检索结果-南通市图书馆

mpact of antioxidants on seminal vesicles function ind fertilizing potential in diabetic rats

Asian Journal of Andrology 2017年第6期19卷 639-646页

作者： Panagiota Tsounapi Masashi Honda Fotios Dimitriadis Bunya Kawamoto Katsuya Hikita Kuniyasu Muraoka motoaki saito Nikolaos Sofikitis Atsushi Takenaka Division of Urology Department of Surgery Tottori University School of Medicine 36-1 Nishimachi Yonago 683-8503 Japan Department of Urology University of Ioannina School of Medicine P.O. Box 1186 45110 Ioannina Greece Department of Pharmacology Kochi University Kochi Medical School Nankoku 783-8505 Japan.

Diabetes mellitus significantly affects the male reproduction and sexual function. In the present study, we investigated the diabetes-induced dysfunction of seminal vesicles （SVs） in the diabetes-rat model and the role of antioxidants. Streptozotocin-induced diabetes after 4 weeks caused smaller size of the organs, hypercontractility, histological abnormalities, increased concentrations of malondialdehyde in the serum and tissue, overexpression of oxidative stress markers, and cleaved caspase-3 as identified by immunohistochemistry in the SVs. In addition, diabetes resulted in deceased levels of serum testosterone and no newborns after the mating studies. Antioxidants significantly normalized all the above parameters, except for the severely decreased serum testosterone levels and the negative outcome of the mating studies. The present study gives evidence for the important role of diabetes-induced oxidative stress in the function and structure of these androgen-dependent organs. Antioxidants may be a promising supplementary therapy for diabetic male patients to alleviate ejaculatory disorders but alone is not efficient treatment for the mitigation of infertility.

关键词： diabetes mellitus male infertility oxidative stress seminal vesicles seminiferous epithelium smooth muscle cellcontractions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cyclohexenonic long-chain fatty alcohol reverses diabetic induced dysfunction of ileum in the rat

Cyclohexenonic long-chain fatty alcohol reverses diabetic in...

引用

第十五届国际药理学大会

作者： Shinbori Chiko saito motoaki Kinoshita Yukako Satoh Itaru Kono To-moharu Hanada Takuya Suzuki Hiroto Yamada Masashi Satoh Keisuke Division of Molecular Pharmacology Tottori University Faculty of Medicine Division of Molecular Pharmacology Tottori University Faculty of Medicine Division of Molecular Pharmacology Tottori University Faculty of Medicine Division of Molecular Pharmacology Tottori University Faculty of Medicine Division of Molecular Pharmacology Tottori University Faculty of Medicine Division of Molecular Pharmacology Tottori University Faculty of Medicine Meiji Dairies Corporation Meiji Dairies Corporation Division of Molecular Pharmacology Tottori University Faculty of Medicine

＜正＞ Objective: Diabetic neuropathy is associated with development of intestinal motilitydysfunction and autonomic neuropathy. We studied the effects of cyclohexenoniclong - chain fatty alcohol （FA） on isolated- ileum in the diabetes induced *** and Results: The rats divided into 5 groups. One is the non - diabetic group,others induced diabetes. 4 weeks after induction of diabetes, one group killed immediately, while other 3 groups were administered FA （0,2 or 8 mg/kg） for more 4 weeks. The serum glucose and serum insulin levels were unchanged by FA. The contractile responses to carbachol and KCl were argumentedin the isolated - diabeticileum. Real - time PCR and histological study showed changes of muscarinic M2 and M3 receptors of the diabetic ileum. Treatment with FA improved the thickness of intestine wall and diabetic - induced hyperreactivityof the rat ileum. Furthermore. FA reversed the diabetes - induced upregulation of muscarinic mRNAs in the diabetic rat ileum. Conclusion: These results indicate that FA has therapeutic effects on hyperreactivity in the diabetic ileum by ameliorating over expression of muscarinic M2 and M3 receptors mRNAs.

