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Open Journal of Pediatrics 2023年第5期13卷 719-726页

作者： Bangoura Kaba Diallo Fatoumata Binta Kolié Ouo-Ouo Camara Salematou Hassimiou Diallo Mohamed Lamine Diop Mamadou moustapha Camara Emmanuel Kouyate moustapha Department of Pediatrics Donka CHU Conakry Guinea Department of Pediatrics Gamal Abdel Nasser Conakry University Conakry Guinea

Renal damage is one of the most frequent and serious manifestations of systemic lupus erythematosus (SLE). Even if this disease is the prerogative of female adults, it can affect children especially during the peri-pubertal period. The aim of this work is to highlight the clinical-biological and progressive characteristics of lupus nephropathy in children.

关键词： Nephropathy Lupus Child

White Blood Cells Detection Using Spectral Tresholding

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Journal of Signal and Information Processing 2023年第1期14卷 1-8页

作者： Kamara Ndèye Lama Boye Mouhamadou moustapha Traore Ali Biomedical Engineering Department Polytechnical University of West Africa Dakar Senegal Laboratory of Fundamental and Applied Microbiology University Cheikh Anta Diop Dakar Senegal

The study of the morphology of White Blood Cells (WBCs) further contributes to the clinical diagnosis of blood diseases. In this research paper, we come up with an image segmentation enhancement by combining Fourier Fast Transform on smear blood capture and classical thresholding. The Fast Fourier Transform (FFT) is a very powerful tool in image processing and it was used to segment and extract the WBCs. Our image processing method uses a Fast Fourier Transform combined with filtering and an Inverse Fast Fourier Transform for the extraction and visualization of the high frequency region of the image. In order to remove residual Red Blood Cells acting as noise in the expected result, a final thresholding step is added at the end of the processing. The results presented in this article report the tests performed using our mathematical implementation. Moreover, we were able to detect and differentiate the sub-families of WBCs.

关键词： Segmentation Fourier Transform White Blood Cell

Peak of Electron Density in F2-Layer Parameters Variability at Quiet Days on Solar Minimum

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Journal of Modern Physics 2019年第3期10卷 302-309页

作者： Emmanuel Nanéma moustapha Konaté Frédéric Ouattara Centre National de la Recherche Scientifique et Technologique (CNRST) Institut de Recherche en Sciences Appliquées et Technologies (IRSAT) Ouagadougou Burkina Faso Université Norbert ZONGO Laboratoire de Recherche en Météorologie de l’Espace (LAREME) Koudougou Burkina Faso

This study deals with Peak of electron density in F2-layer sensibility scale during quiet time on solar minimum. Peaks of electron density in F2-layer (NmF2) values at the quietest days are compared to those carried out from the two nearest days (previous and following of quietest day). The study uses International Reference Ionosphere (IRI) for ionosphere modeling. The located station is Ouagadougou, in West Africa. Solar minimum of phase 22 is considered in this study. Using three core principles of ionosphere modeling under IRI running conditions, the study enables to carry out Peak of electron density in F2-layer values during the quietest days of the characteristic months for the four different seasons. These parameters are compared to those of the previous and the following of the quietest days (the day before and following each quietest selected day) at the same hour. The knowledge of NmF2 values at the quietest days and at the two nearest days enables to calculate the relative error that can be made on this parameter. This calculation highlights insignificant relative errors. This means that NmF2 values at the two nearest days of each quietest day on solar minimum can be used for simulating the quietest days’ behavior. NmF2 values obtained by running IRI model have good correlation with those carried out by Thermosphere-Ionosphere-Electrodynamics-General Circulation Model (TIEGCM).

