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国际服装技术 2006年第3期 52-63页

作者： Ami Yamamoto Gokon（翻译） Makoto yamazaki（摄影）

本期的可爱女孩，来自日本电台数码传媒局的二宫麻郁子小姐。这期中介绍的单品将会以颜色表现的钟织衫、粗花呢夹克、中裤为主，同时还将倾情奉献特别企划的3月着装计划。

关键词：日记搭配异常冬季颜色表

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of E3024, a Novel and Selective Dipeptidyl Peptidase-IV Inhibitor, in Healthy Japanese Male Subjects: Rash Development in Men and Its Possible Mechanism

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Pharmacology & Pharmacy 2013年第9期4卷 663-678页

作者： Yutaka Takeuchi Masayuki Namiki Yasumi Kitahara Setsuo Hasegawa Akihiro Ohnishi Nobuyuki Yasuda Takashi Inoue Richard Clark Kazuto yamazaki Clinical Development Japan/Asia Clinical Research PCU Eisai Co. Ltd. Tokyo Japan Clinical Development Japan/Asia Clinical Research PCU Eisai Co. Ltd. Tokyo Japan Clinical Pharmacology Clinical Science SOCS CFU Eisai Co. Ltd. Tokyo Japan Department of Laboratory Medicine Daisan Hospital Jikei University School of Medicine Tokyo Japan Sekino Clinical Pharmacology Clinic Tokyo Japan Present Address: Pharmaspur Inc. Tokyo Japan Tsukuba Research Laboratories Eisai Co. Ltd. Tsukuba Japan.

E3024 (3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate) is a dipeptidyl peptidase-IV (DPP-IV) inhibitor that was expected to be an antidiabetic agent. Its safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) were investigated in a randomized, double-blind, placebo-controlled, ascending single-dose study in 48 healthy Japanese male subjects. Fasted subjects were orally administered E3024 (5, 10, 20, 40, or 80 mg) or placebo. E3024 was rapidly absorbed, with tmax values ranging between 0.33 and 3 h after dosing. The mean t1/2 ranged from 5.34 to 11.68 h. AUC0-inf and Cmax increased dose-proportionately. PK-PD relationship of E3024 was evaluated by using an Imax model, indicating that plasma E3024 concentrations and inhibitory effects of plasma DPP-IV activity were well correlated. The IC50 value was calculated as 33.7 ng/mL, which was consistent with in vitro data. Thus, E3024 showed a good PK profile and inhibited DPP-IV dose-dependently. Of 30 subjects administered E3024, 12 (40%) experienced adverse events (AEs). Dose escalation to 160 mg was abandoned owing to undesired subjective/objective findings in 4 of 6 subjects receiving 40 mg and 5 of 6 subjects receiving 80 mg. The most prominent AE was rash, but there were no serious AEs or deaths. The maximum tolerated dose was considered to be 20 mg. We hypothesized that histamine was a cause of the rash induction, and examined blood histamine levels of normal Fischer rats treated with E3024. Blood histamine levels were increased significantly by E3024 at 500 mg/kg (p < 0.001), but not by vildagliptin or valine-pyrrolidide (DPP-IV inhibitors) at the same dose. No blood histamine increases were observed in genetically mast cell-deficient Ws/Ws rats treated with E3024 at 500 mg/kg. In in vitro assays, E3024 induced histamine release from normal rat peritoneal mast cells in a concentration-dependent manner, but not from basophils. The structure-activity relati

关键词： Dipeptidyl Peptidase-IV Inhibitor Rash Histamine Structure-Activity Relationship

Spectroscopic Studies on Impurity Transport of Core and Edge Plasmas in LHD

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Plasma Science and Technology 2006年第1期8卷 55-60页

