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Open Journal of Gastroenterology 2024年第3期14卷 93-98页

作者： Sanra Déborah Sanogo Kadiatou Doumbia Hourouma Sow moussa younoussou dicko Youssouf Oumarou Abdoulaye Berthé Sabine Drabo Luc Sidibé Makan Siré Tounkara Abdoulaye Maiga Ouatou Mallé Ganda Soumaré Anselme Konaté moussa Tièmoko Diarra Hepato-Gastroenterology Department CHU Point G Bamako Mali Hepato-Gastroenterology Department CHU Gabriel Touré Bamako Mali Department of Internal Medicine Centre Hospitalier Universitaire Communautaire de Bangui Bangui Central African Republic

Infection with the defective hepatitis D virus (HDV) co-infects or superinfects a patient carrying hepatitis B virus (HBV). Delta virus infection is relatively common. The seriousness of infection with the hepatitis D virus (HDV), a virus defective in a patient carrying the hepatitis B virus (HBV), lies in its aggravating effect on the associated viral hepatitis B. Our aim was to study the serological profile of HDV in HBsAg-positive patients. As this study was fragmentary, we initiated this study with the aim of investigating the serological profile of HDV in HBsAg-positive patients. This was a descriptive and analytical cross-sectional study that ran from March 2019 to February 2020, a 12-month period. It focused on the population of patients seen and screened positive for HBsAg. We obtained a frequency of 10%. The mean age of our patients was 41.8 ± 13.09 years. The sex ratio was 4.5. VHD RNA was detected in 50% of patients. In 100% of cases, the presence of VHD RNA was associated with advanced fibrosis according to the APRI score, but without any statistically significant link. All HBV-infected patients should be screened for anti-HDV Ac. HDV infection leads to rapid progression to complications of liver disease.

关键词： HBsAg VHD RNA Liver Disease

Epidemiological and Serological Profile of Hepatitis B Virus in an Urban Area in Mali

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Open Journal of Gastroenterology 2019年第8期9卷 158-163页

作者： Anselme Konaté H. Sow Wife Coulibaly K. Doumbia Wife Samaké moussa younoussou dicko R. Dembélé Wife Dakouo A. Souckho Wife Kaya Makan Ciré Tounkara Hamadoun Guindo Abdoulaye Maiga Mamadou Dembélé Hamar Alassane Traoré moussa Tiémoko Diarra moussa Youssoufa Maiga Hepato-Gastroenterology Department CHU Gabriel Touré Bamako Mali Department of Internal Medicine of the Point G Hospital Bamako Mali

The objective of our study was to evaluate hepatitis B virus (HBV) infection in an urban population. This longitudinal study was conducted in Bamako District and Kati Commune. After a preparatory phase, the persons who accepted the protocol were assessed for HBsAg. HBsAg carriers had blood collection for HBeAg assay, viral load assessment, genotyping, DNA mutation testing, and severity of hepatic fibrosis and necrosis. At the end of this study, 1475 persons were included, of which 195 had HBsAg positive confirmed, that is to say 13.97%. The mean age of HBsAg positive patients was 35.11 ± 11.12 years with a sex ratio of 2.68. HBeAg was found in 8.9% of the patients tested for this antigen. The viral load was undetectable in 10.52% of patients and greater than 2000 IU/mL in 32.24% of cases. Fibrosis ≥ F2 and necrosis ≥ A2 were found in respectively 19.72% and 6.80% of cases. Genotype E was found in 91.6 patients and an R249S mutation observed in 39.04% of cases. Conclusion: HBV infection has a serious impact on socio-economic development in Mali because it affects mainly the young male population, hence the need to organize preventive measures effectively.

关键词： Hepatitis B Virus Epidemiology Serology Bamako Kati

Anal Pathologies: What Management at the Reference Health Center of Bamako’s Commune V?

