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Airway ultrasound for patients anticipated to have a difficult airway:Perspective for personalized medicine

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World Journal of Clinical Cases 2023年第9期11卷 1951-1962页

作者： Harumasa Nakazawa Kohji Uzawa Joho Tokumine Alan Kawarai Lefor Akira motoyasu Tomoko Yorozu Department of Anesthesiology Kyorin University School of MedicineMitaka 181-8611TokyoJapan Department of Surgery Jichi Medical UniversityShimotsuke 329-0498TochigiJapan

Airway ultrasound allows for precise airway evaluation,particularly for assessing the difficult airway and the potential for front of neck *** studies have shown that identification of the cricothyroid membrane by airway ultrasound is more accurate than digital ***,no reports to date have provided clinical evidence that ultrasound identification of the cricothyroid membrane increases the success rate of *** is a narrative review which describes patients with difficult airways for whom airway ultrasound may have been useful for clinical decision *** role of airway ultrasound for the evaluation of difficult airways is summarized and an approach to the use of ultrasound for airway management is *** goal of this review is to present practical applications of airway ultrasound for patients predicted to have a difficult airway and who undergo cricothyroidotomy.

关键词： Airway ultrasound Difficult airway Point-of-care ultrasound Cricothyroidotomy Intubation Mask ventilation

Combination therapy with daclatasvir and asunaprevir for dialysis patients infected with hepatitis C virus

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World Journal of Clinical Cases 2016年第3期4卷 88-93页

作者： Ken Sato Yuichi Yamazaki Tatsuya Ohyama Takeshi Kobayashi Norio Horiguchi Satoru Kakizaki motoyasu Kusano Masanobu Yamada Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Department of Gastroenterology Heisei Hidaka Clinic Department of Endoscopy and Endoscopic Surgery Gunma University Hospital

The standard antiviral therapy for dialysis patients infected with hepatitis C virus(HCV) is(pegylated) interferon monotherapy, but its efficacy is insufficient. Oral direct-acting antiviral agents(DAAs) have recently been developed for chronic hepatitis C patients. However, some DAAs have contraindications for chronic renal failure(CRF). Daclatasvir and asunaprevir are metabolized largely in the liver and are not contraindicated in CRF. Combination therapy with daclatasvir and asunaprevir was used for 4 dialysis patients infected with genotype 1b HCV. One patient had viral breakthrough, and the 3 others had sustained virological response 12. One patient was admitted for heart failure and percutaneous coronary intervention due to concomitant ischemic disease. Heart failure was unlikely to be caused by the combination therapy, as it was probably due to water overload. The patient continued to receive the combination therapy after the remission of the heart failure. The combination therapy was well tolerated in the other patients.

关键词： Hepatitis C Oral drug Daclatasvir Asunaprevir Dialysis

Effects of Agricultural Machine Fuel Consumption on Paddy Fields

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Journal of Agricultural Science and Technology(B) 2017年第3期7卷 170-178页

作者： Shinsuke Konno Hayato Shindo Mitsuhiko Katahira motoyasu Natsuga Yamagata University 1-23 Wakabamachi Tsuruoka Yamagata 998-8555 Japan Akita Agricultural Experiment Station Yuwa Akita 010-0864 Japan

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导热硅橡胶及其模塑产品

弹性体 2000年第3期10卷 59-60页

作者： Nakanishi,motoyasu

本专利介绍了一种导热硅橡胶及其模塑产品的制备。该组成物包括导热硅橡胶填料和其他导热填料。

关键词：模塑硅橡胶组成物导热填料制备专利产品

MK-0626,a selective DPP-4 inhibitor,attenuates hepatic steatosis in ob/ob mice

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World Journal of Gastroenterology 2014年第43期20卷 16227-16235页

作者： Tatsuya Ohyama Ken Sato Yuichi Yamazaki Hiroaki Hashizume Norio Horiguchi Satoru Kakizaki Masatomo Mori motoyasu Kusano Masanobu Yamada Department of Medicine and Molecular Science Gunma University Graduate School of MedicineGunma 371-8511Japan Department of Endoscopy and Endoscopic Surgery Gunma University HospitalGunma 371-8511Japan

