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Outcomes of early physiotherapy in patients with cerebral aneurysms treated by surgical clipping or endovascular embolization

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Neural Regeneration Research 2012年第24期7卷 1900-1905页

作者： Arzu Guclu-Gunduz sevil Bilgin Nezire Kse hakan Oruckaptan Department of Physiotherapy and Rehabilitation Faculty of Health SciencesGazi UniversityAnkaraTurkey Department of Physiotherapy and Rehabilitation Faculty of Health SciencesHacettepe UniversityAnkaraTurkey Department of Neurosurgery Faculty of MedicineHacettepe UniversityAnkaraTurkey

Early physiotherapy was given to 124 patients with ruptured or unruptured cerebral aneurysms who were treated by surgical clipping or endovascular *** were divided into four groups according to their Hunt and Hess grade at admission and aneurysm treatment modality： Group 1,Hunt and Hess grade≤II and surgical clipping;Group 2,Hunt and Hess grade≤II and endovascular embolization;Group 3,Hunt and Hess grade≥III and surgical clipping;Group 4,Hunt and Hess grade≥III and endovascular *** of consciousness was evaluated using the Glasgow Coma Scale,functional status using the Glasgow Outcome Scale,level of the mobility using the Mobility Scale for acute stroke patients,and independence in activities of daily living using the Barthel *** early physiotherapy,the level of consciousness and functional status improved significantly in Groups 1,3,and 4;mobility improved significantly in all groups;and independence in activities of daily living improved significantly in Groups 1 and *** discharge, Groups 1 and 2 had better functional status than Groups 3 and *** of consciousness,functional status,mobility and independence in activities of daily living improved after early physiotherapy. These findings suggest that early physiotherapy improved the prognosis of patients with cerebral aneurysms who were treated by surgical clipping or endovascular *** with a worse clinical status at presentation had a poorer functional status at *** outcome of physiotherapy was not affected by whether surgical clipping or endovascular embolization was chosen for treatment of the aneurysm.

关键词： cerebral aneurysm Hunt and Hess grade Glasgow Coma Scale Glasgow Outcome Scale functional status surgical clipping endovascular treatment physiotherapy neural regeneration

Oxygen permeability of soft contact lenses in different pH, osmolality and buffering solution

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International Journal of Ophthalmology(English edition) 2015年第5期8卷 1037-1042页

作者： se Eun Lee So Ra Kim Mijung Park Department of Optometry Seoul National University of Science and Technology

AIMTo determine the effect of pH, osmolality, and buffering system on the oxygen permeability (Dk) of soft contact *** hydrogel lenses (nelfilcon A and etafilcon A) and 2 silicone hydrogel lenses (lotrafilcon A and balafilcon A) were used in the study. These lenses were incubated in phosphate-buffered saline (PBS) and borate-buffered saline (BBS) solutions adjusted by 0.8 pH increments to a pH in the range of 5.8-9.0 or in hypotonic (280 mOsmol/kg), isotonic (310 mOsmol/kg) and hypertonic (380 mOsmol/kg) PBS solutions. Polarographic method was used for measuring the Dk and lenses were stacked as 4 layers to correct the boundary *** values of all contact lenses measured in BBS solutions were more stable than those in PBS solutions. Especially the etafilcon A lens showed a relative big change compared with other types of contact lenses at the same conditions. When the osmolality of PBS solution increased from hypotonic to hypertonic, Dk of all contact lenses decreased. Variations in Dk existed depending on lens materials, etafilcon A lens was the most affected and nelfilcon A was the least affected by *** the result obtained, it is revealed that Dk of contact lenses is changed by the pH, osmolality, and buffering condition of tear. Thus, Dk of contact lens can be varied by the lens wearers' physiological and/or pathological conditions.

