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Journal of Biosciences and Medicines 2017年第11期5卷 27-32页

作者： Fusako Mitsunaga Shin Nakamura motofumi ohki Kaizu Laboratory Biomedical Institute NPO Primate Agora Kaizu Japan Intelligence and Technology Lab Inc. Kaizu Japan Biomedical Institute NPO Primate Agora Inuyama Japan Department of Otorhinolaryngology Kitasato University Medical Center Kitamoto Japan

Nasal obstruction, a primary symptom of allergic rhinitis, results in breathing difficulties and decreases quality of life in patients. Quantitative methods are required for diagnosis of nasal obstruction to accurately assess drug efficacy, not only in patients but also in animal models. Acoustic rhinometry is a non-invasive technique to measure nasal airway patency using acoustic reflections. To date, little information on its application in non-human primates (NHP) has been accumulated. Macaque monkeys are a practical NHP model because of their high similarity with humans in their biomedical nature, including genomic and immunologic events and morphology. We established an allergic rhinitis model of cynomolgusmacaque (Macaca fascicularis) sensitized with Japanese cedar pollen and applied acoustic rhinometry to measure nasal congestion. The extent of nasal congestion followed by allergen challenge was successfully quantified as the minimal cross-sectional area (MCA) of the nasal passage for the first time in an NHP allergic model. We also applied this acoustic technique to evaluate the efficacy of an antihistamine drug, fexofenadine. The acoustic assessment achieved quantitative evaluation of the efficacy of fexofenadine on nasal congestion in a macaque allergic model.

关键词： Non-Human Primate Pollinosis Nasal Congestion Allergic Rhinitis Antihistamine

Thermal ageing of soft and hard epoxy resins

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High Voltage 2023年第1期8卷 12-20页

作者： Yoshimichi ohki Naoshi Hirai Research Institute for Materials Science and Technology Waseda UniversityShinjuku-kuTokyoJapan

Two kinds of epoxy resin,a soft one with rubber-based additives and an ordinary hard one,are used as electrical insulators and airtight sealants in electrical penetrations in nuclear power plants(NPPs).Knowing how they behave under adverse environments is important for the safe operation of *** this regard,we gave artificial thermal ageing treatment to the two resins by heating them in air at various *** resins were then subjected to mechanical,thermal,and dielectric *** a result,it has become clear that the soft epoxy resin becomes hard,while its permittivity and loss factor decrease as the heating becomes *** glass transition tends to occur at a high temperature in the soft epoxy resin when it was *** these changes,the soft resin tends to exhibit similar behaviour in various properties to that of the unaged hard *** the other hand,the hard one is hardly affected by the simulated thermal ***,both resins can be useable in NPPs.

关键词： resin resins heated

Broadband FIR absorption spectra of lowdensity polyethylene sheets containing six different antioxidants and estimation of their contents by chemometric analysis

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High Voltage 2019年第3期4卷 161-166页

作者： Takaaki Ogishima Chiaki Kuroda Naoshi Hirai Yoshimichi ohki Department of Electrical Engineering and Bioscience Waseda UniversityShinjuku-kuTokyo 169-8555Japan Research Institute for Materials Science and Technology Waseda UniversityShinjuku-kuTokyo 169-8555Japan Cooperative Major in Nuclear Energy Waseda UniversityShinjuku-kuTokyo169-8555Japan

Antioxidants are usually added to polymeric insulating materials to suppress oxidative ***,the details of antioxidant added to a polymer are often not *** the other hand,compared to mid-infrared absorption spectroscopy,terahertz(THz)absorption spectroscopy,and far-infrared(FIR)absorption spectroscopy have not been performed so *** on the above backgrounds,six different kinds of antioxidants were added into low-density polyethylene sheets with four different contents,and their THz and FIR absorption spectra were *** a result,it has become clear that each antioxidant shows its specific absorption peaks,by which the antioxidants can be ***,the antioxidant content can be estimated by the absorption intensity of the specific peak.A chemometric analysis can make the estimation more accurately than a simple comparison of absorption intensity.

关键词： FIR absorption estimation

Surface flashover in 50 years:Theoretical models and competing mechanisms

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High Voltage 2023年第5期8卷 853-877页

作者： Zhen Li Ji Liu Yoshimichi ohki George Chen He Gao Shengtao Li Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and TechnologyHarbinChina State Key Laboratory of Electrical Insulation and Power Equipment Xi'an Jiaotong UniversityXi'anChina Research Institute for Materials Science and Technology Waseda UniversityShinjuku‐kuJapan School of Electronics and Computer Science University of SouthamptonSouthamptonUK

Surface flashover is a devastating electronic avalanche along the gas–solid interface when a high electric field is applied,which is a potential issue that threatens the safe operations of advanced power electronic,electrical,and spacecraft ***,the underlying physical mechanisms for surface flashover development are still under investigation owing to the complex charge transport processes through the gas phase,solid phase,and gas–solid *** this study,the history of surface flashover theory in the last 50 years is introduced,and several key questions are reviewed from the perspective of the competing mechanisms of charge transport:the role of each phase in a surface flashover,the origin of surface charging,and effects of traps in solid on surface ***,some suggestions involve charge transport processes in each phase,and their correlations are put forward,and a predictable‘charge transport competitive flashover model’is proposed by clarifying the competing mechanisms of charge transport processes through multiple *** study summarises the history and hot topics of physical mechanisms of surface flashover proposed based on classic and recent progress and offers promising routes for developing a more precise surface flashover theory and improving surface flashover performances.

