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Prion Protein Binds to Aldolase A Produced by Bovine Intestinal M Cells

Open Journal of Veterinary Medicine 2015年第3期5卷 43-60页

作者： Yuya Nagasawa Yu Takahashi Wataru Itani Hitoshi Watanabe Yusuke Hidaka Shotaro Morita Kei Suzuki Kouichi Watanabe Shyuichi Ohwada Haruki Kitazawa Morikazu Imamura Takashi Yokoyama motohiro horiuchi Suehiro Sakaguchi Shirou Mohri Michael T. Rose Tomonori Nochi Hisashi Aso Cellular Biology Laboratory Tohoku University Sendai Japan Food Immunology Group Tohoku University Sendai Japan Prion Disease Research Center National Institute of Animal Health Tsukuba Japan Laboratory of Veterinary Hygiene Hokkaido University Sapporo Japan Institute for Enzyme Research The University of Tokushima Tokushima Japan Institute of Biological Environmental and Rural Sciences Aberystwyth University Aberystwyth UK

Microfold (M) cells are a kind of intestinal epithelial cell in the follicle-associated epithelium (FAE) of Peyer’s patches. They can transport antigens and microorganisms to lymphoid tissues. Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative disorder in cattle. It is linked to variant Creutzfeldt-Jakob disease in humans. Although it is thought that M cells transport the BSE agent, the exact mechanism by which it crosses the intestinal barrier is not clear. We have bovine intestinal epithelial cell line (BIE cells), which can differentiate into the M cell type in vitro after stimulation, and which is able to transport the BSE agent. We show here that M cells are able to incorporate large numbers of PrP coated magnetic particles into intracellular vesicles, which we collected. The results of 2-DE show a specific protein associated with the PrP-coated particles, compared with non-coated particles. This protein was identified as aldolase A, a glycolytic pathway enzyme, using LC-MS/MS analysis. Aldolase A was synthesized and secreted by BIE cells, and increased during M cell differentiation. In the villi of the bovine intestine, aldolase A was detected on the surface of the epithelium and in the mucus droplet of goblet cells. In the FAE of bovine jejunal and ileal Peyer’s patches, aldolase A was localized on the surface and the apical part of the M cells. The binding of rbPrP to aldolase A was clearly detected and inhibited by pre-treatment of anti-aldolase A antibody. Aldolase A was co-stained with incorporated PrPSc in M-BIE cells. These results suggest that bovine M cells and goblet cells synthesize aldolase A, and that aldolase A may have the ability to bind PrP and associate with PrP in cellular vesicles. Therefore, aldolase A-positive M cells may play a key role in the invasion of BSE into the body.

关键词： Peyer’s Patch M Cell BIE Cells Aldolase A PrP Binding Protein

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Multi-dimple phenomena in TEHL point contacts

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Science China Chemistry 2002年第2期45卷 127-134页

作者：杨沛然 KANETA motohiro State Key Laboratory of Tribology Tsinghua University Beijing 100084 China Department of Mechanical Engineering Qingdao Institute of Architecture and Engineering Qingdao 266033 China

Theoretical analysis and experimental measurement of the multiple dimples in thermal elastohydrodynamic lubrication (TEHL) point contacts have been carried out. Good agreement is found between the theoretical and expe... 详细信息

关键词： multi-dimple, point contact, temperature, elastohydrodynamic lubrication.

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Coexistence of cluster and shell-model aspects in nuclear systems

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Frontiers of physics 2018年第6期13卷 89-113页

作者： Yoshiko Kanada-En'yo Hisashi horiuchi Department of Physics Kyoto University Kitashirakawa Oiwake-Cho Kyoto 606-8502 Japan Research Center for Nuclear Physics (RCNP) Osaka University Ibaraki Osaka 567-0047 Japan

We discuss cluster phenomena in light nuclei. As examples of typical cluster structures, we first review cluster structures of 12C, 16O, and 20Ne, and then introduce some topics of cluster phenomena in light neutron-rich nuclei such as Be and C isotopes. A particular attention is paid on coexistence of cluster and shell-model aspects.

关键词： cluster nuclear structure

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Decreased incidence followed by comeback of pediatric infections during the COVID‑19 pandemic in Japan

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World Journal of Pediatrics 2022年第8期18卷 564-567页

作者： Cyrus Ghaznavi Haruka Sakamoto Takayuki Kawashima Sayaka horiuchi Masahiro Ishikane Sarah Krull Abe Daisuke Yoneoka Akifumi Eguchi Yuta Tanoue Masahiro Hashizume Shuhei Nomura Department of Health Policy and Management School of MedicineKeio University35 ShinanomachiShinjuku-kuTokyo 160-8582Japan Medical Education Program Washington University School of Medicine in St.LouisSaint LouisUSA Department of Global Health Policy Graduate School of MedicineThe University of TokyoTokyoJapan Tokyo Foundation for Policy Research TokyoJapan Department of Hygiene and Public Health Tokyo Women’s Medical UniversityTokyoJapan Department of Mathematical and Computing Science Tokyo Institute of TechnologyTokyoJapan Center for Birth Cohort Studies University of YamanashiYamanashiJapan Disease Control and Prevention Center National Center for Global Health and MedicineTokyoJapan Division of Prevention National Cancer Center Institute for Cancer ControlTokyoJapan Infectious Disease Surveillance Center National Institute of Infectious DiseasesTokyoJapan Department of Sustainable Health Science Center for Preventive Medical SciencesChiba UniversityChibaJapan Institute for Business and Finance Waseda UniversityTokyoJapan