关键词： soft contact lens oxygen permeability buffer solutions osmolality pH

Effects of chitosan inhibitor on the electrochemical corrosion behavior of 2205 duplex stainless steel

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International Journal of Minerals,Metallurgy and Materials 2017年第11期24卷 1260-1266页

作者： se-fei Yang Ying Wen Pan Yi Kui Xiao Chao-fang Dong Department of Stomatology General Hospital of the People’s Liberation Army Beijing 100853 China Institute for Advanced Materials and Technology University of Science and Technology Beijing Beijing 100083 China Journals Publishing Center University of Science and Technology Beijing Beijing 100083 China

The effects of chitosan inhibitor on the corrosion behavior of 2205 duplex stainless steel were studied by electrochemical measurements, immersion tests, and stereology microscopy. The influences of immersion time, temperature, and chitosan concentration on the corrosion inhibition performance of chitosan were investigated. The optimum parameters of water-soluble chitosan on the corrosion inhibition performance of 2205 duplex stainless steel were also determined. The water-soluble chitosan showed excellent corrosion inhibition performance on the 2205 duplex stainless steel. Polarization curves demonstrated that chitosan acted as a mixed-type inhibitor. When the stainless steel specimen was immersed in the 0.2 g/L chitosan solution for 4 h, a dense and uniform adsorption film covered the sample surface and the inhibition efficiency(IE) reached its maximum value. Moreover, temperature was found to strongly influence the corrosion inhibition of chitosan; the inhibition efficiency gradually decreased with increasing temperature. The 2205 duplex stainless steel specimen immersed in 0.4 g/L water-soluble chitosan at 30°C displayed the best corrosion inhibition among the investigated specimens. Moreover, chitosan decreased the corrosion rate of the 2205 duplex stainless steel in an FeCl_3 solution.

关键词： inhibitor chitosan stainless steel corrosion behavior electrochemistry

Development of a potential PET probe for HDAC6 imaging in Alzheimer's disease

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Acta Pharmaceutica Sinica B 2022年第10期12卷 3891-3904页

作者： Ping Bai Prasenjit Mondal Frederick A.Bagdasarian Nisha Rani Yan Liu Ashley Gomm Darcy R.Tocci se Hoon Choi Hsiao-Ying Wey Rudolph E.Tanzi Can Zhang Changning Wang Athinoula A.Martinos Center for Biomedical Imaging Department of RadiologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA 02129USA Genetics and Aging Research Unit McCance Center for Brain HealthMassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA 02129USA

Although the epigenetic regulatory protein histone deacetylase 6(HDAC6)has been recently implicated in the etiology of Alzheimer’s disease(AD),little is known about the role of HDAC6 in the etiopathogenesis of AD and whether HDAC6 can be a potential therapeutic target for ***,we performed positron emission tomography(PET)imaging in combination with histopathological analysis to better understand the underlying pathomechanisms of HDAC6 in *** first developed[^(18)F]PB118 which was demonstrated as a valid HDAC6 radioligand with excellent brain penetration and high specificity to *** studies of[^(18)F]PB118 in 5xFAD mice showed significantly increased radioactivity in the brain compared to WT animals,with more pronounced changes identified in the cortex and *** translatability of this radiotracer for AD in a potential human use was supported by additional studies,including similar uptake profiles in non-human primates,an increase of HDAC6 in ADrelated human postmortem hippocampal tissues by Western blotting protein analysis,and our ex vivo histopathological analysis of HDAC6 in postmortem brain tissues of our ***,our findings show that HDAC6 may lead to AD by mechanisms that tend to affect brain regions particularly susceptible to AD through an association with amyloid pathology.

关键词： HDAC6 Alzheimer’s disease Radiotracer PET imaging Epigenetic

Analytical analysis of inclined three-layered composite channel with cobalt ferrite nanoparticles and hall current in Darcy medium

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Propulsion and Power Research 2023年第4期12卷 523-538页

作者： P.V.Ananth Subray B.N.hanumagowda C.S.K.Raju S.V.K.Varma Prakash Jagdish se-Jin Yook Nehad Ali Shah Department of Mathematics School of Applied SciencesREVA UniversityBengaluruKarnatakaIndia School of Mechanical Engineering Hanyang University222 Wangsimni-roSeongdong-guSeoul 04763Republic of Korea Department of Mechanical Engineering Science Faculty of Engineering&The Built EnvironmentUniversity of JohannesburgSouth Africa Department of Mechanical Engineering Sejong UniversitySeoul 05006Republic of Korea

