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Mobile blood collection sites and their roles in providing safe andadequate supply： A six-year experience

Frontiers in Biology 2018年第3期13卷 226-234页

作者： mostafa paridar Abbas Khosravi Mohammad-Ali Jalali-Far Sima Zolfaghari Omid Kiani Ghaleh Sardi Mehdi Sajadi Deputy of Management and Resources Development Ministry of Health and Medical Education Tehran Iran Transfusion Research Center High Institute for Research and Education in Transfusion Medicine Tehran Iran Department of Hematolog Iran University of Medical Sciences Tehranlran Faculty of Allied Medicine Bitjand University of Medical Sciences Birjand Iran

The determination of the role of mobile sites, as compared with fixed sites, in providing safe blood supply will help with the planning of future programs. This retrospective study was carried out at the Khuzestan Blood Transfusion Organization from 2007 to 2012. Samples of the blood collected at mobile sites and fixed sites were compared. Comparisons took into consideration noticeable trends as well as the prevalence of major TTIs including HIV, HBV and HCV. The total number of blood donations from 2007 to 2012 was 621117 out of which 89590 (14.43%) were collected from mobile sites. The overall blood donation index was estimated at 23.8 per 1000 population. The prevalence of HIV, HBV and HCV in mobile site donations was 5.31, 320.34 and 117.4, and in fixed sites was 5.31, 214.72 and 104.83 per 100000 donations respectively. HBV prevalence in mobile sites was significantly higher than in fixed sites (p = 0.014). The blood donation index in Khuzestan province is much better when compared with areas of similar socioeconomic status as well as neighboring countries. The allotment of blood units collected by mobile teams is lower than that of national reports. In addition, the prevalence of TTIs in mobile site blood donations was higher than at fixed sites.

关键词： fixed sites, mobile sites, blood donations, TTIs, Iran

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Widely distribution of hematological parameters in thalassemia patients with similar α-globin genotype

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Frontiers in Biology 2018年第6期13卷 469-474页

作者： Bijan Keikhaei Pejman Salehi-Fard mostafa paridar Mehraneh Karimzadeh Razie Dehghani Asma Zamiri Vahideh Takhviji Research Center for Thalassemia and Hemoglobinopathy Health InstituteAhvaz Jundishapur University of Medical SciencesAhvazIran Deputy of Management and Resources Development Ministry of Health and Medical EducationTehranIran School of Medicine Shahid Beheshti University of Medical SciencesTehranIran Pediatric Department Ahvaz Jundishapur University of Medical SciencesAhvazIran School of Medicine Gorgan University of Medical SciencesGorganIran Laboratory Hematology and BloodBanla'ng School of Allied Medical ScienceShahid Beheshti University of Medical ScienceTehranIran

Thalassemia is known as the commonest monogenic disorder with an imbalanced rate of globin chains production of adult hemoglobin. Despite the available information about the thalassemia etiology, its phenotype varies from each patient to another. This study aimed to evaluate the hematological parameters of patients with the same -α3.7 homozygote and heterozygote genotypes to amend screening programs. In this observational study, we evaluated 1301 thalassemia suspected patients who referred to the Thalassemia and Hemoglobinopathy Research Center of Ahvaz University of Medical Sciences, Khuzestan, Iran during 2014–2016. According to the genotyping studies, patients divided into 2 groups with -α3.7/αα (n = 646) and -α3.7/-α3.7 (n = 181) genotypes. Thereafter, distribution of hematological parameters evaluated in both groups. The mean age in heterozygous and homozygous groups was 25.7±4.5 and 26±4.4 years old, respectively. The degree of anemia was considerably varied in patients with the same genotype. MCV, RBC and MCH showed a wide distribution in patients. The findings presented here suggest that other molecular mechanisms along with α-globin gene mutations could be involved in determining the phenotypes of alpha thalassemia patients.

关键词： hematological parameters α-globin genotype alpha thalassemia

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Cytogenetic and molecular basis of BCR-ABL myelodysplastic syndrome: diagnosis and prognostic approach

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Journal of Cancer Metastasis and Treatment 2017年第1期3卷 38-44页

作者： mostafa paridar Omid Kiani Ghalesardi Mohammad Seghatoleslami Ahmad Ahmadzadeh Abbas Khosravi Najmaldin Saki Health Research Institute Thalassemia and Hemoglobinopathy Research CenterAhvaz Jundishapur University of Medical SciencesAhvaz 61357-15794Iran

Myelodysplastic syndromes(MDS)include a heterogeneous group of blood disorders generally afflicting older *** genetic factors have been reported from these patients that have an important role in the diagnosis,prognosis,and treatment of this ***-ABL1 is a genetic factor that has occasionally been reported in some *** review attempts to characterize MDS patients reported to harbor this fusion and to assess the diagnostic,therapeutic,and prognostic potential of BCR-ABL1 fusionin MDS *** review showed that BCR-ABL fusion has been reported in 22 MDS patients whose condition generally transformed to acute myeloblastic leukemia and was not responsive to conventional ***,these patients showed a good response to treatment with tyrosine kinase ***,even though incidence of BCR-ABL fusion appears to be low in MDS patients,its detection is essential in assessing disease prognosis and choosing appropriate treatment.

关键词： Myelodysplastic syndrome cytogenetics BCR-ABL

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