关键词： Ionosphere Peak of Electron Density in F2-Layer Solar Cycle Quiet Day International Reference Ionosphere Model

Monazite Recovery by Magnetic and Gravity Separation of Medium Grade Zircon Concentrate from Senegalese Heavy Mineral Sands Deposit

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Journal of Minerals and Materials Characterization and Engineering 2021年第6期9卷 590-608页

作者： Moumar Dieye Mohamadou moustapha Thiam Anthony Geneyton Mamadou Gueye Earth Science Institute Cheikh Anta Diop Dakar University Dakar Senegal Eramet Ideas Trappes France

Gravity, magnetic and electrostatic separation methods allowed to obtain different titanium oxide concentrates (ilmenite, leucoxene, rutile) and different varieties of zircon concentrates (premium zircon, standard zircon, medium grade zircon standard) from Senegal’s heavy mineral sands. During mining separation, monazite, which is a paramagnetic mineral, was found in a non-negligible concentration of 0.57 wt% on average in the medium grade zircon standard which also contains 37.96 wt% zircon and 44.46 wt% titanium oxides. Magnetic and gravity separation tests were carried out on the Medium grade zircon standard (MGZS) to produce a monazite concentrate at Eramet Ideas laboratory. Magnetic separation at 1.5 teslas intensity resulted in the recovery of 94.8% of the monazite from the MGZS. Gravity separation also recovered 76.6% of the monazite from the MGZS. The combination of these two treatment methods can thus produce three concentrates from MGZS (a monazite concentrate, a zircon concentrate, and a titanium oxide concentrate).

关键词： Monazite Heavy Mineral Sands Separation Gravity Magnetic

Multi-Systemic Inflammatory Syndrome in Children

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Open Journal of Pediatrics 2023年第4期13卷 529-542页

作者： Ilham Tadmori Soukaina Seddiki Samir Atmani moustapha Hida Department of Pediatrics and Pediatric Emergencies Mother and Child Hospital CHU Hassan II Fez Morocco

The objective of our work is to study the multi-systemic inflammatory syndrome (PIMS) in children, to determine its frequency, by analyzing the epidemiological, clinical, paraclinical, therapeutic, and evolutionary profile of these patients. A retrospective study spanning a period of 2 years from April 2020 to March 2022. It concerns all children under the age of 16 admitted and cared for in the pediatric emergency department of the university hospital Hassan II of Fez for multi-system inflammatory syndrome (PIMS). Twenty cases of PIMS were collected over this period. Multi-system inflammatory syndrome in children has been described in temporal association with COVID-19, usually within 2 to 6 weeks of illness or exposure. The age of the patients varies between 8 months and 15 years. All patients presented with fever and cutaneous signs, followed by digestive signs and neurological signs. The inflammatory syndrome is frankly positive in all patients who had a COVID-19 PCR and/or positive serology. The treatment is based on the administration of immunoglobulins in association with corticosteroid therapy and non-specific antibiotic therapy in the majority of cases (80%). The evolution was favorable. PIMS should be considered in all children presenting with a clinical and/or biological inflammatory syndrome associated with COVID-19.

关键词： Multisystemic Inflammatory Syndrome Child COVID-19 PIMS

Genetic and Metabolic Determinants of Plasminogen Activator Inhibitor 1 (PAI-1) in Tunisian Type 2 Diabetes Patients

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Open Journal of Endocrine and Metabolic Diseases 2017年第6期7卷 141-150页

作者： Mohamed moustapha Molka Chadhli-Chaieb Touhami Mahjoub Larbi Chaieb Internal Medicine Department Hospital Cheikh Zayed Nouakchott Mauritania Endocrinology Department CHU Farhat Hachad Sousse Sousse Tunisia Research Unit of Biology Genetics of Cancers Haematological and Autoimmune Diseases Faculty of Pharmacy of Monastir University of Monastir Monastir Tunisia

