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Real-world data on ALK rearrangem.nt test in Chinese advanced non-sm.ll cell lung cancer(RATICAL):a nationwide m.lticenter retrospective study

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Cancer Com.unications 2024年第9期44卷 992-1004页

作者： Lin Li Wencai Li ChunyanWu Yanfeng Xi Lei Guo Yuan Ji Lili Jiang Ji Li Jingping Yun Gang chen Yuan Li Yueping Liu Dianbinm. Yuchen Han Leina Sun Qingxin Xia Xiaodong Teng Nanying che WeiWu Xueshan Qiu Chao Liu Xiaochu Yan Daiqiang Li Zhihong Zhang ZheWang Yujun Li ZhengWang Lingchuan Guo Xiu Nie Jingshu Geng Jianhua Zhou Jianm.ng Ying Departm.nt of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking UnionMedical CollegeBeijingP.R.China Departm.nt of Pathology the First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Departm.nt of Pathology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiP.R.China Departm.nt of Pathology Cancer Hospital Affiliated to Shanxi Medical UniversityShanxi Province Cancer HospitalShanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical SciencesTaiyuanShanxiP.R.China Departm.nt of Pathology Zhongshan HospitalFudan UniversityShanghaiP.R.China Departm.nt of Pathology West China Hospital of Sichuan UniversityChengduSichuanP.R.China Departm.nt of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Departm.nt of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Departm.nt of Pathology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianP.R.China Departm.nt of Pathology Department of OncologyFudan University Cancer CenterShanghaiMedical College of Fudan UniversityShanghaiP.R.China Departm.nt of Pathology The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebeiP.R.China Departm.nt of Pathology Shandong Cancer HospitalJinanShandongP.R.China Departm.nt of Pathology Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiP.R.China Departm.nt of Pathology Tianjin Medical University Cancer Institute and HospitalTianjinP.R.China Departm.nt of Pathology the Affiliated Cancer Hospital of Zhengzhou UniversityHenan Provincial Cancer HospitalZhengzhouHenanP.R.China Departm.nt of Pathology the First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiangP.R.China Departm.nt of Pathology Bei

Background:Anaplastic lym.hom. kinase(ALK)test in advanced non-sm.ll cell lung cancer(NSCLC)can help physicians provide target therapies for patients harboring ALK gene *** study aim.d to investigate the real-world test patterns and positive rates of ALK gene rearrangem.nts in advanced ***:In this real-world study(ChiCTR2000030266),patientswith advanced NSCLC who underwent an ALK rearrangem.nt test in 30 m.dical centers in China between October 1,2018 and Decem.er 31,2019 were retrospectively *** training was conducted before the study was *** controls were perform.d at participating centers using im.unohistochem.stry(IHC)-*** positive ALK gene rearrangem.nt rate and consistency rate were *** associated clinicopathological characteristics of ALK gene rearrangem.nt were investigated as ***:The overall ALK gene rearrangem.nt rate was 6.7%in 23,689 patients with advanced NSCLC and 8.2%in 17,436 patients with advanced lung *** quality control analysis of IHC-VENTANA-D5F3 revealed an intrahospital consistency rate of 98.2%(879/895)and an inter-hospital consistency rate of 99.2%(646/651).IHC-VENTANA-D5F3 was used in 53.6%,real-tim. polym.rase chain reaction(RT-PCR)in 25.4%,next-generation sequencing(NGS)in 18.3%,and fluorescence in-situ hybridization(FISH)in 15.9%in the adenocarcinom. *** specim.ns tested with m.ltiple m.thods,the consistency rates confirm.d by IHC-VENTANA-D5F3 were 98.0%(822/839)for FISH,98.7%(1,222/1,238)forNGS,and 91.3%(146/160)for *** overall ALK gene rearrangem.nt rateswere higher in fem.les,patients of≤35 years old,never sm.kers,tum.r cellularity of>50,and m.tastatic specim.ns used for testing in the total NSCLC population and adenocarcinom. subgroup(all Pm.nstrating a predom.nant use of IHCVENTANA-D5F3 with high co

关键词： anaplastic lym.hom. kinase diagnosis gene fusion non-sm.ll cell lung cancer

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基于0.15μm.GaN工艺的输入输出谐波调谐高效率功率放大器设计

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电子学报 2024年第7期52卷 2320-2330页

作者：蔡奇朱浩慎曾丁元王希瑶薛泉车文荃南京邮电大学通信与信息工程学院江苏南京210023 华南理工大学电子与信息学院广东广州510641 东南大学毫米波国家重点实验室江苏南京211189

文章提出了一种面向毫米波应用的基于谐波调谐的单片集成(m.nolithic m.crowave Integrated Circuit,m.IC)功率放大器(Power Am.lifier,PA).通过在晶体管输入和输出端对谐波终端进行控制,m.IC PA可以在高频实现高效率性能.本文提出的输... 详细信息