The present study explores the influence of electromagnetic effects on the flow of a nanofluid in a saturated permeable medium,confined between a clear viscous fluid in an inclined *** nanofluid consists of cobalt ferrite nanoparticles dispersed in ethylene *** governing equations are derived considering Darcy's law for the permeable medium and Tiwari's model for fluids containing nano-sized ***,radiation and dissipation effects are incorporated into the energy *** equations are transformed into dimensionless form and solved analytically using the perturbation *** results are analyzed through graphs and tables for different material *** findings reveal that higher electric and magnetic strengths have a significant impact on the fluid velocity at the interface of the two fluids,resulting in reduced shear both at the clear fluid surface and the interface between *** highlights the crucial role played by electric and magnetic strengths in modifying flow ***,combining electric and magnetic strengths with nanofluids can be utilized to achieve desired qualities in multi-fluid flow and enhance heat transfer characteristics.

关键词： Three-layered flow Inclined composite channel Electromagnetic field Nanofluid Porous region

Allogeneic stem cell transplantation-A curative treatment for paroxysmal nocturnal hemoglobinuria with PIGT mutation:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5702-5707页

作者： Laurence Schenone Anne-Béatrice Notarantonio Véronique Latger-Cannard Veronique Fremeaux-Bacchi Marcelo De Carvalho-Bittencourt Marie-Thérèse Rubio Marc Muller Maud D'Aveni Department of Hematology CHRU de NancyNancy F-54000France Genetic Laboratory CHRU de NancyNancy F-54000France IMoPA CNRS 7365University of LorraineNancy F-54000France Hematology Laboratory Cytometry PlatformCHRU de NancyNancy F-54000France Immunology Laboratory Hôpital Européen George PompidouParis 75015France Immunology Laboratory CHRU de NancyNancy F-54000France

BACKGROUND Patients with paroxysmal nocturnal hemoglobinuria(PNH)have a clonal population of blood cells deficient in glycosylphosphatidylinositol-anchored(GPIanchored)proteins,most of the time resulting from a mutation in the X-linked gene *** report a patient with PNH resulting from a rare biallelic PIGT mutation on chromosome *** SUMMARY A 47-year-old man was referred to our hospital for febrile *** patient reported a history of recurrent urticaria and arthralgia and he presented during 3 mo recurrent acute dermo-hypodermitis and aseptic *** on clinical cases published with PIGT-PNH,with clinically typical PNH and autoinflammatory symptoms,we treated our patients with repeated infusions of eculizumab to decrease autoinflammatory symptoms and then we performed an allogeneic stem cell transplantation(allo-SCT)with a mismatched unrelated *** patient experienced no acute Graft vs Host disease(GvHD)and a moderate chronic GvHD and is now considered cured at 24 mo after *** This case report suggests that allo-SCT should be considered to cure PIGT-PNH patients.

关键词： Paroxysmal nocturnal hemoglobinuria Allogeneic stem cell transplantation PIGT mutation Recurrent meningitidis Autoinflammatory symptoms Case report

Artemisia kruhsiana leaf extract induces autophagic cell death in human prostate cancer cells

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Chinese Journal of Natural Medicines 2021年第2期19卷 134-142页

作者： LEE se-Eun SIVTseVA Sardana LIM Chiyeon OKHLOPKOVA Zhanna CHO Suin School of Korean Medicine Pusan National UniversityYangsan-si 50612Republic of Korea Department of Biology North-Eastern Federal UniversityYakutsk 677-027Russia College of Medicine Dongguk UniversityGyeonggi-do 10326Republic of Korea

