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Outcome of split liver transplantation vs living donor liver transplantation:A systematic review and meta-analysis

World Journal of Gastrointestinal Surgery 2023年第7期15卷 1522-1531页

作者： Ibrahim Umar Garzali Sami Akbulut Ali Aloun motaz naffa Fuat Aksoy Department of Surgery Aminu Kano Teaching HospitalKano 700101Nigeria Department of Surgery and Liver Transplant Institute Inonu University Faculty of MedicineMalatya 44280Turkey Department of Biostatistics and Medical Informatics Inonu University Faculty of MedicineMalatya 44280Turkey Royal Medical Services King Hussein Medical CenterAmman 11855Jordan Department of Surgery Uludag University Faculty of MedicineBursa 16059Turkey

BACKGROUND The outcomes of liver transplantation(LT)from different grafts have been studied individually and in combination,but the reports were conflicting with some researchers finding no difference in both short-term and long-term outcomes between the deceased donor split LT(DD-SLT)and living donor LT(LDLT).AIM To compare the outcomes of DD-SLT and LDLT we performed this systematic review and *** This systematic review was performed in compliance with the Preferred Reporting Items for Systematic Review and Meta-Analysis *** following databases were searched for articles comparing outcomes of DD-SLT and LDLT:PubMed;Google Scholar;Embase;Cochrane Central Register of Controlled Trials;the Cochrane Database of Systematic Reviews;and Reference Citation Analysis(https://***/).The search terms used were:“liver transplantation;”“liver transplant;”“split liver transplant;”“living donor liver transplant;”“partial liver transplant;”“partial liver graft;”“ex vivo splitting;”and“in vivo splitting.”RESULTS Ten studies were included for the data synthesis and *** were a total of 4836 *** overall survival rate at 1 year,3 years and 5 years was superior in patients that received LDLT compared to *** 1 year,the hazard ratios was 1.44(95%confidence interval:1.16-1.78;P=0.001).The graft survival rate at 3 years and 5 years was superior in the LDLT group(3 year hazard ratio:1.28;95%confidence interval:1.01-1.63;P=0.04).CONCLUSION This meta-analysis showed that LDLT has better graft survival and overall survival when compared to DD-SLT.

关键词： Deceased donor liver transplantation Living donor liver transplantation Split liver transplantation Overall survival Graft survival Acute rejection

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