作者： Shigeru MORITA Motoshi GOTO SadatsuguMUTO Ryuji KATAI Hisamichi yamazaki Hideaki NOZATO AtsuslliI WAMAE Makoto ATAKE Takashi FUJIMOTO Atsushi SAKAUE Hiroaki NISHIMURA Ikuya SAKURAI Chiho MATSUMOTO Akihiro FURUZAWA Yuzuru TAWARA Mitsutoshi ARAMAKI Yuji OKUMURA Koichi SASAKI 龚先祖李建刚万宝年崔正英 National Institute for Fusion Science Toki 509-5292Japan Department of Fusion Science Graduate University for Advanced StudiesToki 509-5292Japan National Institute of Advanced Industrial Science and Technology Tsukuba 305-8563Japan Department of Engineering Physics Kyoto UniversityKyoto 606-8502Japan Institute of Laser Engineering Osaka UniversityOsaka 565-0871Japan Eco Topia Science Institute Nagoya UniversityNagoya 464-8603Japan Department of Electrical Engineering and Computer Science Nagoya UniversityNagoya 464-8603Japan Institute of Plasma Physics Chinese Academy of SciencesHefei 230031China Southwestern Institute of Physics Chengdu 610041China

Spectroscopic diagnostics have been extensively developed for studies of impurity and neutral particle transports at core and edge plasmas in LHD. Diagnostics of core plasmas are similar to a tokamak case, i.e., Zeff from visible bremsstrahlung, K-x-ray measurements from xray spectroscopy using Si（Li） detectors and a compact crystal spectrometer, and high-Z impurity diagnostics from VUV spectroscopy using a flat-field EUV spectrometer. A combination of impurity pellet injection and visible bremsstrahlung is an active tool for determination of the diffusion coeffici＇ent D and convective velocity V. Using this tool the spatial structures of D and V are obtained and discussed with a neoclassical effect. On the other hand, the spectroscopic method for edge diagnostics is considerably different from the tokamak case because of the existence of a thick ergodic layer in addition to the z-points necessarily included into the diagnostic chord view. In order to break this negative situation, Zeeman and polarization spectroscopy are adopted to LHD edge plasmas. As a result, 2-dimensional emission contours of HeI and Ha are successfully obtained. Laser absorption spectroscopy is tried to measure hydrogen neutrals directly. Radial profiles of edge impurities are also measured with a mirror-assembled 3 m VUV spectrometer. Recent results of and progress in LHD spectroscopy are briefly reviewed.

关键词： impurity transport plasma spectroscopy hydrogen neutral

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Fungal pyrrolidine-containing metabolites inhibit alkaline phosphatase activity in bone morphogenetic protein-stimulated myoblastoma cells

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Acta Pharmaceutica Sinica B 2012年第1期2卷 23-27页

作者： Takashi Fukuda Ryuji Uchida Hiroyo Inoue Satoshi Ohte Hiroyuki yamazaki Daisuke Matsuda Takenobu Katagiri Hiroshi Tomoda Graduate School of Pharmaceutical Sciences Kitasato UniversityTokyoJapan Research Center for Genomic Medicine Saitama Medical UniversitySaitamaJapan

Fibrodysplasia ossificans progressiva(FOP)is a rare autosomal dominant congenital disorder characterized by progressive heterotopic ossification in muscle tissues.A constitutively activated mutation of a bone morphogenetic protein(BMP)receptor,ALK2,has been identified in patients with *** report here that four structurally related compounds,lucilactaene,hydroxylucilactaene,NG-391 and NG-393,produced by fungal strain Fusarium sp.B88,inhibit BMP signaling in *** phosphatase activity,a marker enzyme of osteoblastic differentiation,was decreased in C2C12 myoblasts stably expressing mutant ALK2 by treatment with those compounds with IC_(50) values of 5.7,6.8,6.9 and 6.1 mM,***,NG-391 and NG-393 inhibited BMP-specific luciferase reporter activity,which is directly regulated by transcription factor Smads,with IC50 values of 1.4 and 2.1 mM,*** findings suggest that these fungal metabolites may provide a new direction in the development of FOP therapeutics.