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Open Journal of Gastroenterology 2024年第3期14卷 87-92页

作者： Sanra Déborah Sanogo moussa Y. dicko Ousmane Diarra Abou A. Diarra Drissa Katilé Abdoulaye Maiga Ouatou Mallé Sabine Drabo Makan S. Tounkara Hourouma Sow Kadiatou Doumbia Anselme Konaté moussa T. Diarra Hepato-Gastroenterology Department CHU Point G Bamako Mali Service d’hépato-gastroentérologie CHU Gabriel Touré Bamako Mali Hepato-Gastroenterology Unit CSREF Commune V Bamako Mali

Anal pathologies are conditions affecting the anal margin and the anal canal. The aim of our study was to update data on anal diseases. Non-specific, it can reveal an emergency, a serious illness, a chronic disease or a benign condition. It was a prospective, descriptive and analytical study from April 2022 to March 2023, carried out in the hepato-gastroenterology unit of the Centre de Santé de Référence de la commune V du District de Bamako in Mali. Out of seven hundred and forty-nine (749) patients seen in consultation, 98 had anal pathology, i.e. a prevalence of 13.08%. The mean age was 40 ± 15.15 years and the sex ratio was 1.5. Hemorrhoidal disease and anal fissure were the most frequent pathologies in 66.4% and 24.4% of cases respectively. Medical treatment was initiated in 91.9% of patients with hemorrhoidal disease and 91.7% with anal fissure. Anal pathologies are common in young male patients. In our context, they are dominated by benign conditions.

关键词： Anal Pathologies Hemorrhoidal Disease Anal Fissure

Chronic Hepatitis B Virus Infection: Biological Parameters in Patients Treated with Tenofovir Disoproxil Fumarate

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Open Journal of Gastroenterology 2024年第4期14卷 145-151页

作者： Sanra Déborah Sanogo moussa Y. dicko Lamine N’Diaye Ousmane Diarra Drissa Katilé Abdoulaye Maiga Ouatou Mallé Sabine Drabo Makan S. Tounkara Hourouma Sow Kadiatou Doumbia Anselme Konaté moussa T. Diarra Hepato-Gastroenterology Department Centre Hospitalier Universitaire Du Point G Bamako Mali Hepato-Gastroenterology Department Gabriel Toure University Hospital Bamako Mali Hepato-Gastroenterology Unit Csref Commune V Bamako Mali

Chronic hepatitis B causes a liver disease characterized by inflammation of the liver parenchyma. The aim of this study was to investigate the evolution of biological parameters in patients treated with Tenofovir for chronic B infection at the Commune V referral health center in Bamako. We obtained a prevalence of 14.15%. The most represented age group was 31 - 40 years, with 36.8%. The sex ratio was 1.44 in favour of men. Viral load was undetectable after 18 months of treatment in 25 patients (42.37%). Tenofovir, the 1st-line drug in Mali, is effective on the biological parameters monitored in patients.

关键词： Viral Hepatitis B Tenofovir Biological Parameters

Bilharzia Appendicitis: Incidence in a Commune in Mali, about 3CAS

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Surgical Science 2024年第5期15卷 321-329页

作者： Souleymane Bingue Dembélé Yely Dianessy moussa Samake Abdou Guiré Siaka Konaté Ousmane Sy Boubacar Yoro Sidibé Amadou Maïga Thiorno Nadio Boubacar Karembe Amaguiré Saye Sirama Diarra Dorcas Sodjiné Yede Issiaka Diarra Ibrahima Maiga Mahamane dicko moussa Konaté Aliou Bina Diarra Bakary Tientigui Dembélé General Surgery Department of the District Hospital of Commune IV of Bamako Bamako Mali Kolondié ba Reference Health Centre Sikasso Mali Epidemiology and Clinical Research Bamako Mali General Surgery Department of Gabriel Touré University Hospital Bamako Mali Ophthalmology Department of the District Hospital of Commune IV of Bamako Bamako Mali Gynecology and Obstetrics Department of the District Hospital of Commune IV of Bamako Bamako Mali Commune I of the District of Bamako Reference Health Centre Bamako Mali Imaging Department of the District Hospital of Commune IV of Bamako Bamako Mali Commune VI of the District of Bamako Reference Health Centre Bamako Mali Anotomy-Pathology Department of the G Point University Hospital Bamako Mali