AIM:To investigate the mechanism and in vivo effects of MK-0626,a dipeptidyl peptidase-4 inhibitor,on hepatic steatosis using ob/ob ***:We analyzed obese(ob/ob)8-wk-old male mice that had been randomly divided into two groups of ob/ob mice(n=16 each)and were treated with1.5 or 3 mg/kg MK-0626 and two control groups of untreated ob/ob mice and lean littermates(n=16 each).All mice were fed a normal chow diet with or without MK-0626 for either four or eight *** samples were collected,and total hepatectomy was ***:The administration of dietary MK-0626 ameliorated the hepatic lipid accumulation in ob/ob micetreated with 3 mg/kg MK-0626(3 MK),P<0.05,vs untreated ob/ob mice(ob/ob).The MK-0626 treatment reduced the serum alanine aminotransferase levels(both treatment groups,P<0.05 vs ob/ob)and glucoses/insulin levels/calculated HOMA scores(1.5 MK,P<0.05vs ob/ob;3 MK,P<0.01 vs ob/ob)and increased the serum adiponectin levels(3 MK,P<0.05 vs ob/ob)in a dose-dependent *** MK-0626 treatment increased the m RNA expression of peroxisome proliferator-activated receptorα/microsomal triglyceride transfer protein(1.5 MK,P<0.05 vs ob/ob;3 MK,P<0.01vs ob/ob)but reduced the sterol regulatory element binding transcription factor-1c/fatty acid synthase/stearoyl-Co A desaturase-1(both treatment groups,P<0.01 vs ob/ob).The MK-0626 treatment increased the activity of AMP-activated protein kinase(AMPK)(both treatment groups,P<0.01 vs ob/ob).CONCLUSION:MK-0626 could attenuate hepatic steatosis through enhancing AMPK activity,inhibiting hepatic lipogenic gene expression,enhancing triglyceride secretion from liver and increasing serum adiponectin levels.

关键词： Dipeptidyl peptidase-4 inhibitor Hepatic steatosis

Probable case of drug reaction with eosinophilia and systemic symptom syndrome due to combination therapy with daclatasvir and asunaprevir

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World Journal of Clinical Cases 2015年第12期3卷 1005-1010页

作者： Takayoshi Suga Ken Sato Yuichi Yamazaki Tatsuya Ohyama Norio Horiguchi Satoru Kakizaki motoyasu Kusano Masanobu Yamada Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Department of Endoscopy and Endoscopic Surgery Gunma University Hospital

A 66-year-old, interferon-ineligible, treatment-naive man who was diagnosed with chronic hepatitis C due to hepatitis C virus genotype 1b began combination therapy with daclatasvir and asunaprevir. On day 14 of treatment, hepatic reserve and renal function deterioration was observed, while his transaminase levels were normal. Both daclatasvir and asunaprevir were discontinued on day 18 of treatment, because the patient complained of dark urine and a rash on his trunk and four limbs. After discontinuing antiviral therapy, the abnormal laboratory finding and clinical manifestations gradually improved, without recurrence. Our case fulfilled the diagnostic criteria of probable drug reaction with eosinophilia and systemic symptom(DRESS) syndrome. Despite the 18-d treatment, sustained virological response 12 was achieved. Based on the clinical course, we concluded that there was a clear cause-and-effect relationship between the treatment and adverse events. To our knowledge, this patient represents the first case of probable DRESS syndrome that includes concomitant deterioration of hepatic reserve and renal function due to combination therapy with daclatasvir and asunaprevir, regardless of normalization of transaminase levels. Our case suggests that we should pay attention not only to the transaminase levels but also to allergic symptoms associated with organ involvement during combination therapy with daclatasvir and asunaprevir.

关键词： Hepatitis C Daclatasvir Renal dysfunction Asunaprevir Hepatic reserve deterioration

Regulatory T cells percentage in peripheral blood before and after eradication of <i>Helicobacter pylori</i>

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Health 2014年第4期6卷 236-242页

作者： Yuka Satoh Hatsue Ogawara Osamu Kawamura Yasuyuki Shimoyama motoyasu Kusano Akihiko Yokohama Takayuki Saitoh Hiroshi Handa Norifumi Tsukamoto Hirokazu Murakami Department of Blood Transfusion Service Gunma University Hospital Maebashi Japan Department of Endoscopy and Endoscopic Surgery Gunma University Hospital Maebashi Japan Department of Laboratory Sciences Course of Health Sciences Gunma Graduate School of Health Sciences Maebashi Japan Department of Medicine and Clinical Science Gunma Graduate School of Medicine Maebashi Japan Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Maebashi Japan Faculty of Health Sciences Gunma Paz College Takasaki Japan Oncology Center Gunma University Hospital Maebashi Japan

Helicobacter pylori (H. pylori) induces gastroduodenal diseases and vigorous humural and cellular immune abnormalities. In order to clarify the immunological changes before and after eradication of H. pylori, the percentages and ratios of the following cells in the peripheral blood of 32 H. pylori-infected patients and 25 control subjects were analyzed: CD4+ T cells, CD8+ T cells, T helper 1 cells (Th1), T helper 2 cells (Th2), CD4+CD25+ T cells, Foxp3+ regulatory T cells (Treg), CD4/CD8 ratio, and Th1/Th2 ratio. CD4/CD8 ratio was significantly higher in H. pylori-infected patients before (mean ± SD, 2.9 ± 1.9) and after (mean ± SD, 2.8 ± 1.6) eradication of H. pylori than in control subjects (mean ± SD, 2.1 ± 0.9). The percentage of Th2 cells was significantly higher in H. pylori-infected patients (mean ± SD, 2.6 ± 1.1) than in control subjects (mean ± SD, 1.9 ± 1.1;p < 0.02). The percentage of Th2 cells after eradication of H. pylori (mean ± SD, 2.3 ± 1.4) was lower than that before eradication. There was no significant difference between control subjects (mean ± SD, 4.1% ± 1.5%) and patients before H. pylori eradication (mean ± SD, 4.5% ± 2.4%) in the percentage of Tregs, but the percentage was significantly higher in patients after H. pylori eradication (mean ± SD, 5.2% ±2.6%) than in control subjects. The function of peripheral induced Tregs was reported to suppress the excessive immune reaction in chronic inflammation. These data suggest that Tregs may proliferate and be activated to suppress the activation of humoral immunity in H. pylori-infected patients, and these changes continue after 3 months or later of successful eradication of H. pylori.

