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Skin biomechanics:a potential therapeutic intervention target to reduce scarring

Burns & Trauma 2022年第1期10卷 357-371页

作者： motaharesadat hosseini Jason Brown Kiarash Khosrotehrani Ardeshir Bayat Abbas Shafiee Centre for Biomedical Technologies School of MechanicalMedical and Process Engineering(MMPE)Faculty of EngineeringQueensland University of TechnologyBrisbaneQLD 4059Australia Herston Biofabrication Institute Metro North Hospital and Health ServiceBrisbaneQLD 4029Australia Royal Brisbane and Women’s Hospital Metro North Hospital and Health ServiceBrisbaneQLD 4029Australia The University of Queensland Diamantina Institute Translational Research InstituteThe University of QueenslandBrisbaneQLD 4102Australia Centre for Dermatology Research NIHR Manchester Biomedical Research CentreStopford BuildingUniversity of ManchesterOxford RoadManchesterM139PTEnglandUK MRC-SAWound Healing Unit Hair&Skin Research LaboratoryDivision of DermatologyUniversity of Cape TownCape Town 7935South Africa

Pathological scarring imposes a major clinical and social burden *** cutaneous wounds are responsive to mechanical forces and convert mechanical cues to biochemical signals that eventually promote *** understand the mechanotransduction pathways in cutaneous scarring and develop new mechanotherapy approaches to achieve optimal scarring,the current study highlights the mechanical behavior of unwounded and scarred skin as well as intra-and extracellular mechanisms behind keloid and hypertrophic ***,the therapeutic interventions that promote optimal scar healing by mechanical means at the molecular,cellular or tissue level are extensively *** current literature highlights the significant role of fibroblasts in wound contraction and scar formation via differentiation ***,understanding myofibroblasts and their responses to mechanical loading allows the development of new scar therapeutics.A review of the current clinical and preclinical studies suggests that existing treatment strategies only reduce scarring on a small scale after wound closure and result in poor functional and aesthetic ***,the perspective of mechanotherapies needs to consider the application of both mechanical forces and biochemical cues to achieve optimal ***,early intervention is critical in wound management;thus,mechanoregulation should be conducted during the healing process to avoid scar *** studies should either consider combining mechanical loading(pressure)therapies with tension offloading approaches for scar management or developing more effective early therapies based on contraction-blocking biomaterials for the prevention of pathological scarring.

关键词： Dermal fibrosis Mechanotransduction Pressure therapy Tension therapy Wound healing Skin biomechanics

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