Background: PAI-1 (plasminogen activator inhibitor-1) is a powerful regulator of fibrinolysis and plasma level is high in type 2 diabetes and cardio-vascular disease, which is determined by genetic polymorphisms in PAI-1 gene and environmental factors. The aim of the study was to examine the determinants of plasma PAI-1 Ag level among type 2 diabetes patients. Methods: 491 Tunisian type 2 diabetes patients had clinical evaluation (weight, high, BMI, Waist Circumference), laboratory investigations including FBG Hb1Ac, cholesterol, triglyceride;HDL-cholesterol was done;plasma PAI-1 antigen level was done with ELISA;−675 4G/5G and −844 G/A polymorphisms of PAI-1 gene was done by PCR-ASA and PCR-RFLP respectively. Results: The mean age for our patients was 58.3 ± 10.5 years;sex-ratio = 0.92;mean PAI-1 level was 34.6 ± 21.3 ng/ml. We didn’t find correlation between PAI-1 level and BMI, but we have found significant correlation between PAI-1 and waist circumference (p = 0.032), most enhanced in men (P = 0.002), T2D patients who have FBG > 11 mmol/l had PAI-1 Ag level higher than those who have FBG P = 0.034), but no difference found between T2D with high Hb1Ac > 8% and those with Hb1Ac < 8%, significant correlation was seen between PAI-1 level and LDL-cholesterol (P = 0.05), high correlation between PAI-1 Ag level and −675 4G/5G polymorphism genotype was seen, 4G/4G carriers had the highest PAI-1 level, 4G/5G had intermediary level and 5G/5G had the lowest level (P −844G/A polymorphism genotypes. Using multiple variable linear regression analysis, the independent factor associated with plasma PAI-1 level was −675 4G/5G polymorphism (regression coefficient β = 4.6, P Conclusion: the present study identifies −675 4G/5G not −844 G/A polymorphism of PAI gene as the principal determinant of plasma PAI-1 level in Tunisian T2D patients, the android fat distribution, dyslipidemia and hyperglycemia play a modest role in this variation.

关键词： Plasminogen Activator Inhibitor 1 Polymorphism PCR Type 2 Diabetes Mellitus Metabolic Syndrome X

SAPHO Syndrome: About Three Cases and Review of the Literature

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Open Journal of Internal Medicine 2021年第2期11卷 109-121页

作者： Abba Abbasse Niasse moustapha Diaby Ladji Mohamed Ali Hassan Rheumatology Department Aristide Le Dantec Teaching Hospital Dakar Senegal

Background: SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis) is both a dermatological and a rheumatological entity, with the common denominator of an aseptic inflammatory process, the bone manifestations of which are the essential element of the diagnosis. Despite its chronic and recurrent nature, SAPHO syndrome is very rarely the cause of major disability, even after several decades of evolution. Objective: We want to illustrate through three clinical cases, the importance of the anamnesis, the clinic, the diagnostic criteria in the diagnosis of SAPHO syndrome. Presentation of the cases: We studied the clinical file of three patients consulted in the Rheumatology Department of the CHU Aristide LeDantec in Dakar, Senegal, between January 2012 and December 2020, suffering from SAPHO syndrome of diagnosis established in accordance with the diagnostic criteria of SAPHO syndrome proposed by Khan et al. of 1994. Conclusion: SAPHO syndrome is a rare pathological entity, over a period of 8 years we report 3 cases.

关键词： Anamnesis Clinical Diagnostic Criteria Female SAPHO Syndrome Senegal

Improving Disease Prevalence Estimates Using Missing Data Techniques

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Open Journal of Statistics 2016年第6期6卷 1110-1122页

作者： Elhadji moustapha Seck Ngesa Owino Oscar Abdou Ka Diongue Pan African University Institute for Basic Sciences Technology and Innovation (PAUISTI) Nairobi Kenya Taita Taveta University Taita Taveta Kenya Universite Gaston Berger de Saint Louis Saint Louis Senegal

