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Chinese Journal of Integrative Medicine 2020年第1期26卷 26-32页

作者： Hiroshi Kawanami Hirohisa Kawahata Hiroko-Miyuki Mori motokuni aoki Graduate School of Health Sciences Morinomiya University of Medical Sciences

Objective:To examine the effect of moxibustion on the wound healing process and its mechanism using a rat wound ***:Sixty male Sprague-Dawley rats were randomly divided into a sham-treated group(n=30,wound surgery only)and a moxibustion group(n=30,wound treated with moxibustion).Circular fullthick ness skin wounds were produced in *** was applied to the edge of wound and was continued on alternating days till 14 days after surgery,followed by measurement of wound *** of collagens,prolyl-4-hydroxylase(P4H)and transtorming growth factor-β(TGF-β)were evaluated by histochemical study and real-time polymerase chain ***:The size of the wound lesion was significantly reduced in rats treated with moxibustion as compared to that in sham-treated rats at 4-10 days after wounding(P<0.01).Moxibusti on stimulated mRNA expressi on of collage ns at 4 days(P<0.01),but not at 7 days,accompa nied by enhanced proliferation of P4H-positive *** importanee,expression of TGF-β in tissue from the wound lesio n treated with moxibusti on was sign ifica ntly in creased as compared to that in sham-treated rats at 4 days(P<0.01 or P<0.05),but not at 7 ***:The treatment with moxibustion promoted the wound healing process in the early phase through proliferation of fibroblasts and rapid formation of granulation,possibly mediated by induction of TGF-β which is a key molecule in the physiological process of wound *** can be expected to be effective as complementary treatment for intractable ulcers.

关键词： compleme ntary and alter native medicine moxibusti on wound healing granulation tran storming growth factor-β collagen

Principle for obtaining high joint quality in dissimilar friction welding of Ti-6Al-4V alloy and SUS316L stainless steel

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Journal of Materials Science & Technology 2020年第11期42卷 211-224页

作者： Huihong Liu Yo aoki Yasuhiro aoki Kohsaku Ushioda Hidetoshi Fujii Joining and Welding Research Institute Osaka UniversityIbarakiOsaka 567-0047Japan

Ti-6Al-4V alloy(Ti64)and SUS316 L stainless steel rods were dissimilarly friction *** focusing on the detailed observation of interface microstructural evolution during the friction welding(FW),the relationship between the processing conditions,weld interface microstructure,and mechanical properties of the obtained joints were systematically investigated to elucidate the principle for obtaining a high joint quality in the FW of Ti64 and SUS316L.A higher friction pressure produced a lower welding temperature in the FW,hence suppressing the thick intermetallic compound layer ***,hard and brittle Ti64/SUS316L mechanically mixed layers generally formed especially at the weld interface periphery due to the high temperature increasing rate,high rotation linear velocity and high outward flow velocity of the *** harmful layers tended to induce the cracks/voids formation at the weld interfaces hence deteriorating the joints’mechanical *** rotation speed reduction and liquid CO2 cooling during the entire processing decreased the temperature increasing rate,rotation linear velocity and outward flow velocity of the Ti64 at the weld interface ***,they suppressed the formation of the harmful mechanically mixed layers,facilitated the homogeneous and sound interface microstructure generation,and finally produced a high-quality dissimilar joint in the FW of Ti64 and SUS316L.

关键词： Friction welding Titanium alloy Stainless steel Microstructure formation mechanism Mechanically mixed layers

Baryon-Baryon interactions from lattice QCD

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Chinese Physics C 2010年第9期34卷 1236-1240页

作者： S.aoki Graduate School of Pure and Applied Sciences University of Tsukuba

We report on new attempt to investigate baryon-baryon interactions in lattice *** the Bethe-Salpeter （BS） wave function,we have successfully extracted the nucleon-nucleon （NN） potentials in quenched QCD simulations,which reproduce qualitative features of modern NN *** method has been extended to obtain the tensor potential as well as the central potential and also applied to the hyperonnucleon （YN） interactions,in both quenched and full QCD.

关键词： nucelon-nucelon potential Bethe-Salpeter wave function lattice QCD hyperon-nucleon interactions tensor potential

s cascade reinforcement likely when sympatric tnd allopatric populations exchange migrants？

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Current Zoology 2016年第2期62卷 155-167页

作者： Roman YUKILEVICH Fumio aoki Department of Biology Union College Schenectady NY 12308 Department of Ecology and Evolution Stony Brook University Stony Brook NY 11794

