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Spontaneous rupture of splenic hamartoma in a patient with hepatitis C virus-related cirrhosis and portal hypertension:A case report and review of the literature

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World Journal of Gastroenterology 2006年第13期12卷 2133-2135页

作者： Yasuji Seyama Nobutaka Tanaka Yoshio Suzuki motoki nagai Takatoshi Furuya Yukihiro Nomura Jimpei Ishii Masakazu Nobori Department of Surgery Asahi General Hospital ChibaJapan Department of Pathology Asahi General Hospital ChibaJapan

Spontaneous rupture is a rare complication of splenic hamartoma. A review of the literature revealed only four such cases. To the best of our knowledge, this is the first report of spontaneous rupture of splenic hamartoma associated with liver cirrhosis and portal hypertension. A 53-year-old woman, who was followed up for aortic dissection and hepatitis C virus （HCV）-related liver cirrhosis, was referred with sudden left chest and shoulder pain. An abdominal ultrasound showed intraabdominal bleeding, and computed tomography indicated rupture of a splenic tumor. Emergent splenectomy was carried out. The postoperative course was uneventful, and the patient was discharged on the 13th postoperative day. Pathology revealed the tumor to be a ruptured splenic hamartoma. The non-tumorous splenic parenchyma revealed congestive changes. We consider that the presence of liver cirrhosis and portal hypertension are risk factors for spontaneous rupture of the splenic hamartoma.

关键词： Splenic hamartoma Spontaneous rupture Hepatitis C virus Cirrhosis Portal hypertension

The reconstruction after pylorus preserving pancreatoduodenectomy: pancreatogastrostomy with Roux-en-Y reconstruction versus conventional Traverso type reconstruction

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Health 2010年第3期2卷 195-199页

作者： Joji Yamamoto Yoshiaki Shimizu motoki nagai Harufumi Makino Shigehiro Kojima Yuuki Ozamoto Kamagaya General Hospital Japan Kamagaya General Hospital Japan

Objective: To compare the result of pancreatogastrostomy (PG) with Roux-en-Y reconstruction versus pancreatojejunostomy (PJ) with conventional Traverso-type reconstruction following pylorus-preserving pancreatectomy (PP- PD) in a retrospective study. PPPD has been accepted as a radical surgical treatment for malignant periampullary neoplasms. However, the reconstruction of this surgery is technically complicated. The leakage of pancreatic juice and the delayed gastric emptying are the major complications of PPPD and may be fatal. To solve these problems, we have performed PG with Roux-en-Y anastomosis. There are several techniques proposed the reconstruction after PPPD, however there have been no previous study describing the result of PG with Roux- en-Y anastomosis. Since 2002 we have perfor- med 32 cases of PPPD. They were divided into two groups according to the reconstruction procedures: PG with Roux-en-Y reconstruction (group PG-RY) (17 cases) and pancreatojejunostomy with Traverso-type reconstruction (group PJ-T) (15 cases). Results: Patient age, gender, and underlying disease were comparable among the groups. Two groups showed no differences in intraoperative bleeding amount, and the time of surgery. The occurrence of the pancreatic leakage was significantly reduced in the group PG-RY compared with the group PJ-T. There was no case of the delayed gastric emptying in the group PGRY. Conclusions: Pancreatogastrosotmy with Roux-en-Y anastomosis can reduce the occurrence of the pancreatic leakage and delayed gastric emptying following pylorus-preserving pancreatoduodenectomy.

关键词： Pancreatoduodenectomy Pancreatogastrostomy Roux-en-Y Reconstruction Pancreatojejunostomy Traverso-Type Reconstruction

Pancreatic insulinoma combined with glucagon positive cell: A case report

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World Journal of Gastrointestinal Surgery 2013年第3期5卷 68-72页

作者： Suguru Yamashita Nobutaka Tanaka Michiro Takahashi motoki nagai Takatoshi Furuya Yoshio Suzuki Yukihiro Nomura Department of Surgery Asahi General Hospital Department of Surgery Kanto Medical Center NTT EC Department of Pathology Asahi General Hospital

We present a 70-year-old man who was referred for surgery with uncontrollable hypoglycemia. Ultrasonography and abdominal contrast computed tomography revealed a hypervascular tumor of 1 cm in diameter in the pancreatic tail. With a diagnosis of insulinoma, we performed a distal pancreatectomy. The patient showed a good postoperative course without any complications. The patient's early morning fasting hypoglycemia disappeared. The respective levels of C-peptide and insulin dropped from 14.9 ng/mL and 4860 μIU/mL preoperatively to 5.3 ng/mL and 553 μIU/mL after surgery. A histopathological examination demonstrated that the tumor was a pancreatic neuroendocrine tumor, grade 1. Immunostaining was negative for insulin and positive for CD56, chromogranin A, synaptophysin and glucagon. These findings suggested that the tumor was clinically an insulinoma but histopathologically a glucagonoma. Among all insulinoma cases reported between 1985 and 2010, only 5 cases were associated with independent glucagonoma. In this report, we characterize and discuss this rare type of insulinoma by describing the case we experienced in detail.

