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Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations

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World Journal of Gastroenterology 2019年第14期25卷 1753-1763页

作者： Yuichi Matsuno Junji Umeno motohiro esaki Yoichiro Hirakawa Yuta Fuyuno Yasuharu Okamoto Atsushi Hirano Shigeyoshi Yasukawa Fumihito Hirai Toshiyuki Matsui Shuhei Hosomi Kenji Watanabe Naoki Hosoe Haruhiko Ogata Tadakazu Hisamatsu Shunichi Yanai Shuji Kochi Koichi Kurahara Tsuneyoshi Yao Takehiro Torisu Takanari Kitazono Takayuki Matsumoto Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Department of Endoscopic Diagnostics and Therapeutic Saga University Hospital Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University Department of Gastroenterology Fukuoka University Chikushi Hospital Department of Gastroenterology Osaka City University Graduate School of Medicine Department of Intestinal Inflammation Research Hyogo College of Medicine Center for Diagnostic and Therapeutic Endoscopy School of Medicine Keio University the Third Department of Internal Medicine Kyorin University School of Medicine Division of Gastroenterology Department of Internal Medicine Iwate Medical University Division of Gastroenterology Matsuyama Red Cross Hospital Department of Gastroenterology Sada Hospital

BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from *** To examine whether prostaglandin E major urinary metabolites(PGE-MUM) can serve as a biomarker to distinguish CEAS from *** This was a transactional study of 20 patients with CEAS and 98 patients with *** was diagnosed by the confirmation of homozygous or compound heterozygous mutation of SLCO2 A1. We measured the concentration of PGEMUM in spot urine by radioimmunoassay, and the concentration was compared between the two groups of patients. We also determined the optimal cut-off value of PGE-MUM to distinguish CEAS from CD by receiver operating characteristic(ROC) curve *** Twenty Japanese patients with CEAS and 98 patients with CD were ***-MUM concentration in patients with CEAS was significantly higher than that in patients with CD(median 102.7 vs 27.9 μg/g × Cre, P < 0.0001). One log unit increase in PGE-MUM contributed to 7.3 increase in the likelihood for the diagnosis of CEAS [95% confidence interval(CI) 3.2-16.7]. A logistic regression analysis revealed that the association was significant even after adjusting confounding factors(adjusted odds ratio 29.6, 95%CI 4.7-185.7). ROC curve analysis revealed the optimal PGE-MUM cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with 95.0% sensitivity and 79.6% *** PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD.

关键词： Chronic enteropathy associated with SLCO2A1 gene Prostaglandin E major urinary metabolites Chronic nonspecific multiple ulcers of the small intestine Crohn's disease Small intestine

Rapid assessment of regional superficial landslide under heavy rainfall

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Journal of Central South University 2012年第9期19卷 2663-2673页

作者：方薇 T.esaki Key Laboratory of Road Structure and Material of Ministry of Transport(Changsha University of Science and Technology) Research Institute for East Asia Environments Kyushu University

In order to establish a rapid method for regional slope stability analysis under rainfall,matric suction and seepage force were taken into account after obtaining explicit solution of infiltration ***,simplified analysis model under 3D condition was put forward based on identification and division of slope units,as well as modification of sliding direction of each *** result shows that explicit solution of infiltration depth is of good precision;for the given model,safety factors without taking seepage force into account are 1.82-2.94 times higher;the stagnation point of slope angle is located approximately in the range of(45°,50°);the safety factor changes insignificantly when wetting front is deeper than 2 m;when matric suction changes in the specified range,the maximum variations of safety factor are less than 0.5,which proves that matric suction plays an insignificant role in maintaining slope stability compared to the slope angle and infiltration *** with geographic information system,a practical application of regional slope stability assessment verifies the applicability of the proposed method.

关键词： weathered soil infiltration model seepage force safety factor geographic information system (GIS)

Water Resource Development in the Quaternary Ryukyu Limestone Regions of Japan:Application of the GIS to the Site Selection of Underground Dams

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Acta Geologica Sinica(English Edition) 2001年第3期75卷 254-259页

作者： Kaijun JIANG Hiroyasu FURUKAWA Yuji ONOYAMA Testuro esaki Underground Dam Research Group Showa-chika Kogyo Inc. Fukuoka Japan 815-0082Underground Dam Research Group Showa-chika Kogyo Inc. Fukuoka Japan 815-0082Underground Dam Research Group Showa-chika Kogyo Inc. Fukuoka Japan 815-0082Institute of Environmental Systems Kyushu University Fukuoka Japan 812-8581

Based on the natural and social conditions as well as hydrogeological characteristics of the Ryukyu limestone, a major aquifer in the Ryukyu Islands, a conception of underground dam, was proposed in the early 1970s in order to develop ground water resources in the Quaternary Ryukyu limestone regions of Japan. The practice of nearly thirty years has shown that the underground dam is an environment-friendly and effective way for developing ground water in these regions.