关键词： flash transport charge

Experimental investigation of the degradation mechanism of silicone rubber exposed to heat and gamma rays

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High Voltage 2017年第2期2卷 92-101页

作者： Shugo Hanada Maki Miyamoto Naoshi Hirai Liuqing Yang Yoshimichi ohki Department of Electrical Engineering and Bioscience Waseda University3-4-1 OhkuboShinjuku-kuTokyoJapan Research Institute for Materials Science and Technology Waseda University2-8-26 Nishi-WasedaShinjuku-kuTokyoJapan State Key Laboratory for Electrical Insulation and Power Equipment Xi'an Jiaotong UniversityXi'anPeople's Republic of China Cooperative Major in Nuclear Energy Waseda University3-4-1 OhkuboShinjuku-kuTokyoJapan

Cable-grade silicone rubber was aged thermally or by combining heat and gamma-ray radiation,and resultant changes in chemical,thermal,mechanical and electrical properties were *** experimental results obtained in these analyses are clearly consistent with the mechanism that silicone rubber is degraded by forming cross-linked structures via formation of abundant siloxane *** further progress of degradation,decomposition becomes *** these mechanisms,mechanical properties deteriorate dramatically by losing *** the real and imaginary parts of complex permittivity decrease,which is a contrastive difference from typical ageing behaviour of organic insulating *** addition,both the elongation at break and indenter modulus are good indicators of degradation of silicone rubber.

关键词： rubber mechanism modulus

A Contribution to Guy's Conjecture

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Acta Mathematica Sinica,English Series 2022年第10期38卷 1856-1886页

作者： Yukio MATSUMOTO Yoshikazu MATSUTANI Angel MONTESINOS-AMILIBIA Masami ODA Shuichi ohki Tsuyoshi SAKAI Department of Mathematics Gakushuin UniversityMejiroToshima-kuTokyo 171-8588Japan 3-21-1-901 Minamimachi KokubunjiTokyo 185-0021Japan Calle Rio Alberche 8.05260 CebrerosSpain Tsuda University 2-1-1Tsuda-choKodairaTokyo 187-8577Japan Tokyo Japanese Language Educational Center 3-22-7Kita ShinjukuShinjuku-kuTokyo 169-0074Japan Department of Mathematics College of Humanities and SciencesNihon UniversitySetagaya-kuTokyo 156-0045Japan

Let Kdenote the complete graph consisting of n vertices,every pair of which forms an *** want to know the least possible number of the intersections,when we draw the graph Kon the plane or on the sphere using continuous arcs for *** a paper published in 1960,Richard *** conjectured that the least possible number of the intersections is 1/64(n-1)^(2)(n-3)^(2) if n is odd,or 1/64 n(n-2)^(2)(n-4)if n is even.A virgin road V_(n)is a drawing of a Hamiltonian cycle in Kconsisting of n vertices and n edges such that no other edge-representing arcs cross V.A drawing of Kis called virginal if it contains a virgin *** drawings considered in this paper will be virginal with respect to a fixed virgin road *** will present a certain drawing of a subgraph of K,for each n(≥5),which is"characteristic"in the sense that any minimal virginal drawing of Kcontaining this subdrawing satisfies Guy’s conjecture.

关键词： Complete graph virginal drawing Guy’s conjecture

Finite-difference time-domain simulation of partial discharges in a gas insulated switchgear

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High Voltage 2016年第1期1卷 52-56页

作者： Hiroki Tanaka Daiki Tanahashi Yoshihiro Baba Naoto Nagaoka Naoki Okada Hideto ohki Masayasu Takeuchi Department of Electrical Engineering Doshisha UniversityKyotanabeKyoto 610-0321Japan Nissin Electric Co. LtdUkyokuKyoto 615-8686Japan

It is important to estimate the current magnitude and charge amount of a partial discharge (PD) in a gasinsulatedswitchgear (GIS). In this study, electromagnetic fields generated by a PD in an 84 kV-class three-phase GIS fortesting have been measured with a voltage probe installed on the outer surface of an insulation spacer of the GIS tank,and the corresponding simulations have been carried out using the three-dimensional finite-difference time-domain(FDTD) method. FDTD-computed time-domain voltages across spacers agree reasonably well with the correspondingmeasured ones, and the current magnitude of PD and its charge amount have been estimated.