关键词： Helicobacter pylori Regulatory T Cell Th1 Cell Th2 Cell

肺腺癌HIF-1α／HIF-2α的表达与FDG摄取的关系

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中华核医学与分子影像杂志 2017年第8期37卷 523-524页

作者：唐军 Kotaro Higashi Toshiaki Yamagishi Yoshimichi Ueda Yasuhito Ishigaki Miyako Shimasaki Yuka Nakamura Manabu Oguchi Tsutomu Takegami motoyasu Sagawa Hisao Tonami 苏州大学附属第二医院核医学科 215004 Department of Radiology Asanogawa General Hospital Kanazawa Japan

目的乏氧是肿瘤形成和进展的关键因素。乏氧诱导因子-1α（HIF-1α）可在短时间内诱导和调节对急性和重度乏氧的反应，而乏氧诱导因子-2α（HIF-2α）引起的反应持续时间更长，并能调控对慢性和中度乏氧的反应。乏氧可使细胞FDG摄取增... 详细信息

目的乏氧是肿瘤形成和进展的关键因素。乏氧诱导因子-1α（HIF-1α）可在短时间内诱导和调节对急性和重度乏氧的反应，而乏氧诱导因子-2α（HIF-2α）引起的反应持续时间更长，并能调控对慢性和中度乏氧的反应。乏氧可使细胞FDG摄取增加。因此，HIF可能在细胞脱氧葡萄糖（FDG）摄取的过程中起着重要的作用。

关键词： PET ^18F-FDG 肺腺癌乏氧诱导因子复发

Pegylated interferon plus ribavirin for genotype Ib chronic hepatitis C in Japan

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World Journal of Gastroenterology 2008年第47期14卷 7225-7230页

作者： Takayuki Kogure Yoshiyuki Ueno Koji Fukushima Futoshi Nagasaki Yasuteru Kondo Jun Inoue Yasunori Matsuda Eiji Kakazu Takeshi Yamamoto Hiroyoshi Onodera Yutaka Miyazaki Hiromasa Okamoto Takehiro Akahane Tomoo Kobayashi Yutaka Mano Takao Iwasaki motoyasu Ishii Tooru Shimosegawa Division of Gastroenterology Tohoku University HospitalSendai 980-8574Japan Department of Gastroenterology Tohoku Rosai HospitalSendai 980-8574Japan Department of Gastroenterology Miyagi Cancer CenterNatori 981-1293Japan Department of Internal Medicine Tohoku Kosai HospitalSendai 980-0803Japan Department of Internal Medicine Shirakawa Kosei General HospitalShirakawa 961-0005Japan Department of Gastroenterology Ishinomaki Municipal HospitalIshinomaki 986-0835Japan Department of Gastroenterology Osaki Citizen HospitalFurukawa 989-6183Japan Department of Gastroenterology Sendai Medical CenterSendai 983-8520Japan Department of Internal Medicine Miyagi Social Insurance HospitalSendai 981-1103Japan

AIM:To evaluate the efficacy of pegylated interferon α-2b(peg-IFNα-2b) plus ribavirin(RBV) therapy in Japanese patients with chronic hepatitis C(CHC) genotype Ib and a high viral ***:One hundred and twenty CHC patients(58.3% male) who received peg-IFNα-2b plus RBV therapy for 48 wk were *** virological response(SVR) and clinical parameters were ***:One hundred(83.3%) of 120 patients completed 48 wk of treatment.53 patients(44.3%) achieved *** virological response(EVR) and end of treatment response(ETR) rates were 50% and 73.3%,*** clinical parameters(SVR vs non-SVR) associated with SVR,ALT(108.4 IU/L vs 74.5 IU/L,P = 0.063),EVR(76.4% vs 16.4%,P 56 years),SVR in females was significantly lower than that in males(17% vs 50%,P = 0.0262).EVR and adherence to Peg-IFN were demonstrated to be the main factors associated with ***:Peg-IFNα-2b plus RBV combination therapy demonstrated good tolerability in Japanese patients with CHC and resulted in a SVR rate of 44.3%.Treatment of elderly female patients is still challenging and maintenance of adherence to peg-IFNα-2b is important in improving the SVR rate.

关键词：慢性丙肝干扰素病毒唑症状