The prevalence of a disease in a population is defined as the proportion of people who are infected. Selection bias in disease prevalence estimates occurs if non-participation in testing is correlated with disease status. Missing data are commonly encountered in most medical research. Unfortunately, they are often neglected or not properly handled during analytic procedures, and this may substantially bias the results of the study, reduce the study power, and lead to invalid conclusions. The goal of this study is to illustrate how to estimate prevalence in the presence of missing data. We consider a case where the variable of interest (response variable) is binary and some of the observations are missing and assume that all the covariates are fully observed. In most cases, the statistic of interest, when faced with binary data is the prevalence. We develop a two stage approach to improve the prevalence estimates;in the first stage, we use the logistic regression model to predict the missing binary observations and then in the second stage we recalculate the prevalence using the observed data and the imputed missing data. Such a model would be of great interest in research studies involving HIV/AIDS in which people usually refuse to donate blood for testing yet they are willing to provide other covariates. The prevalence estimation method is illustrated using simulated data and applied to HIV/AIDS data from the Kenya AIDS Indicator Survey, 2007.

关键词： Disease Prevalence Missing Data Non-Participant Logistic Regression Model Prevalence Estimates HIV/AIDS

Water Quality from the Purification Unit of Thiakhar (Diourbel, Senegal) and Impact of Discharges from Treatment on Water Resources

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Journal of Water Resource and Protection 2013年第12期5卷 1186-1191页

作者： Cheikh Hamidou Kane moustapha Diène Baba Sarr Department of Géology FST-UCAD University Cheikh Anta Diop of Dakar Dakar Senegal Laboratory of Geology IFAN University Cheikh Anta Diop of Dakar Dakar Senegal Laboratory of Mechanics and Modeling-Sciences of Engineering of Thies Thies Senegal

The installation of a purification unit since 2008 in the village of Thiakhar has improved the physico-chemical and bacteriological quality of the water supply. However about 55% of the raw water comes out of the unit as discharges (approximately 14 m3 per day) highly concentrated in fluoride and chloride ions. Based on historical samples, we find that the volumes of water consumed together with the volumes of water discharged are increasingly significant from year to year. The storage of waste water is carried out in a septic tank connected to a leaking cesspool sink. Significant excesses of these discharges are visible on the site and a flow of concentrate is observed creating a puddle of water that attracts birds and straying cattle. The study describes the following substantial impacts on the natural and human environment: 1) contamination of groundwater, 2) soil salinization 3), impact on flora and fauna, 4) impact on health. The study concludes by identifying measures to mitigate the negative impacts related to the discharges and by proposing alternative solution.

关键词： Drinking Water Treatment Quality Discharges Pollution Mitigation

Ultra-Violet (UV): A Good Bacterial Sterilizer?

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Journal of Biosciences and Medicines 2023年第2期11卷 80-85页

作者： Sira Sidibe Mouhamadou moustapha Boye Maryam Mouhamadou Ali Traore Biomedical Engineering Department Polytechnical University of West Africa Dakar Senegal Laboratory of Fundamental and Applied Microbiology University Cheikh Anta Diop Dakar Senegal

Introduction: The aim of this study was to improve the DISTER-UV and to perform microbiological quality control at the biomedical laboratory of the West African Polytechnic University from January 2022 to November 2022. Methodology: During this eleven-month prospective study, we set up a quality control device (QCD). For microbiological quality control, we performed different cultures of bacteria with different bacteriological and morphological characteristics at T0 (no sterilization) and at T30 (after 30 minutes of sterilization under DISTER-UV). Results: After the realization, the DCQ attached to the DISTER-UV1 allows to display of the UV wavelength present in the light box. This device also displays and alerts when the UV intensity emitted by the lamps is below 250 nm. During microbiological quality control, the cultures carried out at T30 and incubated for 24 hours did not reveal any bacterial colonies. This shows the bactericidal character of DISTER-UV-2. Conclusion: The improvement and the microbiological quality control allowed us to switch from DISTER-UV1 (without sensor) to DISTER-UV-2 (with sensor or DCQ). The biological control allowed us to affirm that the DISTER-UV-2 is bactericidal.

关键词： Sterilization Ultraviolet Radiation Bactericide Quality Control Bacteria