During the coronavirus disease 2019(COVID-19)pandemic,the Japanese government implemented several infection control measures,such as states of emergency(SoE)and school closures,and encouraged universal masking and hand *** activity restrictions and improved hygiene were found to be associated with declines in the incidence of infuenza during the 2019–2020 winter season[1].Prior studies have found that the incidence of seven pediatric infections,such as pharyngoconjunctivitis and varicella,decreased during and after the school closures in Japan[2].As activity restrictions continue to be lifted,there is growing concern that pediatric infections may suddenly return given that the pool of susceptible children increased during the pandemic[3].In this study,we use national infectious disease sentinel data from January 2012 to October 2021 to assess changes in the reported number of pediatric infections in Japan during the COVID-19 *** hypothesize that the reporting of many infectious diseases decreased during the early stages of the pandemic but ultimately returned to normal when activity restrictions were lifted.

关键词： closure return suddenly

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Estimation of culm volume reduction factors in five bamboo species(Phyllostachys spp.)

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Journal of Forestry Research 2019年第6期30卷 2069-2078页

作者： Akio Inoue Miyuki Shimada motohiro Sato Hiroyuki Shima Faculty of Environmental and Symbiotic Sciences Prefectural University of KumamotoKumamoto 862-8502Japan Faculty of Engineering Hokkaido UniversitySapporo 060-8628Japan Department of Environmental Sciences University of YamanashiKofu 400-8510Japan

The hollow cylindrical culm is one of the most remarkable morphological characters of most bamboo *** relation to its hollow structure,there are two different attributes of the culm volume in bamboo:the apparent culm volume(va:the total culm volume including the hollow portion)and the woody culm volume(vw:the volume of the woody walls of the culm).The ratio of vw to va is defined as the reduction factor for culm volume(fv).The quantity fv is useful to quantify the biomass resources of bamboo culms as well as to evaluate the carbon stock of bamboo ***,the direct measurement of fv requires destructive sampling,which consumes time and ***,an alternative method for obtaining fv is *** this study,we examined fv in five species of the genus Phyllostachys and proposed alternative methods to estimate *** data showed that fv varied by species,some of which exhibited a dependency of fv on culm *** findings indicate that the intraspecific and interspecific variation in fv should be considered carefully when converting va into vw by *** on our results,we propose here six approaches for predicting fv and we discuss their advantages and *** results are intended to facilitate evaluation of the carbon sequestration capacity of bamboo forests and the commercial utilization of bamboo culms.

关键词： Apparent culm volume Carbon sequestration Genus Phyllostachys Hollow cylindrical culm Woody culm volume

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Nonlocalized clustering and evolution of cluster structure in nuclei

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Frontiers of physics 2020年第1期15卷 71-134页

作者： Bo Zhou Yasuro Funaki Hisashi horiuchi Akihiro Tohsaki Institute for the Advancement of Higher Education Hokkaido UniversitySapporo 060-0817Japan Department of Physics Hokkaido UniversitySapporo 060-0810Japan College of Science and Engineering Kanto Gakuin UniversityYokohama 236-8501Japan Research Center for Nuclear Physics(RCNP) Osaka UniversityOsaka 567-0047Japan

We explain various facets of the THSR(Tohsaki-horiuchi Schuck-Ropke)wave *** first discuss the THSR,wave function as a wave function of cluster-gas state,since the THSR,wave function was originally introduced to elucidate the 3a-condensate-like character of the Hoyle state(O2^+ state)of *** briefly review the cluster-model studies of the Hoyle state in 1970’s in order to explain how there emerged the idea to assign the a condensate character to the Hoyle *** then explain that the THSR wave function can describe very well also non-gaslike ordinary cluster states with spatial localization of *** fact means that the dynamical motion of clusters is of nonlocalized nature just as in gas-like states of clusters and the localization of clusters is due to the inter-cluster Pauli principle which is against the close approach of two *** nonlocalized cluster dynamics is formulated by the container model of cluster *** container model describes gas-like state and non-gaslike states as the solutions of the Hill Wheeler equation with respect to the size parameter of THSR wave function which is just the size parameter of the *** we notice that fact that the THSR wave function with the smallest value of size parameter is equivalent to the shell-model wave function,we see that the container model describes the evolution of cluster structure from the ground state with shell-model structure up to the gas-like cluster state via ordinary non-gaslike cluster *** the description of various cluster structure,more generation of THSR wave function have been introduced and we review some typical examples with their actual applications.