Some species of Artemisia have been reported to induce apoptosis and autophagy,but little is known of the apoptotic and autophagic effects of the stems and leaves of Artemisia kruhsiana Bess.(AkB).This study was conducted to investigate the antioxidant and anti-autophagic effects of the methanol extracts of the stems(EAkBs)and leaves(EAkBl)of AkB on human prostate cancer PC-3 *** antioxidant effects of EAkBs and EAkBl were measured using in vitro total flavonoid and total phenolic assays and a free radical scavenging *** effects of EAkBl on cell viability,apoptosis,autophagy,intracellular reactive oxygen species(ROS)generation and protein expression levels were also *** was found to induce apoptosis,autophagy,and intracellular ROS generation in PC-3 *** terms of protein levels,EAkBl reduced phospho(p)-protein kinase B(AKT)/AKT,p-mammalian target of rapamycin(mTOR)/mTOR,B-cell lymphoma 2(Bcl-2)/Bcl-2-associated X protein(Bax)ratios,and the activations of beclin 1/β-actin and microtubule-associated protein 1A/1B-light chain 3(LC3)Ⅱ/LC3Ⅰratios in PC-3 *** results of this study indicate EAkBl has antioxidant and anticancer effects on prostate cancer cells,and that these effects are associated with suppressions of p-AKT,p-mTOR,Bcl-2,and Bax,and the activations of beclin 1 and *** results indicate EAkBl has potential as a treatment for prostate cancer.

关键词： Artemisia kruhsiana Pharmacognosy Prostate cancer Autophagy

Dexmededomidine in pediatric unilateral internal inguinal ring ligation

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World Journal of Clinical Cases 2022年第21期10卷 7376-7385页

作者： Guang Liu Ling Zhang Hui-se Wang Yi Lin Hong-Quan Jin Xiao-Dan Wang Wei-Na Qiao Ya-Tao Zhang Jiao-Qian Sun Zhi-Na Liu Department of Anesthesiology Baoding Children's HospitalBaoding 071000Hebei ProvinceChina

BACKGROUND Safe and effective analgesia strategy remains one of the priorities for pediatric inguinal hernia *** To explore safety and efficacy of dexmededomidine monotherapy for postoperative analgesia in children who received laparoscopic unilateral internal inguinal ring *** This randomized single-center controlled trial included 390 children(aged 1-3 years,ASA grade I-II),randomly divided into a dexmededomidine group(D group),a dexmededomidine+sufentanil group(DS group),and a sufentanil group(S group).The primary endpoint was percentage of children with the Face,Legs,Activity,Cry,and Consolability(FLACC)score≤3 points 2 h after *** The comparisons of the FLACC scores at 2,4,6,8,12,and 24 h were not significantly different among the three groups(P>0.05).The sedative effects in the D group were significantly better than those in the S group(P>0.05),but not significantly different from those in the DS *** incidence of nausea and vomiting was significantly lower in the D group than in the S group and DS group(P>0.05).CONCLUSION Analgesic effects of dexmededomidine monotherapy are comparable to those of sufentanil alone or in combination with dexmededomidine for children who underwent laparoscopic unilateral internal inguinal ring ligation,with better sedative effects and a lower incidence of adverse events.

关键词： Child Dexmededomidine Inguinal hernia Pain management Laparoscopy Analgesics

Lichen Planus Pigmentosus Inversus:Two Case Reports

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International Journal of Dermatology and Venereology 2022年第2期5卷 116-118页

作者： se Hoon Lee Minah Cho Yu Jin han Yu Ri Woo Sang Hyun Cho Jeong Deuk Lee Hei Sung Kim Department of Dermatology Incheon St.Mary’s HospitalThe Catholic University of KoreaSeoulSouth Korea Department of Biomedicine&Health Sciences The Catholic University of KoreaSeoulSouth Korea.

Introduction:Lichen planus pigmentosus inversus(LPPI)is a rare a rare variant of lichen planus characterized by hyperpigmented patches with predominating localization in intertriginous *** to its rarity,only a few LPPI cases are *** herein describe two rare cases of *** presentation:The two patients were all with a brownish macular lesion on the intertriginous area.A diagnosis of LPPI was made based on their clinical manifestations,dermoscopic features,and histopathologic features,which revealed an interface change,lichenoid infiltration,and pigmentary ***:LPPI is pruritic or asymptomatic,hyperpigmented macules and patches on the flexural *** axillae and flanks were the most commonly affected areas,followed by the groin and *** half of the female patients had inframammary fold *** shows higher female predominance than Lichen planus *** were fewer cases that lasted more than 3 years compared to ***:LPPI is a rare variant of lichen planus,with a locational characteristic and female ***,in the case of a pigmented disease occurring in the flexural folds,it should be placed in the differential diagnosis.

关键词： lichen planus pigmentosus lichen planus pigmentosus inversus