关键词： Hypoglycemia Insulinoma Pancreas Neuroendocrine tumor Glucagon

Laparoscopic surgery for small-bowel obstruction caused by Meckel's diverticulum

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World Journal of Gastrointestinal Surgery 2016年第2期8卷 169-172页

作者： Takatsugu Matsumoto motoki nagai Daisuke Koike Yukihiro Nomura Nobutaka Tanaka Department of Gastroenterological Surgery Dokkyo Medical University Department of Surgery Asahi General Hospital

A 26-year-old woman was referred to our hospital because of abdominal distention and vomiting. Contrastenhanced computed tomography showed a blind loop of the bowel extending to near the uterus and a fibrotic band connecting the mesentery to the top of the bowel,suggestive of Meckel's diverticulum(MD) and a mesodiverticular band(MDB). After intestinal decompression,elective laparoscopic surgery was carried out. Using three 5-mm ports,MD was dissected from the surrounding adhesion and MDB was divided intracorporeally. And subsequent Meckel's diverticulectomy was performed. The presence of heterotopic gastric mucosa was confirmed histologically. The patient had an uneventful postoperative course and was discharged 5 d after the operation. She has remained healthy and symptom-free during 4 years of follow-up. This was considered to be an unusual case of preoperatively diagnosed and laparoscopically treated small-bowel obstruction due to MD in a young adult woman.

关键词： Surgery Human Meckel’s diverticulum Small-bowel obstruction Laparoscopic surgery

SPERA Hydrogen System^(TM)by LOHC-MCH Method for Massive Hydrogen Storage and Transportation

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Journal of Environmental Science and Engineering(A) 2024年第2期13卷 50-60页

作者： Yoshimi Okada Kaji Naohiro Osamu Ikeda Kenichi Imagawa Hironori Kawai Masashi nagai Yasuhiro Inoue Frontier Business Division Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan Hydrogen Business Department Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan R&D Center Chiyoda Corporation3-13 Moriya-cho Kanagawa-kuYokohama 2208765Japan Technology Development Department Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan

Expanding the hydrogen energy utilization is essential for decarbonization,and the commercialization of hydrogen energy carrier systems that can“store”and“transport”hydrogen in a large scale is *** organic chemical hydride method incorporates hydrogen atoms into the molecular structure of a LOHC(Liquid Organic Hydrogen Carrier)to store and transport hydrogen in a liquid state under normal temperature and pressure,and is a highly safe method with low business *** has been developing the technology since 2002,completed a pilot demonstration in 2014 and named it the SPERA Hydrogen^(TM) System,and successfully completed an international supply chain demonstration that transports hydrogen from Brunei to Japan in a large scale in 2020,moving to the commercialization ***,Chiyoda is conducting feasibility studies with a number of domestic and foreign companies with the aim of commercializing the system as soon as *** this paper,outline,features,development status and our efforts in commercialization of SPERA HydrogenTM System are introduced.

关键词： Hydrogen carrier LOHC Methylcyclohexane MCH toluene

Optimal Building Frame Column Design Based on the Genetic Algorithm

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Computers, Materials & Continua 2019年第3期58卷 641-651页

作者： Tao Shen Yukari nagai Chan Gao Knowledge Science Japan Advanced Institute of Science and TechnologyNomi CityIshikawa 923-1292Japan Architecture Department Huzhou UniversityHuzhouZhejiang313000China.

Building structure is like the skeleton of the building,it bears the effects of various forces and forms a supporting system,which is the material basis on which the building *** building structure design is a vital part in architecture design,architects often explore novel applications of their technologies for building structure ***,such searches relied on experiences,expertise or gut *** this paper,a new design method for the optimal building frame column design based on the genetic algorithm is *** of all,in order to construct the optimal model of the building frame column,building units are divided into three categories in general:building bottom,main building and building ***,the genetic algorithm is introduced to optimize the building frame *** the meantime,a PGA-Skeleton based concurrent genetic algorithm design plan is proposed to improve the optimization efficiency of the genetic ***,effectiveness of the mentioned algorithm is verified through the simulation experiment.

关键词： Structure optimization genetic algorithm concurrent computation conceptual design simulation experiment.

Antimicrobial and synergistic effects of lemongrass and geranium essential oils against Streptococcus mutans,Staphylococcus aureus,and Candida spp.

