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Structural and Functional Annotation of Hypothetical Protein of Fusobacterium nucleatum Strain MJR7757B: An in Silico Approach

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Computational Molecular Bioscience 2024年第1期14卷 17-33页

作者： Md. Isrfil Hossen Fouzia mostafa Nusrat Jahan Jannatul Ferdaus Amgad Albahi Sayed Mashequl Bari College of Food Science and Technology Huazhong Agricultural University Wuhan China Department of Crop Science and Technology Rajshahi University Rajshahi Bangladesh Abdul Malek Ukil Medical College Noakhali Bangladesh Department of Medicine IBN Sina Medical College Dhaka Bangladesh National Food Research Centre Khartoum Sudan Department of Aquatic Animal Health Management Sher-e-Bangla Agricultural University Dhaka Bangladesh

Fusobacterium nucleatum is an anaerobic, commensal, gram-negative oral bacterium that is carcinogenic and causes a wide range of human diseases. The present study focused on the analysis of the hypothetical protein, HMPREF3221_01179, derived from F. nucleatum strain MJR7757B, employing various computational methods to anticipate both its structure and functional characteristics. NCBI conserved domain analysis, NCBI BLASTp and MEGA Phylogenetic tree study characterize the target protein as an outer membrane efflux protein (ToIC family) which facilitate the bacterial transmembrane transport. With a molecular weight of 52120.02 Da, an isoelectric point (pI) of 8.33, and an instability index of 29.47, the protein is anticipated to exhibit good solubility in the extracellular space and crucial stability for pharmaceutical applications. The protein’s structure meets quality standards during the construction and refinement of its 3D model. The efflux inhibitor Arginine beta-naphthylamide exhibits a significant binding affinity (-7.1 kcal/mol) to the binding site of the target protein. The in-silico analysis improves the understanding of the protein and facilitates future investigations into therapeutic medication.

关键词： Fusobacterium nucleatum In Silico Bacteria Hypothetical Protein Molecular Docking

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Designing a Protection Scheme in Micro-Grid Systems with DG Using Central Protection Unite and Multiple Setting Group Protection Relays

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Journal of Power and Energy Engineering 2024年第9期12卷 37-49页

作者： mostafa I. Saleh Gaber El-Saady Ali M. Yousef El-Noby A. Ibrahim Alfanar Company Mecca Saudi Arabia Department of Electrical Engineering Faculty of Engineering Asyut University Asyut Egypt

Distributed generators now is widely used in electrical power networks, in some cases it works seasonally, and some types works at special weather conditions like photo voltaic systems and wind energy, and due to this continuous changes in generation condition, the fault current level in network will be affected, this changes in fault current level will affect in the coordination between protection relays and to keep the coordination at right way, an adaptive protection system is required that can adaptive its setting according to generation changes, the fault current level in each case is evaluated using ETAP software, and the required relay setting in each case is also evaluated using Grey Wolf Optimizer (GWO) algorithm, and to select suitable setting which required in each condition, to select the active setting group of protection relay according to generation capacity, central protection unite can be used, and to improve protection stability and minimizing relays tripping time, a proposed method for selecting suitable backup relay is used, which leads to decrease relays tripping time and increase system stability, output settings for relays in all cases achieved our constrains.

关键词： Directional Overcurrent Relay Protection Coordination Distributed Generators Central Protection Unite Multiple Setting Group Protection Relay

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Improving the operational stability of perovskite solar cells with cesium-doped graphene oxide interlayer

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Journal of Energy Chemistry 2024年第9期96卷 483-490页

作者： Masaud Almalki Katerina Anagnostou Konstantinos Rogdakis Felix T.Eickemeyer mostafa Othman Minas M.Stylianakis Dimitris Tsikritzis Anwar Q.Alanazi Nikolaos Tzoganakis Lukas Pfeifer Rita Therisod Xiaoliang Mo Christian M.Wolff Aïcha Hessler-Wyser Shaik M.Zakeeruddin Hong Zhang Emmanuel Kymakis Michael Grätzel Laboratory of Photonics and Interfaces École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Department of Electrical and Computer Engineering Hellenic Mediterranean UniversityHeraklionCrete 71410Greece Institute of Electrical and Microengineering(IEM)Photovoltaics and Thin-Film Electronics Laboratory(PV-Lab) École Polytechnique Fédérale de Lausanne(EPFL)Neuchâtel 2000Switzerland Department of Nursing Faculty of Health SciencesHellenic Mediterranean UniversityCrete 71410Greece Centre Interdisciplinaire de Microscopie Electronique École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Future Energy Technology Institute King Abdulaziz City for Science and Technology(KACST)P.O.Box 6086Riyadh 11442Saudi Arabia State Key Laboratory of Photovoltaic Science and Technology Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and PerceptionInstitute of OptoelectronicsDepartment of Materials ScienceFudan UniversityShanghai 200433China