When partially reproductively isolated species come back into secondary contact, these taxa may diverge in mating preferences and sexual cues to avoid maladaptive hybridization, a process known as reinforcement. This phenomenon often leads to reproductive character displacement （RCD） between sympatric and allopatric populations of reinforcing species that differ in their exposure to hybridization. Recent discussions have reinvigorated the idea that RCD may give rise to additional speciation between conspecific sympatric and allopatric populations, dubbing the concept ＂cascade reinforcement.＂ Despite some empirical studies supporting cascade reinforcement, we still know very little about the conditions for its evolution. In the present article, we address this question by developing an individual-based population genetic model that explicitly simulates cascade reinforcement when one of the hybridizing species is split into sympatric and allopatric populations. Our results show that when sympatric and allopatric populations reside in the same environment and only differ in their exposure to maladaptive hybridization, migration between them generally inhibits the evolution of cascade by spreading the reinforcement alleles from sympatry into allopatry and erasing RCD. Under these conditions, cascade reinforcement only evolved when migration rate between sympatric and allopatric populations was very low. This indicates that stabilizing sexual selection in allopatry is generally ineffective in preventing the spread of reinforcement alleles. Only when sympatric and allopatric populations experienced divergent ecological selection did cascade reinforcement evolve in the presence of substantial migration. These predictions clarify the conditions for cascade reinforcement and facilitate our understanding of existing cases in nature.

关键词： Dobzhansky-Muller incompatibilities hybrid zones reproductive character displacement reproductive isolation secondary contact sexual isolation speciation

Attenuation and Distortion of Compression Waves Propagating in Very Long Tube

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Journal of Thermal Science 2011年第1期20卷 53-57页

作者： Shinya NAKAMURA Daisuke SASA Toshiyuki aoki Graduate School of Engineering Sciences Kyushu UniversityKasugaFukuoka816-8580Japan

A lot of phenomena related to propagating various waves are seen when the high-speed train goes through the tunnel,the gas pipeline is broken due to an accident or the air brake of the wagon *** instance,a compression wave generated ahead of a high-speed train entering a tunnel propagates to the tunnel exit and spouts as a micro pressure wave,which causes an exploding *** order to estimate the magnitude correctly,the mechanism of the attenuation and distortion of a compression wave propagating along a very long tunnel must be understood and the experimental information on these phenomena is *** experimental investigation is carried out to clarify the attenuation and distortion of the propagating compression wave in a very long *** results show that the strength of a compression wave decreases with *** attenuation and distortion of compression waves are affected by the initial waveform of the compression wave and by the unsteady boundary layer induced by the propagating *** shape of a compression wave becomes different with the propagating distance;that is,a shock wave appears just head of a wavefront and an overshoot on pressure distribution is observed behind a shock wave due to the transition of the unsteady boundary layer.

关键词： Propagating Compression Wave Very Long Tube Micro-pressure Wave High-Speed Train

Changes over time in treatment for obstructive jaundice

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3074-3077页

作者： Hideki aoki Department of Surgery National Hospital Organization Iwakuni Clinical CenterIwakuni 740-8510YamaguchiJapan

This editorial discusses an article by Peng et *** study reviewed the efficacy and safety of a new approach for treating obstructive *** the pathophysiology of obstructive jaundice has not yet been fully elucidated,pro-gress has been made in its *** are two aspects of obstructive jaundice:Cholestatic status and absence of bile in the intestinal *** biliary drainage resolved both the ***,endoscopic retrograde biliary drainage(ERBD)has replaced percutaneous transhepatic biliary drainage,and ERBD is transitioning to endoscopic ultrasound guided biliary *** editorial briefly explains the mechanism and treatment of obstructive jaundice and the prospects of this new internal biliary drainage technique.

关键词： Obstructive jaundice Intestinal permeability Biliary drainage Endoscopic retrograde biliary drainage Endoscopic ultrasound guided biliary drainage

Identification of CO_2 disposal locations in an ocean general circulation model of the North Pacific

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Acta Oceanologica Sinica 2009年第1期28卷 15-24页

作者： XU Yongfu aoki Shigeaki HARADA Koh State Key Laboratory of Atmospheric Boundal7 Layer Physics and Atmospheric Chemistl＇y Institute of Atmos- pheric Physics Chinese Academy of Sciences Beijing 100029 China Institute for Environmental Management Technology National Institute for kdvanced Industrial Science and Technology Tsukuha lbaraki 305-8569 Japan

A basin-wide ocean general circulation model of the North Pacific is used to identify which location is more efficient for ocean CO2 sequestration in the North *** injection depths at each one of fifteen locations are *** terms of effectiveness index（EI） and escape factor（EF）,it is clear that the effectiveness increases with increasing latitude at the end of the 50 a injection ***-by-site differences in the EI can be over 9% for the 1 000 m injection depth in the western North Pacific at the end of 50 a of continuous *** difference is much larger for the 500 m *** difference decreases with increasing injection ***,the site-by-site difference is small for the injection in the eastern North *** sequestration is more efficient for the injection in the east than in the *** the 500 m injection depth,the difference in effectiveness between the west and the east is over 10% at the end of 50 a injection *** largest concentration of sequestered CO2 increases with increasing injection *** the injection in both the western and central North Pacific,the largest exchange flux always appears to be at about 42°N,150°E,whereas for the injection in the eastern area the large flux appears to be in the equatorial region（120°W）.