关键词： underground dam limestone Quaternary GIS ground water

Development of Helicobacter pylori treatment: How do we manage antimicrobial resistance?

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World Journal of Gastroenterology 2019年第16期25卷 1907-1912页

作者： Sho Suzuki Mitsuru esaki Chika Kusano Hisatomo Ikehara Takuji Gotoda Division of Gastroenterology and Hepatology Department of Medicine Nihon University School of Medicine

Helicobacter pylori(H. pylori) antimicrobial resistance is an urgent, global issue. In2017, the World Health Organization designated clarithromycin-resistant *** as a high priority bacterium for antibiotic research and development. In addition to clarithromycin, resistance to metronidazole and fluoroquinolones has also increased worldwide. Recent international guidelines for management of *** infection recommend bismuth or non-bismuth quadruple therapy for 14 d as a first-line treatment for H. pylori in areas of high clarithromycin and/or metronidazole resistance. Although these treatment regimens provide acceptable H. pylori eradication rates, the regimens used should not contribute to future resistance of H. pylori to antimicrobials. Moreover, these regimens can promote resistance, due to prolonged therapy with multiple antibiotics. A new strategy that can eradicate H. pylori as well as reduce the antibiotics used is required to prevent future antimicrobial resistance in H. pylori. Dual-therapy with vonoprazan and amoxicillin could be a breakthrough for H. pylori eradication in an era of growing antimicrobial resistance. This regimen may provide a satisfactory eradication rate of H. pylori and also minimize antimicrobial resistance due to single antibiotic use and the strong inhibitory effect of vonoprazan on gastric acid secretion.

关键词： Helicobacter pylori Antibiotic resistance Antimicrobial resistance Dual therapy Vonoprazan

Common Management Process Model of New TQM Based on the Situation Analysis

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Intelligent Information Management 2016年第6期8卷 181-193页

作者： Kazuhiro esaki Faculty of Science and Engineering HOSEI University Tokyo Japan

In the previous study, we suggested the concept of new TQM based on the consideration of basic concept of Quality Control. Also, in the previous study, we suggested the target domains and entities of product and process based on the TQM Matrix and view point of Three Dimensional Unification Value Models for managing quality of organization systems. Furthermore, in the previous study, we suggest the Common Management Process of organizations. Based on the above suggestion, in this paper, we would like to propose the Common Management Process Model of Total Quality Management based on the consideration of situation analysis and more precise definition of TQM Matrix and Three Dimensional Unification Value Model of “Product and Process”. Improvement of quality and efficiency of organization management can be expected by the integration of conventional different management such as quality assurance, quality improvement, risk management, investment individually from the view point of common management process.

关键词： Common Management Process Model TQM Matrix Three Dimensional Unification Value Model Quality Assurance Quality Improvement Static Risk Management Dynamic Risk Management Investment Management Project Management

Target Entities of Total Quality Management Based on the New TQM and Three-Dimensional Unification Value Models

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Intelligent Information Management 2015年第2期7卷 70-79页

作者： Kazuhiro esaki Faculty of Science and Engineering HOSEI University Tokyo Japan

In recent years, the method of TQM (Total Quality Management) is widely recognized. However, contents of target entities for assessment are various, and it is very difficult to define the whole scope of TQM. On the other hand, it is very important to define the whole target entities of quality management about the TQM because lack of important target entities may cause significant risk of loss in future. Furthermore, target entities of TQM should correspond to needs and priority of an objective requirement and that should be based on the consideration of basic principle of quality management. In the previous study, we have proposed the “framework of new TQM” of assessment for a total quality management of organizations based on the original concept of “TQM matrix”. On the other hand, we have proposed the view point of “Three-Dimensional Unification Value Models” for an evaluation of system product. Therefore, in this paper, we propose the target entities of whole assessment of quality management of organization totally based on the consideration of “New TQM framework” and the view point of “Three-Dimensional Unification Value Models”. Also, this paper proposes the result of verification based on the result of comparison between proposed target entities of assessment and American Malcolm Baldrige Prize for Performance Excellence.