Perovskite solar cells(PSCs)have made great advances in terms of power conversion efficiency(PCE),yet their subpar stability continues to hinder their *** interface between the perovskite layer and the charge-carrier transporting layers plays a crucial role in undermining the stability of *** this work,we propose a strategy to stabilize high-performance PSCs with PCE over 23%by introducing a cesium-doped graphene oxide(GO-Cs)as an interlayer between the perovskite and hole-transporting *** GO-Cs treated PSCs exhibit excellent operational stability with a projected T80(the time where the device PCE reduces to 80%of its initial value)of 2143 h of operation at the maximum powering point under one sun illumination.

关键词： Perovskite solar cells Doped graphene oxide Graphene related material Long-term operational stability

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Challenges to establishing and maintaining kidney transplantation programs in developing countries:What are the coping strategies?

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World Journal of Methodology 2024年第2期14卷 1-16页

作者： Rabea Ahmed Gadelkareem Amr mostafa Abdelgawad Nasreldin Mohammed Mohammed Ali Zarzour Mahmoud Khalil Ahmed Reda Hisham Mokhtar Hammouda Department of Urology Assiut Urology and Nephrology HospitalFaculty of MedicineAssiut UniversityAssiut 71515Egypt

Kidney transplantation(KT)is the optimal form of renal replacement therapy for patients with end-stage renal ***,this health service is not available to all patients,especially in developing *** deceased donor KT programs are mostly absent,and the living donor KT centers are ***-center studies presenting experiences from developing countries usually report a variety of *** review addresses these challenges and the opposing strategies by reviewing the single-center experiences of developing *** financial challenges hamper the infrastructural and material availability,coverage of transplant costs,and qualification of medical *** sociocultural challenges influence organ donation,equity of beneficence,and regular follow-up *** interests and motives for transplantation may result from high medicolegal responsibilities in KT practice,intense potential psychosocial burdens,complex qualification protocols,and low productivity or compensation for KT *** medical literacy about KT advantages is prevalent among clinicians,patients,and the *** inefficient organizational and regulatory oversight is translated into inefficient healthcare systems,absent national KT programs and registries,uncoordinated job descriptions and qualification protocols,uncoordinated on-site investigations with regulatory constraints,and the prevalence of commercial KT *** challenges resulted in noticeable differences between KT services in developed and developing *** coping strategies can be summarized in two main mechanisms:The first mechanism is maximizing the available resources by increasing the rates of living kidney donation,promoting the expertise of medical personnel,reducing material consumption,and supporting the establishment and maintenance of KT *** latter warrants the expansion of the public sector and the elimination of non-ethical KT *** second mechanism is recru

关键词： Challenges Coping strategies Developing countries Kidney transplantation Low resources Single-center

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Transient elastography and diffusion-weighted magnetic resonance imaging for assessment of liver fibrosis in children with chronic hepatitis C

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World Journal of Virology 2024年第3期13卷 89-97页

作者： Mohamed A El-Guindi Alif A Allam Ahmed A Abdel-Razek Gihan A Sobhy Menan E Salem Mohamed A Abd-Allah mostafa M Sira Pediatric Hepatology Gastroenterology and NutritionNational Liver InstituteMenoufia UniversityShebin El-Koom 32511MenoufiaEgypt Department of Diagnostic Radiology Mansoura Faculty MedicineMansoura 13551Egypt