关键词： ocean carbon disposal north Pacific Ocean numerical modelling sequestration

Role of the first mitosis in the remodeling of the parental genomes in mouse embryos

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Cell Research 2005年第2期15卷 127-132页

作者： Kentaro T.HARA,Fugaku aoki Department of Integrated Biosciences Graduate School of Frontier Sciences University of Tokyo Kashiwa Chiba 277-8571 Japan Department of Integrated Biosciences Graduate School of Frontier Sciences University of Tokyo Kashiwa Chiba 277-8571 Japan

Although male and female pronuclei reside in the same zygotic cytoplasm, they differ in many respects, such asvolume and transcriptional activity. The aim of this study is to investigate whether these differences are lost during thefirst mitosis. For this purpose, a new method was developed to inhibit the mixing of two parental chromosomes duringmitosis, thus to induce the formation of two nuclei after they exit from the mitotic phase. In this method, one-cellembryos are arrested at metaphase by treatment with nocodazole, and whn exitting from the mitotic phase, two nucleiwere formed in a single karyocyte following treatment with 6-dimethylaminopurine (6-DMAP). These embryos weredesignated as post-mitotic embryos (PM-embryos), in which the two nuclei were derived from the male and femalegenomes. We found that in the control one-cell embryos that had not been treated with the reagents, the volume of themale pronucleus was about 1.65-fold greater than that of the female pronucleus, whereas the volumes of the two nucleiin the PM-embryos were similar (volume ratio of 1.01). Although a two-fold difference in transcriptional activity wasdetected between the male and female pronuclei in the control embryos, no difference in transcriptional activity wasdetected between the two nuclei of PM-embryos. The ratio of transcriptional activity in the nucleus derived from thepaternal genome to that from the maternal genome was 1.02, for which no significant difference was detected by the χ2fitness test. Therefore, the volumes and transcriptional activities of the male and female nuclei were approximately equalin PM-embryos, which suggests that the asymmetries of pronuclear volume and transcriptional activity between maleand female genomes are somehow losted during the first mitosis.

关键词： mouse zygote parental genomes nuclear volume transcriptional activity.

Prostaglandin E2-EP4 signaling persistently amplifies CD40-mediated induction of IL-23 p19 expression through canonical and non-canonical NF-κB pathways

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Cellular & Molecular Immunology 2016年第2期13卷 240-250页

作者： Xiaojun Ma romohiro aoki Shuh Narumiya Core Research for Evolutional Science and Technology (CREST) Medical Innovation Center Kyoto University Graduate School of Medicine Kyoto 606-8507 Japan Center for Innovation in Immunoregulation Technology and Therapeutics Kyoto University Graduate School of Medicine Kyoto 606-8501 Japan

While there is mounting evidence that interleukin （IL）-23-IL-17 axis plays a critical role in the pathogenesis of various autoimmune diseases, much remains to be elucidated on how IL-23 is induced in the pathological processes. IL-23 is a heterodimer composed of p19 and p40, the latter being shared with IL-12. We previously reported that prostaglandin （PG） E2 promotes CD40-mediated induction of 1123a （p19） expression through its E receptor subtype 4 （EP4） receptor in splenic dendritic cells （DCs）. Here, we have analyzed signaling pathways regulating 1123a induction in the cross talk between EP4 and CD40 in bone marrow-derived DCs. We found that PGE2 synergistically induced 1123a transcription with CD40 signaling. An EP4 agonist, but not agonists of EP1, EP2, or EP3, reproduced this action. Stimulation of CD40 with an agonist antibody evoked biphasic induction of 1123a expression, with the early phase peaking at 1 h and the late phase peaking at 12 h and lasting up to 36 h after stimulation, whereas induction by lipopolysaccharide or tumor necrosis factor-α was transient. The early phase induction by CD40 stimulation was absent in DCs derived from Nfkbl-deficient mice, and the late phase induction was eliminated by RNA interference of nuclear factor-kappa B （NF-κB） p100 subunit. Further, cAMP response element-binding protein （CREB） depletion completely eliminated the induction of 1123a by CD40 stimulation. The addition of the EP4 agonist amplified the induction in both phases through the cAMP-protein kinase A （PKA） pathway. These results suggest that 1123a expression in DCs is synergistically triggered by the PG E2-EP4-cAMP-PKA pathway and canonical/non-canonical NF-KB pathways and CREB activated by CD40 stimulation.

关键词： dendritic cell IL-23 p19 prostaglandin E2 EP4

Introduction to the life of Prof. Dr. Franz Oberwinkler (22 May 1939–15 March 2018)

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Fungal Diversity 2018年第4期91卷 1-4页

作者： Takayuki aoki Genetic Resources Center National Agriculture and Food Research Organization(NARO)2-1-2 KannondaiTsukubaIbaraki 305-8602Japan

It was for me an unexpected,unhappy announcement,concerning the severe disease that the late *** Oberwinkler had been diagnosed,sent from one of his former students in early February *** suffered from a brain tumor an... 详细信息

关键词： suddenly concerning life