关键词： Hoyle state alpha condensation THSR wave function,nonlocalized clustering container model evolution of cluster structure

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Hydraulic model tests for evaluating sediment control function with a grid-type Sabo dam in mountainous torrents

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International Journal of Sediment Research 2013年第4期28卷 511-522页

作者： Takahiro ITOH Shigeo horiuchi Takahisa MIZUYAMA Kazuhiko KAITSUKA NIPPON KOEI Co. Ltd Pasco Corporation Graduate School of Agriculture Kyoto University NIPPON KOEI Co. Ltd.

There are two kinds of Sabo dams in order to control sediment transport by debris flow and flash floods in mountainous area,which arc closed and open-type’s *** Japan,open-type’s Sabo dams are constructed taking into account the continuity of sediment routing from upstream to downstream reach in a basin.A plan to construct a 20 m high grid-type Sabo dam which can capture a sediment volume of 400,000 nr is proposed in the Amahata river basin in *** model tests are conducted to decide on the section for a dam(Section A,B) and the grid size such as clearance of vertical/horizontal bars for evaluating the *** runs of flume tests are conducted and the sediment control function of the Sabo dam is discussed using several experimental data such as dimensionlcss sediment runoff rate from Sabo dam,temporal changes of bed profile and mean diameter and so *** was found that sediment deposition in sediment storage area of Sabo dam was affected by curved channel,and that next the grid size of steel bars and thirdly the section of a dam was able to capture sediment in storage area of Sabo *** was controlled well in the section B and in the grid size of l.0×d95,and the problems related to sediment runoff after sediment capturing in Sabo dam are pointed out.

关键词： Hydraulic model tests Debris flow Grid-type Sabo dam Sediment storage

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Formation of Non-Maxwellian Distribution and Its Role in Collisionless Driven Reconnection

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Communications in Computational Physics 2008年第8期4卷 496-505页

作者： R.horiuchi H.Ohtani National Institute for Fusion Science Toki 509-52Japan The Graduate University for Advanced Studies Toki 509-52Japan

The dynamical evolution of collisionless driven reconnection is investigated by using an electromagnetic particle simulation code in a microscopic open *** in-plane electrostatic field is excited in the central region of current sheet under the influence of an external driving *** a result of the amplification of unmagnetized meandering motion by the electrostatic field particle distribution function is modified from the shifted Maxwellian to an anisotropic one in the current *** ion hole appears at the center of current sheet in the phase space,where distribution becomes two-peaked and no ions exist in low velocity region between two *** strongmodification of distribution function leads to the generation of off-diagonal components of pressure tensor term,which is one of major causes to violate frozen-in constraint and trigger collisionless reconnection.

关键词： Collisionless reconnection particle simulation open system multi-scale physics

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Geographic Tongue:Proposal for the Use of Ultraviolet A Phototherapy

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International Journal of Dermatology and Venereology 2023年第1期6卷 59-59页

作者： Yasuhiro horiuchi Division of Dermatology Tsuruse Orthopedic ClinicMiyoshiSaitama 354-0041Japan

Dear Editor,Geographic tongue(G tongue)is chronic inflammation of the tongue that presents as a map-like pattern of filiform papillary atrophy that changes over time.1 However,the cause of G tongue remains unknown and reliable treatment has not yet been *** has been suggested that the pathogenesis involves the engraftment of oral bacteria in the tongue,however,a specific treatment for G tongue has not been well defined.I propose a potential therapy using long-wave ultraviolet(UV)A,which can penetrate and reach the submucosal tissue to potentially kill bacteria.2 Herein,I discuss the current status and prospects of UV irradiation treatment being studied for gingival diseases that may be applicable for G tongue3-4.

关键词： ultraviolet applicable graft

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Vibrational dynamics of the CN stretching mode of [Ru(CN)_6]^(4-) in D_2O studied by nonlinear infrared spectroscopy

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Science China(Physics,Mechanics & Astronomy) 2010年第6期53卷 1013-1019页

作者： Jumpei TAYAMA motohiro BANNO Kaoru OHTA Keisuke TOMINAGA Graduate School of Science Kobe University Molecular Photoscience Research Center Kobe University PRESTO JST4-1-8 Honcho KawaguchiSaitamaJapan 332-0012Japan

We have studied vibrational dynamics of the T1u mode of the CN stretching mode of [Ru(CN)6 ]4- in D2O by infrared(IR) nonlinear spectroscopy such as an IR three-pulse photon echo experiment and polarization-sensitive IR pump-probe spectroscopy. The isotropic component of the pump-probe signal shows a bi-exponential decay with time constants of 0.8 ps and 20.8 ps. The fast and slow components correspond to the rapid equilibration between the T1u mode and the Raman active modes of the CN stretching mode and the vibrational population relaxation from the v=1 state of the T1u mode,respectively. Anisotropy of the pump-probe signal decays with a time constant of 3.1 ps,which is due to the time evolution of the superposition states of the triply degenerate T1u modes. Three pulse photon echo measurements showed that the time correlation function of the frequency fluctuation decays bi-exponentially with time constants of 80 fs and 1.4 ps. These time constants depend only on the solute and are independent of the solvent,whereas the amplitudes depend on both the solute and solvent.

关键词： nonlinear IR spectroscopy metal complex aqueous solution

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