Appendicitis bilharzia is a very rare condition and we report 3 cases of this pathology that sense clinical and biological similarities with bacterial appendicitis. The etiological diagnosis was exclusively histopathological, this allowed to highlight eggs of Schistosome in the appendicular wall in the three patients. The surgical treatment was supplemented by a specific medical treatment based on praziquantel. The surgical suites were simple for 2 patients, complicated by superficial parietal suppuration in a patient.

关键词： Bilharzial Appendicitis Endemic Histopathology Specific Antiparasitic Treatment

Clipping Effect on Growth and Plant Water Use Response to Diurnal Variation of Vapor Pressure Deficit in Cenchrus biflorus Roxb

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Journal of Agricultural Chemistry and Environment 2024年第2期13卷 183-191页

作者： moussa Oumarou Abdoulaye Issoufou Hassane Bil-Assanou Soulé moussa Mainassara Zaman-Allah Laboratory Ecology and Management of Sahelo-Saharan Biodiversity Department of Biology Faculty of Science and Techniques Andr&#233 Salifou University Zinder Niger Department of Biology Faculty of Sciences and Techniques Dan Dicko Dankoulodo University of Maradi Maradi Niger Department of Science and Technology of Plant Production Faculty of Agronomy and Environmental Sciences Dan Dicko Dankoulodo University of Maradi Maradi Niger

Cenchrus biflorus called Karangiya in the Hausa language is an annual pastoral grass which is a valuable herbaceous fodder in dry land region in the context of climate change. However, little is known about the plant water use under the effects of cut in West Africa Sahel like Niger where the plant is a multipurpose grass species. Therefore, this study investigated the impact of grazing (simulated by shoot cuts) on biomass production. Cenchrus biflorus Roxb was grown on field plots and in pots and subjected to shoot cuts at different levels (3 cm and 5 cm from soil surface). The effect of shoot cuts on drought tolerance was evaluated by assessing the response of transpiration to the diurnal variation of vapor pressure deficit (VPD). Results showed that the biomass production varied in response to shoot cuts depending on the culture system, and the level or frequency of cuts. The mean biomass production increased significantly especially in field plots for 5 cm cuts compared to those at 3 cm and the control treatment. In addition, transpiration was highly increased in response to the VPD increase. Shoot cuts significantly reduced transpiration, whatever the level, largely because they reduced leaf surface. We concluded that moderate grazing (cuts to 5cm) can improve biomass production and allow better adaptation to water deficit as they significantly reduced water loss through transpiration. The study recommends the cropping of the Cenchrus biflorus as climate solution as it performs better under water deficit for improving grazing resilience in Niger.

关键词： Cenchrus biflorus Biomass Vapor Pressure Deficit Cutting Grazing

Knowledge Practical Attitude of Health Professionals on Breast Cancer at the Hospital of the District of the Commune IV of Bamako

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Surgical Science 2024年第5期15卷 342-356页

作者： moussa Samaké Souleymane B. Dembelé Sirama Diarra Yely Dianessy Abdou Guiré Dorcas Laurel Sodjiné Yede Amaguiré Saye Brahima Dembele Birama Traoré Thierno Nadio Ibrahima Maiga Mahamane dicko Modibo Diarra Siaka Konaté Amadou Maiga Bakary Tientigui Dembele Adégné Togo General Surgery Department of Bamako District IV Hospital Bamako Mali Obstetric Gynecology Department of the Bamako District IV Hospital Bamako Mali Department of Ophthalmology of the Hospital of the District of the Commune IV of Bamako Bamako Mali Imaging Service of the Bamako District IV Hospital Bamako Mali Anesthesia and Resuscitation Service of the Hospital of the District of the Commune IV of Bamako Bamako Mali Internal Medicine Department of the District Hospital of Commune IV of Bamako Bamako Mali General Surgery Department Kolondjeba Referral Health Centre Sikasso Mali General Surgery Department of the Gabriel Touré University Hospital Bamako Mali