关键词： Lucilactaenes Fungal metabolites C2C12 myoblasts Fibrodysplasia ossificans progressiva

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高色纯殷钢荫罩彩色显像管

光电子技术 1987年第3期 66-69页

作者： Hidetoshi yamazaki 毛国才显象管工程局

荫罩式彩色显像管工作时,荫罩球面隆起会引起彩色失真,这是因为用来制作荫罩的传统材料的主要成分是热膨胀系数较高的纯铁.东芝公司已经研制出15英寸、21英寸和28英寸全方屏彩色显像管.这些管子使用膨胀系数低的铁镍合金(称为殷钢合金)... 详细信息

荫罩式彩色显像管工作时,荫罩球面隆起会引起彩色失真,这是因为用来制作荫罩的传统材料的主要成分是热膨胀系数较高的纯铁.东芝公司已经研制出15英寸、21英寸和28英寸全方屏彩色显像管.这些管子使用膨胀系数低的铁镍合金(称为殷钢合金)制作的荫罩.殷钢荫罩彩色显像管具有极好的抗彩色失真性能(由球面隆起所引起),适于作中等容量的显示器件,如数字电视及双重用途的电视.

关键词：彩色失真球面晶粒曲面颗粒荫罩殷钢数字电视铁镍合金彩色显像管彩色显象管氢氯酸腐蚀液热膨胀系数

Development of a digital zenith telescope for advanced astrometry

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Science China(Physics,Mechanics & Astronomy) 2012年第4期55卷 723-732页

作者： HANADA Hideo ARAKI Hiroshi TAZAWA Seiichi TSURUTA Seiitsu NODA Hirotomo ASARI Kazuyoshi SASAKI Sho FUNAZAKI Ken'ichi SATOH Atsushi TANIGUCHI Hideo KIKUCHI Mamoru TAKAHASHI Tomoe yamazaki Atsumu PING JinSong KAWANO Nobuyuki PETROVA Natalia GOUDA Naoteru YANO Taihei YAMADA Yoshiyuki NIWA Yoshito KONO Yusuke IWATA Takahiro National Astronomical Observatory of Japan Iwate-ken 0230861Japan Department of Engineering Department Iwate UniversityIwate 0208550Japan National Astronomical Observatory Chinese Academy of SciencesBeijing 100012China Oshu Space&Astronomy Museum Iwate-ken 0230861Japan Department of Astronomy Kazan State UniversityKazan 420008Russia Section of Graduate School of Science Division of Physics and Astronomy Kyoto UniversityKyoto 6068501Japan Japan Aerospace Exploration Agency Kanagawa 2525210Japan

Like other optical astrometric techniques,the Photographic Zenith Tube(PZT) has played a key role in the past observations of the Earth rotation,and it also has a potential to be applied to several other observations by taking advantage of automatic observations with self compensation of tilt of the *** here propose In-situ Lunar Orientation Measurement(ILOM) to study lunar rotational dynamics by direct observations of the lunar rotation from the lunar surface by using a small telescope like PZT with an accuracy of 1 milli-seconds of arc(1 mas) in the post-SELENE *** second application is to obtain local gravity field on the Earth by combining deflection of the vertical measured by PZT and the position measured by Global Positioning System(GPS) or Global Navigation Satellite System(GNSS).The accuracy required for this purpose is not as strict as *** have already developed a Bread Board Model(BBM) of the telescope for ILOM and made some experiments in order to know the performance of the driving mechanism under a similar condition to the lunar environment showing high vacuum,large temperature change and dusty *** have also shown that it is possible to correct the effects of uniform temperature change upon the optical system by using a simple model with an accuracy of better than 1 *** model has the potential to attain the accuracy of 1 mas,based on the results of the experiments and the simulations.

关键词： high accuracy orbit determination SAR LRS SELENE

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非径向叶片旋涡泵性能的研究(报告Ⅰ,性能和内部流动)

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流体机械 1972年第2期 20-26页

作者： Shinzo yamazaki Yukio Tomita 梁贤光

该类泵有与半径倾斜一个角度的叶片,已完成45°～135°的十一个叶片角度和四个流道每一组合的性能试验。作者还用高速照相机和包括新型皮托管在内的几个探针对内部流动进行了观察。结论如下: 1.泵的性能受叶片角度和流道截面积的影响; 2... 详细信息

该类泵有与半径倾斜一个角度的叶片,已完成45°～135°的十一个叶片角度和四个流道每一组合的性能试验。作者还用高速照相机和包括新型皮托管在内的几个探针对内部流动进行了观察。结论如下: 1.泵的性能受叶片角度和流道截面积的影响; 2.关死扬程与最高效率点的扬程之比值和最大功率,随叶片角的增大而减少; 3.有一个规则的液流在流道及叶片之间循环,而

