholesterol food products,the research was undertaken for the extraction of cholesterol from cream powder using supercritical fluid extraction(SCFE)process.Materials and Methods:Face centered composite design(FCCD)was used to design the experiments with three independent variables viz.,extraction temperature(40˚C-75˚C),extraction pressure(100-250 bar)and dynamic time(2.5-3.5 h)taking two responses(cholesterol and fat content).The standardized flow rate and static time were 5 L/min(expanded CO_(2) gas)and 30 min,respectively.Response surface methodology was used for optimizing the process variables.Results:It was found that higher operating pressure,low extraction temperature and moderate amount of dynamic time facilitated the removal of cholesterol.The optimized process conditions of 75˚C,204 bar and 3.5 h dynamic time yielded 39%reduction in cholesterol content and 10.6%reduction in total fat content of the cream powder.Conclusions:Thus,a low cholesterol cream powder was developed with health benefits for people suffering from cardiovascular diseases.

关键词： cholesterol supercritical fluid extraction HPLC face-centred composite design response surface methodology

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Protective effect of ascorbic acid on cyclophosphamide induced testicular gametogenic and androgenic disorders in male rats

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Asian Journal of Andrology 2002年第3期4卷 201-207页

作者： Ujjal Baran Das mousumi Mallick Jogendra Mohan Debnath Debidas ghosh Reproductive Endocrinology and Family Welfare Research Unit Department of Human Physiology with Community Health Vidyasagar University Midnapore-721102 West Bengal India.Reproductive Endocrinology and Family Welfare Research Unit Department of Human Physiology with Community Health Vidyasagar University Midnapore-721102 West Bengal India.Reproductive Endocrinology and Family Welfare Research Unit Department of Human Physiology with Community Health Vidyasagar University Midnapore-721102 West Bengal India.Reproductive Endocrinology and Family Welfare Research Unit Department of Human Physiology with Community Health Vidyasagar University Midnapore-721102 West Bengal India.

Aim: To study the detrimental effects of cyclophosphamide on the testicular androgenic and gametogenic activities through endocrine inhibition and/or induction of oxidative stress in male albino rats and to evaluate the protective effect of ascorbic acid. Methods: The testicular △~5, 3β-hydroxysteroid dehydrogenase (HSD), 17β-HSD, peroxidase and catalase activities along with the levels of malondialdehyde (MDA) and conjugated dienes in testicular tissue were measured for the evaluation of testicular oxidative stress. The plasma testosterone (T) level was measured by immunoassay. Various germ cells at stage Ⅶ of spermatogenic cycle were quantified from testicular stained sections. Results: Cyclophosphamide treatment results in a significant inhibition in the testicular △~5, 3β-HSD and 17β-HSD activities, a decrease in plasma T level and a diminution in the counts of various germ cells. Moreover, this treatment was also associated with a significant inhibition of the peroxidase and catalase activities along with high levels of MDA and conjugated dienes in the testis. All these changes were reversed by ascorbic acid co-administration. Conclusion: Cyclophosphamide treatment at the dosage used caused testicular gametogenic and androgenic disorders as well as induced testicular oxidative stress that can be reversed by ascorbic acid co-administration.

关键词： Cyclophosphamide androgenesis gametogenesis oxidative stress free radicals ascorbic acid catalase peroxidase testosterone

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