Introduction: The level of knowledge and attitude of health professionals about breast cancer are important determinants. General objective: To study the knowledge, attitude and practice of health professionals of the hospital of the district of the commune IV on breast cancer. Methodology: This was a cross-sectional, prospective, descriptive, qualitative and quantitative study. The study period was from 01 October 2022 to December 2022. Results: In one week of survey, 110 health workers (intern, obstetrician nurse, general practitioners and specialists) received the survey sheet, 80 health workers informed it, a participation rate of 73%. The male sex was most represented at 63.75% with a sex ratio of 1.76. The average age was 39.59 years with extremes of 22 and 61 years. The clinical signs evoked by the participants were: breast nodule (81.25%), followed by breast discharge (48.75%). In relation to risk factors: interns and obstetrician nurses had no good knowledge, 51.72% of general practitioners had good knowledge, 43.48% of specialist doctors had good knowledge, and 5.88% of the wise had good knowledge. Conclusion: Breast cancer is a common pathology around the world, health professionals are at the forefront of the fight against breast cancer, and this fight cannot be effective without trained personnel.

关键词： Knowledge Attitude Practice Health Personnel Breast Cancer

Liposarcoma Retro-Peritoneal in the General Surgery Department of the Hospital of the District of the Commune IV

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Surgical Science 2024年第7期15卷 430-437页

作者： moussa Samaké Souleymane Bingué Dembelé Yely Dianessy Abdou Guiré Dorcas Laurel Sodjiné Yede Youssouf Boiré Mahamane dicko Mantia Sara Nouhoum Sanogo Amaguiré Saye Sirama Diarra Brahima Dembele Thierno Nadio Ibrahima Maiga Modibo Diarra Siaka Konaté Birama Cheick Traoré Boubacar Diassana Bathio Traoré Amadou Maiga Boubacar Yoro Sidibé Adégné Togo General Surgery Department of Bamako District IV Hospital Bamako Mali Anesthesia and Resuscitation Service of the Hospital of the District of the Commune IV of Bamako Bamako Mali Anatomopathology Department of the CHU of Point G Bamako Mali Obstetric Gynecology Department of the Bamako District IV Hospital Bamako Mali Department of Ophthalmology of the Hospital of the District of the Commune IV of Bamako Bamako Mali Imaging Service of the Bamako District IV Hospital Bamako Mali Internal Medicine Department of the District Hospital of Commune IV of Bamako Bamako Mali General Surgery Department Kolondjeba Referral Health Centre Sikasso Mali Gynecology and Obstetrics Department of the San Reference Health Center Segou Mali General Surgery Department of Sikasso Hospital Sikasso Mali General Surgery Department of the Gabriel Tour University Hospital Bamako Mali

Retroperitoneal soft tissue sarcomas in the retroperitoneal/intra-abdominal regions represent 10% - 15% of all cases of soft tissue sarcoma. Liposarcomas, which are the most common histological type, account for 20% - 45% of retroperitoneal/intra-abdominal sarcoma cases, and 20% of liposarcomas cases are primary retroperitoneal liposarcomas. Surgical resection in case of malignancy remains the treatment of choice for liposarcomas, according to the guidelines of most major international companies. Our goal was to improve the management of retroperitoneal liposarcoma. This was a 65-year-old patient, with no medical or surgical history, who was referred to us for abdominal swelling, in whom clinical and paraclinical examination found retroperitoneal liposarcoma stage IV, and the surgical treatment consisted in making a tumor reduction. Conclusion: Retro-peritoneal liposarcoma is an undervalued malignant tumor, and the diagnosis is often late.