BACKGROUND Chronic hepatitis C(CHC)is a health burden with consequent morbidity and *** biopsy is the gold standard for evaluating fibrosis and assessing disease severity and prognostic purposes *** altern-atives for liver biopsy such as transient elastography(TE)and diffusion-weighted magnetic resonance imaging(DW-MRI)are critical *** To evaluate TE and DW-MRI as noninvasive tools for predicting liver fibrosis in children with *** This prospective cross-sectional study initially recruited 100 children with CHC virus ***-four children completed the full set of investigations including liver stiffness measurement(LSM)using TE and measurement of apparent diffusion coefficient(ADC)of the liver and spleen using *** biopsies were evaluated for fibrosis using Ishak scoring *** and liver and spleen ADC were compared in different fibrosis stages and correlation analysis was performed with histopathological findings and other laboratory *** Most patients had moderate fibrosis(73.5%)while 26.5%had mild *** had severe fibrosis or *** majority(68.8%)had mild activity,while only 7.8%had moderate *** scores had a significant direct correlation with LSM(P=0.008)and were negatively correlated with both liver and spleen ADC but with no statistical significance(P=0.086 and P=0.145,respectively).Similarly,histopatho-logical activity correlated significantly with LSM(P=0.002)but not with liver or spleen ADC(P=0.84 and 0.98 respectively).LSM and liver ADC were able to significantly discriminate F3 from lower fibrosis stages(area under the curve=0.700 and 0.747,respectively)with a better performance of liver *** TE and liver ADC were helpful in predicting significant fibrosis in children with chronic hepatitis C virus infection with a better performance of liver ADC.

关键词： Apparent diffusion coefficient Chronic hepatitis C Diffusion-weighted magnetic resonance imaging Liver fibrosis Liver stiffness Transient elastography

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Analysis of human B cell response to recombinant Leishmania LPG3

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Asian Pacific Journal of Tropical Medicine 2015年第8期8卷 615-619页

作者： mostafa Haji Fatahaliha Maryam Hosseini Sanaz Rasolzadeh Dariush Shane Bandi Behzad Baradaran Farhad Jadidi-Niaragh Mehdi yousefi Drug Applied Research Center Tabriz University of Medical Sciences Immunology Research Center Tabriz University of Medical Sciences Department of Immunology Faculty of MedicineTabriz University of Medical Sciences Department of Immunology School of Public HealthTehran University of Medical Sciences

Objective: To evaluate the capability of recombinant Leishmania LPG3 and its fragments in the activation of B cells. Methods: In the present study, human B cells were purified from peripheral blood of 10 adult healthy subjects using magnetic-activated cell sorting technique. Subsequently, purified B cells were treated with recombinant LPG3, and its N-terminal and C-terminal fragments at different concentrations(2, 10 and 20 μg/m L). B cell activation was assessed through expression of CD69 molecule by flowcytometry and secretion of IL-6, TNF-α and IL-10 cytokines via enzyme-linked immunosorbent assay following treatment with recombinant antigens. Results: Our results showed that while the recombinant LPG-3 could significantly increase the production of IL-6 and TNF-α(P<0.05) in B cells, it had no effect on the secretion of IL-10 by B cells. Conclusions: Our study indicated that recombinant LPG-3 and especially its N-terminal fragment could stimulate B cell response as an important immune response component against leishmaniasis. Thus, it seems that it can be considered as an effective adjuvant in vaccine developments against leishmaniasis.

关键词： Leishmania LPG3 Vaccine Cytokine B cell CD69

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Erratum to “Time-Series Embeddings from Language Models:A Tool for Wind Direction Nowcasting”

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Journal of Meteorological Research 2024年第4期38卷 844-844页

作者： Decio ALVES Fabio MENDONCA Sheikh Shanawaz mostafa Fernando MORGADO-DIAS University of Madeira Campus Universitario da Penteada 9020-105 FunchalPortugal Interactive Technologies Institute/Laboratory for Robotics and Engineering Systems and Agencia Regional para o Desenvolvimento da Investigaao Tecnologia e InovagaoEdif.Madeira TecnopoloCaminho da Penteada piso-29020-105 FunchalPortugal

The article “Time-series embeddings from language models: A tool for wind direction nowcasting”, written by Décio ALVES, Fábio MENDON?A, Sheikh Shanawaz mostafa, and Fernando MORGADO-DIAS was originally published ... 详细信息

关键词： Embedding electronic Time

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Intermittent fasting and the liver: Focus on the Ramadan model

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World Journal of Hepatology 2024年第8期16卷 1070-1083页