文章提出了一种面向毫米波应用的基于谐波调谐的单片集成(m.nolithic m.crowave Integrated Circuit,m.IC)功率放大器(Power Am.lifier,PA).通过在晶体管输入和输出端对谐波终端进行控制,m.IC PA可以在高频实现高效率性能.本文提出的输出网络在匹配基频阻抗的同时,可以控制二次和三次谐波阻抗.此外,为了进一步提升功放效率,输入端的二次谐波阻抗也进行了调谐.在0.15μm.化硅基氮化镓(Gallium.Nitride on Silicon Carbide,GaNon-SiC)工艺上对所提出的功放架构和设计方法进行了仿真和测试验证.测试结果表明,PA在21.4~23 GHz的频带范围内,功率附加效率(Power Added Efficiency,PAE)大于39.2%,输出功率大于33 dBm.而PA工作频率为22.2 GHz时,测试的漏极效率最大达到63.7%,对应的PAE为50.2%,输出功率为34.1 dBm.仿真和测试结果基本吻合.整体电路尺寸只有1.87 m.^(2),因此单位面积的输出功率为1.31 W/m.^(2).和其他工作相比,本文提出的功放实现了较高的效率和功率密度.

关键词：漏极效率氮化镓功放二次和三次谐波调谐输入谐波调谐

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Water m.ss characteristics in the western North Pacific based on a stream.unction projection

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Science China Earth Sciences 2015年第11期58卷 2067-2077页

作者： m. Xiao SUN che Institute of Oceanology Chinese Academy of Sciences College of Earth Sciences University of Chinese Academy of Sciences

A stream.unction projection m.thod called gravest em.irical m.de(GEm. is applied to the hydrographic section at 137°E to filter out eddy noises in the western North Pacific and derive quantitative ensem.le-average water m.ss properties in the North Equatorial Current region. The GEm.fields capture m.re than 80% of total property variances in the therm.cline layer. The core layer structures of key water m.sses, including the North Pacific Tropical Water(NPTW) and the North Pacific Interm.diate Water(NPIW), are exam.ned with a definition of water m.ss boundary based on property gradient. It shows that a tongue of m.xim.l root-m.an-square(Rm.) residual exists in the upper half of NPIW for all water properties. These subsurface Rm. tongues appear to be close to sharp property gradients. It is the first tim. a GEm.diagnosis is applied to nutrient data, which reveals a drastic difference of N/P reaction rate ratio above and below the m.xim.l-nutrient core at 1250 m. Additionally, a GEm.velocity reconstruction successfully produces the North Equatorial Undercurrent(NEUC), dem.nstrating the stable therm.l-wind nature of this newly-discovered current.

关键词： stream.unction projection gravest em.irical m.de water m.sses western North Pacific

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随掘地震地质构造精细监测在山西王坡煤矿的应用

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煤田地质与勘探 2024年第6期52卷 137-144页

作者：赵会波覃思陈超关奇赵星伟车建航山西天地王坡煤业有限公司山西晋城048021 中煤科工西安研究院(集团)有限公司陕西西安710077 煤炭智能开采与岩层控制全国重点实验室陕西西安710077

【目的】传统巷道地震超前探技术受限于炸药使用、停掘需求、预报速度、探测范围及能力等方面的不足,难以满足智能掘进工作面的高精度地质构造探测需求。【方法】随掘地震以掘进机截割煤壁的震动为震源,采用数据实时上传、自动处理及动... 详细信息

【目的】传统巷道地震超前探技术受限于炸药使用、停掘需求、预报速度、探测范围及能力等方面的不足,难以满足智能掘进工作面的高精度地质构造探测需求。【方法】随掘地震以掘进机截割煤壁的震动为震源,采用数据实时上传、自动处理及动态成像的工作模式,充分利用信息技术和软件支撑,借助于海量数据支撑下的实时连续超饱和叠加,大幅提升了对掘进工作面前方地质异常体的成像精细度。以山西王坡煤矿为研究对象,在2条掘进巷道中部署了随掘地震监测系统,开展地质构造精细探查。【结果和结论】实际工作中,利用监测作业开展后48 h内积累的数据,即可对掘进工作面前方200 m.围内地质异常体成像。在3217工作面回风巷中,成功揭示了掘进工作面前方97 m.矸石挤压带反射异常,预报误差1 m.在3303工作面运输巷中,揭示了掘进工作面前方39 m.陷落柱,预报误差2 m.在3303工作面运输巷中,揭示了2处煤层破碎带异常区,其中,一处位于掘进工作前方148 m.预报误差1 m.另一处位于掘进工作面前方211 m.,在前序陷落柱和煤层破碎带遮挡下,依然足以形成较强的成像结果,预报误差3 m.结果表明:该技术探测精度高、探测距离远且探测能力强,可为瓦斯灾害的防治提供技术支持,为煤矿巷道安全高效掘进提供可靠的地质保障。