关键词： Target Entity TQM TQM Matrix Quality Assurance Quality Improvement Static Risk Management Dynamic Risk Management Investment Management Project Management

Design-Stage Prediction of Project Correctness or Incorrectness

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Intelligent Information Management 2018年第2期10卷 49-68页

作者： Kazuhiro esaki Faculty of Science and Engineering HOSEI University Tokyo Japan

The success of a software development project requires the early objective determination of the project’s correctness or incorrectness and the identification of the most effective solution for project management. However, few studies have been conducted on the reliable quantitative early judgment of correctness or incorrectness. In recent years, the collection and accumulation of actual attribute data from Japanese domestic software development projects have been conducted by the Software Engineering Centre of the Information-Technology Promotion Agency of Japan. In a previous article, we proposed a precise definition of project correctness or incorrectness and identified the important factors in successful projects;we also proposed a quantitative decision-making method for judging project correctness or incorrectness objectively and quantitatively on the basis of discriminant analysis using project completion attribute data. On the basis of the previous results, we propose a quantitative decision-making technique for the early judging of project correctness or incorrectness based on the attribute data of design stage as early stage of development.

关键词： Software Reliability Software Development Project Correctness or Incorrectness Prediction Model Project Management Success Degree Judgment Technique

Three Dimensional Integrated Value Models Based on ISO/IEC9126 System Quality Model

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American Journal of Operations Research 2013年第3期3卷 342-349页

作者： Kazuhiro esaki Faculty of Science and Engineering HOSEI University Tokyo Japan

When introduce a distribution system, it is necessary performing an assessment of system quality generally to evaluate the characteristic of system from candidates targeted product for the purchase and evaluating the superiority and inferiority. The general quality assessment for the system is performed by the integration test based on the quality requirements of the customer till now. But, it is very difficult to perform the integration test completely, because the system testing may depend on the individual person’s high skill and experiences. Recently, the method of the quantitative quality requirements and evaluation based on the ISO/IEC9126 quality model is widely recognized for the purpose of a quality evaluation and improvement of the system product. In the precedent study, I have performed the confirmation of the method of evaluation for the system quality from the viewpoint of six quality characteristics included in the quality model defined in ISO/IEC9126, and the effectiveness of whose quality model could have confirmed quantitatively and statistically. However, it is very difficult to assess superiority and inferiority of the system totally even if evaluating the quality of the distribution system from the viewpoint of six quality characteristics for a customer individually. Therefore, if we could display total quality of the target system visually, we could evaluate and compare the total quality of system objectively and intuitively. Based on these assumptions, in this paper, we propose the concept and effectiveness of the “Three Dimensional Integrated Value Model” based on the result of precedent study about six quality characteristics.

关键词： System Software Quality Requirement Quality Evaluation Quality Model Quality Characteristic Quality Attribute Quality Measure Requirement Process Evaluation Process Customer Satisfaction Customer Needs

General Frame Work of New TQM Based on the ISO/IEC25000 Series of Standard

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Intelligent Information Management 2013年第4期5卷 126-135页

作者： Kazuhiro esaki HOUSEI University Faculty of Science and Engineering Kajino-cho Koganei-shi TokyoJapan

Generally, for quality improvement of an organization management, TQM (Total Quality Management) is used worldwide and recognized. However, contents of activity are various, and it is difficult for organization to define the whole scope of TQM. It is very important that the activity theme about the TQM is based on the consideration of the needs and priority from the objective requirement, which should correspond to the basic consideration of quality management. If we have selected the wrong theme, and missed understanding about importance and priority of target for TQM, it may cause a significant risk in the organization management. For example, the company which got a high evaluation about the quality of management has poor management and disgraceful affair after several years, and it is a case reaching the bankruptcy. We worked on a study for improvement of technique for quality requirement and evaluation of system for many years, and have participated in the development of international standard for supporting the quality requirements and evaluation of system in ISO/IECJTC1/SC7. The organization having a specific purpose is a kind of system. It is thought that evaluation technique of the system quality is adaptive for a quality evaluation of the organization management. Therefore, this study suggests the new framework of TQM from the view point of the general framework of management defined in ISO/IEC25040 and TQM matrix. Furthermore, this paper presents the result of comparison between proposed action theme derived from a framework of new TQM and the example of existing TQM, and reports an inspection result of the effectiveness.

关键词： TQM Structure of Quality TQM Matrix Quality Assurance Quality Improvement Investment Management Project Management Static Risk Management Dynamic Risk Management