关键词：内部流动径向叶片流量曲线关死叶片角度流道尺寸叶轮宽度

基于生活地名法的传统聚落空间结构研究--以云南西双版纳曼海聚落为例

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国际城市规划 2017年第2期32卷 72-78页

作者：冯旭山崎寿一中国城市规划设计研究院日本神户大学工学研究科

本文首先梳理了日本聚落地理学研究的发展及生活地名法的产生背景。融合了地理学、历史学、民俗学等学科视角的生活地名法,是在基于"吸收相关学科内容重新审视聚落人地关系,注重居住群体客观视角"的日本现代聚落地理学发展背景下,作为... 详细信息

本文首先梳理了日本聚落地理学研究的发展及生活地名法的产生背景。融合了地理学、历史学、民俗学等学科视角的生活地名法,是在基于"吸收相关学科内容重新审视聚落人地关系,注重居住群体客观视角"的日本现代聚落地理学发展背景下,作为分析聚落空间结构的重要方法被提出的。2010年,生活地名法被首次运用到日本以外的案例研究中,以中国云南西双版纳曼海聚落为对象,通过采集生活地名,分析其中所隐含的空间意识,提炼了中心、边界与方向观、水路与道路、公共与信仰空间等空间类型,并总结出曼海的传统空间结构。

关键词：聚落地理学生活地名传统聚落空间结构曼海

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伊豆-小笠原弧、马里亚纳弧和马里亚纳海槽的磁异常

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海洋地质前沿 1992年第8期 15-16页

作者： Toshitsugu yamazaki 董贻平

1984—1989年在伊豆-小笠原弧和马里亚纳海槽进行了磁法调查,它是作为"伊豆-小笠原弧海底热液活动"研究项目的一部分。此项目是为了更好地了解该区域的地质构造。调查区包括从八丈群岛到Minami-硫黄岛群岛的全部伊豆-小笠原弧,小笠原海... 详细信息

1984—1989年在伊豆-小笠原弧和马里亚纳海槽进行了磁法调查,它是作为"伊豆-小笠原弧海底热液活动"研究项目的一部分。此项目是为了更好地了解该区域的地质构造。调查区包括从八丈群岛到Minami-硫黄岛群岛的全部伊豆-小笠原弧,小笠原海槽,小笠原海台和邻近的海山,马里亚纳海岭和20°N以北的马里亚纳海槽,以及沿着18°N附近马里亚纳海槽的扩张中心。

关键词：马里亚纳海槽扩张速率

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高可靠ZnO薄膜SAW TV奈氏滤波器

压电与声光 1981年第4期 13-15+18页

作者： O.yamazaki 钟冠群松下电器公司材料研究室

本报告叙述ZnO薄膜SAW TV接收机奈氏(Nyquist)滤波器及TV台解调器.滤波器由层状结构组成.溅射ZnO压电薄膜沉积在硼硅玻璃基片上,Al叉指电极插在ZnO膜和玻璃基片之间,而Al对向电极沉积在ZnO膜表面 ZnO膜的厚度大约是SAW波长的3%,变迹用... 详细信息

本报告叙述ZnO薄膜SAW TV接收机奈氏(Nyquist)滤波器及TV台解调器.滤波器由层状结构组成.溅射ZnO压电薄膜沉积在硼硅玻璃基片上,Al叉指电极插在ZnO膜和玻璃基片之间,而Al对向电极沉积在ZnO膜表面 ZnO膜的厚度大约是SAW波长的3%,变迹用改变对向电极形状来实现.找到了降低TV-VIF滤波器不可避免的插入损耗的先进的SAW设计,因此VIF级可以在没有任何前置放大器的情况下工作.精确的设计实现TV台的标准解调器;在通带内振幅平坦度0.05dB而群延迟波纹为10ns,这些滤波器显示出10ppm/℃和100ppm/25,000小时的漂移这样极好的频率稳定性.这种SAW滤波器目前正在生产.

关键词：滤波器电子设备压电薄膜电介质薄膜 SAW TV ZnO TV