关键词：矿井安全随掘地震地质构造煤层破碎带挤压带陷落柱

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降水和地下水开采对通辽市科尔沁区潜水位的影响

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吉林大学学报（地球科学版） 2024年第3期54卷 954-966页

作者：束龙仓张彤豪澈丽木格刘圣昱刘波河海大学水文水资源学院南京210098 河海大学水灾害防御全国重点实验室南京210098 通辽市水利事业发展中心内蒙古通辽028000

变化环境下(气候变化和人类活动)潜水位动态演化过程识别是当前我国乃至全球水资源领域面临的主要科学问题。为了分析多影响因素下的潜水位时空动态变化,以降水和地下水开采为例,基于通辽市科尔沁区2016年1月—2019年12月实测地下水位... 详细信息

变化环境下(气候变化和人类活动)潜水位动态演化过程识别是当前我国乃至全球水资源领域面临的主要科学问题。为了分析多影响因素下的潜水位时空动态变化,以降水和地下水开采为例,基于通辽市科尔沁区2016年1月—2019年12月实测地下水位动态数据,采用m.nn-Kendall(m.)趋势检验和栅格代数法分析了区域潜水位的时空变化规律,并利用交叉小波分析、斯皮尔曼相关系数和多元线性回归法进一步量化分析了不同区域降水和地下水开采对潜水位的影响。结果表明:研究时段内科尔沁区潜水位总体呈下降趋势,年均降幅为0.36 m.中部和西部地区潜水位下降较为严重;根据潜水位差值空间分布特征,将研究区划分为潜水位基本平衡区、下降区和严重下降区,其分别占研究区总面积的9.88%、49.65%和40.47%;基本平衡区的潜水位受降水因素影响显著,受地下水开采变化影响极小,下降区和严重下降区潜水位受地下水开采的影响相较于降水影响更大。

关键词：通辽市科尔沁区潜水位动态降水地下水开采交叉小波

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Long-term.trends in the abundance and breeding perform.nce in Adélie penguins:the Argentine Ecosystem.m.nitoring Program

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Advances in Polar Science 2024年第1期35卷 132-140页

作者： m.riana A.JUÁRES Anahím.SILVESTRO Brenda C.ALFONSO m.m.rcedes SANTOS Departam.nto Biología de Predadores Tope Instituto Antártico Argentino(IAA)Buenos Aires B1650CSPArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Buenos Aires C1425FQBArgentina Laboratorios Anexos Facultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataLa Plata B1904AMAArgentina INEDES(CONICET-UNLu) Buenos Aires C1425FQBArgentina Facultad de Ciencias Naturales y m.seo Universidad Nacional de La PlataLa Plata B1900FWAArgentina Instituto Antártico Argentino(IAA) Buenos Aires B1650CSPArgentina

In this work,we report long-term.trends in the abundance and breeding perform.nce of Adélie penguins(Pygoscelis adeliae)nesting in three Antarctic colonies(i.e.,at m.rtin Point,South Orkneys Islands;Stranger Point/Cabo Funes,South Shetland Islands;and Esperanza/Hope Bay in the Antarctic Peninsula)from.1995/96 to 2022/*** yearly count data of breeding groups selected,we observed a decline in the num.er of breeding pairs and chicks in crèche at all colonies ***,the m.gnitude of change was higher at Stranger Point than that in the rem.ining ***,the index of breeding success,which was calculated as the ratio of chicks in crèche to breeding pairs,exhibited no apparent trend throughout the study ***,it displayed greater variability at m.rtin Point com.ared to the other two colonies under *** the num.er of chicks in crèche of Adélie penguins showed a declining pattern,the average breeding perform.nce was sim.lar to that reported in gentoo penguin colonies,specifically,those undergoing a population increase(even in sym.atric colonies facing sim.lar local conditions).Consequently,it is plausible to assum. a reduction of the over-winter survival as a likely cause of the declining trend observed,at least in the Stranger Point and Esperanza ***,we cannot rule out local effects during the breeding season affecting the Adélie population of m.rtin Point.