关键词： Retroperitoneal Liposarcoma Diagnostic Delay

Characteristics of Gold and Its Mineralization Style in the Boulon Djounga Eastern Perimeter of Liptako Mining Company (Central Southwestern Niger)

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Natural Resources 2024年第1期15卷 28-50页

作者： Gambo Ranaou Noura Kamayé Tourba Karimou Dia Hantchi Bouba Hassane moussa Konaté Department of Geology Faculty of Science and Techniques Abdou Moumouni University Niamey Niger Department of Geology Faculty of Science and Techniques Dan Dicko Dankoulodo University Maradi Niger

The Boulon Djounga eastern perimeter is part of the Tiawa operating permit of the Société des Mines du Liptako (SML), located in the central southwestern part of Liptako (Niger). In this study, we used field data, Reverse Circulation (RC) surveys and chemical analyzes of gold to determine the characteristics of gold and its mineralization style. The eastern perimeter of Boulon Djounga is represented by a succession of metabasalts and metasediments both intersected by intrusions of quartz and dolerite dykes, and covered by sandstone and clayey rocks. Gold is present in low contents (0.00 - 0.30 ppm) in the sedimentary cover and in medium (0.30 - 1.00 ppm) or high contents (1.00 - 4.534 ppm) in the metasediments, and in the gray quartz veins and locally in the volcanics. It exists in a disseminated state or in a concentrated state in the surrounding areas in the form of discrete grains associated with sulphurous minerals (pyrite: FeS2, chalcopyrite: CuFeS2 or arsenopyrite: FeAsS). The presence of gold in the quartz veins, and the NE-SW and NW-SE orientations of the ore bodies suggest that the eastern Boulon Djounga gold mineralization would be established during a late magmatic extensive phase.

关键词： Liptako Gold Mineralization Metasediments-Volcanics Quartz Veins Sulphurous Minerals Niger

Sickle Cell Disease in the Zinder Region in 2023: Prevalence and Sociodemographic Factors

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Open Journal of Blood Diseases 2024年第1期14卷 1-7页

作者： Brah Moustapha Maman Amadou Djibrilla-Almoustapha Moustapha Elhadji-Chefou Illa Hamidine moussa Diongolé Hassane Badé Malam-Abdou Department of Medicine Université André Salifou de Zinder Zinder Niger Department of Medicine H&#244pital National de Zinder Zinder Niger Department of Medicine Université Abdou Moumouni de Niamey Niamey Niger Department of Medicine Université Dan Dicko Dan Koulodo de Maradi Maradi Niger

Introduction: In view of the number of sickle cell patients and due to a low production of descriptive studies, we decided to determine the prevalence of genes S and C of the disease in the Zinder region. The objective was to contribute to improving the management of sickle cell disease in Zinder. Methodology: This was a systematic screening by the “Sickle Scan” test of any blood donor admitted to the Zinder Regional Blood Transfusion Center during the 6-month study period, from January to June 2023. The Sickle Scan is a qualitative lateral flow chromatography immunoassay using whole blood samples that aid in the rapid diagnosis of sickle cell disease. Results: The study was carried out on 613 samples during the period concerned. The frequency of sickle cell genes was 26.9% (n = 165) in all samples collected, with 23.1% (n = 142) and 3.8% (n = 23) for the S gene and the C gene, respectively. The 18 - 30 age group was the most represented with 64.4% (n = 395) cases. The median age of blood donors was 26 years ± 10 years (min = 18 years/max = 60 years). The sex ratio was 2.5. Donors of Nigerien nationality accounted for 84.1% (n = 516). There is a predominance of blood donors with an average monthly income between 34,000 and 70,000 CFA francs in 44.3% (n = 272), lived in permanent housing with drinking water supply. Sickle cell trait (SMA) was found in 22.5% (n = 138). Conclusion: The analysis of these results highlights a high frequency of the S gene for sickle cell disease. The population with an average monthly income is the most affected, with a male predominance.

关键词： Sickle Cell Anemia Blood Donors Sickle Scan