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World Journal of Critical Care Medicine 2024年第3期13卷 63-74页

作者： Patrícia Michelle nagai de Lima Thaís Cristine Pereira Lara Steffany de Carvalho Letícia Ferreira dos Santos Carlos Eduardo Rocha Oliveira Lucas de Paula Ramos Maria Cristina Marcucci Amjad Abu Hasna Luciane Dias de Oliveira Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000SPBrazil Anhembi Morumbi University School of MedicineSão Josédos Campos 12230-002SPBrazil Department of Restorative Dentistry Endodontics DivisionInstitute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000São PauloBrazil

BACKGROUND The oral cavity harbors more than 700 species of bacteria,which play crucial roles in the development of various oral diseases including caries,endodontic infection,periodontal infection,and diverse oral *** To investigate the antimicrobial action of Cymbopogon Schoenanthus and Pelargonium graveolens essential oils against Streptococcus mutans,Staphylococcus aureus,Candida albicans,***,and *** Minimum microbicidal concentration was determined following Clinical and Laboratory Standards Institute *** synergistic antimicrobial activity was evaluated using the Broth microdilution checkerboard method,and the antibiofilm activity was evaluated with the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide *** were analyzed by one-way analysis of variance followed by the Tukey post-hoc test(P≤0.05).RESULTS *** and *** essential oils were as effective as 0.12%chlorhexidine against *** and *** monotypic biofilms after 24 *** 24 h *** essential oil at 0.25%was more effective than the nystatin group,and *** essential oil at 0.25%was as effective as the nystatin *** *** and *** essential oils are effective against ***,***,***,***,and *** at different concentrations after 5 min and 24 h.

关键词： Antifungal effect Lemongrass Geranium Candida albicans Candida dubliniensis Candida krusei Staphylococcus aureus Streptococcus mutans

Diffuse large B-cell lymphoma successfully treated with amplified natural killer therapy alone: A case report

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World Journal of Clinical Cases 2023年第30期11卷 7432-7439页

作者： Kenjiro nagai Syo nagai Yuji Okubo Keisuke Teshigawara Department of Internal Medicine Medical Corporation Ebino Centro ClinicEbino 889-4304Japan Department of Internal Medicine Higashinotoin ClinicKyoto 604-8175Japan

BACKGROUND The prognosis of patients with advanced diffuse large B-cell lymphoma(DLBCL)is poor,with a 5-year survival rate of approximately 50%.The mainstay of treatment is multidrug combination chemotherapy,which has been associated with serious side *** natural killer(ANK)cell therapy amplifies and activates natural killer(NK)cells to attack only malignant *** ANK cells attack programmed death ligand 1(PD-L1)-positive tumor cells,ANK therapy is considered effective against adult T-cell lymphoma and malignant *** SUMMARY Herein,we report a case of an older patient with advanced DLBCL who was successfully treated with ANK immunotherapy.A 91-year-old female visited our hospital with sudden swelling of the right axillary lymph node in April *** patient was diagnosed with stage II disease,given the absence of splenic involvement or contralateral *** therapy was *** rounds of lymphocyte sampling were performed on July 28,*** reduce the occurrence of side effects,the six samples were diluted by half to obtain 12 *** NK cells were administered twice *** treatment efficacy was evaluated by performing computed tomography and serological tests every 1 or 2 *** treatment suppressed lesion growth,and the antitumor effect persisted for several *** patient experienced mild side ***-L1 immunostaining was positive,indicating that the treatment was highly *** ANK therapy can be used as a first-line treatment for malignant lymphoma;the PD-L1 positivity rate can predict treatment efficacy.

关键词： Diffuse large B-cell lymphoma Natural killer cells Immunostaining Hodgkin's lymphoma Older adult Case report

Completing density functional theory by machine learning hidden messages from molecules

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npj Computational Materials 2020年第1期6卷 1306-1313页

作者： Ryo nagai Ryosuke Akashi Osamu Sugino Department of Physics The University of TokyoHongoBunkyo-KuTokyo 113-0033Japan Institute for Solid State Physics The University of TokyoKashiwaChiba 277-8581Japan

Kohn–Sham density functional theory(DFT)is the basis of modern computational approaches to electronic *** accuracy heavily relies on the exchange-correlation energy functional,which encapsulates electron–electron interaction beyond the classical *** its universal form remains undiscovered,approximated functionals constructed with heuristic approaches are used for practical ***,there are problems in their accuracy and transferability,while any systematic approach to improve them is yet *** this study,we demonstrate that the functional can be systematically constructed using accurate density distributions and energies in reference molecules via machine ***,a trial functional machine learned from only a few molecules is already applicable to hundreds of molecules comprising various first-and second-row elements with the same accuracy as the standard *** is achieved by relating density and energy using a flexible feed-forward neural network,which allows us to take a functional derivative via the back-propagation *** addition,simply by introducing a nonlocal density descriptor,the nonlocal effect is included to improve accuracy,which has hitherto been *** approach thus will help enrich the DFT framework by utilizing the rapidly advancing machine-learning technique.

关键词： technique functional theory