关键词： magnitude difference insulation

A Simplified Numerical Simulation Method Considering Active Devices for Opto-Electronic Mixed Modules

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光学学报 2003年第S1期23卷 321-322页

作者： Tomoaki Yoshida Hideaki Kimura Shuichiro Asakawa Akira ohki Kiyomi Kumozaki NTT Access Network Service Systems Laboratories NTT CorporationNTT Access Network Service Systems Laboratories NTT CorporationNTT Photonics Laboratories NTT Corporation. 11-6 Nakase Mihamaku Chiba-shi Chiba Japan 261-0023.NTT Photonics Laboratories NTT Corporation. 11-6 Nakase Mihamaku Chiba-shi Chiba Japan 261-0023.NTT Access Network Service Systems Laboratories NTT Corporation

A simplified simulation method based on the FDTD technique that can handle active devices is proposed. This method well suits the electrical crosstalk analysis of multi-channel integrated, opto-electronic mixed modules. We apply this method to an 8-channel integrated super-compact high-sensitivity optical module. The results show good agreement between simulations and measurements.

关键词：口口 of In FDTD as be by for A Simplified Numerical Simulation Method Considering Active Devices for Opto-Electronic Mixed Modules

Influence of morphology of hollow silica-alumina composite spheres on their activity for hydrolytic dehydrogenation of ammonia borane

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Journal of Advanced Ceramics 2017年第4期6卷 368-375页

作者： Naoki TOYAMA Ryota OGAWA Haruki INOUE Shinobu ohki Masataka TANSHO Tadashi SHIMIZU Tetsuo UMEGAKI Yoshiyuki KOJIMA Department of Materials&Applied Chemistry College of Science&EngineeringNihon University1-8-14Kanda-SurugadaiChiyoda-KuTokyo 101-8308Japan National Institute for Materials Science 3-13SakuraTsukubaIbaraki 305-0003Japan

Hollow silica-alumina composite spheres were prepared by a polystyrene(PS)template method using various amounts of PS *** hollow spheres prepared using 40 g were found to be with a diameter of about 300 nm in scanning electron microscopy,and transmission electron microscopy demonstrated their hollow sphere *** the nitrogen adsorption isotherm results,the homogeneous hollow spheres prepared using 40 g of the PS suspension were found to be an ordered pore *** activities of the hollow spheres prepared using various amounts of the PS suspension for hydrolytic dehydrogenation of ammonia borane were *** results showed that 10,7,and 6 mL of hydrogen were evolved from the aqueous ammonia borane solution in about 40 min in the presence of the hollow spheres prepared using 40,80,and 120 g of PS suspension,*** homogeneous hollow spheres with an ordered pore structure showed the highest activity among all the hollow *** amount of acid sites and the coordination number of aluminum active species were characterized using neutralization titration and solid-state ^(27)Al magic angle spinning nuclear magnetic resonance *** homogeneous hollow spheres with an ordered pore structure had high amount of acid sites and 4-coordinated aluminum *** relative proportion of 4-coordinated aluminum species was related to the dispersion of aluminum *** results indicate that the homogeneous hollow spheres with an ordered pore structure showed the high activity because of high amount of acid sites induced by the highly dispersed aluminum species.

关键词： ammonia borane morphology hollow silica-alumina composite spheres dispersion acid sites

Efficacy of percutaneous radiofrequency ablation for hepatocellular carcinoma treatment in patients aged≥80 years

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Liver Research 2020年第4期4卷 206-211页

作者： Kyohei Tsuchiya Takamasa ohki Koki Sato Mayuko Kondo Nobuo Toda Kazumi Tagawa Department of Gastroenterology Mitsui Memorial HospitalTokyoJapan Department of Gastroenterology Tokyo Metropolitan Bokuto HospitalTokyoJapan

Background:Although radiofrequency ablation(RFA)is a minimally invasive treatment for early-stage hepatocellular carcinoma(HCC),it remains unclear whether RFA achieves favorable outcomes in pa-tients aged≥80 *** study aimed to determine the efficacy and safety of RFA for HCC in patients aged≥80 ***:A total of 512 naïve patients with HCC who had undergone RFA from January 2001 to December 2016 were *** were categorized into the≥80-year-old group and the control group(aged<80 years).The primary endpoint was overall survival(OS),and the secondary endpoints were recurrence-free survival,complications associated with RFA,and cause of *** score matching was performed to adjust for patients’sex,liver function,tumor number,tumor diameter,and hepatitis C virus ***,the data of 68 patients in the≥80-year-old group and 68 in the control group were analyzed;their baseline characteristics,primary endpoint,and secondary endpoints were ***:There were significant differences in the alanine aminotransferase level and prothrombin time between the *** cumulative OS rate was not significantly different between the groups(P=0.83):98.5%,87.9%,and 50.5%in the≥80-year-old group and 94.1%,72.8%,and 49.3%in the control group at 1,3,and 5 years,***≥80 years was not significantly associated with OS in multivariate ***-related death occurred in 17 patients in the≥80 year-old group and in 16 patients in the control group(P=1.00).Conclusions:RFA is safe and effective for the treatment of patients with HCC aged≥80 years.

关键词： Hepatocellular carcinoma(HCC) Locoregional therapy Radiofrequency ablation(RFA) Elderly patients Propensity score matching