关键词： long-term.m.nitoring Adélie penguin breeding pairs chicks crèched breeding success population trends

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m.soporous Silica m.crospheres Com.osited with SBA-15s for Resonance Frequency Reduction in a m.niature Loudspeaker

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chem.cal Research in Chinese Universities 2020年第5期36卷 760-767页

作者： ZHANG Xinyue che Shunai School of chem.stry and chem.cal Engineering State Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240P.R.China

m.crospheres com.osited with m.soporous SBA-15 particles and silica were investigated as fillers in m.niature loudspeakers to study the factors influencing the resonance frequency offsets(RFOs).m.soporous silica m.crospheres(m.m.)were prepared by self-assem.ling SBA-15 m.soporous silica in a m.croem.lsion synthesis *** form.tion process involved the fabrication of a stable O/W m.croem.lsion of tetrabutyl orthosili-cate(TBOS)and hexadecyltrim.thylam.onium.brom.de(C16TAB)and encapsulation of *** RFO increased and then decreased with increasing particle size(in the length range of 0.7—5.5 μm.and in the width range of 0.2—0.45 μm.,increased with increasing pore size(in the range of 7.0—9.4 nm.of SBA-15s,and increased with decreasing particle size(105—900 μm.of m.m..

关键词： m.soporous silica m.crosphere m.croem.lsion SBA-15 Resonance frequency offset

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Density fluctuations in baryon-rich quark m.tter

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Nuclear Science and Techniques 2016年第6期27卷 17-24页

作者： che m.ng Ko Feng Li Cyclotron Institute and Departm.nt of Physics and Astronom. Texas A&M UniversityCollege Station

At finite baryon chem.cal potential,the density of a quark m.tter develops large fluctuations when it undergoes a first-order phase *** on the transport equation derived from.the Nam.u–Jona-Lasinio(NJL) m.del,we have studied the density fluctuations in a baryon-rich quark m.tter that is confined in a finite *** the expansion of the quark m.tter using initial conditions from.either a blast wave m.del or a m.ltiphase transport(Am.T) m.del,we have further studied the survivability of the density fluctuations as the density and tem.erature of the quark m.tter *** experim.ntal signatures of the density fluctuations are suggested.

关键词：密度涨落夸克物质重子输运方程一级相变体积密度 Am.T 可生存性

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m.BCJR Algorithm.with Channel Shortening Based on Ungerboeck Observation m.del for Faster-than-Nyquist Signaling

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China Com.unications 2021年第4期18卷 88-98页

作者： Hui che Yong Bai School of Inform.tion and Com.unication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China School of Inform.tion and Com.unication Engineering Hainan UniversityHaikou 570228China

The m.BCJR algorithm.based on the Ungerboeck observation m.del is a recent study to reduce the com.utational com.lexity for faster-than-Nyquist(FTN)signaling[1].In this paper,we propose a m.thod that can further reduce the com.lexity with the approxim.tely sam. or better bit error rate(BER)perform.nce com.ared to[1].The inform.tion rate(IR)loss for the proposed m.thod is less than 1%com.ared to the true achievable IR(AIR).The proposed im.rovem.nt is m.inly by introducing channel shortening(CS)before the m.BCJR *** our proposal,the Ungerboeck m.BCJR algorithm.and CS can work together to defeat severe inter-sym.ol interference(ISI)introduced by FTN *** ISI length for the m.BCJR algorithm.with CS is optim.zed based on the criterion of the IR *** the two cases=0.5 and=0.35,com.ared to Ungerboeck m.BCJR without CS benchm.rk[1],the com.utational com.lexities of Ungerboeck m.BCJR with CS are reduced by 75%.m.reover,for the case=0.35,the BER perform.nce of Ungerboeck m.BCJR with CS outperform. that of the conventional m.BCJR in[1]at the low signal to noise ratio region.

关键词： m.BCJR Ungerboeck m.del channel shortening FTN reduced-com.lexity turbo equalization

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一种街景图像中建筑物高度估算方法

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遥感信息 2024年第3期39卷 1-6页

作者：戈士博刘纪平王勇车向红中国测绘科学研究院北京100036

建筑物高度信息是城市三维建模的基础数据,但已有的建筑物高度估算研究多采用LiDAR和SAR等遥感影像。随着计算机和互联网的快速发展,街景数据因采集容易和成本低等特点成为了一种新兴的建筑物高度估算数据源。文章提出一种街景图像中建... 详细信息

建筑物高度信息是城市三维建模的基础数据,但已有的建筑物高度估算研究多采用LiDAR和SAR等遥感影像。随着计算机和互联网的快速发展,街景数据因采集容易和成本低等特点成为了一种新兴的建筑物高度估算数据源。文章提出一种街景图像中建筑物高度估算方法,首先利用segm.nt anything m.del实现图像中建筑物像素高度提取;然后利用图像元数据和电子地图数据获取建筑物与相机之间的距离、图像焦距,根据街景图像与建筑物实体的几何关系改进针孔相机模型,构建建筑物高度估算方法;最后选取北京、柏林的m.pillary街景图像开展实验验证。结果表明,与改进前相比,改进后针孔相机模型明显提升了高度估算准确度,Rm.E降低了11.31 m.R^(2)提高了0.4,具备实用价值。

关键词：街景图像建筑物高度估算针孔相机模型 segm.nt anything m.del m.pillary

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