作者： Mohamed H Emara Hanan Soliman Ebada M Said Hassan Elbatae mostafa Elazab Shady Elhefnawy Tarik I Zaher Ahmed Abdel-Razik Mohamed Elnadry Department of Hepatology Gastroenterology and Infectious DiseasesKafrelsheikh UniversityKafr-Elshikh 33516Egypt Department of Medicine Alyousif HospitalAlkhobar 34622Saudi Arabia Department of Tropical Medicine and Infectious Diseases Tanta UniversityTanta 31512Egypt Department of Hepatology Gastroenterology and Infectious DiseasesBenha UniversityBenha 13511Egypt Department of Tropical Medicine Zagazig UniversityZagazig 44519Egypt Department of Tropical Medicine Mansoura UniversityMansoura 35516Egypt Department of Hepato-Gastroenterology and Infectious Diseases Al-Azhar UniversityCairo 11651Egypt

Intermittent fasting(IF)is an intervention that involves not only dietary modific-ations but also behavioral changes with the main core being a period of fasting alternating with a period of controlled *** duration of fasting differs from one regimen to *** fasting(RF)is a religious fasting for Muslims,it lasts for only one month every one lunar *** this model of fasting,observers abstain from food and water for a period that extends from dawn to *** period of daily fasting is variable(12-18 hours)as Ramadan rotates in all seasons of the ***,longer duration of daily fasting is observed during the *** fact,RF is a peculiar type of *** is a dry IF as no water is allowed during the fasting hours,also there are no calorie restrictions during feeding hours,and the mealtime is exclusively *** three variables of the RF model are believed to have a variable impact on different liver *** was evaluated by different observational and interventional studies among patients with non-alcoholic fatty liver disease and it was associated with improve-ments in anthropometric measures,metabolic profile,and liver biochemistry regardless of the calorie restriction among lean and obese *** situation is rather different for patients with liver *** was associated with adverse events among patients with liver cirrhosis irrespective of the underlying etiology of *** patients developed new ascites,ascites were increased,had higher serum bilirubin levels after Ramadan,and frequently developed hepatic encephalopathy and acute upper gastrointestinal *** complications were higher among patients with Child class B and C cirrhosis,and some fatalities occurred due to *** transplant recipients as a special group of patients,are vulnerable to dehydration,fluctuation in blood immunosuppressive levels,likelihood of deterioration and hence observing RF without special precautions

关键词： Intermittent fasting Ramadan fasting Non-alcoholic fatty liver disease Liver cirrhosis Peptic ulcer Liver transplantation Gilbert syndrome

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Catalytic behaviors of Co-Mn/TiO_2 catalysts for Fischer-Tropsch synthesis

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燃料化学学报 2012年第12期40卷 1435-1443页

作者： mostafa Feyzi Faculty of Chemistry Razi UniversityKermanshahIran

The 15%(Co-Mn)/TiO2,(Co/Mn=1/6) catalyst was prepared using fusion procedure and studied for the conversion of synthesis gas to C2 ～ 4 *** effects of calcination conditions and operation conditions such as the H 2 / CO molar feed ratio at different temperatures,gas hourly space velocity(GHSV) and total reaction pressure on the catalytic performance of catalyst were *** stability of the catalyst during 150 h at optimal operation conditions(t = 250℃ H2 /CO= 2/1,GHSV=1 500 h-1 and p =0.3 MPa) has been *** is found that this catalyst is high stable for production C2 ～ 4 *** of both precursors and calcined catalysts by powder X-ray diffraction,scanning electron microscopy(SEM),Brunauer-Emmett-Teller(BET) specific surface area measurement and thermal analysis methods such as thermal gravimetric analysis(TGA) and differential scanning calorimetry(DSC) show that the different preparation method influences the catalyst precursor structure and morphology.

关键词：气化理论燃料化学研究发展

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Cooperative distributed state estimation:resilient topologies against smart spoofers

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Control Theory and Technology 2022年第4期20卷 488-503页

作者： mostafa Safi Amirkabir University of Technology HafezTehran 424Iran

A network of observers is considered,where through asynchronous(with bounded delay)communications,they cooperatively estimate the states of a linear time-invariant(LTI)*** such a setting,a new type of adversary might affect the observation process by impersonating the identity of the regular node,which is a violation of communication *** adversaries also inherit the capabilities of Byzantine nodes,making them more powerful threats called smart *** show how asynchronous networks are vulnerable to smart spoofing *** the estimation scheme considered in this paper,information flows from the sets of source nodes,which can detect a portion of the state variables each,to the other follower *** regular nodes,to avoid being misguided by the threats,distributively filter the extreme values received from the nodes in their *** conditions based on strong robustness are proposed to guarantee the *** simulation scenarios are provided to verify the results.

关键词： Cyber-physical systems Smart spoofing Distributed resilient algorithm Secure observers

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