关键词： FA. neuropathy muscarinic receptor ileum

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Genetic and epigenetic risks of intracytoplasmic sperm injection method

引用

Asian Journal of Andrology 2006年第6期8卷 643-673页

作者： Ioannis Georgiou Maria Syrrou Nicolaos Pardalidis Konstantinos Karakitsios Themis Mantzavinos Nikolaos Giotitsas Dimitrios Loutradis Fotis Dimitriadis motoaki saito Ikuo Miyagawa Pavlos Tzoumis Anastasios Sylakos Nikolaos Kanakas Theodoros Moustakareas Dimitrios Baltogiannis Stavros Touloupides Dimitrios Giannakis Michael Fatouros Nikolaos Sofikitis Laboratory of Molecular Urology and Genetics of Human Reproduction Department of Urology loannina University School of Medicine loannina 45110 Greece Cytogenetics Unit Laboratory of General Biology Medical School University of loannina loannina 45110 Greece Department of Urology Tottori University School of Medicine Yonago 683 Japan Department of Molecular Pharmacology Tottori University School of Medicine Yonago 683 Japan

Pregnancies achieved by assisted reproduction technologies, particularly by intracytoplasmic sperm injection （ICSI） procedures, are susceptible to genetic risks inherent to the male population treated with ICSI and additional risks inherent to this innovative procedure. The documented, as well as the theoretical, risks are discussed in the present review study. These risks mainly represent thatconsequences of the genetic abnormalities underlying male subfertility （or infertility） and might become stimulators for the development of novel approaches and applications in the treatment of infertility. In addition, risks with a polygenic background appearing at birth as congenital anomalies and other theoretical or stochastic risks are discussed. Recent data suggest that assisted reproductive technology might also affect epigenetic characteristics of the male gamete, the female gamete, or might have an impact on early embryogenesis. It might be also associated with an increased risk for genomic imprinting abnormalities.

关键词： genetic risks epigenetic risks intracytoplasmic sperm injection testis male infertility

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CO_2 insufflation for potentially diffi cult colonoscopies: Effi cacy when used by less experienced colonoscopists

引用

World Journal of Gastroenterology 2009年第41期15卷 5186-5192页

作者： Toshio Uraoka Jun Kato motoaki Kuriyama Keisuke Hori Shin Ishikawa Keita Harada Koji Takemoto Sakiko Hiraoka Hideyuki Fujita Joichiro Horii Yutaka saito Kazuhide Yamamoto Department of Endoscopy Okayama University Hospital Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Division of Endoscopy National Cancer Center Hospital

AIM： To clarify the effectiveness of CO2 insufflation in potentially difficult colonoscopy cases, particularly in relation to the experience level of colonoscopists. METHODS： One hundred twenty potentially difficult cases were included in this study, which involved females with a low body mass index and patients with earlier abdominal and/or pelvic open surgery or previously diagnosed left-side colon diverticulosis. Patients receiving colonoscopy examinations without sedation using a pediatric variable-stiffness colonoscope were divided into two groups based on either CO2 or standard air insuffiation. Both insufflation procedures were also evaluated according to the experience level of the respective colonoscopists who were divided into an experienced colonoscopist （EC） group and a less experienced colonoscopist （LEC） group. Study measurements included a 100-mm visual analogue scale （VAS） for patient pain during and after colonoscopy examinations, in addition to insertion to the cecum and withdrawal times. RESULTS： Examination times did not differ, however, VAS scores in the CO2 group were significantly better than in the air group （P〈 0.001, two-way ANOVA） from immediately after the procedure and up to 2 h later. There were no significant differences between either insufflation method in the EC group （P = 0.29）, however, VAS scores for CO2 insufflation were significantly better than air insufflation in the LEC group （P = 0.023） immediately after colonoscopies and up to 4 h afterwards. CONCLUSION： CO2 insufflation reduced patient pain after colonoscopy in potentially difficult cases when performed by LECs.

关键词： CO2 insufflation Colonoscopy Difficult colonoscopy Experienced colonoscopist Training

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：